Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 91 (07 Apr 2021)
Sequence version 1 (02 Sep 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Cytosolic phospholipase A2 beta

Gene

Pla2g4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. The PLA1 versus PLA2 activity ratio appears to depend on the phospholipid headgroup, with mainly PLA2 activity toward anionic phospholipids such as phosphatidylglycerols. Hydrolyzes with high efficiency lysophospholipids enabling complete deacylation.1 Publication

Caution

Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by cytosolic Ca2+ in the presence of cardiolipin. Activated by phosphoinositides. Inhibited by electrophilic ketone inhibitors.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The specific activity is 394 nmol/min/µg enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine. The specific PLA2 activity is 11 nmol/min/µg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine (in the presence of cardiolipin). The specific PLA1 activity is 0.13 nmol/min/µg with 1-hexadecanoyl-2-(9Z-octadecenoyl)-phosphatidylcholine. The specific PLA2 activity is 0.04 nmol/min/µg enzyme with 1-hexadecanoyl-2-(9Z-octadecenoyl)-phosphatidylethanolamine. The specific PLA2 activity is 0.13 nmol/min/µg enzyme with 1-hexadecanoyl-2-(9Z-octadecenoyl)-phosphatidylserine. The specific PLA2 activity is 0.03 with 1-hexadecanoyl-2-(9Z-octadecenoyl)-phosphatidylinositol. The specific PLA2 activity is 0.24 with 1-hexadecanoyl-2-(9Z-octadecenoyl)-phosphatidylglycerol. The specific PLA2 activity is 0.25 with 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate.1 Publication

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi25Calcium 1PROSITE-ProRule annotation1
      Metal bindingi25Calcium 2PROSITE-ProRule annotation1
      Metal bindingi31Calcium 1PROSITE-ProRule annotation1
      Metal bindingi81Calcium 1PROSITE-ProRule annotation1
      Metal bindingi81Calcium 2PROSITE-ProRule annotation1
      Metal bindingi83Calcium 1PROSITE-ProRule annotation1
      Metal bindingi83Calcium 2PROSITE-ProRule annotation1
      Metal bindingi89Calcium 2PROSITE-ProRule annotation1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei333NucleophileBy similarity1
      Active sitei613Proton acceptorBy similarity1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionHydrolase
      Biological processLipid degradation, Lipid metabolism
      LigandCalcium, Metal-binding

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-MMU-1482788, Acyl chain remodelling of PC
      R-MMU-1482801, Acyl chain remodelling of PS
      R-MMU-1482839, Acyl chain remodelling of PE
      R-MMU-1482925, Acyl chain remodelling of PG
      R-MMU-1483115, Hydrolysis of LPC
      R-MMU-1483166, Synthesis of PA

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Cytosolic phospholipase A2 beta (EC:3.1.1.41 Publication)
      Short name:
      cPLA2-beta1 Publication
      Alternative name(s):
      Lysophospholipase A1 group IVB1 Publication (EC:3.1.1.51 Publication)
      Phospholipase A2 group IVB
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:Pla2g4b
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

      Organism-specific databases

      Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

      More...
      MGIi
      MGI:2384819, Pla2g4b

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Keywords - Cellular componenti

      Cytoplasm, Endosome, Membrane, Mitochondrion

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Mutagenesis

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24K → N: Impairs calcium-dependent binding to phospholipids; when associated with N-49 and N-52. 1 Publication1
      Mutagenesisi44H → N: Significantly decreases calcium-dependent binding to phospholipids; when associated with N-82. 1 Publication1
      Mutagenesisi49R → N: Impairs calcium-dependent binding to phospholipids; when associated with N-24 and N-52. 1 Publication1
      Mutagenesisi52K → N: Impairs calcium-dependent binding to phospholipids; when associated with N-24 and N-49. 1 Publication1
      Mutagenesisi78K → N: Significantly decreases calcium-dependent binding to phospholipids. 1 Publication1
      Mutagenesisi82H → N: Significantly decreases calcium-dependent binding to phospholipids; when associated with N-44. 1 Publication1

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470221 – 782Cytosolic phospholipase A2 betaAdd BLAST782

      Proteomic databases

      MaxQB - The MaxQuant DataBase

      More...
      MaxQBi
      P0C871

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      P0C871

      PRoteomics IDEntifications database

      More...
      PRIDEi
      P0C871

      ProteomicsDB: a multi-organism proteome resource

      More...
      ProteomicsDBi
      295449

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      P0C871

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      P0C871

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGRID)

      More...
      BioGRIDi
      229231, 1 interactor

      STRING: functional protein association networks

      More...
      STRINGi
      10090.ENSMUSP00000118458

      Miscellaneous databases

      RNAct, Protein-RNA interaction predictions for model organisms.

      More...
      RNActi
      P0C871, protein

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      P0C871

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 112C2PROSITE-ProRule annotationAdd BLAST112
      Domaini245 – 782PLA2cPROSITE-ProRule annotationAdd BLAST538

      <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

      The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG1028, Eukaryota
      KOG1325, Eukaryota

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      P0C871

      Database of Orthologous Groups

      More...
      OrthoDBi
      302848at2759

      Family and domain databases

      Conserved Domains Database

      More...
      CDDi
      cd04036, C2_cPLA2, 1 hit

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      2.60.40.150, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR016035, Acyl_Trfase/lysoPLipase
      IPR041847, C2_cPLA2
      IPR000008, C2_dom
      IPR035892, C2_domain_sf
      IPR040723, cPLA2_C2
      IPR002642, LysoPLipase_cat_dom

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF00168, C2, 1 hit
      PF18695, cPLA2_C2, 1 hit
      PF01735, PLA2_B, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00239, C2, 1 hit
      SM00022, PLAc, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF52151, SSF52151, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS50004, C2, 1 hit
      PS51210, PLA2C, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

      P0C871-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MQAKVPETCL LTVRVLRASG LPSKDLVTSS DCYVTLNLPT ASSHTLQTRT
      60 70 80 90 100
      VKNSRNPVWN QNFHFRIHRQ LKNVMELKVF DHDLVTRDDP VLSVLFDVGT
      110 120 130 140 150
      LQIGTQRQSF SLGTQEKGCL EVEFRLQTLT DCEEQLISNG IVVARELSCL
      160 170 180 190 200
      HVELKRTGDP KRSERKVQLV VAGACEGPQD ASAGTGSFHF HYPACWEQEL
      210 220 230 240 250
      NVHLQDDPHE QLKVPLRTLP SSQLVRLVFP TSQEPLMRLE LKKEEGPKEL
      260 270 280 290 300
      AVRLGCGPCP EEQAFLSKRK QVVAAALKKA LQLDQDLHED EIPVIAVMAT
      310 320 330 340 350
      GGGIRAMTSL YGQLAGLQEL GLLDCISYIT GASGSTWALA NLYEDPEWSQ
      360 370 380 390 400
      KDLAGPTEVL KTQVTKSKLG ALAPSQLWRY RQELAERARL GHPTCFTNLW
      410 420 430 440 450
      ALINEALLHD KPHEHKLSDQ REALSRGQNP LPIYCALNSK EQGLSTFDFG
      460 470 480 490 500
      EWCEFSPYEV GFPKYGAFIS SELFGSEFFM GRLVKQLPES RICFLEGIWS
      510 520 530 540 550
      NLFAASLQDS LYWSSEPSQF WDRWAQDQAN LDKEQVPHLK IAEPPTMAGR
      560 570 580 590 600
      IAELFTDLLT KRPLAHATHN FTRGLHFHKD YFQNSHFSAW KASKLDRLPN
      610 620 630 640 650
      QLTPTEPHLC LLDVGYLINT SCPPLLQPTR DVDLILSLDY NLYGAFQQLQ
      660 670 680 690 700
      LLSRFCQEQG IPFPSISPSP EEQRQPQECH LFCDPAQPEA PAVLHFPLVN
      710 720 730 740 750
      DSFQDYSAPG VPRTSEEKAA GEVNLSSSDS PYHYTKVTYS QEDVDKLLRL
      760 770 780
      THYNICNNQD RLREAMHQAV QRRRKRKQFR PE
      Length:782
      Mass (Da):88,448
      Last modified:September 2, 2008 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD803A02439F6846
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      B7ZCM8B7ZCM8_MOUSE
      Phospholipase A2
      Pla2g4b
      791Annotation score:

      Annotation score:2 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence CAM22684 differs from that shown. Reason: Erroneous gene model prediction.Curated

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75M → I in BC098210 (PubMed:15489334).Curated1
      Sequence conflicti79V → A in BC098210 (PubMed:15489334).Curated1
      Sequence conflicti605T → A in AAH42758 (PubMed:15489334).Curated1
      Sequence conflicti617L → F in AAH42758 (PubMed:15489334).Curated1

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AL833774 Genomic DNA Translation: CAM22684.1 Sequence problems.
      BC042758 mRNA Translation: AAH42758.1
      BC098210 mRNA No translation available.

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_663353.3, NM_145378.3

      Genome annotation databases

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      211429

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      mmu:211429

      UCSC genome browser

      More...
      UCSCi
      uc008luz.2, mouse

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AL833774 Genomic DNA Translation: CAM22684.1 Sequence problems.
      BC042758 mRNA Translation: AAH42758.1
      BC098210 mRNA No translation available.
      RefSeqiNP_663353.3, NM_145378.3

      3D structure databases

      SMRiP0C871
      ModBaseiSearch...

      Protein-protein interaction databases

      BioGRIDi229231, 1 interactor
      STRINGi10090.ENSMUSP00000118458

      PTM databases

      iPTMnetiP0C871
      PhosphoSitePlusiP0C871

      Proteomic databases

      MaxQBiP0C871
      PaxDbiP0C871
      PRIDEiP0C871
      ProteomicsDBi295449

      Genome annotation databases

      GeneIDi211429
      KEGGimmu:211429
      UCSCiuc008luz.2, mouse

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      100137049
      MGIiMGI:2384819, Pla2g4b

      Phylogenomic databases

      eggNOGiKOG1028, Eukaryota
      KOG1325, Eukaryota
      InParanoidiP0C871
      OrthoDBi302848at2759

      Enzyme and pathway databases

      ReactomeiR-MMU-1482788, Acyl chain remodelling of PC
      R-MMU-1482801, Acyl chain remodelling of PS
      R-MMU-1482839, Acyl chain remodelling of PE
      R-MMU-1482925, Acyl chain remodelling of PG
      R-MMU-1483115, Hydrolysis of LPC
      R-MMU-1483166, Synthesis of PA

      Miscellaneous databases

      Protein Ontology

      More...
      PROi
      PR:P0C871
      RNActiP0C871, protein

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Family and domain databases

      CDDicd04036, C2_cPLA2, 1 hit
      Gene3Di2.60.40.150, 1 hit
      InterProiView protein in InterPro
      IPR016035, Acyl_Trfase/lysoPLipase
      IPR041847, C2_cPLA2
      IPR000008, C2_dom
      IPR035892, C2_domain_sf
      IPR040723, cPLA2_C2
      IPR002642, LysoPLipase_cat_dom
      PfamiView protein in Pfam
      PF00168, C2, 1 hit
      PF18695, cPLA2_C2, 1 hit
      PF01735, PLA2_B, 1 hit
      SMARTiView protein in SMART
      SM00239, C2, 1 hit
      SM00022, PLAc, 1 hit
      SUPFAMiSSF52151, SSF52151, 1 hit
      PROSITEiView protein in PROSITE
      PS50004, C2, 1 hit
      PS51210, PLA2C, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24B_MOUSE
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C871
      Secondary accession number(s): A2AP62
      , Q4QQM1, Q80VV8, Q91W88
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
      Last sequence update: September 2, 2008
      Last modified: April 7, 2021
      This is version 91 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Reference proteome

      Documents

      1. MGD cross-references
        Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
      UniProt is an ELIXIR core data resource
      Main funding by: National Institutes of Health

      We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

      Do not show this banner again