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Protein

Putative oncomodulin-2

Gene

OCM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi58Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi91Calcium 1By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi95Calcium 2By similarity1
Metal bindingi97Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi102Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1022PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oncomodulin-2
Gene namesi
Name:OCM2
Synonyms:OCMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000135175.5
HGNCiHGNC:34396 OCM2
neXtProtiNX_P0CE71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135175
PharmGKBiPA164724233

Polymorphism and mutation databases

BioMutaiOCM2
DMDMi292630842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003926431 – 109Putative oncomodulin-2Add BLAST109

Proteomic databases

PaxDbiP0CE71
PeptideAtlasiP0CE71
PRIDEiP0CE71
ProteomicsDBi52440

PTM databases

iPTMnetiP0CE71
PhosphoSitePlusiP0CE71

Expressioni

Gene expression databases

BgeeiENSG00000135175 Expressed in 15 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiP0CE71 HS

Organism-specific databases

HPAiHPA046422

Interactioni

Protein-protein interaction databases

BioGridi111005, 3 interactors
IntActiP0CE71, 3 interactors
STRINGi9606.ENSP00000257627

Structurei

3D structure databases

ProteinModelPortaliP0CE71
SMRiP0CE71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
InParanoidiP0CE71
OMAiQVKDIFR
OrthoDBiEOG091G0XK0
PhylomeDBiP0CE71
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

P0CE71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSITDVLSAD DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDVFRF
60 70 80 90 100
IDNDQSGYLD EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA

EEFQEMVHS
Length:109
Mass (Da):12,129
Last modified:March 23, 2010 - v1
Checksum:i5C7A0D3D25634A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004967 Genomic DNA Translation: AAQ96880.1
CCDSiCCDS5653.1
RefSeqiNP_006179.2, NM_006188.3
UniGeneiHs.510456

Genome annotation databases

EnsembliENST00000257627; ENSP00000257627; ENSG00000135175
GeneIDi4951
KEGGihsa:4951
UCSCiuc003upc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004967 Genomic DNA Translation: AAQ96880.1
CCDSiCCDS5653.1
RefSeqiNP_006179.2, NM_006188.3
UniGeneiHs.510456

3D structure databases

ProteinModelPortaliP0CE71
SMRiP0CE71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111005, 3 interactors
IntActiP0CE71, 3 interactors
STRINGi9606.ENSP00000257627

PTM databases

iPTMnetiP0CE71
PhosphoSitePlusiP0CE71

Polymorphism and mutation databases

BioMutaiOCM2
DMDMi292630842

Proteomic databases

PaxDbiP0CE71
PeptideAtlasiP0CE71
PRIDEiP0CE71
ProteomicsDBi52440

Protocols and materials databases

DNASUi4951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257627; ENSP00000257627; ENSG00000135175
GeneIDi4951
KEGGihsa:4951
UCSCiuc003upc.4 human

Organism-specific databases

CTDi4951
EuPathDBiHostDB:ENSG00000135175.5
GeneCardsiOCM2
HGNCiHGNC:34396 OCM2
HPAiHPA046422
neXtProtiNX_P0CE71
OpenTargetsiENSG00000135175
PharmGKBiPA164724233
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
InParanoidiP0CE71
OMAiQVKDIFR
OrthoDBiEOG091G0XK0
PhylomeDBiP0CE71
TreeFamiTF332342

Miscellaneous databases

GeneWikiiLOC4951
GenomeRNAii4951

Gene expression databases

BgeeiENSG00000135175 Expressed in 15 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiP0CE71 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOCM2_HUMAN
AccessioniPrimary (citable) accession number: P0CE71
Secondary accession number(s): P32930, Q6ISI5, Q75MW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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