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Entry version 40 (02 Jun 2021)
Sequence version 1 (23 Mar 2010)
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Protein

Glucuronide carrier protein

Gene

uidB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by UidC (GusC, AC Q47706).

Miscellaneous

In some K12 strains, the protein is inactive for transport, probably due to a mutation at position 100.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Symport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.2.3.1, the glycoside-pentoside-hexuronide (gph):cation symporter family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucuronide carrier protein
Alternative name(s):
Glucuronide permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uidB
Synonyms:gusB, uidP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 79CytoplasmicSequence analysisAdd BLAST19
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 108PeriplasmicSequence analysis8
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 180PeriplasmicSequence analysisAdd BLAST13
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 228CytoplasmicSequence analysisAdd BLAST27
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 263PeriplasmicSequence analysisAdd BLAST14
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 296CytoplasmicSequence analysisAdd BLAST12
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Topological domaini317 – 320PeriplasmicSequence analysis4
Transmembranei321 – 343HelicalSequence analysisAdd BLAST23
Topological domaini344 – 372CytoplasmicSequence analysisAdd BLAST29
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 408PeriplasmicSequence analysisAdd BLAST15
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 457CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003922051 – 457Glucuronide carrier proteinAdd BLAST457

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0CE45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In the presence of glucuronides.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CE45

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11328, PTHR11328, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00792, gph, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CE45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQQLSWRTI VGYSLGDVAN NFAFAMGALF LLSYYTDVAG VGAAAAGTML
60 70 80 90 100
LLVRVFDAFA DVFAGRVVDS VNTRWGKFRP FLLFGTAPLM IFSVLVFWVP
110 120 130 140 150
TDWSHGSKVV YAYLTYMGLG LCYSLVNIPY GSLATAMTQQ PQSRARLGAA
160 170 180 190 200
RGIAASLTFV CLAFLIGPSI KNSSPEEMVS VYHFWTIVLA IAGMVLYFIC
210 220 230 240 250
FKSTRENVVR IVAQPSLNIS LQTLKRNRPL FMLCIGALCV LISTFAVSAS
260 270 280 290 300
SLFYVRYVLN DTGLFTVLVL VQNLVGTVAS APLVPGMVAR IGKKNTFLIG
310 320 330 340 350
ALLGTCGYLL FFWVSVWSLP VALVALAIAS IGQGVTMTVM WALEADTVEY
360 370 380 390 400
GEYLTGVRIE GLTYSLFSFT RKCGQAIGGS IPAFILGLSG YIANQVQTPE
410 420 430 440 450
VIMGIRTSIA LVPCGFMLLA FVIIWFYPLT DKKFKEIVVE IDNRKKVQQQ

LISDITN
Length:457
Mass (Da):49,892
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC47CCB538AC088C1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14641 Genomic DNA Translation: AAA68924.1

NCBI Reference Sequences

More...
RefSeqi
WP_001075863.1, NZ_SSZK01000001.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA Translation: AAA68924.1
RefSeqiWP_001075863.1, NZ_SSZK01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.2.3.1, the glycoside-pentoside-hexuronide (gph):cation symporter family

Proteomic databases

PRIDEiP0CE45

Phylogenomic databases

PhylomeDBiP0CE45

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P0CE45

Family and domain databases

InterProiView protein in InterPro
IPR039672, MFS_2
IPR036259, MFS_trans_sf
IPR001927, Na/Gal_symport
IPR018043, Na/Gal_symport_CS
PANTHERiPTHR11328, PTHR11328, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00792, gph, 1 hit
PROSITEiView protein in PROSITE
PS00872, NA_GALACTOSIDE_SYMP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUIDB2_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CE45
Secondary accession number(s): P30868, P77457
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: June 2, 2021
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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