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Protein

Conantokin-Pr1

Gene
N/A
Organism
Conus parius (Cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has highest potency for the NR2B/GRIN2B subunit. It induces sleep in 10-day-old mice when injected intracranially, and hyperactivity in 24-day-old mice.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.Curated

Cofactori

Ca2+1 Publication, Mg2+1 PublicationNote: Adopts alpha-helical conformations in the presence of divalent cations and is unstructured in the absence of divalent cations.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7Divalent metal cation; via 4-carboxyglutamateBy similarity1
Metal bindingi11Divalent metal cation; via 4-carboxyglutamateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin
LigandCalcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-Pr11 Publication
Short name:
Con-Pr11 Publication
OrganismiConus parius (Cone snail)
Taxonomic identifieri505247 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri3537 Conantokin-Pr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003531271 – 19Conantokin-Pr11 PublicationAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44-carboxyglutamate1 Publication1
Modified residuei74-carboxyglutamate1 Publication1
Modified residuei114-carboxyglutamate1 Publication1

Keywords - PTMi

Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C8E0-1 [UniParc]FASTAAdd to basket
« Hide
        10 
GEDEYAEGIR EYQLIHGKI
Length:19
Mass (Da):2,220
Last modified:November 4, 2008 - v1
Checksum:i737421677E167DE3
GO

Mass spectrometryi

Molecular mass is 2352.8 Da from positions 1 - 19. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3537 Conantokin-Pr1

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCKP1_CONPI
AccessioniPrimary (citable) accession number: P0C8E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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