UniProtKB - P0CG08 (GPHRB_HUMAN)

BLAST

>sp|P0CG08|GPHRB_HUMAN Golgi pH regulator B OS=Homo sapiens OX=9606 GN=GPR89B PE=1 SV=1
MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIF
EILGVLNSSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTF
MYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRN
VTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASG
SENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWK
IFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLL
ITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFN
FYHRWFDVIFLVSALSSILFLYLAHKQAPEKQMAP

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History
Entry version 62 (12 Sep 2018)
Sequence version 1 (15 Jun 2010)
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Protein

Golgi pH regulator B

Gene

GPR89B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity1 Publication

Miscellaneous

Does not seem to be able to bind GTP.

GO - Molecular functionⁱ

voltage-gated anion channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular pH reduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein transport Source: UniProtKB-KW
regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Voltage-gated channel
Biological process	Ion transport, Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Golgi pH regulator B Alternative name(s): Protein GPR89B
Gene namesⁱ	Name:GPR89B Synonyms:GPHRB, GPR89C ORF Names:HSPC201
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188092.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13840 GPR89B
MIMⁱ	612806 gene
neXtProtⁱ	NX_P0CG08

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	5 – 25	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	46 – 66	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	79 – 99	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	114 – 134	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	150 – 170	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	290 – 310	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	343 – 363	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	378 – 398	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	425 – 445	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA134986137 PA143485481

PharmGKBⁱ

PA134986137
PA143485481

Polymorphism and mutation databases

DMDMⁱ	298351693

DMDMⁱ

298351693

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000395006	1 – 455	Golgi pH regulator BAdd BLAST		455

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	243	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P0CG08
PeptideAtlas More...PeptideAtlasⁱ	P0CG08
PRIDEⁱ	P0CG08
ProteomicsDBⁱ	1413 52451

PTM databases

iPTMnetⁱ	P0CG08
PhosphoSitePlusⁱ	P0CG08
SwissPalmⁱ	P0CG08

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000188092 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	P0CG08 baseline and differential
Genevisibleⁱ	P0CG08 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA076096

HPAⁱ

HPA076096

Interactionⁱ

Subunit structureⁱ

Homotrimer.By similarity

Protein-protein interaction databases

BioGridⁱ	119554, 21 interactors 575849, 55 interactors

BioGridⁱ

119554, 21 interactors
575849, 55 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0CG08
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Golgi pH regulator (TC 1.A.38) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2417 Eukaryota ENOG410XQ8R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000684
HOGENOMⁱ	HOG000240999
HOVERGENⁱ	HBG054909
InParanoidⁱ	P0CG08
KEGG Orthology (KO) More...KOⁱ	K22193
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06HP
PhylomeDBⁱ	P0CG08
TreeFamⁱ	TF313484

Family and domain databases

InterProⁱ	View protein in InterPro IPR025969 ABA_GPCR_dom IPR022535 Golgi_pH-regulator_cons_dom IPR015672 GPHR/GTG
PANTHERⁱ	PTHR15948 PTHR15948, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12430 ABA_GPCR, 1 hit PF12537 GPHR_N, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P0CG08-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF 
        60         70         80         90        100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS 
       110        120        130        140        150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV 
       160        170        180        190        200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI 
       210        220        230        240        250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE 
       260        270        280        290        300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 
       310        320        330        340        350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI 
       360        370        380        390        400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM 
       410        420        430        440        450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE 

KQMAP

Length:455

Mass (Da):52,917

Last modified:June 15, 2010 - v1

Checksum:ⁱD831F66E682643F9

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

U3KPV2	U3KPV2_HUMAN	Golgi pH regulator B Golgi pH regulator B	GPR89B	216	Annotation score:
A0A087WW82	A0A087WW82_HUMAN	Golgi pH regulator B Golgi pH regulator B	GPR89B	128	Annotation score:
A0A087WW78	A0A087WW78_HUMAN	Golgi pH regulator B Golgi pH regulator B	GPR89B	93	Annotation score:

Sequence cautionⁱ

The sequence AAF36121 differs from that shown. Reason: Erroneous termination at position 297. Translated as Cys.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	244 – 247	LTLI → NTMA in CAH56393 (PubMed:17974005).Curated	4
Sequence conflictⁱ	251	V → E in AAF36121 (PubMed:11042152).Curated	1
Sequence conflictⁱ	418	Q → R in AAF36121 (PubMed:11042152).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78723 mRNA Translation: AAF21463.1 AL356004 Genomic DNA Translation: CAI17085.1 AL445591, BX537254 Genomic DNA Translation: CAH72386.1 BX537254, AL445591 Genomic DNA Translation: CAI18821.1 AL133020 mRNA Translation: CAH56393.1 AF151035 mRNA Translation: AAF36121.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS930.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001091081.1, NM_001097612.1 NP_057418.1, NM_016334.3 XP_005277458.1, XM_005277401.3 XP_006711555.1, XM_006711492.3 XP_011507915.1, XM_011509613.2 XP_011508212.1, XM_011509910.2
UniGeneⁱ	Hs.504320 Hs.559115 Hs.645432

Genome annotation databases

Ensemblⁱ	ENST00000314163; ENSP00000358233; ENSG00000188092
GeneIDⁱ	51463 653519
KEGGⁱ	hsa:51463 hsa:653519

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0CG08	Golgi pH regulator A		HUMAN		455	UniRef100_B7ZAQ6
G protein-coupled receptor 89A		PANTR		455
Uncharacterized protein		PANPA		433
G protein-coupled receptor 89A isoform C (Fragment)		HUMAN		455
Uncharacterized protein		PANPA		430
+2

Protein	Similar proteins		Species	Score	Length	Source
P0CG08	Golgi pH regulator A		HUMAN		455	UniRef90_B7ZAQ6
Golgi pH regulator		XENLA		455
Golgi pH regulator		SALSA		455
Golgi pH regulator		MOUSE		455
Golgi pH regulator		CRIGR		455
+369

Protein	Similar proteins		Species	Score	Length	Source
P0CG08	Golgi pH regulator A		HUMAN		455	UniRef50_B7ZAQ6
Golgi pH regulator		CRIGR		455
Golgi pH regulator		CHICK		455
Golgi pH regulator		XENLA		455
Golgi pH regulator		SALSA		455
+627

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U78723 mRNA Translation: AAF21463.1 AL356004 Genomic DNA Translation: CAI17085.1 AL445591, BX537254 Genomic DNA Translation: CAH72386.1 BX537254, AL445591 Genomic DNA Translation: CAI18821.1 AL133020 mRNA Translation: CAH56393.1 AF151035 mRNA Translation: AAF36121.1 Sequence problems.
CCDSⁱ	CCDS930.1
RefSeqⁱ	NP_001091081.1, NM_001097612.1 NP_057418.1, NM_016334.3 XP_005277458.1, XM_005277401.3 XP_006711555.1, XM_006711492.3 XP_011507915.1, XM_011509613.2 XP_011508212.1, XM_011509910.2
UniGeneⁱ	Hs.504320 Hs.559115 Hs.645432

3D structure databases

ProteinModelPortalⁱ	P0CG08
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119554, 21 interactors 575849, 55 interactors

BioGridⁱ

119554, 21 interactors
575849, 55 interactors

PTM databases

iPTMnetⁱ	P0CG08
PhosphoSitePlusⁱ	P0CG08
SwissPalmⁱ	P0CG08

Polymorphism and mutation databases

DMDMⁱ	298351693

DMDMⁱ

298351693

Proteomic databases

EPDⁱ	P0CG08
PeptideAtlasⁱ	P0CG08
PRIDEⁱ	P0CG08
ProteomicsDBⁱ	1413 52451

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51463
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314163; ENSP00000358233; ENSG00000188092
GeneIDⁱ	51463 653519
KEGGⁱ	hsa:51463 hsa:653519

Organism-specific databases

CTDⁱ	51463 653519
EuPathDBⁱ	HostDB:ENSG00000188092.14
GeneCardsⁱ	GPR89B
H-InvDBⁱ	HIX0000982 HIX0056760 HIX0159660
HGNCⁱ	HGNC:13840 GPR89B
HPAⁱ	HPA076096
MIMⁱ	612806 gene
neXtProtⁱ	NX_P0CG08
PharmGKBⁱ	PA134986137 PA143485481
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2417 Eukaryota ENOG410XQ8R LUCA
GeneTreeⁱ	ENSGT00390000000684
HOGENOMⁱ	HOG000240999
HOVERGENⁱ	HBG054909
InParanoidⁱ	P0CG08
KOⁱ	K22193
OrthoDBⁱ	EOG091G06HP
PhylomeDBⁱ	P0CG08
TreeFamⁱ	TF313484

Miscellaneous databases

ChiTaRSⁱ	GPR89B human
Protein Ontology More...PROⁱ	PR:P0CG08
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000188092 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	P0CG08 baseline and differential
Genevisibleⁱ	P0CG08 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025969 ABA_GPCR_dom IPR022535 Golgi_pH-regulator_cons_dom IPR015672 GPHR/GTG
PANTHERⁱ	PTHR15948 PTHR15948, 1 hit
Pfamⁱ	View protein in Pfam PF12430 ABA_GPCR, 1 hit PF12537 GPHR_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPHRB_HUMAN
Accessionⁱ	P0CG08Primary (citable) accession number: P0CG08 Secondary accession number(s): A6NKF9 Q9Y302
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
	Last sequence update:	June 15, 2010
	Last modified:	September 12, 2018
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0CG08 (GPHRB_HUMAN)

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Golgi pH regulator B

GPR89B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ