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Protein

Phosphoinositide-interacting protein

Gene

PIRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide-interacting protein
Gene namesi
Name:PIRT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000233670.6
HGNCiHGNC:37239 PIRT
MIMi612068 gene
neXtProtiNX_P0C851

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000233670

Polymorphism and mutation databases

BioMutaiPIRT
DMDMi308153473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003470601 – 137Phosphoinositide-interacting proteinAdd BLAST137

Proteomic databases

PaxDbiP0C851
PeptideAtlasiP0C851
PRIDEiP0C851
ProteomicsDBi52394

Expressioni

Gene expression databases

BgeeiENSG00000233670 Expressed in 65 organ(s), highest expression level in dorsal root ganglion
GenevisibleiP0C851 HS

Organism-specific databases

HPAiHPA042337

Interactioni

Subunit structurei

Interacts with TRPV1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000462046

Structurei

3D structure databases

ProteinModelPortaliP0C851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWQ6 Eukaryota
ENOG410YYIW LUCA
GeneTreeiENSGT00390000016891
HOGENOMiHOG000082413
HOVERGENiHBG106144
InParanoidiP0C851
OMAiWEIYHKP
OrthoDBiEOG091G0ZPU
PhylomeDBiP0C851
TreeFamiTF328608

Family and domain databases

InterProiView protein in InterPro
IPR028068 PIRT
PfamiView protein in Pfam
PF15099 PIRT, 1 hit

Sequencei

Sequence statusi: Complete.

P0C851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMETLPKVL EVDEKSPEAK DLLPSQTASS LCISSRSESV WTTTPRSNWE
60 70 80 90 100
IYRKPIVIMS VGGAILLFGV VITCLAYTLK LSDKSLSILK MVGPGFLSLG
110 120 130
LMMLVCGLVW VPIIKKKQKH RQKSNFLRSL KSFFLTR
Length:137
Mass (Da):15,334
Last modified:October 5, 2010 - v2
Checksum:i588C1AA13A5BDD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299808 mRNA Translation: BAH13134.1
DC332889 mRNA No translation available.
AC015908 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW89989.1
CCDSiCCDS45614.1
RefSeqiNP_001094857.1, NM_001101387.1
UniGeneiHs.553909

Genome annotation databases

EnsembliENST00000580256; ENSP00000462046; ENSG00000233670
GeneIDi644139
KEGGihsa:644139
UCSCiuc010col.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299808 mRNA Translation: BAH13134.1
DC332889 mRNA No translation available.
AC015908 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW89989.1
CCDSiCCDS45614.1
RefSeqiNP_001094857.1, NM_001101387.1
UniGeneiHs.553909

3D structure databases

ProteinModelPortaliP0C851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000462046

Polymorphism and mutation databases

BioMutaiPIRT
DMDMi308153473

Proteomic databases

PaxDbiP0C851
PeptideAtlasiP0C851
PRIDEiP0C851
ProteomicsDBi52394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000580256; ENSP00000462046; ENSG00000233670
GeneIDi644139
KEGGihsa:644139
UCSCiuc010col.4 human

Organism-specific databases

CTDi644139
EuPathDBiHostDB:ENSG00000233670.6
GeneCardsiPIRT
HGNCiHGNC:37239 PIRT
HPAiHPA042337
MIMi612068 gene
neXtProtiNX_P0C851
OpenTargetsiENSG00000233670
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWQ6 Eukaryota
ENOG410YYIW LUCA
GeneTreeiENSGT00390000016891
HOGENOMiHOG000082413
HOVERGENiHBG106144
InParanoidiP0C851
OMAiWEIYHKP
OrthoDBiEOG091G0ZPU
PhylomeDBiP0C851
TreeFamiTF328608

Miscellaneous databases

GenomeRNAii644139
PROiPR:P0C851
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000233670 Expressed in 65 organ(s), highest expression level in dorsal root ganglion
GenevisibleiP0C851 HS

Family and domain databases

InterProiView protein in InterPro
IPR028068 PIRT
PfamiView protein in Pfam
PF15099 PIRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIRT_HUMAN
AccessioniPrimary (citable) accession number: P0C851
Secondary accession number(s): B7Z648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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