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UniProtKB - P0CF97 (F200B_HUMAN)

Entry version 55 (13 Feb 2019)
Sequence version 1 (18 May 2010)
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Protein

Protein FAM200B

Gene

FAM200B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM200BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM200BImported
Synonyms:C4orf53Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000237765.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:27740 FAM200B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P0CF97

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000237765

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165664101

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM200B

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439620

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003942621 – 657Protein FAM200BAdd BLAST657

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0CF97

PRoteomics IDEntifications database

More...PRIDEi		P0CF97

ProteomicsDB human proteome resource

More...ProteomicsDBi		52445

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0CF97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0CF97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000237765 Expressed in 201 organ(s), highest expression level in metanephros

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P0CF97 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P0CF97 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017855

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130142, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P0CF97

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0CF97

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 24Poly-Ser4
Compositional biasi54 – 57Poly-Lys4
Compositional biasi600 – 603Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM200 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JB8D Eukaryota
ENOG41115J8 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164387

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000253000

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0CF97

Identification of Orthologs from Complete Genome Data

More...OMAi		CNNILAN

Database of Orthologous Groups

More...OrthoDBi		875619at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0CF97

TreeFam database of animal gene trees

More...TreeFami		TF328297

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel

The PANTHER Classification System

More...PANTHERi		PTHR11697 PTHR11697, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0CF97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHFFIKRKR NSEVKYTEAC SSSSVESGIV NSDNIEKNTD SNLQTSTSFE 
        60         70         80         90        100
PHFKKKKVSA RRYNEDYLKY GFIKCEKPFE NDRPQCVICN NILANESLKP 
       110        120        130        140        150
SKLKRHLETQ HAELIDKPLE YFQRKKKDIK LSTQFLSCST AVSEKALLSS 
       160        170        180        190        200
YLVAYRVAKE KIANTAAEKI ILPACLDMVR TIFDDKSADK LKTIPNDNTV 
       210        220        230        240        250
SLRICTIAEH LETMLITRLQ SGIDFAIQLD ESTDIGSCTT LLVYVRYAWQ 
       260        270        280        290        300
DDFLEDFLCF LNLTSHLSGL DIFTELERRI VGQYKLNWKN CKGITSDGTA 
       310        320        330        340        350
TMTGKHSRVI KKLLEVTNNG AVWNHCFIHR EGLASREIPQ NLMEVLKNAV 
       360        370        380        390        400
KVVNFIKGSS LNSRLLETFC SEIGTNHTHL LYHTKIRWLS QGKILSRVYE 
       410        420        430        440        450
LRNEIHFFLI EKKSHLASIF EDDTWVTKLA YLTDIFSILN ELSLKLQGKN 
       460        470        480        490        500
SDVFQHVERI QGFRKTLLLW QVRLKSNRPS YYMFPRFLQH IEENIINENI 
       510        520        530        540        550
LKEIKLEILL HLTSLSQTFN HFFPEEKFET LRENSWVKDP FAFRHPESII 
       560        570        580        590        600
ELNLVPEEEN ELLQLSSSYT LKNDYETLSL SAFWMKVKED FPLLSRKSVL 
       610        620        630        640        650
LLLPFTTTSL CELGFSILTQ LKTKERNGLN CAAVMRVALS SCVPDWNELM 

NRQAHPS
Length:657
Mass (Da):76,034
Last modified:May 18, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCAD05E23FEFD376
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAC6D6RAC6_HUMAN
Protein FAM200B
FAM200B
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC114744 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47028.1

NCBI Reference Sequences

More...RefSeqi		NP_001138663.1, NM_001145191.1
XP_016863537.1, XM_017008048.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.399980
Hs.619367
Hs.731718

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000422728; ENSP00000393017; ENSG00000237765
ENST00000622362; ENSP00000483930; ENSG00000237765

Database of genes from NCBI RefSeq genomes

More...GeneIDi		285550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:285550

UCSC genome browser

More...UCSCi		uc003gof.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114744 Genomic DNA No translation available.
CCDSiCCDS47028.1
RefSeqiNP_001138663.1, NM_001145191.1
XP_016863537.1, XM_017008048.1
UniGeneiHs.399980
Hs.619367
Hs.731718

3D structure databases

ProteinModelPortaliP0CF97
SMRiP0CF97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130142, 2 interactors

PTM databases

iPTMnetiP0CF97
PhosphoSitePlusiP0CF97

Polymorphism and mutation databases

BioMutaiFAM200B
DMDMi296439620

Proteomic databases

PaxDbiP0CF97
PRIDEiP0CF97
ProteomicsDBi52445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422728; ENSP00000393017; ENSG00000237765
ENST00000622362; ENSP00000483930; ENSG00000237765
GeneIDi285550
KEGGihsa:285550
UCSCiuc003gof.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		285550
EuPathDBiHostDB:ENSG00000237765.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM200B
HGNCiHGNC:27740 FAM200B
HPAiHPA017855
neXtProtiNX_P0CF97
OpenTargetsiENSG00000237765
PharmGKBiPA165664101

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JB8D Eukaryota
ENOG41115J8 LUCA
GeneTreeiENSGT00940000164387
HOGENOMiHOG000253000
InParanoidiP0CF97
OMAiCNNILAN
OrthoDBi875619at2759
PhylomeDBiP0CF97
TreeFamiTF328297

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM200B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		285550

Protein Ontology

More...PROi		PR:P0CF97

Gene expression databases

BgeeiENSG00000237765 Expressed in 201 organ(s), highest expression level in metanephros
ExpressionAtlasiP0CF97 baseline and differential
GenevisibleiP0CF97 HS

Family and domain databases

InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel
PANTHERiPTHR11697 PTHR11697, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF200B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CF97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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