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Protein

Bactridin-1

Gene
N/A
Organism
Tityus discrepans (Venezuelan scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows antibacterial activity against both Gram-positive bacteria (B.subtilis, M.luteus, E.faecalis) and Gram-negative bacteria (P.aeruginosa, Y.enterocolitica, A.calcoaceticus). Modifies membrane sodium permeability on Y.enterocolitica. Is toxic to cockroaches and crabs, but is not to mice. Does not induce haemolysis in human erythrocytes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Bactridin-1
Short name:
Bact1
Short name:
Bactridine 1
Alternative name(s):
P-Arthr-Antm-beta* NaTx2.6
OrganismiTityus discrepans (Venezuelan scorpion)
Taxonomic identifieri57059 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934441 – 61Bactridin-1Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 61PROSITE-ProRule annotation
Disulfide bondi15 ↔ 37PROSITE-ProRule annotation
Disulfide bondi23 ↔ 42PROSITE-ProRule annotation
Disulfide bondi27 ↔ 44PROSITE-ProRule annotation
Modified residuei61Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0CF39
SMRiP0CF39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

P0CF39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KDGYIIEHRG CKYSCFFGTN SWCNTECTLK KGSSGYCAWP ACWCYGLPDN
60
VKIFDSNNLK C
Length:61
Mass (Da):6,928
Last modified:April 20, 2010 - v1
Checksum:i673E48C4E8387FB7
GO

Mass spectrometryi

Molecular mass is 6916 Da from positions 1 - 61. Determined by ESI. Monoisotopic.1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0CF39
SMRiP0CF39
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMP1_TITDI
AccessioniPrimary (citable) accession number: P0CF39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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