UniProtKB - P0C7W6 (CC172_HUMAN)
Protein
Coiled-coil domain-containing protein 172
Gene
CCDC172
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 172 |
Gene namesi | Name:CCDC172 Synonyms:C10orf96 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182645.5 |
HGNCi | HGNC:30524, CCDC172 |
neXtProti | NX_P0C7W6 |
Subcellular locationi
Other locations
Note: In spermatozoa, localized in the middle piece, predominantly concentrated at the mitochondrial sheath of the flagella and to a lesser extent with outer dense fibers (ODF) (By similarity). Colocalized with TEKT2 at the perinuclear region (By similarity).By similarity
Other locations
- cytoplasm Source: UniProtKB
- sperm midpiece Source: UniProtKB
Keywords - Cellular componenti
Cell projection, CytoplasmPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000182645 |
PharmGKBi | PA134867240 |
Miscellaneous databases
Pharosi | P0C7W6, Tdark |
Polymorphism and mutation databases
BioMutai | CCDC172 |
DMDMi | 206557852 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000344513 | 1 – 258 | Coiled-coil domain-containing protein 172Add BLAST | 258 |
Proteomic databases
EPDi | P0C7W6 |
MassIVEi | P0C7W6 |
MaxQBi | P0C7W6 |
PaxDbi | P0C7W6 |
PeptideAtlasi | P0C7W6 |
PRIDEi | P0C7W6 |
ProteomicsDBi | 52381 |
PTM databases
iPTMneti | P0C7W6 |
PhosphoSitePlusi | P0C7W6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182645, Expressed in testis and 34 other tissues |
Genevisiblei | P0C7W6, HS |
Organism-specific databases
HPAi | ENSG00000182645, Tissue enriched (testis) |
Interactioni
Subunit structurei
May interact with TEKT2.
By similarityBinary interactionsi
Hide detailsP0C7W6
Protein-protein interaction databases
BioGRIDi | 131893, 27 interactors |
IntActi | P0C7W6, 30 interactors |
MINTi | P0C7W6 |
STRINGi | 9606.ENSP00000329860 |
Miscellaneous databases
RNActi | P0C7W6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 13 – 90 | Sequence analysisAdd BLAST | 78 | |
Coiled coili | 123 – 191 | Sequence analysisAdd BLAST | 69 | |
Coiled coili | 226 – 256 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the CCDC172 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RZCX, Eukaryota |
GeneTreei | ENSGT00390000005203 |
HOGENOMi | CLU_094609_0_0_1 |
InParanoidi | P0C7W6 |
OMAi | KMEMKSM |
OrthoDBi | 1399070at2759 |
PhylomeDBi | P0C7W6 |
TreeFami | TF333231 |
Family and domain databases
InterProi | View protein in InterPro IPR029618, CCDC172 |
PANTHERi | PTHR22419, PTHR22419, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C7W6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLESLFQHI IFTEHQAEES RRLMREVRSE ITRCREKIKK ATEELNEEKI
60 70 80 90 100
KLESKVQQFF EKSFFLQLLK AHENALEKQY SEITNHRNML LQTFEAIKKQ
110 120 130 140 150
MIEEEDKFIK EITDFNNDYE ITKKRELLMK ENVKIEISDL ENQANMLKSE
160 170 180 190 200
MKSMEHDSSQ LNELQKQKSE LIQELFTLQR KLKVFEDEEN ESICTTKYLE
210 220 230 240 250
AEKIKISEKP QNDTECLRLK KELELYKEDD MESVYEALQT EIEFLELTLA
QKDLQESK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011328 Genomic DNA No translation available. BC044830 mRNA Translation: AAH44830.1 |
CCDSi | CCDS31291.1 |
RefSeqi | NP_940917.1, NM_198515.2 XP_016871695.1, XM_017016206.1 |
Genome annotation databases
Ensembli | ENST00000333254; ENSP00000329860; ENSG00000182645 |
GeneIDi | 374355 |
KEGGi | hsa:374355 |
UCSCi | uc001lck.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011328 Genomic DNA No translation available. BC044830 mRNA Translation: AAH44830.1 |
CCDSi | CCDS31291.1 |
RefSeqi | NP_940917.1, NM_198515.2 XP_016871695.1, XM_017016206.1 |
3D structure databases
SMRi | P0C7W6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131893, 27 interactors |
IntActi | P0C7W6, 30 interactors |
MINTi | P0C7W6 |
STRINGi | 9606.ENSP00000329860 |
PTM databases
iPTMneti | P0C7W6 |
PhosphoSitePlusi | P0C7W6 |
Polymorphism and mutation databases
BioMutai | CCDC172 |
DMDMi | 206557852 |
Proteomic databases
EPDi | P0C7W6 |
MassIVEi | P0C7W6 |
MaxQBi | P0C7W6 |
PaxDbi | P0C7W6 |
PeptideAtlasi | P0C7W6 |
PRIDEi | P0C7W6 |
ProteomicsDBi | 52381 |
Protocols and materials databases
Antibodypediai | 46242, 47 antibodies |
DNASUi | 374355 |
Genome annotation databases
Ensembli | ENST00000333254; ENSP00000329860; ENSG00000182645 |
GeneIDi | 374355 |
KEGGi | hsa:374355 |
UCSCi | uc001lck.3, human |
Organism-specific databases
CTDi | 374355 |
EuPathDBi | HostDB:ENSG00000182645.5 |
GeneCardsi | CCDC172 |
HGNCi | HGNC:30524, CCDC172 |
HPAi | ENSG00000182645, Tissue enriched (testis) |
neXtProti | NX_P0C7W6 |
OpenTargetsi | ENSG00000182645 |
PharmGKBi | PA134867240 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZCX, Eukaryota |
GeneTreei | ENSGT00390000005203 |
HOGENOMi | CLU_094609_0_0_1 |
InParanoidi | P0C7W6 |
OMAi | KMEMKSM |
OrthoDBi | 1399070at2759 |
PhylomeDBi | P0C7W6 |
TreeFami | TF333231 |
Enzyme and pathway databases
PathwayCommonsi | P0C7W6 |
Miscellaneous databases
BioGRID-ORCSi | 374355, 12 hits in 839 CRISPR screens |
ChiTaRSi | CCDC172, human |
GenomeRNAii | 374355 |
Pharosi | P0C7W6, Tdark |
PROi | PR:P0C7W6 |
RNActi | P0C7W6, protein |
Gene expression databases
Bgeei | ENSG00000182645, Expressed in testis and 34 other tissues |
Genevisiblei | P0C7W6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029618, CCDC172 |
PANTHERi | PTHR22419, PTHR22419, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC172_HUMAN | |
Accessioni | P0C7W6Primary (citable) accession number: P0C7W6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | July 22, 2008 | |
Last modified: | December 2, 2020 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM