UniProtKB - P0C8J8 (GATZ_ECOLI)
Protein
D-tagatose-1,6-bisphosphate aldolase subunit GatZ
Gene
gatZ
Organism
Escherichia coli (strain K12)
Status
Functioni
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol.2 Publications
: D-tagatose 6-phosphate degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ), D-tagatose-1,6-bisphosphate aldolase subunit GatZ (gatZ), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY), D-tagatose-1,6-bisphosphate aldolase subunit GatY (gatY), D-tagatose-1,6-bisphosphate aldolase subunit KbaZ (kbaZ)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.
GO - Molecular functioni
- catalytic activity Source: InterPro
GO - Biological processi
- D-tagatose 6-phosphate catabolic process Source: UniProtKB-UniPathway
- galactitol catabolic process Source: UniProtKB-UniRule
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: GO_Central
Keywordsi
Biological process | Galactitol metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:G7128-MONOMER MetaCyc:G7128-MONOMER |
SABIO-RKi | P0C8J8 |
UniPathwayi | UPA00704;UER00716 |
Names & Taxonomyi
Protein namesi | Recommended name: D-tagatose-1,6-bisphosphate aldolase subunit GatZ |
Gene namesi | Name:gatZ Ordered Locus Names:b2095, JW2082 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087433 | 1 – 420 | D-tagatose-1,6-bisphosphate aldolase subunit GatZAdd BLAST | 420 |
Proteomic databases
jPOSTi | P0C8J8 |
PaxDbi | P0C8J8 |
PRIDEi | P0C8J8 |
Expressioni
Inductioni
Constitutively expressed.1 Publication
Interactioni
Subunit structurei
Forms a complex with GatY.
Protein-protein interaction databases
BioGRIDi | 4260431, 10 interactors 850986, 1 interactor |
ComplexPortali | CPX-6023, GatYZ tagatose-1,6-bisphosphate aldolase complex |
DIPi | DIP-48243N |
IntActi | P0C8J8, 17 interactors |
STRINGi | 511145.b2095 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG4573, Bacteria |
HOGENOMi | CLU_053334_0_0_6 |
InParanoidi | P0C8J8 |
PhylomeDBi | P0C8J8 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01296, Tagatose_aldol_GatZ, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012062, GatZ/KbaZ-like IPR023436, TagBP_ald_GatZ |
Pfami | View protein in Pfam PF08013, GatZ_KbaZ-like, 1 hit |
PIRSFi | PIRSF009264, TagBP_ald_AgaZ, 1 hit |
TIGRFAMsi | TIGR02810, agaZ_gatZ, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C8J8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTLIARHKA GEHIGICSVC SAHPLVIEAA LAFDRNSTRK VLIEATSNQV
60 70 80 90 100
NQFGGYTGMT PADFREFVFT IADKVGFARE RIILGGDHLG PNCWQQENAD
110 120 130 140 150
AAMEKSVELV KEYVRAGFSK IHLDASMSCA GDPIPLAPET VAERAAVLCF
160 170 180 190 200
AAESVATDCQ REQLSYVIGT EVPVPGGEAS AIQSVHITHV EDAANTLRTH
210 220 230 240 250
QKAFIARGLT EALTRVIAIV VQPGVEFDHS NIIHYQPQEA QPLAQWIENT
260 270 280 290 300
RMVYEAHSTD YQTRTAYWEL VRDHFAILKV GPALTFALRE AIFALAQIEQ
310 320 330 340 350
ELIAPENRSG CLAVIEEVML DEPQYWKKYY RTGFNDSLLD IRYSLSDRIR
360 370 380 390 400
YYWPHSRIKN SVETMMVNLE GVDIPLGMIS QYLPKQFERI QSGELSAIPH
410 420
QLIMDKIYDV LRAYRYGCAE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75156.1 AP009048 Genomic DNA Translation: BAA15965.1 |
PIRi | F64976 S55902 |
RefSeqi | NP_416598.1, NC_000913.3 WP_000853883.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75156; AAC75156; b2095 BAA15965; BAA15965; BAA15965 |
GeneIDi | 946641 |
KEGGi | ecj:JW2082 eco:b2095 |
PATRICi | fig|511145.12.peg.2172 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75156.1 AP009048 Genomic DNA Translation: BAA15965.1 |
PIRi | F64976 S55902 |
RefSeqi | NP_416598.1, NC_000913.3 WP_000853883.1, NZ_LN832404.1 |
3D structure databases
SMRi | P0C8J8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260431, 10 interactors 850986, 1 interactor |
ComplexPortali | CPX-6023, GatYZ tagatose-1,6-bisphosphate aldolase complex |
DIPi | DIP-48243N |
IntActi | P0C8J8, 17 interactors |
STRINGi | 511145.b2095 |
Proteomic databases
jPOSTi | P0C8J8 |
PaxDbi | P0C8J8 |
PRIDEi | P0C8J8 |
Genome annotation databases
EnsemblBacteriai | AAC75156; AAC75156; b2095 BAA15965; BAA15965; BAA15965 |
GeneIDi | 946641 |
KEGGi | ecj:JW2082 eco:b2095 |
PATRICi | fig|511145.12.peg.2172 |
Organism-specific databases
EchoBASEi | EB2317 |
Phylogenomic databases
eggNOGi | COG4573, Bacteria |
HOGENOMi | CLU_053334_0_0_6 |
InParanoidi | P0C8J8 |
PhylomeDBi | P0C8J8 |
Enzyme and pathway databases
UniPathwayi | UPA00704;UER00716 |
BioCyci | EcoCyc:G7128-MONOMER MetaCyc:G7128-MONOMER |
SABIO-RKi | P0C8J8 |
Miscellaneous databases
PROi | PR:P0C8J8 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_01296, Tagatose_aldol_GatZ, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR012062, GatZ/KbaZ-like IPR023436, TagBP_ald_GatZ |
Pfami | View protein in Pfam PF08013, GatZ_KbaZ-like, 1 hit |
PIRSFi | PIRSF009264, TagBP_ald_AgaZ, 1 hit |
TIGRFAMsi | TIGR02810, agaZ_gatZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GATZ_ECOLI | |
Accessioni | P0C8J8Primary (citable) accession number: P0C8J8 Secondary accession number(s): P37191, P76414 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families