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Protein

Kappa-conotoxin-like Ac4.3b

Gene
N/A
Organism
Conus achatinus (Little frog cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like Ac4.3b
OrganismiConus achatinus (Little frog cone)
Taxonomic identifieri369967 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri565 Ac4.3b precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000377454‹1 – 11By similarityAdd BLAST›11
PeptideiPRO_000037745512 – 48Kappa-conotoxin-like Ac4.3bAdd BLAST37
PropeptideiPRO_000037745649 – 53By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Pyrrolidone carboxylic acidBy similarity1
Modified residuei144-carboxyglutamateBy similarity1
Modified residuei284-hydroxyprolineBy similarity1
Modified residuei334-hydroxyprolineBy similarity1
Modified residuei484-hydroxyprolineBy similarity1
Modified residuei48Proline amideBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Amidation, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP0CAQ3

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP0CAQ3
SMRiP0CAQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CAQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SDVRNAAVHE RQKELVPSKI TTCCGYSPGT ACPSCMCTNT CKKKNKKPGR

RND
Length:53
Mass (Da):5,814
Last modified:June 16, 2009 - v1
Checksum:i9FD8773F7E6094F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ311075 Genomic DNA Translation: ABD33867.1

Similar proteinsi

Entry informationi

Entry nameiCA43B_CONAH
AccessioniPrimary (citable) accession number: P0CAQ3
Secondary accession number(s): A3DT45, A3DT46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 12, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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