Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromosome transmission fidelity protein 8 homolog

Gene

CHTF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.2 Publications

Caution

mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog
Short name:
hCTF8
Gene namesi
Name:CHTF8
Synonyms:CTF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168802.12
HGNCiHGNC:24353 CHTF8
MIMi613202 gene
neXtProtiNX_P0CG13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168802
PharmGKBiPA164717934

Polymorphism and mutation databases

BioMutaiHAS3
DMDMi298351632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272531 – 121Chromosome transmission fidelity protein 8 homologAdd BLAST121

Proteomic databases

EPDiP0CG13
MaxQBiP0CG13
PaxDbiP0CG13
PeptideAtlasiP0CG13
PRIDEiP0CG13
ProteomicsDBi52453

PTM databases

iPTMnetiP0CG13
PhosphoSitePlusiP0CG13

Expressioni

Tissue specificityi

Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.1 Publication

Gene expression databases

BgeeiENSG00000168802
ExpressionAtlasiP0CG13 baseline and differential
GenevisibleiP0CG13 HS

Interactioni

Subunit structurei

Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.3 Publications

Protein-protein interaction databases

BioGridi120262, 19 interactors
CORUMiP0CG13
IntActiP0CG13, 1 interactor
STRINGi9606.ENSP00000381290

Structurei

3D structure databases

ProteinModelPortaliP0CG13
SMRiP0CG13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF8 family.Curated

Phylogenomic databases

eggNOGiENOG410J3HT Eukaryota
ENOG4111SBI LUCA
GeneTreeiENSGT00400000025006
KOiK11270
TreeFamiTF314676

Family and domain databases

InterProiView protein in InterPro
IPR018607 Ctf8
PfamiView protein in Pfam
PF09696 Ctf8, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0CG13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQIVISSAR AGGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP
60 70 80 90 100
VLIVGHHILY GKIIHLEKPF AVLVKHTPGD QDCDELGRET GTRYLVTALI
110 120
KDKILFKTRP KPIITSVPKK V
Length:121
Mass (Da):13,314
Last modified:June 15, 2010 - v1
Checksum:i17F58496A479DA3F
GO
Isoform 2 (identifier: P0CG12-1) [UniParc]FASTAAdd to basket
Also known as: DERPC
The sequence of this isoform can be found in the external entry P0CG12.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:524
Mass (Da):51,391
GO

Sequence cautioni

The sequence AAQ08897 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA91144 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW83250 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525164 mRNA Translation: AAQ08897.1 Sequence problems.
AK000407 mRNA Translation: BAA91144.1 Sequence problems.
AC009027 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83250.1 Sequence problems.
BC018700 mRNA Translation: AAH18700.4
CCDSiCCDS42185.1 [P0CG13-1]
RefSeqiNP_001034779.1, NM_001039690.3 [P0CG13-1]
NP_001035236.1, NM_001040146.3 [P0CG13-1]
XP_011521469.1, XM_011523167.1
XP_011521470.1, XM_011523168.1
XP_016878859.1, XM_017023370.1 [P0CG13-1]
UniGeneiHs.85962

Genome annotation databases

EnsembliENST00000398235; ENSP00000381290; ENSG00000168802 [P0CG13-1]
ENST00000448552; ENSP00000408367; ENSG00000168802 [P0CG13-1]
GeneIDi54921
KEGGihsa:54921
UCSCiuc002ewn.3 human [P0CG13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCTF8_HUMAN
AccessioniPrimary (citable) accession number: P0CG13
Secondary accession number(s): A8MYX8
, Q71E72, Q8NDH8, Q8WV66, Q9NX73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health