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Entry version 90 (22 Apr 2020)
Sequence version 1 (26 May 2009)
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Protein

DNA-directed RNA polymerase II subunit GRINL1A

Gene

POLR2M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.1 Publication

Miscellaneous

The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A
Alternative name(s):
DNA-directed RNA polymerase II subunit M
Glutamate receptor-like protein 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR2M
Synonyms:GRINL1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14862 POLR2M

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606485 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0CAP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100820829
145781

Open Targets

More...
OpenTargetsi
ENSG00000255529

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28986

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P0CAP2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLR2M

Domain mapping of disease mutations (DMDM)

More...
DMDMi
238064986

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50000895461 – 368DNA-directed RNA polymerase II subunit GRINL1AAdd BLAST368

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0CAP2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0CAP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P0CAP2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0CAP2

PeptideAtlas

More...
PeptideAtlasi
P0CAP2

PRoteomics IDEntifications database

More...
PRIDEi
P0CAP2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52428 [P0CAP2-1]
52429 [P0CAP2-2]
52430 [P0CAP2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0CAP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0CAP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255529 Expressed in kidney and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0CAP2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0CAP2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000255529 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 is a component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and POLR2M isoform 1. Pol II(G) appears to be an abundant form of Pol II.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123498, 69 interactors

Database of interacting proteins

More...
DIPi
DIP-61933N

Protein interaction database and analysis system

More...
IntActi
P0CAP2, 41 interactors

Molecular INTeraction database

More...
MINTi
P0CAP2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299638

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P0CAP2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0CAP2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili301 – 335Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRINL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_051512_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0CAP2

KEGG Orthology (KO)

More...
KOi
K21987

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTERQGQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0CAP2

TreeFam database of animal gene trees

More...
TreeFami
TF332945

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026213 GRINL1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15328 GCOM2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02085 POLR2GRINL1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P0CAP2-1) [UniParc]FASTAAdd to basket
Also known as: Gdown1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCSLPRGFEP QAPEDLAQRS LVELREMLKR QERLLRNEKF ICKLPDKGKK
60 70 80 90 100
IFDSFAKLKA AIAECEEVRR KSELFNPVSL DCKLRQKAIA EVDVGTDKAQ
110 120 130 140 150
NSDPILDTSS LVPGCSSVDN IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV
160 170 180 190 200
NKGPASSNRD RVPPSSEASE HHPRHRVSSQ AEDTSSSFDN LFIDRLQRIT
210 220 230 240 250
IADQGEQQSE ENASTKNLTG LSSGTEKKPH YMEVLEMRAK NPVPQLRKFK
260 270 280 290 300
TNVLPFRQND SSSHCQKSGS PISSEERRRR DKQHLDDITA ARLLPLHHMP
310 320 330 340 350
TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERLNIKM RSYNPEGESS
360
GRYREVRDED DDWSSDEF
Length:368
Mass (Da):41,740
Last modified:May 26, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2F3ADAC21793D1E
GO
Isoform 2 (identifier: P0CAP2-2) [UniParc]FASTAAdd to basket
Also known as: Gdown6

The sequence of this isoform differs from the canonical sequence as follows:
     39-195: Missing.

Show »
Length:211
Mass (Da):24,533
Checksum:i02CD8ED77ADC9983
GO
Isoform 3 (identifier: P0CAP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-368: MQAKLAAQKL...EDDDWSSDEF → RPFYSPQYRS...MGSLALLTKL

Show »
Length:363
Mass (Da):40,734
Checksum:i9EBE33AF873AC052
GO
Isoform 4 (identifier: Q6EEV4-1) [UniParc]FASTAAdd to basket
Also known as: Gdown4
The sequence of this isoform can be found in the external entry Q6EEV4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:148
Mass (Da):15,131
GO
Isoform 5 (identifier: Q6EEV4-2) [UniParc]FASTAAdd to basket
Also known as: Gdown3
The sequence of this isoform can be found in the external entry Q6EEV4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:86
Mass (Da):8,827
GO
Isoform 11 (identifier: P0CAP1-11) [UniParc]FASTAAdd to basket
Also known as: Gcom1, GRINL1A complex locus protein 1
The sequence of this isoform can be found in the external entry P0CAP1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:550
Mass (Da):64,046
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP13E9PP13_HUMAN
DNA-directed RNA polymerase II subu...
POLR2M
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171H → D in CAB43263 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03738739 – 195Missing in isoform 2. 2 PublicationsAdd BLAST157
Alternative sequenceiVSP_037388323 – 368MQAKL…SSDEF → RPFYSPQYRSSMNLLSLAAA AKDTRGSKSGKMGSLALLTK L in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF326773 mRNA Translation: AAK92284.2
AY207007 mRNA Translation: AAO39707.1
AY353061 mRNA Translation: AAQ76837.1
AK074767 mRNA Translation: BAC11193.1
AK074955 mRNA Translation: BAC11313.1
AK128618 mRNA Translation: BAC87533.1
AC090651 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77525.1
BC001510 mRNA Translation: AAH01510.1
AL050091 mRNA Translation: CAB43263.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32252.1 [P0CAP2-1]
CCDS42045.1 [P0CAP2-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08740

NCBI Reference Sequences

More...
RefSeqi
NP_001018112.1, NM_001018102.2 [P0CAP2-2]
NP_056347.1, NM_015532.4 [P0CAP2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299638; ENSP00000299638; ENSG00000255529 [P0CAP2-1]
ENST00000380557; ENSP00000369930; ENSG00000255529 [P0CAP2-2]
ENST00000482852; ENSP00000432615; ENSG00000255529 [P0CAP2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81488

UCSC genome browser

More...
UCSCi
uc002aet.6 human [P0CAP2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326773 mRNA Translation: AAK92284.2
AY207007 mRNA Translation: AAO39707.1
AY353061 mRNA Translation: AAQ76837.1
AK074767 mRNA Translation: BAC11193.1
AK074955 mRNA Translation: BAC11313.1
AK128618 mRNA Translation: BAC87533.1
AC090651 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77525.1
BC001510 mRNA Translation: AAH01510.1
AL050091 mRNA Translation: CAB43263.1
CCDSiCCDS32252.1 [P0CAP2-1]
CCDS42045.1 [P0CAP2-2]
PIRiT08740
RefSeqiNP_001018112.1, NM_001018102.2 [P0CAP2-2]
NP_056347.1, NM_015532.4 [P0CAP2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DRDelectron microscopy3.90M300-316[»]
SMRiP0CAP2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123498, 69 interactors
DIPiDIP-61933N
IntActiP0CAP2, 41 interactors
MINTiP0CAP2
STRINGi9606.ENSP00000299638

PTM databases

iPTMnetiP0CAP2
PhosphoSitePlusiP0CAP2

Polymorphism and mutation databases

BioMutaiPOLR2M
DMDMi238064986

Proteomic databases

EPDiP0CAP2
jPOSTiP0CAP2
MassIVEiP0CAP2
PaxDbiP0CAP2
PeptideAtlasiP0CAP2
PRIDEiP0CAP2
ProteomicsDBi52428 [P0CAP2-1]
52429 [P0CAP2-2]
52430 [P0CAP2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57855 90 antibodies

The DNASU plasmid repository

More...
DNASUi
81488

Genome annotation databases

EnsembliENST00000299638; ENSP00000299638; ENSG00000255529 [P0CAP2-1]
ENST00000380557; ENSP00000369930; ENSG00000255529 [P0CAP2-2]
ENST00000482852; ENSP00000432615; ENSG00000255529 [P0CAP2-3]
GeneIDi81488
KEGGihsa:81488
UCSCiuc002aet.6 human [P0CAP2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81488
DisGeNETi100820829
145781

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POLR2M
HGNCiHGNC:14862 POLR2M
HPAiENSG00000255529 Low tissue specificity
MIMi606485 gene
neXtProtiNX_P0CAP2
OpenTargetsiENSG00000255529
PharmGKBiPA28986

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVF6 Eukaryota
ENOG410ZKMZ LUCA
GeneTreeiENSGT00950000183065
HOGENOMiCLU_051512_0_0_1
InParanoidiP0CAP2
KOiK21987
OMAiWTERQGQ
PhylomeDBiP0CAP2
TreeFamiTF332945

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POLR2M human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81488
PharosiP0CAP2 Tbio
RNActiP0CAP2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000255529 Expressed in kidney and 233 other tissues
ExpressionAtlasiP0CAP2 baseline and differential
GenevisibleiP0CAP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR026213 GRINL1
PfamiView protein in Pfam
PF15328 GCOM2, 1 hit
PRINTSiPR02085 POLR2GRINL1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRL1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0CAP2
Secondary accession number(s): Q6EER8
, Q6EES2, Q6EEV3, Q6EF00, Q6EF01, Q6EF02, Q6EF46, Q6EFN8, Q6EM48, Q6K046, Q6K050, Q6K051, Q6ZQZ3, Q8NC58, Q8NCF3, Q96DI5, Q96JB7, Q96NF5, Q9Y3V6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 22, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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