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UniProtKB - P0C8D9 (CKE_CONER)
Protein
Conantokin-E
Gene
N/A
Organism
Conus ermineus (Agate cone) (Chelyconus ermineus)
Status
Functioni
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit, followed by NR2A/GRIN2A, NR2C/GRIN2C, and NR2D/GRIN2D subunits.
By similarityMiscellaneous
Adopts an alpha-helical conformation in presence and in absence of divalent cations. Calcium facilitates disulfide bond formation of the synthetic peptide.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 82 | Divalent metal cation; via 4-carboxyglutamateBy similarity | 1 | |
Metal bindingi | 86 | Divalent metal cation; via 4-carboxyglutamateBy similarity | 1 |
GO - Molecular functioni
- ion channel regulator activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Ligand | Calcium, Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Conantokin-E1 PublicationShort name: Con-E1 Publication |
Organismi | Conus ermineus (Agate cone) (Chelyconus ermineus) |
Taxonomic identifieri | 55423 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Chelyconus |
Organism-specific databases
ConoServeri | 3533, Conantokin-E1 precursor |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- host cell postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 – 24 | Sequence analysisAdd BLAST | ›24 | |
PropeptideiPRO_0000353125 | 25 – 72 | 1 PublicationAdd BLAST | 48 | |
PeptideiPRO_0000353126 | 73 – 96 | Conantokin-E1 PublicationAdd BLAST | 24 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 75 | 4-carboxyglutamateBy similarity1 Publication | 1 | |
Modified residuei | 76 | 4-carboxyglutamateBy similarity1 Publication | 1 | |
Modified residuei | 82 | 4-carboxyglutamateBy similarity1 Publication | 1 | |
Disulfide bondi | 83 ↔ 96 | 1 Publication | ||
Modified residuei | 86 | 4-carboxyglutamateBy similarity1 Publication | 1 | |
Modified residuei | 95 | 4-carboxyglutamate1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Gamma-carboxyglutamic acidExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 57 | DisorderedSequence analysisAdd BLAST | 30 |
Domaini
The cysteine framework is C-C.Curated
Sequence similaritiesi
Belongs to the conotoxin B superfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR005918, Conantokin_CS |
Pfami | View protein in Pfam PF10550, Toxin_36, 1 hit |
PROSITEi | View protein in PROSITE PS60025, CONANTOKIN, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C8D9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
LLVPLVTFHL ILGMGTLDHG GALTERRSAD ATALKPEPVL LQKSDARSTD
60 70 80 90
DNDKDRLTQM KRILKKRGNK ARGEEEHSKY QECLREIRVN NVQQEC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0C8D9 |
ModBasei | Search... |
Organism-specific databases
ConoServeri | 3533, Conantokin-E1 precursor |
Family and domain databases
InterProi | View protein in InterPro IPR005918, Conantokin_CS |
Pfami | View protein in Pfam PF10550, Toxin_36, 1 hit |
PROSITEi | View protein in PROSITE PS60025, CONANTOKIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CKE_CONER | |
Accessioni | P0C8D9Primary (citable) accession number: P0C8D9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 4, 2008 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 23, 2022 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |