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UniProtKB - P0CB47 (UBFL1_HUMAN)

Entry version 76 (07 Oct 2020)
Sequence version 1 (03 Nov 2009)
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Protein

Upstream-binding factor 1-like protein 1

Gene

UBTFL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi100 – 168HMG box 1PROSITE-ProRule annotationAdd BLAST69
DNA bindingi222 – 288HMG box 2PROSITE-ProRule annotationAdd BLAST67

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P0CB47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Upstream-binding factor 1-like protein 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBTFL1Imported
Synonyms:C11orf27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000255009.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:14533, UBTFL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613696, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P0CB47

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000255009

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164727456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P0CB47, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBTFL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		263545802

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003866401 – 393Upstream-binding factor 1-like protein 1Add BLAST393

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P0CB47

PeptideAtlas

More...PeptideAtlasi		P0CB47

PRoteomics IDEntifications database

More...PRIDEi		P0CB47

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52437

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P0CB47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P0CB47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000255009, Expressed in pituitary gland and 4 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000255009, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		568124, 30 interactors

Protein interaction database and analysis system

More...IntActi		P0CB47, 26 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000485108

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P0CB47, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0CB47

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0381, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021068_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P0CB47

Identification of Orthologs from Complete Genome Data

More...OMAi		LECMENN

Database of Orthologous Groups

More...OrthoDBi		1237679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P0CB47

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.30.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00398, HMG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095, SSF47095, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50118, HMG_BOX_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0CB47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPRSQGHW SNKDILRLLE CMENNRPSDD NSTFSSTQSH MDWGKVAFKN 
        60         70         80         90        100
FSGEMCRLKW LEISCNLRKF GTLKELVLEA KKCVKKMNKS QKYRNGPDFP 
       110        120        130        140        150
KRPLTAYNRF FKESWPQYSQ MYPGMRSQEL TKILSKKYRE LPEQMKQKYI 
       160        170        180        190        200
QDFRKEKQEF EEKLARFREE HPDLVQKAKK SSVSKRTQNK VQKKFQKNIE 
       210        220        230        240        250
EVRSLPKTDR FFKKVKFHGE PQKPPMNGYH KFHQDSWSSK EMQHLSVRER 
       260        270        280        290        300
MVEIGRRWQR IPQSQKDHFK SQAEELQKQY KVKLDLWLKT LSPENYAAYK 
       310        320        330        340        350
ESTYAKGKNM AMTGGPDPRL KQADPQSSSA KGLQEGFGEG QGLQAAGTDS 
       360        370        380        390 
SQTIWVNCHV SMEPEENRKK DREKEESSNS SDCSSGEEIE VDV
Length:393
Mass (Da):46,134
Last modified:November 3, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82B979D273A5ED63
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AP000827 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44704.1

NCBI Reference Sequences

More...RefSeqi		NP_001137447.1, NM_001143975.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000530464; ENSP00000485108; ENSG00000255009

Database of genes from NCBI RefSeq genomes

More...GeneIDi		642623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:642623

UCSC genome browser

More...UCSCi		uc010rub.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000827 Genomic DNA No translation available.
CCDSiCCDS44704.1
RefSeqiNP_001137447.1, NM_001143975.1

3D structure databases

SMRiP0CB47
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi568124, 30 interactors
IntActiP0CB47, 26 interactors
STRINGi9606.ENSP00000485108

PTM databases

iPTMnetiP0CB47
PhosphoSitePlusiP0CB47

Polymorphism and mutation databases

BioMutaiUBTFL1
DMDMi263545802

Proteomic databases

MassIVEiP0CB47
PeptideAtlasiP0CB47
PRIDEiP0CB47
ProteomicsDBi52437

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		74795, 23 antibodies

Genome annotation databases

EnsembliENST00000530464; ENSP00000485108; ENSG00000255009
GeneIDi642623
KEGGihsa:642623
UCSCiuc010rub.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		642623
EuPathDBiHostDB:ENSG00000255009.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBTFL1
HGNCiHGNC:14533, UBTFL1
HPAiENSG00000255009, Tissue enhanced (blood)
MIMi613696, gene
neXtProtiNX_P0CB47
OpenTargetsiENSG00000255009
PharmGKBiPA164727456

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0381, Eukaryota
GeneTreeiENSGT00940000163858
HOGENOMiCLU_021068_0_0_1
InParanoidiP0CB47
OMAiLECMENN
OrthoDBi1237679at2759
PhylomeDBiP0CB47

Enzyme and pathway databases

PathwayCommonsiP0CB47

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		642623, 1 hit in 55 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		642623
PharosiP0CB47, Tdark

Protein Ontology

More...PROi		PR:P0CB47
RNActiP0CB47, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000255009, Expressed in pituitary gland and 4 other tissues

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
PfamiView protein in Pfam
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 2 hits
SUPFAMiSSF47095, SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBFL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CB47
Secondary accession number(s): C9JMX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 7, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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