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Entry version 62 (16 Jan 2019)
Sequence version 1 (02 Sep 2008)
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Protein

Spermatogenesis-associated protein 31D3

Gene

SPATA31D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in spermatogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spermatogenesis-associated protein 31D3
Alternative name(s):
Protein FAM75D3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATA31D3
Synonyms:FAM75D3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186788.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:38603 SPATA31D3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C874

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATA31D3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205831115

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492411 – 917Spermatogenesis-associated protein 31D3Add BLAST917

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0C874

PeptideAtlas

More...
PeptideAtlasi
P0C874

PRoteomics IDEntifications database

More...
PRIDEi
P0C874

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52409

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C874

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C874

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186788 Expressed in 5 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0C874 HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C874

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi187 – 247Pro-richAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPATA31 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063191

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097810

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C874

Identification of Orthologs from Complete Genome Data

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OMAi
CAHRHEP

Database of Orthologous Groups

More...
OrthoDBi
76827at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENILCFLNS YTETGLSPDS HCLDIDLNFI CLSGLGLFIL YLFYMVLTLY
60 70 80 90 100
SSPTEKNNDT QKHQGRARRK RKSVTFKDRK SLQKEAEEER KLHSFLKSFG
110 120 130 140 150
PPVSCSPLGQ HHDTTLFRRL LCPDPVCRVC NRATADIQRL LSWESLKDAA
160 170 180 190 200
PSVSPLASSA SGAESSFTLA STPSATTPED LILSSRPKPS PPPPLILSPD
210 220 230 240 250
LITTLADLFS PSPLRDPLPP QPVSPLDSKF PIDHSPPQQL PFPLLPPHHI
260 270 280 290 300
ERVEPSLQPE ASLSLNTIFS FGSTLCQDIS QAVNRTDSCA RHHGPPTPSA
310 320 330 340 350
LPPEDCTVTQ SKSNLTVLKT FPEMLSLGGS GGSSTSAPTT KGIDHSCPAS
360 370 380 390 400
SEFSWWQPHA KDSFSSNFVP SDFMEELLTL HSSEASLGGH SVANIIQPVN
410 420 430 440 450
ISFLSHDIPA LLERQVKRRG DFLMWKENGK KPGSFPTQLR PNYQLNSSRN
460 470 480 490 500
MLTSTAVKHD LAESFPFWAS KGKLEWQHIH QQPPYSKCFE DHLEQKYVQL
510 520 530 540 550
FWGLPSLHSE SLHPTVFVQH GRSSMFVFFN GITNTSMSHE SPVLPPPQPL
560 570 580 590 600
FLPSTQPLPL PQTLPRGQSL HLTQVKSLAQ PQSPFPALPP SPLFLIRVCG
610 620 630 640 650
VCFHRPQNEA RSLMPSEINH LEWNVLQKVQ ESVWGLPSVV QKSQEDFCPP
660 670 680 690 700
APNPVLVRKS FKVHVPISII PGDFPLSSEV RKKLEQHIRK RLIQRRWGLP
710 720 730 740 750
RRIHESLSLL RPQNKISELS VSESIHGPLN ISLVEGQRCN VLKKSASSFP
760 770 780 790 800
RSFHERSSNM LSMENVGNYQ GCSQETAPKN HLLHDPETSS EEDLRSNSER
810 820 830 840 850
DLGTHMMHLS GNDSGVRLGQ KQLENALTVH LSKKFEEINE GRMPGTVHSS
860 870 880 890 900
WHSVKQTICL PEKSHSQIKH RNLAALVSED HRVDTSQEMS FLSSNKQKML
910
EAHIKSFHMK PILNLSI
Length:917
Mass (Da):102,419
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB9FB7B800EA3322
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK126070 differs from that shown. Reason: Frameshift at position 780.Curated
The sequence AK308327 differs from that shown. Reason: Frameshift at position 780.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389G → R in AK308327 (PubMed:14702039).Curated1
Sequence conflicti541S → F in AK308327 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK126070 mRNA No translation available.
AK308327 mRNA No translation available.
AL158154 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS83380.1

NCBI Reference Sequences

More...
RefSeqi
NP_997299.2, NM_207416.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.522246

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000445385; ENSP00000488117; ENSG00000186788

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389762

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126070 mRNA No translation available.
AK308327 mRNA No translation available.
AL158154 Genomic DNA No translation available.
CCDSiCCDS83380.1
RefSeqiNP_997299.2, NM_207416.2
UniGeneiHs.522246

3D structure databases

SMRiP0C874
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP0C874
PhosphoSitePlusiP0C874

Polymorphism and mutation databases

BioMutaiSPATA31D3
DMDMi205831115

Proteomic databases

jPOSTiP0C874
PeptideAtlasiP0C874
PRIDEiP0C874
ProteomicsDBi52409

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000445385; ENSP00000488117; ENSG00000186788
GeneIDi389762
KEGGihsa:389762

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389762
EuPathDBiHostDB:ENSG00000186788.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPATA31D3
HGNCiHGNC:38603 SPATA31D3
neXtProtiNX_P0C874

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00530000063191
HOVERGENiHBG097810
InParanoidiP0C874
OMAiCAHRHEP
OrthoDBi76827at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389762

Protein Ontology

More...
PROi
PR:P0C874

Gene expression databases

BgeeiENSG00000186788 Expressed in 5 organ(s), highest expression level in right testis
GenevisibleiP0C874 HS

Family and domain databases

InterProiView protein in InterPro
IPR027970 DUF4599
IPR039509 SPATA31/FAM205
PfamiView protein in Pfam
PF15371 DUF4599, 1 hit
PF14650 FAM75, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS31D3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C874
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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