CHTF8

Functionⁱ

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.2 Publications

Caution

mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2.Curated

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: UniProtKB-KW
mitotic sister chromatid cohesion Source: InterPro
positive regulation of DNA-directed DNA polymerase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12930902

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Cell cycle, DNA replication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chromosome transmission fidelity protein 8 homolog Short name: hCTF8
Gene namesⁱ	Name:CHTF8 Synonyms:CTF8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168802.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24353 CHTF8
MIMⁱ	613202 gene
neXtProtⁱ	NX_P0CG13

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168802
PharmGKBⁱ	PA164717934

Polymorphism and mutation databases

BioMutaⁱ	HAS3
DMDMⁱ	298351632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000327253	1 – 121	Chromosome transmission fidelity protein 8 homologAdd BLAST		121

Proteomic databases

EPDⁱ	P0CG13
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P0CG13
PaxDbⁱ	P0CG13
PeptideAtlas More...PeptideAtlasⁱ	P0CG13
PRIDEⁱ	P0CG13
ProteomicsDBⁱ	52453

PTM databases

iPTMnetⁱ	P0CG13
PhosphoSitePlusⁱ	P0CG13

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168802 Expressed in 195 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P0CG13 baseline and differential
Genevisibleⁱ	P0CG13 HS

Interactionⁱ

Subunit structureⁱ

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.3 Publications

Protein-protein interaction databases

BioGridⁱ	120262, 20 interactors
CORUMⁱ	P0CG13
IntActⁱ	P0CG13, 1 interactor
STRINGⁱ	9606.ENSP00000381290

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0CG13
SMRⁱ	P0CG13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CTF8 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J3HT Eukaryota ENOG4111SBI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000025006
KEGG Orthology (KO) More...KOⁱ	K11270
TreeFamⁱ	TF314676

Family and domain databases

InterProⁱ	View protein in InterPro IPR018607 Ctf8
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09696 Ctf8, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P0CG13-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQIVISSAR AGGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP 
        60         70         80         90        100
VLIVGHHILY GKIIHLEKPF AVLVKHTPGD QDCDELGRET GTRYLVTALI 
       110        120 
KDKILFKTRP KPIITSVPKK V

Length:121

Mass (Da):13,314

Last modified:June 15, 2010 - v1

Checksum:ⁱ17F58496A479DA3F

GO

Isoform 2 (identifier: P0CG12-1) [UniParc]FASTA Add to basket

Also known as: DERPC

The sequence of this isoform can be found in the external entry P0CG12.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:524

Mass (Da):51,391

GO

Sequence cautionⁱ

The sequence AAQ08897 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

The sequence BAA91144 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

The sequence EAW83250 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525164 mRNA Translation: AAQ08897.1 Sequence problems. AK000407 mRNA Translation: BAA91144.1 Sequence problems. AC009027 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83250.1 Sequence problems. BC018700 mRNA Translation: AAH18700.4
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42185.1 [P0CG13-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001034779.1, NM_001039690.3 [P0CG13-1] NP_001035236.1, NM_001040146.3 [P0CG13-1] XP_011521469.1, XM_011523167.1 XP_011521470.1, XM_011523168.1 XP_016878859.1, XM_017023370.1
UniGeneⁱ	Hs.85962

Genome annotation databases

Ensemblⁱ	ENST00000398235; ENSP00000381290; ENSG00000168802 [P0CG13-1] ENST00000448552; ENSP00000408367; ENSG00000168802 [P0CG13-1]
GeneIDⁱ	54921
KEGGⁱ	hsa:54921
UCSC genome browser More...UCSCⁱ	uc002ewn.3 human [P0CG13-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0CG13	Chromosome transmission fidelity protein 8 homolog		BOVIN		121	UniRef90_P0CG13
Chromosome transmission fidelity protein 8 homolog		MOUSE		121
Chromosome transmission fidelity protein 8 homolog		RAT		121
CTF8, chromosome transmission fidelity factor 8-like protein (Fragment)		MUSPF		133
Uncharacterized protein		CAVPO		122
+79

Protein	Similar proteins		Species	Score	Length	Source
P0CG13	Chromosome transmission fidelity protein 8 homolog		MOUSE		121	UniRef50_P0CG13
Chromosome transmission fidelity protein 8 homolog		BOVIN		121
Chromosome transmission fidelity protein 8 homolog		RAT		121
CTF8, chromosome transmission fidelity factor 8-like protein (Fragment)		MUSPF		133
Uncharacterized protein		CAVPO		122
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF525164 mRNA Translation: AAQ08897.1 Sequence problems. AK000407 mRNA Translation: BAA91144.1 Sequence problems. AC009027 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83250.1 Sequence problems. BC018700 mRNA Translation: AAH18700.4
CCDSⁱ	CCDS42185.1 [P0CG13-1]
RefSeqⁱ	NP_001034779.1, NM_001039690.3 [P0CG13-1] NP_001035236.1, NM_001040146.3 [P0CG13-1] XP_011521469.1, XM_011523167.1 XP_011521470.1, XM_011523168.1 XP_016878859.1, XM_017023370.1
UniGeneⁱ	Hs.85962

3D structure databases

ProteinModelPortalⁱ	P0CG13
SMRⁱ	P0CG13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120262, 20 interactors
CORUMⁱ	P0CG13
IntActⁱ	P0CG13, 1 interactor
STRINGⁱ	9606.ENSP00000381290

PTM databases

iPTMnetⁱ	P0CG13
PhosphoSitePlusⁱ	P0CG13

Polymorphism and mutation databases

BioMutaⁱ	HAS3
DMDMⁱ	298351632

Proteomic databases

EPDⁱ	P0CG13
MaxQBⁱ	P0CG13
PaxDbⁱ	P0CG13
PeptideAtlasⁱ	P0CG13
PRIDEⁱ	P0CG13
ProteomicsDBⁱ	52453

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000398235; ENSP00000381290; ENSG00000168802 [P0CG13-1] ENST00000448552; ENSP00000408367; ENSG00000168802 [P0CG13-1]
GeneIDⁱ	54921
KEGGⁱ	hsa:54921
UCSCⁱ	uc002ewn.3 human [P0CG13-1]

Organism-specific databases

CTDⁱ	54921
EuPathDBⁱ	HostDB:ENSG00000168802.12
GeneCardsⁱ	CHTF8
HGNCⁱ	HGNC:24353 CHTF8
MIMⁱ	613202 gene
neXtProtⁱ	NX_P0CG13
OpenTargetsⁱ	ENSG00000168802
PharmGKBⁱ	PA164717934
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J3HT Eukaryota ENOG4111SBI LUCA
GeneTreeⁱ	ENSGT00400000025006
KOⁱ	K11270
TreeFamⁱ	TF314676

Miscellaneous databases

ChiTaRSⁱ	CHTF8 human
GeneWikiⁱ	CTF8
GenomeRNAiⁱ	54921
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168802 Expressed in 195 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasⁱ	P0CG13 baseline and differential
Genevisibleⁱ	P0CG13 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018607 Ctf8
Pfamⁱ	View protein in Pfam PF09696 Ctf8, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CTF8_HUMAN
Accessionⁱ	P0CG13Primary (citable) accession number: P0CG13 Secondary accession number(s): A8MYX8 , Q71E72, Q8NDH8, Q8WV66, Q9NX73
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
	Last sequence update:	June 15, 2010
	Last modified:	October 10, 2018
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0CG13 (CTF8_HUMAN)

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Chromosome transmission fidelity protein 8 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ