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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:PG_1541
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682571 – 1472-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST147

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1541

Structurei

3D structure databases

ProteinModelPortaliP0C936
SMRiP0C936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U Bacteria
COG0801 LUCA
KOiK00950
OMAiKDERWGP

Family and domain databases

CDDicd00483 HPPK, 1 hit
Gene3Di3.30.70.5601 hit
InterProiView protein in InterPro
IPR000550 Hppk
IPR035907 Hppk_sf
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
SUPFAMiSSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01498 folK, 1 hit

Sequencei

Sequence statusi: Complete.

P0C936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVYLSLGS NLGDRHSLLS AALEMLQTRV GRLLTLSRFY ETEPWGFESP
60 70 80 90 100
HPFLNAVVAL RSELKPQDIL HITQAIEREL GRTQKSNGGV YHDRPIDIDI
110 120 130 140
LLHSVYPKVQ SPELELPHPQ MWQRDFVRMP LSDVAPWLHP EAPTPNL
Length:147
Mass (Da):16,765
Last modified:May 5, 2009 - v1
Checksum:i786A9180F116FC3B
GO

Sequence cautioni

The sequence AAQ66579 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015924 Genomic DNA Translation: AAQ66579.1 Different initiation.
RefSeqiWP_004585365.1, NC_002950.2

Genome annotation databases

EnsemblBacteriaiAAQ66579; AAQ66579; PG_1541
GeneIDi29255793
KEGGipgi:PG_1541

Similar proteinsi

Entry informationi

Entry nameiHPPK_PORGI
AccessioniPrimary (citable) accession number: P0C936
Secondary accession number(s): O83019
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome