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Protein

Conotoxin di16a

Gene
N/A
Organism
Conus distans (Distant cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Injection of the synthetic peptide causes a hyperexcitable phenotype in mice greater than three weeks of age at lower doses, and lethargy at higher doses.1 Publication

Miscellaneous

Has no effect on glutamate (NMDA) receptors, Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.6/KCNA6, Nav1.2/SCN2A and Nav1.4/SCN4A channels, and acetylcholine receptors alpha-9/alpha-10.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin di16a
OrganismiConus distans (Distant cone)
Taxonomic identifieri72281 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusFraterconus

Organism-specific databases

ConoServeri2842 Di19A precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000036609320 – 49By similarityAdd BLAST30
PeptideiPRO_000036609450 – 98Conotoxin di16aAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-hydroxyproline1 Publication1
Modified residuei634-carboxyglutamate1 Publication1
Modified residuei684-hydroxyproline1 Publication1
Modified residuei934-hydroxyproline1 Publication1
Modified residuei974-hydroxyproline1 Publication1

Post-translational modificationi

Contains 5 disulfide bonds.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0C8W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XIX (C-C-C-CCC-C-C-C-C).

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8W0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLGILLPI ALLLPLANPA ENGDGQAMPR TRNLRSLSFG RTLRRLEKRG
60 70 80 90
CDPTDGCQTT VCETDTGPCC CKPNFTCQIS NSGTKSCSCS GQPSDCPV
Length:98
Mass (Da):10,379
Last modified:March 3, 2009 - v1
Checksum:iFCFD9E2A699011F2
GO

Mass spectrometryi

Molecular mass is 5065.33 Da from positions 50 - 98. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

SMRiP0C8W0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri2842 Di19A precursor

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCGA_CONDI
AccessioniPrimary (citable) accession number: P0C8W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 12, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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