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Protein

Lysophospholipase 3

Gene

plb3

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 3 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 3
Gene namesi
Name:plb3
ORF Names:AFUA_3G14680
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu3g14680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Protein family/group databases

Allergomei8988 Asp f LPL3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000024555817 – 606Lysophospholipase 3Add BLAST590
PropeptideiPRO_0000245559607 – 630Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi606GPI-like-anchor amidated asparagineSequence analysis1

Post-translational modificationi

The GPI-like anchor contains a phosphoceramide lipid group.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

Strongly induced by lecithin.

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00003378

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 587PLA2cPROSITE-ProRule annotationAdd BLAST549

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547
InParanoidiP0C958
KOiK13333
OMAiSYQFIND
OrthoDBiEOG092C2IZ9

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLSLLTA VAVATATPLD LSLRALPNAP DGYTPAKVSC PATRPSIRGA
60 70 80 90 100
GSLSPNETSW LEIRRKNTVQ PMTDLLGRLN LGFDAAGYID RVSSNASNLP
110 120 130 140 150
NIAIAVSGGG YRALTNGAGA IKAFDSRTQG STQSGHLGGL LQSATYVSGL
160 170 180 190 200
SGGGWLVGSV YLNNFTTIAD LQSGDHGNVW QFSTSILEGP KAKHLQFLST
210 220 230 240 250
ADYWKDLLKA VDGKSDAGFN TSLTDYWGRA LSYQFINDRT GNGGLSYTWS
260 270 280 290 300
SIALTDPFRR GEMPLPILVA DGRNPGELLI GSNSTVYEFN PWEFGSFDPS
310 320 330 340 350
IFGFAPLEYL GSRFDNGQLP RGEPCVRGFD NAGFVMGTSS SLFNQFILRL
360 370 380 390 400
NKTDLPDLAK DVFSKILTAI GRDGDDIAVY GPNPFYGYRN STAAYSRSRE
410 420 430 440 450
LDVVDGGEDG QNIPLHPLIQ PVRHVDVIFA VDSSADGPYS WPNGSALVAT
460 470 480 490 500
YERSLNSSGI GNGTVFPAVP DVNTFVNLGL NTRPTFFGCD PANLSAPAPL
510 520 530 540 550
VVYLPNAPYS THSNTSTFQL AYSDSERDEI ITNGYNVVTR GNATVDKSWP
560 570 580 590 600
SCVGCAILQR SMYRTNTSMP AVCNSCFKEY CWNGTVDSKT PRTYEPTLLL
610 620 630
GSTSTNAAYT QGVTWLVGIL AVGVAMGMTA
Length:630
Mass (Da):67,417
Last modified:May 5, 2009 - v1
Checksum:i0E83E7D7F149CA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA Translation: EAL92119.1
RefSeqiXP_754157.1, XM_749064.1

Genome annotation databases

EnsemblFungiiCADAFUAT00005659; CADAFUAP00005659; CADAFUAG00005659
GeneIDi3512360
KEGGiafm:AFUA_3G14680

Similar proteinsi

Entry informationi

Entry nameiPLB3_ASPFU
AccessioniPrimary (citable) accession number: P0C958
Secondary accession number(s): Q4WYY4, Q6U819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: April 25, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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