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Entry version 76 (08 May 2019)
Sequence version 1 (02 Sep 2008)
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Protein

Radial spoke head 10 homolog B

Gene

RSPH10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Radial spoke head 10 homolog B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSPH10B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27362 RSPH10B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C881

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000155026

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RSPH10B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205829389

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003119431 – 870Radial spoke head 10 homolog BAdd BLAST870

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C881

PeptideAtlas

More...
PeptideAtlasi
P0C881

PRoteomics IDEntifications database

More...
PRIDEi
P0C881

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52415

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C881

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C881

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155026 Expressed in 73 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P0C881 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0C881 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128823, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P0C881, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000385443

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C881

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 108MORN 1Add BLAST23
Repeati109 – 131MORN 2Add BLAST23
Repeati132 – 154MORN 3Add BLAST23
Repeati155 – 177MORN 4Add BLAST23
Repeati179 – 201MORN 5Add BLAST23
Repeati204 – 226MORN 6Add BLAST23
Repeati227 – 249MORN 7Add BLAST23
Repeati251 – 273MORN 8Add BLAST23
Repeati284 – 306MORN 9Add BLAST23
Repeati307 – 329MORN 10Add BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili784 – 811Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0231 Eukaryota
COG4642 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154057

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C881

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAPPYEL

Database of Orthologous Groups

More...
OrthoDBi
1309439at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C881

TreeFam database of animal gene trees

More...
TreeFami
TF328649

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003409 MORN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02493 MORN, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00698 MORN, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0C881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKEKKKADK KGEKSARSPS SLSDNLDFSK QDGNTTRQEM SPAGVPLLGM
60 70 80 90 100
QLNEVKPKKD RQNVQQNEDA TQYEESILTK LIVESYEGEK VRGLYEGEGF
110 120 130 140 150
AAFQGGCTYR GMFSEGLMHG QGTYIWADGL KYEGDFVKNV PMNHGVYTWP
160 170 180 190 200
DGSMYEGEVV NGMRNGFGMF KCSTQPVSYI GHWCNGKRHG KGSIYYNQEG
210 220 230 240 250
TCWYEGDWVQ NIKKGWGIRC YKSGNIYEGQ WEDNMRHGEG RMRWLTTNEE
260 270 280 290 300
YTGRWERGIQ NGFGTHTWFL KRIRSSQYPL RNEYIGEFVN GYRHGRGKFY
310 320 330 340 350
YASGAMYDGE WVSNKKHGMG RLTFKNGRVY EGAFSNDHIA GFPDLEVEFI
360 370 380 390 400
SCLDLSSGVA PRLSRSAELI RKLDGSESHS VLGSSIELDL NLLLDMYPET
410 420 430 440 450
VQPEEKKQVE YAVLRNITEL RRIYSFYSSL GCGHSLDNTF LMTKLHFWRF
460 470 480 490 500
LKDCKFHHHK LTLADMDRIL SANNDIPVEE IHSPFTTILL RTFLNYLLHL
510 520 530 540 550
AYHIYHEEFQ KRSPSLFLCF TKLMTENIRP NAFQIKGNLF REQQRTLYSM
560 570 580 590 600
SYMNKCWEIY LAYCRPSAAP PHEPTMKMRH FLWMLKDFKM INKELTAATF
610 620 630 640 650
MEVIAEDNRF IYDGIDSNFE PELVFLEFFE ALLSFAFICV TDQMTKSYTN
660 670 680 690 700
VPADDVSGNK HETIYTILNQ DAQNKSPSAV MSHESDAAHS DSARSSSSKL
710 720 730 740 750
ELSPDVNKIR KSEPKIKKSV SHERVSKMNF KLTGKGITFF SSESKKYERP
760 770 780 790 800
KDDREEEFNT WVNNMYVFFV NTLFHAYKRE EAIKEKIRAD RLRSTAQAQQ
810 820 830 840 850
RKMEDDELEA RLNIFILREE EAKRHDYEVD ITVLKEPADV SSSHLILDPP
860 870
KEDVTVSPSS KTITSKKKKK
Length:870
Mass (Da):100,635
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE397C887499675C0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZE0F5GZE0_HUMAN
Radial spoke head 10 homolog B
RSPH10B
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005995 Genomic DNA No translation available.
AA382672 mRNA No translation available.
AW474289 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34598.1

NCBI Reference Sequences

More...
RefSeqi
XP_005249716.1, XM_005249659.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337579; ENSP00000338556; ENSG00000155026
ENST00000404406; ENSP00000384097; ENSG00000155026
ENST00000405415; ENSP00000385443; ENSG00000155026

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
222967

UCSC genome browser

More...
UCSCi
uc003sph.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005995 Genomic DNA No translation available.
AA382672 mRNA No translation available.
AW474289 mRNA No translation available.
CCDSiCCDS34598.1
RefSeqiXP_005249716.1, XM_005249659.3

3D structure databases

SMRiP0C881
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128823, 1 interactor
IntActiP0C881, 1 interactor
STRINGi9606.ENSP00000385443

PTM databases

iPTMnetiP0C881
PhosphoSitePlusiP0C881

Polymorphism and mutation databases

BioMutaiRSPH10B
DMDMi205829389

Proteomic databases

PaxDbiP0C881
PeptideAtlasiP0C881
PRIDEiP0C881
ProteomicsDBi52415

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337579; ENSP00000338556; ENSG00000155026
ENST00000404406; ENSP00000384097; ENSG00000155026
ENST00000405415; ENSP00000385443; ENSG00000155026
GeneIDi222967
UCSCiuc003sph.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
222967

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RSPH10B
HGNCiHGNC:27362 RSPH10B
HPAiHPA049182
neXtProtiNX_P0C881
OpenTargetsiENSG00000155026

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00940000159899
HOGENOMiHOG000154057
InParanoidiP0C881
OMAiTAPPYEL
OrthoDBi1309439at2759
PhylomeDBiP0C881
TreeFamiTF328649

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
222967

Protein Ontology

More...
PROi
PR:P0C881

Gene expression databases

BgeeiENSG00000155026 Expressed in 73 organ(s), highest expression level in testis
ExpressionAtlasiP0C881 baseline and differential
GenevisibleiP0C881 HS

Family and domain databases

InterProiView protein in InterPro
IPR003409 MORN
PfamiView protein in Pfam
PF02493 MORN, 10 hits
SMARTiView protein in SMART
SM00698 MORN, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR10B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C881
Secondary accession number(s): A6NMW7, Q86ST9, Q8NE68
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 8, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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