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Protein

Endogenous Bornavirus-like nucleoprotein 1

Gene

EBLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).By similarity

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 1
Alternative name(s):
Endogenous Borna-like N element-1
Short name:
EBLN-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EBLN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000223601.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:39430 EBLN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613249 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0CF75

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000223601

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EBLN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296537812

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003939111 – 366Endogenous Bornavirus-like nucleoprotein 1Add BLAST366

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0CF75

PRoteomics IDEntifications database

More...
PRIDEi
P0CF75

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52444

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CF75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0CF75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression detected by RT-PCR in a few cell lines, including OL, HEK293T and MOLT-4. Not observed in HeLa cells (PubMed:20054395).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000223601 Expressed in 10 organ(s), highest expression level in right testis

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0CF75

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0CF75

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00490000044176

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CF75

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANYWAKR

Database of Orthologous Groups

More...
OrthoDBi
684241at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06407 BDV_P40, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101399 SSF101399, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CF75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI
60 70 80 90 100
GDVKVIEKAT KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK
110 120 130 140 150
RSNIVIGNEN KETGTLYASK FEDVLPTFTA LEMSSILRHC CDLIGIAAGS
160 170 180 190 200
SDPICTNSLQ VQRQFKAMMI SIGRPLHSES ADLLISYNAG PAIDWINSRP
210 220 230 240 250
WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV RMFLDQCVDG
260 270 280 290 300
STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN
310 320 330 340 350
LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD
360
PYTLNILRGY GISGFE
Length:366
Mass (Da):40,313
Last modified:March 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA7E68FDB877E53A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149G → R in EAW86159 (Ref. 2) Curated1
Sequence conflicti235M → T in EAW86159 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL157831 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86159.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS60498.1

NCBI Reference Sequences

More...
RefSeqi
NP_001186867.1, NM_001199938.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.450519

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000422359; ENSP00000473842; ENSG00000223601

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340900

UCSC genome browser

More...
UCSCi
uc021pob.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157831 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86159.1
CCDSiCCDS60498.1
RefSeqiNP_001186867.1, NM_001199938.1
UniGeneiHs.450519

3D structure databases

ProteinModelPortaliP0CF75
SMRiP0CF75
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0CF75
PhosphoSitePlusiP0CF75

Polymorphism and mutation databases

BioMutaiEBLN1
DMDMi296537812

Proteomic databases

EPDiP0CF75
PRIDEiP0CF75
ProteomicsDBi52444

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422359; ENSP00000473842; ENSG00000223601
GeneIDi340900
KEGGihsa:340900
UCSCiuc021pob.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340900
EuPathDBiHostDB:ENSG00000223601.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EBLN1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0169315
HGNCiHGNC:39430 EBLN1
MIMi613249 gene
neXtProtiNX_P0CF75
OpenTargetsiENSG00000223601

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00490000044176
InParanoidiP0CF75
OMAiANYWAKR
OrthoDBi684241at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340900

Protein Ontology

More...
PROi
PR:P0CF75

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000223601 Expressed in 10 organ(s), highest expression level in right testis

Family and domain databases

Gene3Di1.10.3040.10, 1 hit
InterProiView protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir
PfamiView protein in Pfam
PF06407 BDV_P40, 1 hit
SUPFAMiSSF101399 SSF101399, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEBLN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CF75
Secondary accession number(s): S4R316
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 19, 2014
Last modified: January 16, 2019
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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