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Protein

Kappa-conotoxin-like S4.3

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Kappa-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like S4.3
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri3547 S4.3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003450991 – 34Kappa-conotoxin-like S4.3Add BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acidBy similarity1
Glycosylationi7O-linked (HexNAc...) serineBy similarity1
Modified residuei174-hydroxyprolineBy similarity1
Modified residuei224-hydroxyprolineBy similarity1
Modified residuei324-hydroxyprolineBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0C830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Sequencei

Sequence statusi: Complete.

P0C830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
QKELVPSKTT TCCGYSPGTM CPSCMCTNTC PPQK
Length:34
Mass (Da):3,626
Last modified:July 22, 2008 - v1
Checksum:iA00F1A67578E9CD6
GO

Cross-referencesi

3D structure databases

SMRiP0C830
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3547 S4.3

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCA43_CONST
AccessioniPrimary (citable) accession number: P0C830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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