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Entry version 63 (23 Feb 2022)
Sequence version 1 (23 Mar 2010)
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Protein

ABC transporter NFT1

Gene

NFT1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi686 – 693ATPPROSITE-ProRule annotation8
Nucleotide bindingi1319 – 1326ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter NFT1
Alternative name(s):
New full-length MRP-type transporter 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4932 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YKR103W
FungiDB:YKR104W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 50HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini51 – 103CytoplasmicSequence analysisAdd BLAST53
Transmembranei104 – 124HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini125 – 130ExtracellularSequence analysis6
Transmembranei131 – 151HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini152 – 169CytoplasmicSequence analysisAdd BLAST18
Transmembranei170 – 190HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini191 – 201ExtracellularSequence analysisAdd BLAST11
Transmembranei202 – 222HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini223 – 302CytoplasmicSequence analysisAdd BLAST80
Transmembranei303 – 323HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini324 – 351ExtracellularSequence analysisAdd BLAST28
Transmembranei352 – 374HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini375 – 449CytoplasmicSequence analysisAdd BLAST75
Transmembranei450 – 470HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini471 – 481ExtracellularSequence analysisAdd BLAST11
Transmembranei482 – 504HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini505 – 558CytoplasmicSequence analysisAdd BLAST54
Transmembranei559 – 579HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini580 – 584ExtracellularSequence analysis5
Transmembranei585 – 605HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini606 – 953CytoplasmicSequence analysisAdd BLAST348
Transmembranei954 – 974HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini975 – 1013ExtracellularSequence analysisAdd BLAST39
Transmembranei1014 – 1034HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1035 – 1082CytoplasmicSequence analysisAdd BLAST48
Transmembranei1083 – 1105HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini1106 – 1109ExtracellularSequence analysis4
Transmembranei1110 – 1132HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini1133 – 1199CytoplasmicSequence analysisAdd BLAST67
Transmembranei1200 – 1220HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1221 – 1222ExtracellularSequence analysis2
Transmembranei1223 – 1243HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1244 – 1558CytoplasmicSequence analysisAdd BLAST315

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003926141 – 1558ABC transporter NFT1Add BLAST1558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P0CE70, 3 interactors

Molecular INTeraction database

More...
MINTi
P0CE70

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CE70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini311 – 621ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST311
Domaini651 – 892ABC transporter 1PROSITE-ProRule annotationAdd BLAST242
Domaini961 – 1251ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST291
Domaini1285 – 1538ABC transporter 2PROSITE-ProRule annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni410 – 434DisorderedSequence analysisAdd BLAST25
Regioni892 – 926DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi420 – 434Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CE70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKNGTCPYW ERDDLSECAR REYIEFKFPL FILLTGMIYA FCKVFRAFYL
60 70 80 90 100
RGKNHTNEAP EFEEQGNGNH EYARFSVLRL KSAWESRSFC NVNNRSTFDK
110 120 130 140 150
FKKFIEGAFI VLQLTIHLYI LSSMPMDNKK FFHQGFLVQM FLWILLLVVI
160 170 180 190 200
TLRLISASQS FRWVLACKRD LWAVSFYSYA SLFTLSILPL RSVFIGKIKD
210 220 230 240 250
KIMVKYIISE TFIDLALLLL LSTSSIEGTR YSFLVENENK KLPPAPTVFG
260 270 280 290 300
LLTFSRIDRL IWKAYKHCLG NADIWDLDIN NKSIAILANF EMSSKKGRLL
310 320 330 340 350
PNIICYFKAV FISQLFLAFV SSFLNFVPSL LMPRILSYVN DPKSKSWNLV
360 370 380 390 400
SLYVSSMLVS KIIATTCRGQ GLFLGEKGTM QLRTVLISNI YSKTLRRTIL
410 420 430 440 450
KDSTTSLQKN ASTSFEENPD SSEAEPRKKS SRKDNSVNNV MSIDAFKVSE
460 470 480 490 500
AMNTFYLACE AVFMTVTALM ILYSLLGWSA FAGTFALLAM IPLNFWCATF
510 520 530 540 550
YGNYQADQLI LTDKRTSGIS EALNSIRVIK LLAWENLFYQ KIINVRDGEI
560 570 580 590 600
RLLKKKATIF FLNHLIWFFG PTLVSAITFS VFIKFQNQTL TPTIAFTALS
610 620 630 640 650
LFAILRTPMD QIASTVSLLI QSFISLERIQ DYLNESETRK YEILEQSNTK
660 670 680 690 700
FGFEDASMEW EAAETSFKLK NISIDFKLNS LNAIIGPTGS GKSSLLLGLL
710 720 730 740 750
GELNLLSGKI YVPTVESRDD LEIGKDGMTN SMAYCSQTPW LISGTIKDNV
760 770 780 790 800
VFGEIFNKQK FDDVMKSCCL DKDIKAMTAG IRTDVGDGGF SLSGGQQQRI
810 820 830 840 850
ALARAIYSSS RYLILDDCLS AVDPETALYI YEECLCGPMM KGRTCIITSH
860 870 880 890 900
NISLVTKRAD WLVILDRGEV KSQGKPSDLI KSNEFLRESI NNDSKNTTHN
910 920 930 940 950
QIDLKRSTTS KKTKNGDPEG GNSQDEVCAE VENFEETKME GSVKFSAYKW
960 970 980 990 1000
LADYFGGLGV VFVFTSSSIL IHGITLSQGF WLRYWLDTGS SGSKSTWLYR
1010 1020 1030 1040 1050
IVEGHSNIYF LLTYIIIGLV SSFLTSGKVW IAIISGTNVT KKIFAKLLSS
1060 1070 1080 1090 1100
ILYAKLRFHN VTPTGRIMNR FSKDMDIIDQ QLIPNFEGLS YSVVVCLWII
1110 1120 1130 1140 1150
LLIGYVTPQF LLFAIPLCAL YYTVCTLYLR ASRELKRIDN INISPIHQLF
1160 1170 1180 1190 1200
AEAIKGVTTI RALADERRFI TQSLVAIDRS NAPFFYLNMA TEWITYRVDI
1210 1220 1230 1240 1250
IGTLVLFSSS VMIIMKASYL DAGLAGILLS NAFSFTETAQ WIIKVFSSVE
1260 1270 1280 1290 1300
LLMSSVERIK EYTDIPSESN GYISPPANWP QTGDVELKNL SLRYSPHSSK
1310 1320 1330 1340 1350
ALDNVSFKVK AGTKVGIVGR TGAGKSSIIA AIYRLSDWEN GTITIDNKDI
1360 1370 1380 1390 1400
KHIPLERLRN SISCIPQDPT LFDGTVRSNL DPFDRYSDVQ IYGVLSKVGL
1410 1420 1430 1440 1450
IEECDELCLI FEQEQPNFSS HKLRNRFIDL NTVVKSGGSN LSQGQRQLLC
1460 1470 1480 1490 1500
LARSMLGARN IMLIDEATAS IDYISDAKIQ KTIRETMKNT TILTIAHRLR
1510 1520 1530 1540 1550
SVIDYDKILV MEMGRVKEYD HPYTLISDRN TIFYRLCRQS GEFENLFELA

KVSFDNKR
Length:1,558
Mass (Da):176,331
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9F596EF39996A47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY230264 Genomic DNA Translation: AAO73540.1
AY230265 Genomic DNA Translation: AAO73541.1
AY230266 Genomic DNA Translation: AAO73542.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY230264 Genomic DNA Translation: AAO73540.1
AY230265 Genomic DNA Translation: AAO73541.1
AY230266 Genomic DNA Translation: AAO73542.1

3D structure databases

SMRiP0CE70
ModBaseiSearch...

Protein-protein interaction databases

IntActiP0CE70, 3 interactors
MINTiP0CE70

Organism-specific databases

VEuPathDBiFungiDB:YKR103W
FungiDB:YKR104W

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like_ATP-bd
IPR017871, ABC_transporter-like_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFT1_YEASX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CE70
Secondary accession number(s): P36028
, P36171, Q53ZY4, Q6Q5L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: February 23, 2022
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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