UniProtKB - P0CG13 (CTF8_HUMAN)
Protein
Chromosome transmission fidelity protein 8 homolog
Gene
CHTF8
Organism
Homo sapiens (Human)
Status
Functioni
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression.2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- DNA duplex unwinding Source: GOC
- DNA replication Source: UniProtKB-KW
- mitotic sister chromatid cohesion Source: InterPro
- positive regulation of DNA-directed DNA polymerase activity Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, DNA replication |
Enzyme and pathway databases
PathwayCommonsi | P0CG13 |
Reactomei | R-HSA-174411, Polymerase switching on the C-strand of the telomere |
Names & Taxonomyi
Protein namesi | Recommended name: Chromosome transmission fidelity protein 8 homologCuratedShort name: hCTF81 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168802.12 |
HGNCi | HGNC:24353, CHTF8 |
MIMi | 613202, gene |
neXtProti | NX_P0CG13 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Associates with chromatin during S phase.1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- Ctf18 RFC-like complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000168802 |
PharmGKBi | PA164717934 |
Miscellaneous databases
Pharosi | P0CG13, Tbio |
Polymorphism and mutation databases
BioMutai | CHTF8 |
DMDMi | 298351632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000327253 | 1 – 121 | Chromosome transmission fidelity protein 8 homologAdd BLAST | 121 |
Proteomic databases
EPDi | P0CG13 |
jPOSTi | P0CG13 |
MassIVEi | P0CG13 |
MaxQBi | P0CG13 |
PaxDbi | P0CG13 |
PeptideAtlasi | P0CG13 |
PRIDEi | P0CG13 |
PTM databases
iPTMneti | P0CG13 |
PhosphoSitePlusi | P0CG13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168802, Expressed in fallopian tube and 211 other tissues |
ExpressionAtlasi | P0CG13, baseline and differential |
Genevisiblei | P0CG13, HS |
Organism-specific databases
HPAi | ENSG00000168802, Low tissue specificity |
Interactioni
Subunit structurei
Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex does not interact with the Rad9/Rad1/Hus1 complex. The CTF18-RFC complex interacts with POLH. CTF18/CTF8/DCC1 associate with PCNA. CTF8 exists as a dimer with DCC1.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 120262, 21 interactors |
CORUMi | P0CG13 |
IntActi | P0CG13, 7 interactors |
STRINGi | 9606.ENSP00000408367 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CTF8 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S2DB, Eukaryota |
GeneTreei | ENSGT00400000025006 |
HOGENOMi | CLU_066293_3_0_1 |
OrthoDBi | 639828at2759 |
TreeFami | TF314676 |
Family and domain databases
InterProi | View protein in InterPro IPR018607, Ctf8 |
Pfami | View protein in Pfam PF09696, Ctf8, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P0CG13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQIVISSAR AGGLAEWVLM ELQGEIEARY STGLAGNLLG DLHYTTEGIP
60 70 80 90 100
VLIVGHHILY GKIIHLEKPF AVLVKHTPGD QDCDELGRET GTRYLVTALI
110 120
KDKILFKTRP KPIITSVPKK V
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSJ7 | J3KSJ7_HUMAN | Chromosome transmission fidelity pr... | CHTF8 | 65 | Annotation score: | ||
E5RGY5 | E5RGY5_HUMAN | Chromosome transmission fidelity pr... | CHTF8 | 58 | Annotation score: | ||
E5RHL4 | E5RHL4_HUMAN | Chromosome transmission fidelity pr... | CHTF8 | 75 | Annotation score: | ||
H3BQB7 | H3BQB7_HUMAN | Chromosome transmission fidelity pr... | CHTF8 | 99 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009027 Genomic DNA No translation available. BC018700 mRNA Translation: AAH18700.4 |
CCDSi | CCDS42185.1 |
RefSeqi | NP_001034779.1, NM_001039690.3 NP_001035236.1, NM_001040146.3 XP_016878859.1, XM_017023370.1 |
Genome annotation databases
Ensembli | ENST00000398235; ENSP00000381290; ENSG00000168802 ENST00000448552; ENSP00000408367; ENSG00000168802 |
GeneIDi | 54921 |
KEGGi | hsa:54921 |
UCSCi | uc002ewn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009027 Genomic DNA No translation available. BC018700 mRNA Translation: AAH18700.4 |
CCDSi | CCDS42185.1 |
RefSeqi | NP_001034779.1, NM_001039690.3 NP_001035236.1, NM_001040146.3 XP_016878859.1, XM_017023370.1 |
3D structure databases
SMRi | P0CG13 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120262, 21 interactors |
CORUMi | P0CG13 |
IntActi | P0CG13, 7 interactors |
STRINGi | 9606.ENSP00000408367 |
PTM databases
iPTMneti | P0CG13 |
PhosphoSitePlusi | P0CG13 |
Polymorphism and mutation databases
BioMutai | CHTF8 |
DMDMi | 298351632 |
Proteomic databases
EPDi | P0CG13 |
jPOSTi | P0CG13 |
MassIVEi | P0CG13 |
MaxQBi | P0CG13 |
PaxDbi | P0CG13 |
PeptideAtlasi | P0CG13 |
PRIDEi | P0CG13 |
Protocols and materials databases
Antibodypediai | 66354, 15 antibodies |
Genome annotation databases
Ensembli | ENST00000398235; ENSP00000381290; ENSG00000168802 ENST00000448552; ENSP00000408367; ENSG00000168802 |
GeneIDi | 54921 |
KEGGi | hsa:54921 |
UCSCi | uc002ewn.3, human |
Organism-specific databases
CTDi | 54921 |
EuPathDBi | HostDB:ENSG00000168802.12 |
GeneCardsi | CHTF8 |
HGNCi | HGNC:24353, CHTF8 |
HPAi | ENSG00000168802, Low tissue specificity |
MIMi | 613202, gene |
neXtProti | NX_P0CG13 |
OpenTargetsi | ENSG00000168802 |
PharmGKBi | PA164717934 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2DB, Eukaryota |
GeneTreei | ENSGT00400000025006 |
HOGENOMi | CLU_066293_3_0_1 |
OrthoDBi | 639828at2759 |
TreeFami | TF314676 |
Enzyme and pathway databases
PathwayCommonsi | P0CG13 |
Reactomei | R-HSA-174411, Polymerase switching on the C-strand of the telomere |
Miscellaneous databases
BioGRID-ORCSi | 54921, 336 hits in 851 CRISPR screens |
ChiTaRSi | CHTF8, human |
GeneWikii | CTF8 |
GenomeRNAii | 54921 |
Pharosi | P0CG13, Tbio |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168802, Expressed in fallopian tube and 211 other tissues |
ExpressionAtlasi | P0CG13, baseline and differential |
Genevisiblei | P0CG13, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018607, Ctf8 |
Pfami | View protein in Pfam PF09696, Ctf8, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTF8_HUMAN | |
Accessioni | P0CG13Primary (citable) accession number: P0CG13 Secondary accession number(s): A8MYX8 Q9NX73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | June 15, 2010 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM