Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Conantokin-Pr3

Gene
N/A
Organism
Conus parius (Cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit. It induces sleep in 10-day-old mice when injected intracranially, and hyperactivity in 24-day-old mice.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.Curated
Adopts an alpha-helical conformation in presence and in absence of divalent cations.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi14Divalent metal cation; via 4-carboxyglutamateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-Pr31 Publication
Short name:
Con-Pr31 Publication
OrganismiConus parius (Cone snail)
Taxonomic identifieri505247 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri3535 Conantokin-Pr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003531291 – 19Conantokin-Pr31 PublicationAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34-hydroxyproline1 Publication1
Modified residuei44-carboxyglutamate1 Publication1
Modified residuei104-carboxyglutamate1 Publication1
Modified residuei144-carboxyglutamate1 Publication1
Modified residuei19Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C8E2-1 [UniParc]FASTAAdd to basket
« Hide
        10 
GEPEVAKWAE GLREKAASN
Length:19
Mass (Da):2,042
Last modified:November 4, 2008 - v1
Checksum:i2E30E5F710CC43DC
GO

Mass spectrometryi

Molecular mass is 2189.6 Da from positions 1 - 19. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3535 Conantokin-Pr3

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCKP3_CONPI
AccessioniPrimary (citable) accession number: P0C8E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again