Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate kinase

Gene

pyk

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33SubstrateBy similarity1
Metal bindingi35PotassiumBy similarity1
Metal bindingi37PotassiumBy similarity1
Metal bindingi67PotassiumBy similarity1
Metal bindingi68Potassium; via carbonyl oxygenBy similarity1
Sitei219Transition state stabilizerBy similarity1
Metal bindingi221MagnesiumBy similarity1
Binding sitei244Substrate; via amide nitrogenBy similarity1
Metal bindingi245MagnesiumBy similarity1
Binding sitei245Substrate; via amide nitrogenBy similarity1
Binding sitei277SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-351-MONOMER
UniPathwayi
UPA00109;UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Synonyms:pykF
Ordered Locus Names:CT_332
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001120631 – 485Pyruvate kinaseAdd BLAST485

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0CE21
SMRiP0CE21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CA9 Bacteria
COG0469 LUCA
InParanoidiP0CE21
KOiK00873
OMAiKHEAIEQ

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit

Sequencei

Sequence statusi: Complete.

P0CE21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI
60 70 80 90 100
LKELREKRQV PLAIMLDTKG PEIRLGQVES PIKVQPGDRL TLVSKEILGS
110 120 130 140 150
KESGVTLYPS CVFPYVRERA PVLIDDGYIQ AVVVNAQEHM VEIEFQNSGE
160 170 180 190 200
IKSNKSLSIK DIDVALPFMT EKDIADLKFG VEQELDLIAA SFVRCNEDID
210 220 230 240 250
SMRKVLESFG RPNMPIIAKI ENHLGVQNFQ EIARAADGIM IARGDLGIEL
260 270 280 290 300
SIVEVPGLQK FMARASRETG RFCITATQML ESMIRNPLPT RAEVSDVANA
310 320 330 340 350
IYDGTSAVML SGETALGAHP VHAVKTMRSI IQETEKTFDY HAFFQLNDKN
360 370 380 390 400
SALKVSPYLE AIGFSGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI
410 420 430 440 450
IAVTPNRNVY YRLAVEWGVY PMLTLESNRT VWRHQACVYG VEKGILSNYD
460 470 480
KILVFSRGAG MQDTNNLTLT TVHDVLSPSL DEIVP
Length:485
Mass (Da):53,685
Last modified:March 2, 2010 - v1
Checksum:i0C638F0605326C55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67927.1
PIRiG71527
RefSeqiNP_219839.1, NC_000117.1
WP_009872569.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67927; AAC67927; CT_332
GeneIDi35551681
884787
KEGGictr:CT_332
PATRICifig|272561.5.peg.358

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67927.1
PIRiG71527
RefSeqiNP_219839.1, NC_000117.1
WP_009872569.1, NC_000117.1

3D structure databases

ProteinModelPortaliP0CE21
SMRiP0CE21
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67927; AAC67927; CT_332
GeneIDi35551681
884787
KEGGictr:CT_332
PATRICifig|272561.5.peg.358

Phylogenomic databases

eggNOGiENOG4105CA9 Bacteria
COG0469 LUCA
InParanoidiP0CE21
KOiK00873
OMAiKHEAIEQ

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

BioCyciCTRA272561:G1G18-351-MONOMER

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKPYK_CHLTR
AccessioniPrimary (citable) accession number: P0CE21
Secondary accession number(s): O84336, P94685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again