Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 110 (02 Jun 2021)
Sequence version 2 (13 Jul 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Cytosolic phospholipase A2 beta

Gene

PLA2G4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.

3 Publications

Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.

1 Publication

Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.

3 Publications

Caution

Most tissues also express read-through transcripts from this gene into the upstream gene (JMJD7), some of which may encode fusion proteins.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The specific activity is 0.8 nmol/min/µg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 0.3 nmol/min/µg enzyme with 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 1.6 nmol/min/µg enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate.1 Publication
      The specific activity is 2.1 nmol/min/µg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine as substrate. The specific activity is 0.6 nmol/min/µg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate. The specific activity is 140 nmol/min/µg enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate.1 Publication

          Sites

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi26Calcium 1PROSITE-ProRule annotation1
          Metal bindingi26Calcium 2PROSITE-ProRule annotation1
          Metal bindingi32Calcium 1PROSITE-ProRule annotation1
          Metal bindingi82Calcium 1PROSITE-ProRule annotation1
          Metal bindingi82Calcium 2PROSITE-ProRule annotation1
          Metal bindingi84Calcium 1PROSITE-ProRule annotation1
          Metal bindingi84Calcium 2PROSITE-ProRule annotation1
          Metal bindingi90Calcium 2PROSITE-ProRule annotation1
          <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei335NucleophileBy similarity1
          Active sitei615Proton acceptorBy similarity1

          <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

          GO - Biological processi

          <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

          Molecular functionHydrolase
          Biological processLipid degradation, Lipid metabolism
          LigandCalcium, Metal-binding

          Enzyme and pathway databases

          Pathway Commons web resource for biological pathway data

          More...
          PathwayCommonsi
          P0C869

          Reactome - a knowledgebase of biological pathways and processes

          More...
          Reactomei
          R-HSA-1482788, Acyl chain remodelling of PC
          R-HSA-1482801, Acyl chain remodelling of PS
          R-HSA-1482839, Acyl chain remodelling of PE
          R-HSA-1482925, Acyl chain remodelling of PG
          R-HSA-1483115, Hydrolysis of LPC
          R-HSA-1483166, Synthesis of PA
          R-HSA-381038, XBP1(S) activates chaperone genes

          Chemistry databases

          SwissLipids knowledge resource for lipid biology

          More...
          SwissLipidsi
          SLP:000000616 [P0C869-8]
          SLP:000000617 [P0C869-6]

          <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
          Recommended name:
          Cytosolic phospholipase A2 beta1 Publication (EC:3.1.1.43 Publications)
          Short name:
          cPLA2-beta1 Publication
          Alternative name(s):
          Lysophospholipase A1 group IVB1 Publication (EC:3.1.1.52 Publications)
          Phospholipase A2 group IVB
          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
          Name:PLA2G4B
          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
          <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
          • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

          Organism-specific databases

          Human Gene Nomenclature Database

          More...
          HGNCi
          HGNC:9036, PLA2G4B

          Online Mendelian Inheritance in Man (OMIM)

          More...
          MIMi
          606088, gene

          neXtProt; the human protein knowledge platform

          More...
          neXtProti
          NX_P0C869

          Eukaryotic Pathogen, Vector and Host Database Resources

          More...
          VEuPathDBi
          HostDB:ENSG00000168970.21
          HostDB:ENSG00000243708.9

          <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

          Keywords - Cellular componenti

          Cytoplasm, Endosome, Membrane, Mitochondrion

          <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

          Mutagenesis

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi335S → A: Abolishes enzyme activity. 1 Publication1
          Mutagenesisi417H → A: No effect. 1 Publication1
          Mutagenesisi615D → A: Abolishes enzyme activity. 1 Publication1
          Mutagenesisi632R → A: Abolishes enzyme activity. 1 Publication1

          Organism-specific databases

          DisGeNET

          More...
          DisGeNETi
          100137049
          8681

          Open Targets

          More...
          OpenTargetsi
          ENSG00000168970
          ENSG00000243708

          The Pharmacogenetics and Pharmacogenomics Knowledge Base

          More...
          PharmGKBi
          PA165479070

          Miscellaneous databases

          Pharos NIH Druggable Genome Knowledgebase

          More...
          Pharosi
          P0C869, Tchem

          Chemistry databases

          ChEMBL database of bioactive drug-like small molecules

          More...
          ChEMBLi
          CHEMBL4136

          Genetic variation databases

          BioMuta curated single-nucleotide variation and disease association database

          More...
          BioMutai
          PLA2G4B

          Domain mapping of disease mutations (DMDM)

          More...
          DMDMi
          300669659

          <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

          Molecule processing

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470211 – 781Cytosolic phospholipase A2 betaAdd BLAST781

          Proteomic databases

          jPOST - Japan Proteome Standard Repository/Database

          More...
          jPOSTi
          P0C869

          MassIVE - Mass Spectrometry Interactive Virtual Environment

          More...
          MassIVEi
          P0C869

          MaxQB - The MaxQuant DataBase

          More...
          MaxQBi
          P0C869

          PaxDb, a database of protein abundance averages across all three domains of life

          More...
          PaxDbi
          P0C869

          PeptideAtlas

          More...
          PeptideAtlasi
          P0C869

          PRoteomics IDEntifications database

          More...
          PRIDEi
          P0C869

          ProteomicsDB: a multi-organism proteome resource

          More...
          ProteomicsDBi
          52403
          52404 [P0C869-4]
          52405 [P0C869-6]
          52406 [P0C869-7]
          52407 [P0C869-8]

          PTM databases

          iPTMnet integrated resource for PTMs in systems biology context

          More...
          iPTMneti
          P0C869

          Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

          More...
          PhosphoSitePlusi
          P0C869

          <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

          <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

          Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.3 Publications

          Gene expression databases

          Bgee dataBase for Gene Expression Evolution

          More...
          Bgeei
          ENSG00000168970, Expressed in right hemisphere of cerebellum and 112 other tissues

          ExpressionAtlas, Differential and Baseline Expression

          More...
          ExpressionAtlasi
          P0C869, baseline and differential

          Genevisible search portal to normalized and curated expression data from Genevestigator

          More...
          Genevisiblei
          P0C869, HS

          Organism-specific databases

          Human Protein Atlas

          More...
          HPAi
          ENSG00000243708, Tissue enhanced (lymphoid tissue, skin, tongue)

          <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

          Protein-protein interaction databases

          The Biological General Repository for Interaction Datasets (BioGRID)

          More...
          BioGRIDi
          114229, 2 interactors
          936685, 6 interactors

          Protein interaction database and analysis system

          More...
          IntActi
          P0C869, 5 interactors

          STRING: functional protein association networks

          More...
          STRINGi
          9606.ENSP00000396045

          Chemistry databases

          BindingDB database of measured binding affinities

          More...
          BindingDBi
          P0C869

          Miscellaneous databases

          RNAct, Protein-RNA interaction predictions for model organisms.

          More...
          RNActi
          P0C869, protein

          <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

          3D structure databases

          SWISS-MODEL Repository - a database of annotated 3D protein structure models

          More...
          SMRi
          P0C869

          Database of comparative protein structure models

          More...
          ModBasei
          Search...

          <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

          Domains and Repeats

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 112C2PROSITE-ProRule annotationAdd BLAST112
          Domaini246 – 781PLA2cPROSITE-ProRule annotationAdd BLAST536

          <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

          The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ (By similarity).By similarity

          Phylogenomic databases

          evolutionary genealogy of genes: Non-supervised Orthologous Groups

          More...
          eggNOGi
          KOG1028, Eukaryota
          KOG1325, Eukaryota

          Ensembl GeneTree

          More...
          GeneTreei
          ENSGT01030000234606

          The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

          More...
          HOGENOMi
          CLU_011663_0_0_1

          InParanoid: Eukaryotic Ortholog Groups

          More...
          InParanoidi
          P0C869

          Identification of Orthologs from Complete Genome Data

          More...
          OMAi
          FRFRIHS

          Database of Orthologous Groups

          More...
          OrthoDBi
          302848at2759

          Database for complete collections of gene phylogenies

          More...
          PhylomeDBi
          P0C869

          TreeFam database of animal gene trees

          More...
          TreeFami
          TF325228

          Family and domain databases

          Conserved Domains Database

          More...
          CDDi
          cd04036, C2_cPLA2, 1 hit

          Gene3D Structural and Functional Annotation of Protein Families

          More...
          Gene3Di
          2.60.40.150, 1 hit

          Integrated resource of protein families, domains and functional sites

          More...
          InterProi
          View protein in InterPro
          IPR016035, Acyl_Trfase/lysoPLipase
          IPR041847, C2_cPLA2
          IPR000008, C2_dom
          IPR035892, C2_domain_sf
          IPR040723, cPLA2_C2
          IPR002642, LysoPLipase_cat_dom

          Pfam protein domain database

          More...
          Pfami
          View protein in Pfam
          PF00168, C2, 1 hit
          PF18695, cPLA2_C2, 1 hit
          PF01735, PLA2_B, 1 hit

          Simple Modular Architecture Research Tool; a protein domain database

          More...
          SMARTi
          View protein in SMART
          SM00239, C2, 1 hit
          SM00022, PLAc, 1 hit

          Superfamily database of structural and functional annotation

          More...
          SUPFAMi
          SSF52151, SSF52151, 1 hit

          PROSITE; a protein domain and family database

          More...
          PROSITEi
          View protein in PROSITE
          PS50004, C2, 1 hit
          PS51210, PLA2C, 1 hit

          <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

          <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

          This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

          This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

          Isoform 1 (identifier: P0C869-1) [UniParc]FASTAAdd to basket

          This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

          « Hide
                  10         20         30         40         50
          MAVAEVSRTC LLTVRVLQAH RLPSKDLVTP SDCYVTLWLP TACSHRLQTR
          60 70 80 90 100
          TVKNSSSPVW NQSFHFRIHR QLKNVMELKV FDQDLVTGDD PVLSVLFDAG
          110 120 130 140 150
          TLRAGEFRRE SFSLSPQGEG RLEVEFRLQS LADRGEWLVS NGVLVARELS
          160 170 180 190 200
          CLHVQLEETG DQKSSEHRVQ LVVPGSCEGP QEASVGTGTF RFHCPACWEQ
          210 220 230 240 250
          ELSIRLQDAP EEQLKAPLSA LPSGQVVRLV FPTSQEPLMR VELKKEAGLR
          260 270 280 290 300
          ELAVRLGFGP CAEEQAFLSR RKQVVAAALR QALQLDGDLQ EDEIPVVAIM
          310 320 330 340 350
          ATGGGIRAMT SLYGQLAGLK ELGLLDCVSY ITGASGSTWA LANLYEDPEW
          360 370 380 390 400
          SQKDLAGPTE LLKTQVTKNK LGVLAPSQLQ RYRQELAERA RLGYPSCFTN
          410 420 430 440 450
          LWALINEALL HDEPHDHKLS DQREALSHGQ NPLPIYCALN TKGQSLTTFE
          460 470 480 490 500
          FGEWCEFSPY EVGFPKYGAF IPSELFGSEF FMGQLMKRLP ESRICFLEGI
          510 520 530 540 550
          WSNLYAANLQ DSLYWASEPS QFWDRWVRNQ ANLDKEQVPL LKIEEPPSTA
          560 570 580 590 600
          GRIAEFFTDL LTWRPLAQAT HNFLRGLHFH KDYFQHPHFS TWKATTLDGL
          610 620 630 640 650
          PNQLTPSEPH LCLLDVGYLI NTSCLPLLQP TRDVDLILSL DYNLHGAFQQ
          660 670 680 690 700
          LQLLGRFCQE QGIPFPPISP SPEEQLQPRE CHTFSDPTCP GAPAVLHFPL
          710 720 730 740 750
          VSDSFREYSA PGVRRTPEEA AAGEVNLSSS DSPYHYTKVT YSQEDVDKLL
          760 770 780
          HLTHYNVCNN QEQLLEALRQ AVQRRRQRRP H
          Length:781
          Mass (Da):87,978
          Last modified:July 13, 2010 - v2
          <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C5C6861E7BAB1B8
          GO
          Isoform 2 (identifier: P0C869-7) [UniParc]FASTAAdd to basket
          Also known as: beta2

          The sequence of this isoform differs from the canonical sequence as follows:
               1-3: MAV → MAEAALEAVR...KVVDEEAMEK
               650-662: QLQLLGRFCQEQG → GSGGHPRRRQLGR
               663-781: Missing.

          Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.Curated
          Show »
          Length:893
          Mass (Da):100,516
          Checksum:i0A7C3BE752C48F55
          GO
          Isoform 3 (identifier: P0C869-8) [UniParc]FASTAAdd to basket
          Also known as: beta3

          The sequence of this isoform differs from the canonical sequence as follows:
               1-3: MAV → MAEAALEAVR...KVVDEEAMEK
               641-765: Missing.

          Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.Curated
          Show »
          Length:887
          Mass (Da):100,094
          Checksum:i4C5CC6D084F2DF99
          GO
          Isoform 4 (identifier: P0C869-4) [UniParc] [UniParc]FASTAAdd to basket

          The sequence of this isoform differs from the canonical sequence as follows:
               1-299: Missing.

          Show »
          Length:482
          Mass (Da):54,679
          Checksum:iEB8FC2F2EB2AE258
          GO
          Isoform 5 (identifier: P0C869-6) [UniParc]FASTAAdd to basket
          Also known as: Beta1

          The sequence of this isoform differs from the canonical sequence as follows:
               1-3: MAV → MAEAALEAVR...KVVDEEAMEK

          Note: Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.Curated
          Show »
          Length:1,012
          Mass (Da):114,121
          Checksum:i989EDB4AD3CF19DD
          GO

          <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

          There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
          EntryEntry nameProtein names
          Gene namesLengthAnnotation
          H3BSX5H3BSX5_HUMAN
          Cytosolic phospholipase A2 beta
          PLA2G4B
          30Annotation score:

          Annotation score:1 out of 5

          <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

          <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

          The sequence BAD92387 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

          Experimental Info

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138L → F in AAD32135 (PubMed:10358058).Curated1
          Sequence conflicti162Q → P in ABF69195 (PubMed:16617059).Curated1
          Sequence conflicti162Q → P in ABF69196 (PubMed:16617059).Curated1
          Sequence conflicti438A → V in ABF69195 (PubMed:16617059).Curated1
          Sequence conflicti517S → P in ABF69195 (PubMed:16617059).Curated1
          Sequence conflicti575R → C in BAG61401 (PubMed:14702039).Curated1
          Sequence conflicti723G → E in BAG61401 (PubMed:14702039).Curated1

          Natural variant

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027047191R → C1 PublicationCorresponds to variant dbSNP:rs3816533Ensembl.1
          Natural variantiVAR_027048239M → I. Corresponds to variant dbSNP:rs2290552Ensembl.1
          Natural variantiVAR_034365391R → H. Corresponds to variant dbSNP:rs34807597Ensembl.1
          Natural variantiVAR_060082591T → I. Corresponds to variant dbSNP:rs36126315Ensembl.1

          Alternative sequence

          Feature keyPosition(s)DescriptionActionsGraphical viewLength
          <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198711 – 299Missing in isoform 4. 1 PublicationAdd BLAST299
          Alternative sequenceiVSP_0393871 – 3MAV → MAEAALEAVRSELREFPAAA RELCVPLAVPYLDKPPTPLH FYRDWVCPNRPCIIRNALQH WPALQKWSLPYFRATVGSTE VSVAVTPDGYADAVRGDRFM MPAERRLPLSFVLDVLEGRA QHPGVLYVQKQCSNLPSELP QLLPDLESHVPWASEALGKM PDAVNFWLGEAAAVTSLHKD HYENLYCVVSGEKHFLFHPP SDRPFIPYELYTPATYQLTE EGTFKVVDEEAMEK in isoform 2, isoform 3 and isoform 5. 3 Publications3
          Alternative sequenceiVSP_039388641 – 765Missing in isoform 3. 1 PublicationAdd BLAST125
          Alternative sequenceiVSP_039389650 – 662QLQLL…CQEQG → GSGGHPRRRQLGR in isoform 2. 1 PublicationAdd BLAST13
          Alternative sequenceiVSP_039390663 – 781Missing in isoform 2. 1 PublicationAdd BLAST119

          Sequence databases

          Select the link destinations:

          EMBL nucleotide sequence database

          More...
          EMBLi

          GenBank nucleotide sequence database

          More...
          GenBanki

          DNA Data Bank of Japan; a nucleotide sequence database

          More...
          DDBJi
          Links Updated
          AF065215 mRNA Translation: AAC78836.1
          AF121908 mRNA Translation: AAD32135.1
          DQ523799 mRNA Translation: ABF69195.1
          DQ523800 mRNA Translation: ABF69196.1
          AK299419 mRNA Translation: BAG61401.1
          AB209150 mRNA Translation: BAD92387.1 Different initiation.
          AC020659 Genomic DNA No translation available.

          The Consensus CDS (CCDS) project

          More...
          CCDSi
          CCDS45241.1

          NCBI Reference Sequences

          More...
          RefSeqi
          NP_001108105.1, NM_001114633.1 [P0C869-1]
          NP_001185517.1, NM_001198588.1 [P0C869-7]
          NP_005081.1, NM_005090.3 [P0C869-6]

          Genome annotation databases

          Ensembl eukaryotic genome annotation project

          More...
          Ensembli
          ENST00000452633; ENSP00000396045; ENSG00000243708 [P0C869-1]
          ENST00000458483; ENSP00000416610; ENSG00000243708 [P0C869-1]

          Database of genes from NCBI RefSeq genomes

          More...
          GeneIDi
          100137049
          8681

          KEGG: Kyoto Encyclopedia of Genes and Genomes

          More...
          KEGGi
          hsa:100137049
          hsa:8681

          UCSC genome browser

          More...
          UCSCi
          uc010bco.4, human

          Keywords - Coding sequence diversityi

          Alternative splicing

          <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

          <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

          Sequence databases

          Select the link destinations:
          EMBLi
          GenBanki
          DDBJi
          Links Updated
          AF065215 mRNA Translation: AAC78836.1
          AF121908 mRNA Translation: AAD32135.1
          DQ523799 mRNA Translation: ABF69195.1
          DQ523800 mRNA Translation: ABF69196.1
          AK299419 mRNA Translation: BAG61401.1
          AB209150 mRNA Translation: BAD92387.1 Different initiation.
          AC020659 Genomic DNA No translation available.
          CCDSiCCDS45241.1
          RefSeqiNP_001108105.1, NM_001114633.1 [P0C869-1]
          NP_001185517.1, NM_001198588.1 [P0C869-7]
          NP_005081.1, NM_005090.3 [P0C869-6]

          3D structure databases

          SMRiP0C869
          ModBaseiSearch...

          Protein-protein interaction databases

          BioGRIDi114229, 2 interactors
          936685, 6 interactors
          IntActiP0C869, 5 interactors
          STRINGi9606.ENSP00000396045

          Chemistry databases

          BindingDBiP0C869
          ChEMBLiCHEMBL4136
          SwissLipidsiSLP:000000616 [P0C869-8]
          SLP:000000617 [P0C869-6]

          PTM databases

          iPTMnetiP0C869
          PhosphoSitePlusiP0C869

          Genetic variation databases

          BioMutaiPLA2G4B
          DMDMi300669659

          Proteomic databases

          jPOSTiP0C869
          MassIVEiP0C869
          MaxQBiP0C869
          PaxDbiP0C869
          PeptideAtlasiP0C869
          PRIDEiP0C869
          ProteomicsDBi52403
          52404 [P0C869-4]
          52405 [P0C869-6]
          52406 [P0C869-7]
          52407 [P0C869-8]

          Protocols and materials databases

          Antibodypedia a portal for validated antibodies

          More...
          Antibodypediai
          70595, 66 antibodies

          The DNASU plasmid repository

          More...
          DNASUi
          8681

          Genome annotation databases

          EnsembliENST00000452633; ENSP00000396045; ENSG00000243708 [P0C869-1]
          ENST00000458483; ENSP00000416610; ENSG00000243708 [P0C869-1]
          GeneIDi100137049
          8681
          KEGGihsa:100137049
          hsa:8681
          UCSCiuc010bco.4, human

          Organism-specific databases

          Comparative Toxicogenomics Database

          More...
          CTDi
          100137049
          8681
          DisGeNETi100137049
          8681

          GeneCards: human genes, protein and diseases

          More...
          GeneCardsi
          PLA2G4B
          HGNCiHGNC:9036, PLA2G4B
          HPAiENSG00000243708, Tissue enhanced (lymphoid tissue, skin, tongue)
          MIMi606088, gene
          neXtProtiNX_P0C869
          OpenTargetsiENSG00000168970
          ENSG00000243708
          PharmGKBiPA165479070
          VEuPathDBiHostDB:ENSG00000168970.21
          HostDB:ENSG00000243708.9

          GenAtlas: human gene database

          More...
          GenAtlasi
          Search...

          Phylogenomic databases

          eggNOGiKOG1028, Eukaryota
          KOG1325, Eukaryota
          GeneTreeiENSGT01030000234606
          HOGENOMiCLU_011663_0_0_1
          InParanoidiP0C869
          OMAiFRFRIHS
          OrthoDBi302848at2759
          PhylomeDBiP0C869
          TreeFamiTF325228

          Enzyme and pathway databases

          PathwayCommonsiP0C869
          ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
          R-HSA-1482801, Acyl chain remodelling of PS
          R-HSA-1482839, Acyl chain remodelling of PE
          R-HSA-1482925, Acyl chain remodelling of PG
          R-HSA-1483115, Hydrolysis of LPC
          R-HSA-1483166, Synthesis of PA
          R-HSA-381038, XBP1(S) activates chaperone genes

          Miscellaneous databases

          BioGRID ORCS database of CRISPR phenotype screens

          More...
          BioGRID-ORCSi
          100137049, 22 hits in 959 CRISPR screens
          8681, 10 hits in 889 CRISPR screens

          The Gene Wiki collection of pages on human genes and proteins

          More...
          GeneWikii
          PLA2G4B
          PharosiP0C869, Tchem

          Protein Ontology

          More...
          PROi
          PR:P0C869
          RNActiP0C869, protein

          The Stanford Online Universal Resource for Clones and ESTs

          More...
          SOURCEi
          Search...

          Gene expression databases

          BgeeiENSG00000168970, Expressed in right hemisphere of cerebellum and 112 other tissues
          ExpressionAtlasiP0C869, baseline and differential
          GenevisibleiP0C869, HS

          Family and domain databases

          CDDicd04036, C2_cPLA2, 1 hit
          Gene3Di2.60.40.150, 1 hit
          InterProiView protein in InterPro
          IPR016035, Acyl_Trfase/lysoPLipase
          IPR041847, C2_cPLA2
          IPR000008, C2_dom
          IPR035892, C2_domain_sf
          IPR040723, cPLA2_C2
          IPR002642, LysoPLipase_cat_dom
          PfamiView protein in Pfam
          PF00168, C2, 1 hit
          PF18695, cPLA2_C2, 1 hit
          PF01735, PLA2_B, 1 hit
          SMARTiView protein in SMART
          SM00239, C2, 1 hit
          SM00022, PLAc, 1 hit
          SUPFAMiSSF52151, SSF52151, 1 hit
          PROSITEiView protein in PROSITE
          PS50004, C2, 1 hit
          PS51210, PLA2C, 1 hit

          MobiDB: a database of protein disorder and mobility annotations

          More...
          MobiDBi
          Search...

          <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

          <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24B_HUMAN
          <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C869
          Secondary accession number(s): B4DRT9
          , O95712, Q19KD5, Q19KD6, Q59GF9, Q8TB10, Q9UKV7
          <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
          Last sequence update: July 13, 2010
          Last modified: June 2, 2021
          This is version 110 of the entry and version 2 of the sequence. See complete history.
          <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
          Annotation programChordata Protein Annotation Program
          DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

          <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

          Keywords - Technical termi

          Reference proteome

          Documents

          1. Human chromosome 15
            Human chromosome 15: entries, gene names and cross-references to MIM
          2. Human entries with genetic variants
            List of human entries with genetic variants
          3. Human variants curated from literature reports
            Index of human variants curated from literature reports
          4. MIM cross-references
            Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
          UniProt is an ELIXIR core data resource
          Main funding by: National Institutes of Health

          We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

          Do not show this banner again