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Protein

Cytosolic phospholipase A2 beta

Gene

Pla2g4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A (By similarity).By similarity

Caution

Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.Curated

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Activity regulationi

Stimulated by cytosolic Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei333NucleophileBy similarity1
Active sitei613Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic phospholipase A2 beta (EC:3.1.1.4)
Short name:
cPLA2-beta
Alternative name(s):
Phospholipase A2 group IVB
Gene namesi
Name:Pla2g4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384819 Pla2g4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470221 – 782Cytosolic phospholipase A2 betaAdd BLAST782

Proteomic databases

MaxQBiP0C871
PaxDbiP0C871
PRIDEiP0C871

PTM databases

iPTMnetiP0C871
PhosphoSitePlusiP0C871

Interactioni

Protein-protein interaction databases

BioGridi229231, 1 interactor
STRINGi10090.ENSMUSP00000118458

Structurei

3D structure databases

ProteinModelPortaliP0C871
SMRiP0C871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 102C2PROSITE-ProRule annotationAdd BLAST102
Domaini245 – 782PLA2cPROSITE-ProRule annotationAdd BLAST538

Domaini

The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
KOG1325 Eukaryota
ENOG410XR72 LUCA
HOGENOMiHOG000231788
HOVERGENiHBG080412
InParanoidiP0C871
KOiK16342

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51210 PLA2C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P0C871-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAKVPETCL LTVRVLRASG LPSKDLVTSS DCYVTLNLPT ASSHTLQTRT
60 70 80 90 100
VKNSRNPVWN QNFHFRIHRQ LKNVMELKVF DHDLVTRDDP VLSVLFDVGT
110 120 130 140 150
LQIGTQRQSF SLGTQEKGCL EVEFRLQTLT DCEEQLISNG IVVARELSCL
160 170 180 190 200
HVELKRTGDP KRSERKVQLV VAGACEGPQD ASAGTGSFHF HYPACWEQEL
210 220 230 240 250
NVHLQDDPHE QLKVPLRTLP SSQLVRLVFP TSQEPLMRLE LKKEEGPKEL
260 270 280 290 300
AVRLGCGPCP EEQAFLSKRK QVVAAALKKA LQLDQDLHED EIPVIAVMAT
310 320 330 340 350
GGGIRAMTSL YGQLAGLQEL GLLDCISYIT GASGSTWALA NLYEDPEWSQ
360 370 380 390 400
KDLAGPTEVL KTQVTKSKLG ALAPSQLWRY RQELAERARL GHPTCFTNLW
410 420 430 440 450
ALINEALLHD KPHEHKLSDQ REALSRGQNP LPIYCALNSK EQGLSTFDFG
460 470 480 490 500
EWCEFSPYEV GFPKYGAFIS SELFGSEFFM GRLVKQLPES RICFLEGIWS
510 520 530 540 550
NLFAASLQDS LYWSSEPSQF WDRWAQDQAN LDKEQVPHLK IAEPPTMAGR
560 570 580 590 600
IAELFTDLLT KRPLAHATHN FTRGLHFHKD YFQNSHFSAW KASKLDRLPN
610 620 630 640 650
QLTPTEPHLC LLDVGYLINT SCPPLLQPTR DVDLILSLDY NLYGAFQQLQ
660 670 680 690 700
LLSRFCQEQG IPFPSISPSP EEQRQPQECH LFCDPAQPEA PAVLHFPLVN
710 720 730 740 750
DSFQDYSAPG VPRTSEEKAA GEVNLSSSDS PYHYTKVTYS QEDVDKLLRL
760 770 780
THYNICNNQD RLREAMHQAV QRRRKRKQFR PE
Length:782
Mass (Da):88,448
Last modified:September 2, 2008 - v1
Checksum:iBD803A02439F6846
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCM8B7ZCM8_MOUSE
Phospholipase A2
Pla2g4b
791Annotation score:

Sequence cautioni

The sequence CAM22684 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75M → I in BC098210 (PubMed:15489334).Curated1
Sequence conflicti79V → A in BC098210 (PubMed:15489334).Curated1
Sequence conflicti605T → A in AAH42758 (PubMed:15489334).Curated1
Sequence conflicti617L → F in AAH42758 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833774 Genomic DNA Translation: CAM22684.1 Sequence problems.
BC042758 mRNA Translation: AAH42758.1
BC098210 mRNA No translation available.
RefSeqiNP_663353.3, NM_145378.3
UniGeneiMm.41467

Genome annotation databases

GeneIDi211429
KEGGimmu:211429
UCSCiuc008luz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833774 Genomic DNA Translation: CAM22684.1 Sequence problems.
BC042758 mRNA Translation: AAH42758.1
BC098210 mRNA No translation available.
RefSeqiNP_663353.3, NM_145378.3
UniGeneiMm.41467

3D structure databases

ProteinModelPortaliP0C871
SMRiP0C871
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229231, 1 interactor
STRINGi10090.ENSMUSP00000118458

PTM databases

iPTMnetiP0C871
PhosphoSitePlusiP0C871

Proteomic databases

MaxQBiP0C871
PaxDbiP0C871
PRIDEiP0C871

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi211429
KEGGimmu:211429
UCSCiuc008luz.2 mouse

Organism-specific databases

CTDi100137049
MGIiMGI:2384819 Pla2g4b

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
KOG1325 Eukaryota
ENOG410XR72 LUCA
HOGENOMiHOG000231788
HOVERGENiHBG080412
InParanoidiP0C871
KOiK16342

Miscellaneous databases

PROiPR:P0C871
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51210 PLA2C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA24B_MOUSE
AccessioniPrimary (citable) accession number: P0C871
Secondary accession number(s): A2AP62
, Q4QQM1, Q80VV8, Q91W88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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