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Protein

Prosalusin

Gene

Tor2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 100ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • protein homooligomerization Source: MGI

Keywordsi

Molecular functionHormone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Prosalusin
Alternative name(s):
Torsin family 2 member A
Torsin-2A
Cleaved into the following chain:
Gene namesi
Name:Tor2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353596 Tor2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000034561428 – 231ProsalusinAdd BLAST204
PropeptideiPRO_000034561528 – 189Sequence analysisAdd BLAST162
PeptideiPRO_0000345616192 – 231Salusin-betaBy similarityAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PeptideAtlasiP0C7W3
PRIDEiP0C7W3

Expressioni

Gene expression databases

CleanExiMM_TOR2A

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP0C7W3
SMRiP0C7W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni192 – 211Partial activation of MRGPRA1Add BLAST20

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2170 Eukaryota
ENOG410XR06 LUCA
HOVERGENiHBG094082

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR010448 Torsin
PANTHERiPTHR10760 PTHR10760, 1 hit
PfamiView protein in Pfam
PF06309 Torsin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: P0C7W3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVARHGYRP WGSILGLLGL ALAAAAAWDV ASLRCTFGSF CECDFWPDLP
60 70 80 90 100
GLECDLAQHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS
110 120 130 140 150
YVSSLLAQHL FRDGLRSPHV HHFSPIIHFP HPSRTEQYKK ELKSWVQGNL
160 170 180 190 200
TACGRSLFLF DEMDKLPPGL MEVLQPFLGP SWVVYGTNYR KAIFIFIRWL
210 220 230
LAVWHHGGAP AGRCGALPPA PAASRAPLRT Q
Note: Salusin-beta peptide is derived from isoform 3.
Length:231
Mass (Da):25,377
Last modified:July 22, 2008 - v1
Checksum:i56DC8F6C09F5EFC5
GO
Isoform 1 (identifier: Q8R1J9-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8R1J9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:321
Mass (Da):35,897
GO
Isoform 2 (identifier: Q8R1J9-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8R1J9.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:159
Mass (Da):18,088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772271 Genomic DNA No translation available.
UniGeneiMm.200695

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772271 Genomic DNA No translation available.
UniGeneiMm.200695

3D structure databases

ProteinModelPortaliP0C7W3
SMRiP0C7W3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP0C7W3
PRIDEiP0C7W3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1353596 Tor2a

Phylogenomic databases

eggNOGiKOG2170 Eukaryota
ENOG410XR06 LUCA
HOVERGENiHBG094082

Miscellaneous databases

ChiTaRSiTor2a mouse
SOURCEiSearch...

Gene expression databases

CleanExiMM_TOR2A

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR010448 Torsin
PANTHERiPTHR10760 PTHR10760, 1 hit
PfamiView protein in Pfam
PF06309 Torsin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOR2X_MOUSE
AccessioniPrimary (citable) accession number: P0C7W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: January 31, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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