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Protein

Chromosome transmission fidelity protein 8 homolog isoform 2

Gene

CHTF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.1 Publication

Miscellaneous

Found in a common chromosomal region of deletion in breast cancer.

Caution

mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2
Alternative name(s):
Decreased expression in renal and prostate cancer protein
Gene namesi
Name:CHTF8
Synonyms:DERPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168802.12
HGNCiHGNC:24353 CHTF8
MIMi613202 gene
neXtProtiNX_P0CG12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168802

Polymorphism and mutation databases

DMDMi298351628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003263961 – 524Chromosome transmission fidelity protein 8 homolog isoform 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei302PhosphoserineCombined sources1
Modified residuei364Asymmetric dimethylarginineBy similarity1
Modified residuei387Omega-N-methylarginineBy similarity1
Modified residuei423PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP0CG12
PaxDbiP0CG12
PeptideAtlasiP0CG12
PRIDEiP0CG12
ProteomicsDBi52452

PTM databases

iPTMnetiP0CG12
PhosphoSitePlusiP0CG12

Expressioni

Tissue specificityi

Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.2 Publications

Gene expression databases

BgeeiENSG00000168802 Expressed in 195 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP0CG12 baseline and differential
GenevisibleiP0CG12 HS

Organism-specific databases

HPAiHPA051872
HPA065522

Interactioni

Protein-protein interaction databases

IntActiP0CG12, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliP0CG12
SMRiP0CG12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 524Pro-richAdd BLAST521
Compositional biasi101 – 328Gly-richAdd BLAST228

Sequence similaritiesi

Belongs to the DERPC family.Curated

Phylogenomic databases

eggNOGiENOG410IVFI Eukaryota
ENOG410ZRNR LUCA
GeneTreeiENSGT00400000025006
HOGENOMiHOG000243059
InParanoidiP0CG12
OMAiPTIFPRA
OrthoDBiEOG091G076T
PhylomeDBiP0CG12

Family and domain databases

InterProiView protein in InterPro
IPR018607 Ctf8
PANTHERiPTHR28605 PTHR28605, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P0CG12-1) [UniParc]FASTAAdd to basket
Also known as: DERPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP
60 70 80 90 100
FLMAAGSLGG NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR
110 120 130 140 150
GMNPTGTGAV SFPRPGGLLG PGPGPGPTLN PRTGALPGPG PLSNPRLGGL
160 170 180 190 200
PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG SGPNLRAGVL LTSGNGPPNP
210 220 230 240 250
RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP SGLGPGPNLD
260 270 280 290 300
ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG
310 320 330 340 350
TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR
360 370 380 390 400
PVGPMGVNAN PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP
410 420 430 440 450
RASGPLGPNP ANFPRATGLQ GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG
460 470 480 490 500
PSPAGPVGIN PAPFTRPTGT LGLNPASFPR MNGPAGKSFV PFPRVGSLPG
510 520
TNPAAFPRPG GPMAAMYPNG MLPP
Length:524
Mass (Da):51,391
Last modified:June 15, 2010 - v1
Checksum:iC917FEEC7BC3702E
GO
Isoform 1 (identifier: P0CG13-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CG13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:121
Mass (Da):13,314
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPP1H3BPP1_HUMAN
Chromosome transmission fidelity pr...
CHTF8
104Annotation score:
H0YAV5H0YAV5_HUMAN
Chromosome transmission fidelity pr...
CHTF8
144Annotation score:
J3KSJ7J3KSJ7_HUMAN
Chromosome transmission fidelity pr...
CHTF8
65Annotation score:
H3BQB7H3BQB7_HUMAN
Chromosome transmission fidelity pr...
CHTF8
99Annotation score:
E5RGY5E5RGY5_HUMAN
Chromosome transmission fidelity pr...
CHTF8
58Annotation score:
E5RHL4E5RHL4_HUMAN
Chromosome transmission fidelity pr...
CHTF8
75Annotation score:
E5RGL1E5RGL1_HUMAN
Chromosome transmission fidelity pr...
CHTF8
12Annotation score:

Sequence cautioni

The sequence CAD38758 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833902 mRNA Translation: CAD38758.1 Different initiation.
AC009027 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83250.1
RefSeqiXP_011521469.1, XM_011523167.1 [P0CG12-1]
XP_011521470.1, XM_011523168.1 [P0CG12-1]
UniGeneiHs.85962

Genome annotation databases

EnsembliENST00000306585; ENSP00000305687; ENSG00000168802 [P0CG12-1]
GeneIDi54921
UCSCiuc059wiz.1 human [P0CG12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833902 mRNA Translation: CAD38758.1 Different initiation.
AC009027 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83250.1
RefSeqiXP_011521469.1, XM_011523167.1 [P0CG12-1]
XP_011521470.1, XM_011523168.1 [P0CG12-1]
UniGeneiHs.85962

3D structure databases

ProteinModelPortaliP0CG12
SMRiP0CG12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CG12, 3 interactors

PTM databases

iPTMnetiP0CG12
PhosphoSitePlusiP0CG12

Polymorphism and mutation databases

DMDMi298351628

Proteomic databases

EPDiP0CG12
PaxDbiP0CG12
PeptideAtlasiP0CG12
PRIDEiP0CG12
ProteomicsDBi52452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306585; ENSP00000305687; ENSG00000168802 [P0CG12-1]
GeneIDi54921
UCSCiuc059wiz.1 human [P0CG12-1]

Organism-specific databases

CTDi54921
EuPathDBiHostDB:ENSG00000168802.12
GeneCardsiCHTF8
H-InvDBiHIX0013181
HGNCiHGNC:24353 CHTF8
HPAiHPA051872
HPA065522
MIMi613202 gene
neXtProtiNX_P0CG12
OpenTargetsiENSG00000168802
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVFI Eukaryota
ENOG410ZRNR LUCA
GeneTreeiENSGT00400000025006
HOGENOMiHOG000243059
InParanoidiP0CG12
OMAiPTIFPRA
OrthoDBiEOG091G076T
PhylomeDBiP0CG12

Miscellaneous databases

ChiTaRSiCHTF8 human
GenomeRNAii54921
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168802 Expressed in 195 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiP0CG12 baseline and differential
GenevisibleiP0CG12 HS

Family and domain databases

InterProiView protein in InterPro
IPR018607 Ctf8
PANTHERiPTHR28605 PTHR28605, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTF8A_HUMAN
AccessioniPrimary (citable) accession number: P0CG12
Secondary accession number(s): A8MYX8
, Q71E72, Q8NDH8, Q8WV66, Q9NX73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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