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Protein

Conantokin-P

Gene
N/A
Organism
Conus purpurascens (Purple cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit, followed by NR2A/GRIN2A, NR2C/GRIN2C, and NR2D/GRIN2D subunits.1 Publication

Miscellaneous

Adopts an alpha-helical conformation in presence and in absence of divalent cations. Calcium facilitates disulfide bond formation of the synthetic peptide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi94Divalent metal cation; via 4-carboxyglutamateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-P1 Publication
Short name:
Con-P1 Publication
OrganismiConus purpurascens (Purple cone)
Taxonomic identifieri41690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusChelyconus

Organism-specific databases

ConoServeri3531 Conantokin-P precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000035313027 – 801 PublicationAdd BLAST54
PeptideiPRO_000035313181 – 104Conantokin-P1 PublicationAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei834-carboxyglutamateBy similarity1 Publication1
Modified residuei844-carboxyglutamateBy similarity1 Publication1
Modified residuei904-carboxyglutamateBy similarity1 Publication1
Disulfide bondi91 ↔ 1041 Publication
Modified residuei944-carboxyglutamateBy similarity1 Publication1
Modified residuei1034-carboxyglutamate1 Publication1

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0C8E3
SMRiP0C8E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is C-C.Curated

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005918 Conantokin_CS
PROSITEiView protein in PROSITE
PS60025 CONANTOKIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C8E3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLYTYLYLL VPLVTFHLIL STGTLAHGGT LTERRSTDTT ALKPEPVLLQ
60 70 80 90 100
KSDARSTDDN DKDRLTQMKR ILKKRGNKAR GEEEHSKYQE CLREIRVNKV

QQEC
Length:104
Mass (Da):12,033
Last modified:November 4, 2008 - v1
Checksum:iC6364066BBC1D04B
GO

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP0C8E3
SMRiP0C8E3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3531 Conantokin-P precursor

Family and domain databases

InterProiView protein in InterPro
IPR005918 Conantokin_CS
PROSITEiView protein in PROSITE
PS60025 CONANTOKIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCKP_CONPU
AccessioniPrimary (citable) accession number: P0C8E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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