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Protein

Cytosolic phospholipase A2 beta

Gene

PLA2G4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.3 Publications

Caution

Most tissues also express read-through transcripts from this gene into the upstream gene (JMJD7), some of which may encode fusion proteins.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=7.9 pmol/min/mg enzyme (isoform 5)1 Publication
    2. Vmax=3.6 pmol/min/µg enzyme with cAMP as substrate (isoform 4)1 Publication
    3. Vmax=140 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5)1 Publication
    4. Vmax=1.6 nmol/min/µg enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3)1 Publication
    5. Vmax=2.1 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5)1 Publication
    6. Vmax=0.6 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5)1 Publication
    7. Vmax=0.8 nmol/min/µg enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3)1 Publication
    8. Vmax=0.3 nmol/min/µg enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei335NucleophileBy similarity1
    Active sitei615Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482801 Acyl chain remodelling of PS
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482925 Acyl chain remodelling of PG
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483166 Synthesis of PA
    R-HSA-381038 XBP1(S) activates chaperone genes

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000616 [P0C869-8]
    SLP:000000617 [P0C869-6]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 beta (EC:3.1.1.4)
    Short name:
    cPLA2-beta
    Alternative name(s):
    Phospholipase A2 group IVB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PLA2G4B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000168970.21
    HostDB:ENSG00000243708.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9036 PLA2G4B

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606088 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P0C869

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane, Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi335S → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi417H → A: No effect. 1 Publication1
    Mutagenesisi615D → A: Abolishes enzyme activity. 1 Publication1
    Mutagenesisi632R → A: Abolishes enzyme activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    100137049
    8681

    Open Targets

    More...
    OpenTargetsi
    ENSG00000168970
    ENSG00000243708

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA165479070

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4136

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PLA2G4B

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    300669659

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470211 – 781Cytosolic phospholipase A2 betaAdd BLAST781

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P0C869

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P0C869

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P0C869

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P0C869

    PeptideAtlas

    More...
    PeptideAtlasi
    P0C869

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P0C869

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    52403
    52404 [P0C869-4]
    52405 [P0C869-6]
    52406 [P0C869-7]
    52407 [P0C869-8]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P0C869

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P0C869

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000168970 Expressed in 86 organ(s), highest expression level in right hemisphere of cerebellum

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P0C869 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P0C869 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA005726

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114229, 2 interactors
    936685, 4 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P0C869, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000396045

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P0C869

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P0C869

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P0C869

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 97C2PROSITE-ProRule annotationAdd BLAST97
    Domaini246 – 781PLA2cPROSITE-ProRule annotationAdd BLAST536

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1028 Eukaryota
    KOG1325 Eukaryota
    ENOG410XR72 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153271

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG080412

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P0C869

    KEGG Orthology (KO)

    More...
    KOi
    K16342

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FRFRIHS

    Database of Orthologous Groups

    More...
    OrthoDBi
    302848at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P0C869

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325228

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.150, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR000008 C2_dom
    IPR035892 C2_domain_sf
    IPR002642 LysoPLipase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00168 C2, 1 hit
    PF01735 PLA2_B, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00239 C2, 1 hit
    SM00022 PLAc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52151 SSF52151, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50004 C2, 1 hit
    PS51210 PLA2C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: P0C869-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAVAEVSRTC LLTVRVLQAH RLPSKDLVTP SDCYVTLWLP TACSHRLQTR
    60 70 80 90 100
    TVKNSSSPVW NQSFHFRIHR QLKNVMELKV FDQDLVTGDD PVLSVLFDAG
    110 120 130 140 150
    TLRAGEFRRE SFSLSPQGEG RLEVEFRLQS LADRGEWLVS NGVLVARELS
    160 170 180 190 200
    CLHVQLEETG DQKSSEHRVQ LVVPGSCEGP QEASVGTGTF RFHCPACWEQ
    210 220 230 240 250
    ELSIRLQDAP EEQLKAPLSA LPSGQVVRLV FPTSQEPLMR VELKKEAGLR
    260 270 280 290 300
    ELAVRLGFGP CAEEQAFLSR RKQVVAAALR QALQLDGDLQ EDEIPVVAIM
    310 320 330 340 350
    ATGGGIRAMT SLYGQLAGLK ELGLLDCVSY ITGASGSTWA LANLYEDPEW
    360 370 380 390 400
    SQKDLAGPTE LLKTQVTKNK LGVLAPSQLQ RYRQELAERA RLGYPSCFTN
    410 420 430 440 450
    LWALINEALL HDEPHDHKLS DQREALSHGQ NPLPIYCALN TKGQSLTTFE
    460 470 480 490 500
    FGEWCEFSPY EVGFPKYGAF IPSELFGSEF FMGQLMKRLP ESRICFLEGI
    510 520 530 540 550
    WSNLYAANLQ DSLYWASEPS QFWDRWVRNQ ANLDKEQVPL LKIEEPPSTA
    560 570 580 590 600
    GRIAEFFTDL LTWRPLAQAT HNFLRGLHFH KDYFQHPHFS TWKATTLDGL
    610 620 630 640 650
    PNQLTPSEPH LCLLDVGYLI NTSCLPLLQP TRDVDLILSL DYNLHGAFQQ
    660 670 680 690 700
    LQLLGRFCQE QGIPFPPISP SPEEQLQPRE CHTFSDPTCP GAPAVLHFPL
    710 720 730 740 750
    VSDSFREYSA PGVRRTPEEA AAGEVNLSSS DSPYHYTKVT YSQEDVDKLL
    760 770 780
    HLTHYNVCNN QEQLLEALRQ AVQRRRQRRP H
    Length:781
    Mass (Da):87,978
    Last modified:July 13, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C5C6861E7BAB1B8
    GO
    Isoform 2 (identifier: P0C869-7) [UniParc]FASTAAdd to basket
    Also known as: beta2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MAV → MAEAALEAVR...KVVDEEAMEK
         650-662: QLQLLGRFCQEQG → GSGGHPRRRQLGR
         663-781: Missing.

    Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
    Show »
    Length:893
    Mass (Da):100,516
    Checksum:i0A7C3BE752C48F55
    GO
    Isoform 3 (identifier: P0C869-8) [UniParc]FASTAAdd to basket
    Also known as: beta3

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MAV → MAEAALEAVR...KVVDEEAMEK
         641-765: Missing.

    Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
    Show »
    Length:887
    Mass (Da):100,094
    Checksum:i4C5CC6D084F2DF99
    GO
    Isoform 4 (identifier: P0C869-4) [UniParc] [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-299: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:482
    Mass (Da):54,679
    Checksum:iEB8FC2F2EB2AE258
    GO
    Isoform 5 (identifier: P0C869-6) [UniParc]FASTAAdd to basket
    Also known as: Beta1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MAV → MAEAALEAVR...KVVDEEAMEK

    Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.
    Show »
    Length:1,012
    Mass (Da):114,121
    Checksum:i989EDB4AD3CF19DD
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H3BSX5H3BSX5_HUMAN
    Cytosolic phospholipase A2 beta
    PLA2G4B
    30Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAD92387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138L → F in AAD32135 (PubMed:10358058).Curated1
    Sequence conflicti162Q → P in ABF69195 (PubMed:16617059).Curated1
    Sequence conflicti162Q → P in ABF69196 (PubMed:16617059).Curated1
    Sequence conflicti438A → V in ABF69195 (PubMed:16617059).Curated1
    Sequence conflicti517S → P in ABF69195 (PubMed:16617059).Curated1
    Sequence conflicti575R → C in BAG61401 (PubMed:14702039).Curated1
    Sequence conflicti723G → E in BAG61401 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027047191R → C1 PublicationCorresponds to variant dbSNP:rs3816533Ensembl.1
    Natural variantiVAR_027048239M → I. Corresponds to variant dbSNP:rs2290552Ensembl.1
    Natural variantiVAR_034365391R → H. Corresponds to variant dbSNP:rs34807597Ensembl.1
    Natural variantiVAR_060082591T → I. Corresponds to variant dbSNP:rs36126315Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198711 – 299Missing in isoform 4. 1 PublicationAdd BLAST299
    Alternative sequenceiVSP_0393871 – 3MAV → MAEAALEAVRSELREFPAAA RELCVPLAVPYLDKPPTPLH FYRDWVCPNRPCIIRNALQH WPALQKWSLPYFRATVGSTE VSVAVTPDGYADAVRGDRFM MPAERRLPLSFVLDVLEGRA QHPGVLYVQKQCSNLPSELP QLLPDLESHVPWASEALGKM PDAVNFWLGEAAAVTSLHKD HYENLYCVVSGEKHFLFHPP SDRPFIPYELYTPATYQLTE EGTFKVVDEEAMEK in isoform 2, isoform 3 and isoform 5. 3 Publications3
    Alternative sequenceiVSP_039388641 – 765Missing in isoform 3. 1 PublicationAdd BLAST125
    Alternative sequenceiVSP_039389650 – 662QLQLL…CQEQG → GSGGHPRRRQLGR in isoform 2. 1 PublicationAdd BLAST13
    Alternative sequenceiVSP_039390663 – 781Missing in isoform 2. 1 PublicationAdd BLAST119

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF065215 mRNA Translation: AAC78836.1
    AF121908 mRNA Translation: AAD32135.1
    DQ523799 mRNA Translation: ABF69195.1
    DQ523800 mRNA Translation: ABF69196.1
    AK299419 mRNA Translation: BAG61401.1
    AB209150 mRNA Translation: BAD92387.1 Different initiation.
    AC020659 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS45241.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001108105.1, NM_001114633.1 [P0C869-1]
    NP_001185517.1, NM_001198588.1 [P0C869-7]
    NP_005081.1, NM_005090.3 [P0C869-6]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.198161

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000452633; ENSP00000396045; ENSG00000243708 [P0C869-1]
    ENST00000458483; ENSP00000416610; ENSG00000243708 [P0C869-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    100137049
    8681

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:100137049
    hsa:8681

    UCSC genome browser

    More...
    UCSCi
    uc010bco.4 human

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF065215 mRNA Translation: AAC78836.1
    AF121908 mRNA Translation: AAD32135.1
    DQ523799 mRNA Translation: ABF69195.1
    DQ523800 mRNA Translation: ABF69196.1
    AK299419 mRNA Translation: BAG61401.1
    AB209150 mRNA Translation: BAD92387.1 Different initiation.
    AC020659 Genomic DNA No translation available.
    CCDSiCCDS45241.1
    RefSeqiNP_001108105.1, NM_001114633.1 [P0C869-1]
    NP_001185517.1, NM_001198588.1 [P0C869-7]
    NP_005081.1, NM_005090.3 [P0C869-6]
    UniGeneiHs.198161

    3D structure databases

    ProteinModelPortaliP0C869
    SMRiP0C869
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi114229, 2 interactors
    936685, 4 interactors
    IntActiP0C869, 3 interactors
    STRINGi9606.ENSP00000396045

    Chemistry databases

    BindingDBiP0C869
    ChEMBLiCHEMBL4136
    SwissLipidsiSLP:000000616 [P0C869-8]
    SLP:000000617 [P0C869-6]

    PTM databases

    iPTMnetiP0C869
    PhosphoSitePlusiP0C869

    Polymorphism and mutation databases

    BioMutaiPLA2G4B
    DMDMi300669659

    Proteomic databases

    EPDiP0C869
    jPOSTiP0C869
    MaxQBiP0C869
    PaxDbiP0C869
    PeptideAtlasiP0C869
    PRIDEiP0C869
    ProteomicsDBi52403
    52404 [P0C869-4]
    52405 [P0C869-6]
    52406 [P0C869-7]
    52407 [P0C869-8]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    8681
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000452633; ENSP00000396045; ENSG00000243708 [P0C869-1]
    ENST00000458483; ENSP00000416610; ENSG00000243708 [P0C869-1]
    GeneIDi100137049
    8681
    KEGGihsa:100137049
    hsa:8681
    UCSCiuc010bco.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    100137049
    8681
    DisGeNETi100137049
    8681
    EuPathDBiHostDB:ENSG00000168970.21
    HostDB:ENSG00000243708.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PLA2G4B
    HGNCiHGNC:9036 PLA2G4B
    HPAiHPA005726
    MIMi606088 gene
    neXtProtiNX_P0C869
    OpenTargetsiENSG00000168970
    ENSG00000243708
    PharmGKBiPA165479070

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1028 Eukaryota
    KOG1325 Eukaryota
    ENOG410XR72 LUCA
    GeneTreeiENSGT00940000153271
    HOVERGENiHBG080412
    InParanoidiP0C869
    KOiK16342
    OMAiFRFRIHS
    OrthoDBi302848at2759
    PhylomeDBiP0C869
    TreeFamiTF325228

    Enzyme and pathway databases

    ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
    R-HSA-1482801 Acyl chain remodelling of PS
    R-HSA-1482839 Acyl chain remodelling of PE
    R-HSA-1482925 Acyl chain remodelling of PG
    R-HSA-1483115 Hydrolysis of LPC
    R-HSA-1483166 Synthesis of PA
    R-HSA-381038 XBP1(S) activates chaperone genes

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PLA2G4B

    Protein Ontology

    More...
    PROi
    PR:P0C869

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000168970 Expressed in 86 organ(s), highest expression level in right hemisphere of cerebellum
    ExpressionAtlasiP0C869 baseline and differential
    GenevisibleiP0C869 HS

    Family and domain databases

    Gene3Di2.60.40.150, 1 hit
    InterProiView protein in InterPro
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR000008 C2_dom
    IPR035892 C2_domain_sf
    IPR002642 LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF00168 C2, 1 hit
    PF01735 PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00239 C2, 1 hit
    SM00022 PLAc, 1 hit
    SUPFAMiSSF52151 SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS50004 C2, 1 hit
    PS51210 PLA2C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24B_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C869
    Secondary accession number(s): B4DRT9
    , O95712, Q19KD5, Q19KD6, Q59GF9, Q8TB10, Q9UKV7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: July 13, 2010
    Last modified: January 16, 2019
    This is version 95 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
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