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UniProtKB - P0CF08 (INSA2_ECOLI)

Entry version 71 (25 May 2022)
Sequence version 1 (20 Apr 2010)
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Protein

Insertion element IS1 2 protein InsA

Gene

insA2

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Absolutely required for transposition of IS1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • transposition, DNA-mediated Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA recombination, Transposition

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G6139-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insertion element IS1 2 protein InsA
Alternative name(s):
IS1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:insA2
Ordered Locus Names:b0265, JW0257
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003161581 – 91Insertion element IS1 2 protein InsAAdd BLAST91

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P0CF08

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		511145.b0265

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P0CF08

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IS1 elements InsA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3677, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_076276_6_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0CF08

Identification of Orthologs from Complete Genome Data

More...OMAi		IIDMAMD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0CF08

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024431, InsA_HTH_dom
IPR003220, InsA_N_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12759, HTH_Tnp_IS1, 1 hit
PF03811, Zn_Tnp_IS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CF08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVSISCPS CSATDGVVRN GKSTAGHQRY LCSHCRKTWQ LQFTYTASQP 
        60         70         80         90 
GTHQKIIDMA MNGVGCRATA RIMGVGLNTI FRHLKNSGRS R
Length:91
Mass (Da):9,902
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8249502B66B91FC5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L20943 Unassigned DNA Translation: AAA69642.1
X17345 Genomic DNA Translation: CAA35227.1
U70214 Genomic DNA Translation: AAB08685.1
U00096 Genomic DNA Translation: AAC73368.1
AP009048 Genomic DNA Translation: BAE76051.1

Protein sequence database of the Protein Information Resource

More...PIRi		B93826, IEECB9
JN0134

NCBI Reference Sequences

More...RefSeqi		NP_414799.1, NC_000913.3
NP_414809.1, NC_000913.3
NP_862965.1, NC_004998.1
NP_863031.1, NC_004998.1
NP_957637.1, NC_005327.1
YP_001096420.1, NC_009133.1
YP_001096518.1, NC_009133.1
YP_001816581.1, NC_010558.1
YP_001816635.1, NC_010558.1
YP_002527566.1, NC_011964.1
YP_003108318.1, NC_013122.1
YP_006953891.1, NC_019090.1
YP_006954228.1, NC_019095.1
YP_006990704.1, NC_019424.1
YP_007447506.1, NC_020278.2
YP_009071497.1, NC_025183.1
YP_588445.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73368; AAC73368; b0265
BAE76051; BAE76051; BAE76051

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1450250
944946
944951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0257
eco:b0265
eco:b0275
eco:b4516

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20943 Unassigned DNA Translation: AAA69642.1
X17345 Genomic DNA Translation: CAA35227.1
U70214 Genomic DNA Translation: AAB08685.1
U00096 Genomic DNA Translation: AAC73368.1
AP009048 Genomic DNA Translation: BAE76051.1
PIRiB93826, IEECB9
JN0134
RefSeqiNP_414799.1, NC_000913.3
NP_414809.1, NC_000913.3
NP_862965.1, NC_004998.1
NP_863031.1, NC_004998.1
NP_957637.1, NC_005327.1
YP_001096420.1, NC_009133.1
YP_001096518.1, NC_009133.1
YP_001816581.1, NC_010558.1
YP_001816635.1, NC_010558.1
YP_002527566.1, NC_011964.1
YP_003108318.1, NC_013122.1
YP_006953891.1, NC_019090.1
YP_006954228.1, NC_019095.1
YP_006990704.1, NC_019424.1
YP_007447506.1, NC_020278.2
YP_009071497.1, NC_025183.1
YP_588445.1, NC_000913.3

3D structure databases

AlphaFoldDBiP0CF08
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi511145.b0265

Proteomic databases

PaxDbiP0CF08

Genome annotation databases

EnsemblBacteriaiAAC73368; AAC73368; b0265
BAE76051; BAE76051; BAE76051
GeneIDi1450250
944946
944951
KEGGiecj:JW0257
eco:b0265
eco:b0275
eco:b4516

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB4706

Phylogenomic databases

eggNOGiCOG3677, Bacteria
HOGENOMiCLU_076276_6_3_6
InParanoidiP0CF08
OMAiIIDMAMD
PhylomeDBiP0CF08

Enzyme and pathway databases

BioCyciEcoCyc:G6139-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P0CF08

Family and domain databases

InterProiView protein in InterPro
IPR024431, InsA_HTH_dom
IPR003220, InsA_N_dom
PfamiView protein in Pfam
PF12759, HTH_Tnp_IS1, 1 hit
PF03811, Zn_Tnp_IS1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINSA2_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CF08
Secondary accession number(s): P03827
, P0ADH0, P0C651, Q2EER2, Q2MCF5, Q2MCH2, Q933I5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 25, 2022
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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