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Protein

Endogenous Bornavirus-like nucleoprotein 1

Gene

EBLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).By similarity

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 1
Alternative name(s):
Endogenous Borna-like N element-1
Short name:
EBLN-1
Gene namesi
Name:EBLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000223601.2
HGNCiHGNC:39430 EBLN1
MIMi613249 gene
neXtProtiNX_P0CF75

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000223601

Polymorphism and mutation databases

DMDMi296537812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939111 – 366Endogenous Bornavirus-like nucleoprotein 1Add BLAST366

Proteomic databases

EPDiP0CF75
PRIDEiP0CF75
ProteomicsDBi52444

PTM databases

iPTMnetiP0CF75
PhosphoSitePlusiP0CF75

Expressioni

Tissue specificityi

Expression detected by RT-PCR in a few cell lines, including OL, HEK293T and MOLT-4. Not observed in HeLa cells (PubMed:20054395).1 Publication

Gene expression databases

BgeeiENSG00000223601 Expressed in 10 organ(s), highest expression level in right testis

Structurei

3D structure databases

ProteinModelPortaliP0CF75
SMRiP0CF75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00490000044176
InParanoidiP0CF75
OMAiANYWAKR
OrthoDBiEOG091G08P6

Family and domain databases

Gene3Di1.10.3040.10, 1 hit
InterProiView protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir
PfamiView protein in Pfam
PF06407 BDV_P40, 1 hit
SUPFAMiSSF101399 SSF101399, 1 hit

Sequencei

Sequence statusi: Complete.

P0CF75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI
60 70 80 90 100
GDVKVIEKAT KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK
110 120 130 140 150
RSNIVIGNEN KETGTLYASK FEDVLPTFTA LEMSSILRHC CDLIGIAAGS
160 170 180 190 200
SDPICTNSLQ VQRQFKAMMI SIGRPLHSES ADLLISYNAG PAIDWINSRP
210 220 230 240 250
WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV RMFLDQCVDG
260 270 280 290 300
STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN
310 320 330 340 350
LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD
360
PYTLNILRGY GISGFE
Length:366
Mass (Da):40,313
Last modified:March 19, 2014 - v2
Checksum:iDA7E68FDB877E53A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149G → R in EAW86159 (Ref. 2) Curated1
Sequence conflicti235M → T in EAW86159 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157831 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86159.1
CCDSiCCDS60498.1
RefSeqiNP_001186867.1, NM_001199938.1
UniGeneiHs.450519

Genome annotation databases

EnsembliENST00000422359; ENSP00000473842; ENSG00000223601
GeneIDi340900
KEGGihsa:340900
UCSCiuc021pob.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157831 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86159.1
CCDSiCCDS60498.1
RefSeqiNP_001186867.1, NM_001199938.1
UniGeneiHs.450519

3D structure databases

ProteinModelPortaliP0CF75
SMRiP0CF75
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0CF75
PhosphoSitePlusiP0CF75

Polymorphism and mutation databases

DMDMi296537812

Proteomic databases

EPDiP0CF75
PRIDEiP0CF75
ProteomicsDBi52444

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422359; ENSP00000473842; ENSG00000223601
GeneIDi340900
KEGGihsa:340900
UCSCiuc021pob.2 human

Organism-specific databases

CTDi340900
EuPathDBiHostDB:ENSG00000223601.2
GeneCardsiEBLN1
H-InvDBiHIX0169315
HGNCiHGNC:39430 EBLN1
MIMi613249 gene
neXtProtiNX_P0CF75
OpenTargetsiENSG00000223601
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00490000044176
InParanoidiP0CF75
OMAiANYWAKR
OrthoDBiEOG091G08P6

Miscellaneous databases

GenomeRNAii340900
PROiPR:P0CF75
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000223601 Expressed in 10 organ(s), highest expression level in right testis

Family and domain databases

Gene3Di1.10.3040.10, 1 hit
InterProiView protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir
PfamiView protein in Pfam
PF06407 BDV_P40, 1 hit
SUPFAMiSSF101399 SSF101399, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEBLN1_HUMAN
AccessioniPrimary (citable) accession number: P0CF75
Secondary accession number(s): S4R316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 19, 2014
Last modified: September 12, 2018
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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