UniProtKB - P0C8K0 (KBAZ_ECOLI)
Protein
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
Gene
kbaZ
Organism
Escherichia coli (strain K12)
Status
Functioni
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity.1 Publication
Miscellaneous
In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds.
Caution
Was originally thought to be a tagatose 6-phosphate kinase.1 Publication
: D-tagatose 6-phosphate degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ), D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.
GO - Molecular functioni
- catalytic activity Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-UniRule
- D-tagatose 6-phosphate catabolic process Source: UniProtKB-UniPathway
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: GO_Central
Enzyme and pathway databases
BioCyci | EcoCyc:G7631-MONOMER MetaCyc:G7631-MONOMER |
SABIO-RKi | P0C8K0 |
UniPathwayi | UPA00704;UER00716 |
Names & Taxonomyi
Protein namesi | Recommended name: D-tagatose-1,6-bisphosphate aldolase subunit KbaZ |
Gene namesi | Name:kbaZ Synonyms:agaZ, yhaX Ordered Locus Names:b3132, JW3101 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- integral component of plasma membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064493 | 1 – 426 | D-tagatose-1,6-bisphosphate aldolase subunit KbaZAdd BLAST | 426 |
Proteomic databases
jPOSTi | P0C8K0 |
PaxDbi | P0C8K0 |
PRIDEi | P0C8K0 |
Interactioni
Subunit structurei
Forms a complex with KbaY.
Protein-protein interaction databases
BioGRIDi | 4263374, 9 interactors |
DIPi | DIP-9075N |
IntActi | P0C8K0, 7 interactors |
STRINGi | 511145.b3132 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG4573, Bacteria |
HOGENOMi | CLU_053334_0_0_6 |
InParanoidi | P0C8K0 |
PhylomeDBi | P0C8K0 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01295, Tagatose_aldol_KbaZ, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012062, GatZ/KbaZ-like IPR023435, TagBP_ald_KbaZ |
Pfami | View protein in Pfam PF08013, GatZ_KbaZ-like, 1 hit |
PIRSFi | PIRSF009264, TagBP_ald_AgaZ, 1 hit |
TIGRFAMsi | TIGR02810, agaZ_gatZ, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C8K0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHLTEMVRQ HKAGKTNGIY AVCSAHPLVL EAAIRYASAN QTPLLIEATS
60 70 80 90 100
NQVDQFGGYT GMTPADFRGF VCQLADSLNF PQDALILGGD HLGPNRWQNL
110 120 130 140 150
PAAQAMANAD DLIKSYVAAG FKKIHLDCSM SCQDDPIPLT DDIVAERAAR
160 170 180 190 200
LAKVAEETCL EHFGEADLEY VIGTEVPVPG GAHETLSELA VTTPDAARAT
210 220 230 240 250
LEAHRHAFEK QGLNAIWPRI IALVVQPGVE FDHTNVIDYQ PAKASALSQM
260 270 280 290 300
VENYETLIFE AHSTDYQTPQ SLRQLVIDHF AILKVGPALT FALREALFSL
310 320 330 340 350
AAIEEELVPA KACSGLRQVL EDVMLDRPEY WQSHYHGDGN ARRLARGYSY
360 370 380 390 400
SDRVRYYWPD SQIDDAFAHL VRNLADSPIP LPLISQYLPL QYVKVRSGEL
410 420
QPTPRELIIN HIQDILAQYH TACEGQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57935.1 U00096 Genomic DNA Translation: AAC76166.1 AP009048 Genomic DNA Translation: BAE77179.1 |
PIRi | H65102 |
RefSeqi | NP_417601.1, NC_000913.3 WP_000681920.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76166; AAC76166; b3132 BAE77179; BAE77179; BAE77179 |
GeneIDi | 947637 |
KEGGi | ecj:JW3101 eco:b3132 |
PATRICi | fig|1411691.4.peg.3599 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57935.1 U00096 Genomic DNA Translation: AAC76166.1 AP009048 Genomic DNA Translation: BAE77179.1 |
PIRi | H65102 |
RefSeqi | NP_417601.1, NC_000913.3 WP_000681920.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0C8K0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263374, 9 interactors |
DIPi | DIP-9075N |
IntActi | P0C8K0, 7 interactors |
STRINGi | 511145.b3132 |
Proteomic databases
jPOSTi | P0C8K0 |
PaxDbi | P0C8K0 |
PRIDEi | P0C8K0 |
Protocols and materials databases
DNASUi | 947637 |
Genome annotation databases
EnsemblBacteriai | AAC76166; AAC76166; b3132 BAE77179; BAE77179; BAE77179 |
GeneIDi | 947637 |
KEGGi | ecj:JW3101 eco:b3132 |
PATRICi | fig|1411691.4.peg.3599 |
Organism-specific databases
EchoBASEi | EB2616 |
Phylogenomic databases
eggNOGi | COG4573, Bacteria |
HOGENOMi | CLU_053334_0_0_6 |
InParanoidi | P0C8K0 |
PhylomeDBi | P0C8K0 |
Enzyme and pathway databases
UniPathwayi | UPA00704;UER00716 |
BioCyci | EcoCyc:G7631-MONOMER MetaCyc:G7631-MONOMER |
SABIO-RKi | P0C8K0 |
Miscellaneous databases
PROi | PR:P0C8K0 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01295, Tagatose_aldol_KbaZ, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012062, GatZ/KbaZ-like IPR023435, TagBP_ald_KbaZ |
Pfami | View protein in Pfam PF08013, GatZ_KbaZ-like, 1 hit |
PIRSFi | PIRSF009264, TagBP_ald_AgaZ, 1 hit |
TIGRFAMsi | TIGR02810, agaZ_gatZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KBAZ_ECOLI | |
Accessioni | P0C8K0Primary (citable) accession number: P0C8K0 Secondary accession number(s): P42903, Q2M977 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families