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Protein

Zinc finger protein 688

Gene

ZNF688

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 688
Gene namesi
Name:ZNF688
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000229809.8
HGNCiHGNC:30489 ZNF688
neXtProtiNX_P0C7X2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000229809
PharmGKBiPA142670487

Polymorphism and mutation databases

BioMutaiZNF688
DMDMi205636136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340071 – 276Zinc finger protein 688Add BLAST276

Proteomic databases

MaxQBiP0C7X2
PaxDbiP0C7X2
PeptideAtlasiP0C7X2
PRIDEiP0C7X2
ProteomicsDBi52386

PTM databases

iPTMnetiP0C7X2
PhosphoSitePlusiP0C7X2

Expressioni

Gene expression databases

BgeeiENSG00000229809
CleanExiHS_ZNF688
ExpressionAtlasiP0C7X2 baseline and differential
GenevisibleiP0C7X2 HS

Organism-specific databases

HPAiHPA048922

Interactioni

Protein-protein interaction databases

BioGridi126996, 2 interactors
IntActiP0C7X2, 41 interactors
STRINGi9606.ENSP00000223459

Structurei

3D structure databases

ProteinModelPortaliP0C7X2
SMRiP0C7X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 97KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00560000077257
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP0C7X2
KOiK09228
OMAiELVKHNP
OrthoDBiEOG091G0P6J
PhylomeDBiP0C7X2
TreeFamiTF339643

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C7X2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPPAPLLA PRPGETRPGC RKPGTVSFAD VAVYFSPEEW GCLRPAQRAL
60 70 80 90 100
YRDVMQETYG HLGALGFPGP KPALISWMEQ ESEAWSPAAQ DPEKGERLGG
110 120 130 140 150
ARRGDVPNRK EEEPEEVPRA KGPRKAPVKE SPEVLVERNP DPAISVAPAR
160 170 180 190 200
AQPPKNAAWD PTTGAQPPAP IPSMDAQAGQ RRHVCTDCGR RFTYPSLLVS
210 220 230 240 250
HRRMHSGERP FPCPECGMRF KRKFAVEAHQ WIHRSCSGGR RGRRPGIRAV
260 270
PRAPVRGDRD PPVLFRHYPD IFEECG
Length:276
Mass (Da):30,575
Last modified:July 22, 2008 - v1
Checksum:i11D583A6D671CBFE
GO
Isoform 2 (identifier: P0C7X2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MAPPPAPLLA...QETYGHLGAL → MPRSPLRSSL...IGRCVLRVQR

Show »
Length:262
Mass (Da):28,905
Checksum:i6478F38218E22066
GO

Sequence cautioni

The sequence AAC31673 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: ZNF688 and ZNF785.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153P → A in BM011208 (Ref. 5) Curated1
Sequence conflicti193T → S in BM011208 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052896131S → I. Corresponds to variant dbSNP:rs33997546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469551 – 65MAPPP…HLGAL → MPRSPLRSSLSTEASGPRGP FKCPASPRPITAQLLPGSSP IIGRCVLRVQR in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122680 mRNA Translation: BAG53663.1
AC002310 Genomic DNA Translation: AAC31673.1 Sequence problems.
CH471192 Genomic DNA Translation: EAW52233.1
CH471192 Genomic DNA Translation: EAW52235.1
BC018997 mRNA Translation: AAH18997.1
BM011208 mRNA No translation available.
CCDSiCCDS10684.1 [P0C7X2-1]
CCDS42151.1 [P0C7X2-5]
RefSeqiNP_001019854.1, NM_001024683.1 [P0C7X2-5]
NP_660314.1, NM_145271.3 [P0C7X2-1]
UniGeneiHs.301463
Hs.513509
Hs.710991

Genome annotation databases

EnsembliENST00000223459; ENSP00000223459; ENSG00000229809 [P0C7X2-1]
ENST00000563276; ENSP00000455227; ENSG00000229809 [P0C7X2-5]
GeneIDi146542
KEGGihsa:146542
UCSCiuc002dyt.4 human [P0C7X2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN688_HUMAN
AccessioniPrimary (citable) accession number: P0C7X2
Secondary accession number(s): A8MV39
, B3KV51, O75701, Q8IW91, Q8WV14, Q96MN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 18, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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