UniProtKB - P0CB47 (UBFL1_HUMAN)
Protein
Upstream-binding factor 1-like protein 1
Gene
UBTFL1
Organism
Homo sapiens (Human)
Status
Functioni
Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 100 – 168 | HMG box 1PROSITE-ProRule annotationAdd BLAST | 69 | |
DNA bindingi | 222 – 288 | HMG box 2PROSITE-ProRule annotationAdd BLAST | 67 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- blastocyst growth Source: Ensembl
- embryo implantation Source: Ensembl
- regulation of gene expression Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P0CB47 |
Names & Taxonomyi
Protein namesi | Recommended name: Upstream-binding factor 1-like protein 1Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14533, UBTFL1 |
MIMi | 613696, gene |
neXtProti | NX_P0CB47 |
VEuPathDBi | HostDB:ENSG00000255009.4 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000255009 |
PharmGKBi | PA164727456 |
Miscellaneous databases
Pharosi | P0CB47, Tdark |
Genetic variation databases
BioMutai | UBTFL1 |
DMDMi | 263545802 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000386640 | 1 – 393 | Upstream-binding factor 1-like protein 1Add BLAST | 393 |
Proteomic databases
MassIVEi | P0CB47 |
PeptideAtlasi | P0CB47 |
PRIDEi | P0CB47 |
ProteomicsDBi | 52437 |
PTM databases
iPTMneti | P0CB47 |
PhosphoSitePlusi | P0CB47 |
Expressioni
Gene expression databases
Bgeei | ENSG00000255009, Expressed in pituitary gland and 4 other tissues |
Organism-specific databases
HPAi | ENSG00000255009, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsP0CB47
Protein-protein interaction databases
BioGRIDi | 568124, 30 interactors |
IntActi | P0CB47, 26 interactors |
STRINGi | 9606.ENSP00000485108 |
Miscellaneous databases
RNActi | P0CB47, protein |
Family & Domainsi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000163858 |
HOGENOMi | CLU_021068_0_0_1 |
InParanoidi | P0CB47 |
OMAi | LECMENN |
OrthoDBi | 1237679at2759 |
PhylomeDBi | P0CB47 |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits |
SUPFAMi | SSF47095, SSF47095, 2 hits |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P0CB47-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPRSQGHW SNKDILRLLE CMENNRPSDD NSTFSSTQSH MDWGKVAFKN
60 70 80 90 100
FSGEMCRLKW LEISCNLRKF GTLKELVLEA KKCVKKMNKS QKYRNGPDFP
110 120 130 140 150
KRPLTAYNRF FKESWPQYSQ MYPGMRSQEL TKILSKKYRE LPEQMKQKYI
160 170 180 190 200
QDFRKEKQEF EEKLARFREE HPDLVQKAKK SSVSKRTQNK VQKKFQKNIE
210 220 230 240 250
EVRSLPKTDR FFKKVKFHGE PQKPPMNGYH KFHQDSWSSK EMQHLSVRER
260 270 280 290 300
MVEIGRRWQR IPQSQKDHFK SQAEELQKQY KVKLDLWLKT LSPENYAAYK
310 320 330 340 350
ESTYAKGKNM AMTGGPDPRL KQADPQSSSA KGLQEGFGEG QGLQAAGTDS
360 370 380 390
SQTIWVNCHV SMEPEENRKK DREKEESSNS SDCSSGEEIE VDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000827 Genomic DNA No translation available. |
CCDSi | CCDS44704.1 |
RefSeqi | NP_001137447.1, NM_001143975.1 |
Genome annotation databases
Ensembli | ENST00000530464; ENSP00000485108; ENSG00000255009 |
GeneIDi | 642623 |
KEGGi | hsa:642623 |
UCSCi | uc010rub.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000827 Genomic DNA No translation available. |
CCDSi | CCDS44704.1 |
RefSeqi | NP_001137447.1, NM_001143975.1 |
3D structure databases
SMRi | P0CB47 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 568124, 30 interactors |
IntActi | P0CB47, 26 interactors |
STRINGi | 9606.ENSP00000485108 |
PTM databases
iPTMneti | P0CB47 |
PhosphoSitePlusi | P0CB47 |
Genetic variation databases
BioMutai | UBTFL1 |
DMDMi | 263545802 |
Proteomic databases
MassIVEi | P0CB47 |
PeptideAtlasi | P0CB47 |
PRIDEi | P0CB47 |
ProteomicsDBi | 52437 |
Protocols and materials databases
Antibodypediai | 74795, 23 antibodies |
Genome annotation databases
Ensembli | ENST00000530464; ENSP00000485108; ENSG00000255009 |
GeneIDi | 642623 |
KEGGi | hsa:642623 |
UCSCi | uc010rub.2, human |
Organism-specific databases
CTDi | 642623 |
GeneCardsi | UBTFL1 |
HGNCi | HGNC:14533, UBTFL1 |
HPAi | ENSG00000255009, Tissue enhanced (blood) |
MIMi | 613696, gene |
neXtProti | NX_P0CB47 |
OpenTargetsi | ENSG00000255009 |
PharmGKBi | PA164727456 |
VEuPathDBi | HostDB:ENSG00000255009.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000163858 |
HOGENOMi | CLU_021068_0_0_1 |
InParanoidi | P0CB47 |
OMAi | LECMENN |
OrthoDBi | 1237679at2759 |
PhylomeDBi | P0CB47 |
Enzyme and pathway databases
PathwayCommonsi | P0CB47 |
Miscellaneous databases
BioGRID-ORCSi | 642623, 1 hit in 64 CRISPR screens |
GenomeRNAii | 642623 |
Pharosi | P0CB47, Tdark |
PROi | PR:P0CB47 |
RNActi | P0CB47, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000255009, Expressed in pituitary gland and 4 other tissues |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits |
SUPFAMi | SSF47095, SSF47095, 2 hits |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBFL1_HUMAN | |
Accessioni | P0CB47Primary (citable) accession number: P0CB47 Secondary accession number(s): C9JMX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM