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UniProtKB - P0CD98 (YLL53_YEAST)
Protein
Putative uncharacterized protein YLL053C
Gene
YLL053C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Caution
Could be the product of a pseudogene. This is the C-terminal part of aquaporin-2. In strain S288c and many laboratory strains, a natural 11 bp deletion in position 109 leads to a frameshift, which disrupts the gene coding for this protein and produces two ORFs YLL052C and YLL053C. A contiguous sequence for aquaporin-2 can be found in strain Sigma 1278B (AC P0CD89).Curated
GO - Molecular functioni
- water channel activity Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Putative uncharacterized protein YLL053C |
Gene namesi | Ordered Locus Names:YLL053C ORF Names:L0587 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003976, YLL053C |
VEuPathDBi | FungiDB:YLL053C |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 6 – 26 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 27 – 38 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 65 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 110 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 152 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000391656 | 1 – 152 | Putative uncharacterized protein YLL053CAdd BLAST | 152 |
Proteomic databases
PaxDbi | P0CD98 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 31262, 98 interactors |
STRINGi | 4932.YLL053C |
Miscellaneous databases
RNActi | P0CD98, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 92 – 94 | NPA | 3 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0223, Eukaryota |
GeneTreei | ENSGT00940000176123 |
HOGENOMi | CLU_127260_0_0_1 |
InParanoidi | P0CD98 |
OMAi | HWIYWIS |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR034294, Aquaporin_transptr IPR000425, MIP |
PANTHERi | PTHR19139, PTHR19139, 1 hit |
Pfami | View protein in Pfam PF00230, MIP, 1 hit |
PRINTSi | PR00783, MINTRINSICP |
SUPFAMi | SSF81338, SSF81338, 1 hit |
i Sequence
Sequence statusi: Complete.
P0CD98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWFPQIIAGM AAGGAASAMT PGKVLFTNAL GLGCSRSRGL FLEMFGTAVL
60 70 80 90 100
CLTVLMTAVE KRETNFMAAL PIGISLFMAH MALTGYTGTG VNPARSLGAA
110 120 130 140 150
VAARYFPHYH WIYWISPLLG AFLAWSVWQL LQILDYTTYV NAEKAAGQKK
ED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73158 Genomic DNA Translation: CAA97505.1 Z47973 Genomic DNA Translation: CAA88004.1 BK006945 Genomic DNA Translation: DAA09271.1 |
PIRi | S50967 |
RefSeqi | NP_013047.1, NM_001181873.1 |
Genome annotation databases
EnsemblFungii | YLL053C_mRNA; YLL053C; YLL053C |
GeneIDi | 850673 |
KEGGi | sce:YLL053C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73158 Genomic DNA Translation: CAA97505.1 Z47973 Genomic DNA Translation: CAA88004.1 BK006945 Genomic DNA Translation: DAA09271.1 |
PIRi | S50967 |
RefSeqi | NP_013047.1, NM_001181873.1 |
3D structure databases
SMRi | P0CD98 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31262, 98 interactors |
STRINGi | 4932.YLL053C |
Proteomic databases
PaxDbi | P0CD98 |
Genome annotation databases
EnsemblFungii | YLL053C_mRNA; YLL053C; YLL053C |
GeneIDi | 850673 |
KEGGi | sce:YLL053C |
Organism-specific databases
SGDi | S000003976, YLL053C |
VEuPathDBi | FungiDB:YLL053C |
Phylogenomic databases
eggNOGi | KOG0223, Eukaryota |
GeneTreei | ENSGT00940000176123 |
HOGENOMi | CLU_127260_0_0_1 |
InParanoidi | P0CD98 |
OMAi | HWIYWIS |
Miscellaneous databases
RNActi | P0CD98, protein |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR034294, Aquaporin_transptr IPR000425, MIP |
PANTHERi | PTHR19139, PTHR19139, 1 hit |
Pfami | View protein in Pfam PF00230, MIP, 1 hit |
PRINTSi | PR00783, MINTRINSICP |
SUPFAMi | SSF81338, SSF81338, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YLL53_YEAST | |
Accessioni | P0CD98Primary (citable) accession number: P0CD98 Secondary accession number(s): D6VXV5 Q9C411 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 2, 2010 |
Last sequence update: | March 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families