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Protein

Golgi pH regulator B

Gene

GPR89B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity1 Publication

Miscellaneous

Does not seem to be able to bind GTP.

GO - Molecular functioni

  • voltage-gated anion channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator B
Alternative name(s):
Protein GPR89B
Gene namesi
Name:GPR89B
Synonyms:GPHRB, GPR89C
ORF Names:HSPC201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188092.14
HGNCiHGNC:13840 GPR89B
MIMi612806 gene
neXtProtiNX_P0CG08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986137
PA143485481

Polymorphism and mutation databases

DMDMi298351693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003950061 – 455Golgi pH regulator BAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP0CG08
PeptideAtlasiP0CG08
PRIDEiP0CG08
ProteomicsDBi1413
52451

PTM databases

iPTMnetiP0CG08
PhosphoSitePlusiP0CG08
SwissPalmiP0CG08

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000188092 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP0CG08 baseline and differential
GenevisibleiP0CG08 HS

Organism-specific databases

HPAiHPA076096

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi119554, 21 interactors
575849, 55 interactors

Structurei

3D structure databases

ProteinModelPortaliP0CG08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2417 Eukaryota
ENOG410XQ8R LUCA
GeneTreeiENSGT00390000000684
HOGENOMiHOG000240999
HOVERGENiHBG054909
InParanoidiP0CG08
KOiK22193
OrthoDBiEOG091G06HP
PhylomeDBiP0CG08
TreeFamiTF313484

Family and domain databases

InterProiView protein in InterPro
IPR025969 ABA_GPCR_dom
IPR022535 Golgi_pH-regulator_cons_dom
IPR015672 GPHR/GTG
PANTHERiPTHR15948 PTHR15948, 1 hit
PfamiView protein in Pfam
PF12430 ABA_GPCR, 1 hit
PF12537 GPHR_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P0CG08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KQMAP
Length:455
Mass (Da):52,917
Last modified:June 15, 2010 - v1
Checksum:iD831F66E682643F9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPV2U3KPV2_HUMAN
Golgi pH regulator B
GPR89B
216Annotation score:
A0A087WW82A0A087WW82_HUMAN
Golgi pH regulator B
GPR89B
128Annotation score:
A0A087WW78A0A087WW78_HUMAN
Golgi pH regulator B
GPR89B
93Annotation score:

Sequence cautioni

The sequence AAF36121 differs from that shown. Reason: Erroneous termination at position 297. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244 – 247LTLI → NTMA in CAH56393 (PubMed:17974005).Curated4
Sequence conflicti251V → E in AAF36121 (PubMed:11042152).Curated1
Sequence conflicti418Q → R in AAF36121 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA Translation: AAF21463.1
AL356004 Genomic DNA Translation: CAI17085.1
AL445591, BX537254 Genomic DNA Translation: CAH72386.1
BX537254, AL445591 Genomic DNA Translation: CAI18821.1
AL133020 mRNA Translation: CAH56393.1
AF151035 mRNA Translation: AAF36121.1 Sequence problems.
CCDSiCCDS930.1
RefSeqiNP_001091081.1, NM_001097612.1
NP_057418.1, NM_016334.3
XP_005277458.1, XM_005277401.3
XP_006711555.1, XM_006711492.3
XP_011507915.1, XM_011509613.2
XP_011508212.1, XM_011509910.2
UniGeneiHs.504320
Hs.559115
Hs.645432

Genome annotation databases

EnsembliENST00000314163; ENSP00000358233; ENSG00000188092
GeneIDi51463
653519
KEGGihsa:51463
hsa:653519

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA Translation: AAF21463.1
AL356004 Genomic DNA Translation: CAI17085.1
AL445591, BX537254 Genomic DNA Translation: CAH72386.1
BX537254, AL445591 Genomic DNA Translation: CAI18821.1
AL133020 mRNA Translation: CAH56393.1
AF151035 mRNA Translation: AAF36121.1 Sequence problems.
CCDSiCCDS930.1
RefSeqiNP_001091081.1, NM_001097612.1
NP_057418.1, NM_016334.3
XP_005277458.1, XM_005277401.3
XP_006711555.1, XM_006711492.3
XP_011507915.1, XM_011509613.2
XP_011508212.1, XM_011509910.2
UniGeneiHs.504320
Hs.559115
Hs.645432

3D structure databases

ProteinModelPortaliP0CG08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119554, 21 interactors
575849, 55 interactors

PTM databases

iPTMnetiP0CG08
PhosphoSitePlusiP0CG08
SwissPalmiP0CG08

Polymorphism and mutation databases

DMDMi298351693

Proteomic databases

EPDiP0CG08
PeptideAtlasiP0CG08
PRIDEiP0CG08
ProteomicsDBi1413
52451

Protocols and materials databases

DNASUi51463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314163; ENSP00000358233; ENSG00000188092
GeneIDi51463
653519
KEGGihsa:51463
hsa:653519

Organism-specific databases

CTDi51463
653519
EuPathDBiHostDB:ENSG00000188092.14
GeneCardsiGPR89B
H-InvDBiHIX0000982
HIX0056760
HIX0159660
HGNCiHGNC:13840 GPR89B
HPAiHPA076096
MIMi612806 gene
neXtProtiNX_P0CG08
PharmGKBiPA134986137
PA143485481
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2417 Eukaryota
ENOG410XQ8R LUCA
GeneTreeiENSGT00390000000684
HOGENOMiHOG000240999
HOVERGENiHBG054909
InParanoidiP0CG08
KOiK22193
OrthoDBiEOG091G06HP
PhylomeDBiP0CG08
TreeFamiTF313484

Miscellaneous databases

ChiTaRSiGPR89B human
PROiPR:P0CG08
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188092 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP0CG08 baseline and differential
GenevisibleiP0CG08 HS

Family and domain databases

InterProiView protein in InterPro
IPR025969 ABA_GPCR_dom
IPR022535 Golgi_pH-regulator_cons_dom
IPR015672 GPHR/GTG
PANTHERiPTHR15948 PTHR15948, 1 hit
PfamiView protein in Pfam
PF12430 ABA_GPCR, 1 hit
PF12537 GPHR_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPHRB_HUMAN
AccessioniPrimary (citable) accession number: P0CG08
Secondary accession number(s): A6NKF9
, A6NN37, B2RUV3, B3KMN3, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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