PRR29

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proline-rich protein 29
Gene namesⁱ	Name:PRR29 Synonyms:C17orf72
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000224383.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25673 PRR29
neXtProtⁱ	NX_P0C7W0

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000224383
PharmGKBⁱ	PA142672220

Polymorphism and mutation databases

BioMutaⁱ	C17orf72

BioMutaⁱ

C17orf72

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000344468	1 – 189	Proline-rich protein 29Add BLAST		189

Proteomic databases

PaxDbⁱ	P0C7W0
PRIDEⁱ	P0C7W0
ProteomicsDBⁱ	52380

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000224383 Expressed in 161 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_C17orf72
ExpressionAtlasⁱ	P0C7W0 baseline and differential
Genevisibleⁱ	P0C7W0 HS

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000396936

STRINGⁱ

9606.ENSP00000396936

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P0C7W0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	73 – 166	Pro-richAdd BLAST		94

Phylogenomic databases

eggNOGⁱ	ENOG410J4MP Eukaryota ENOG4112CSZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002000
HOGENOMⁱ	HOG000111941
HOVERGENⁱ	HBG107756
InParanoidⁱ	P0C7W0
OMAⁱ	RIQHCPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SKX

Family and domain databases

InterProⁱ	View protein in InterPro IPR027904 DUF4587 IPR038915 PRR29-like
PANTHERⁱ	PTHR28604 PTHR28604, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15248 DUF4587, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P0C7W0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL 
        60         70         80         90        100
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV 
       110        120        130        140        150
REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP 
       160        170        180 
ASREREVRAV PPPPPPSATG TVGADVPPAS DYYDAESLL

Length:189

Mass (Da):20,715

Last modified:February 6, 2013 - v2

Checksum:ⁱ1110D9410668AD7C

GO

Isoform 2 (identifier: P0C7W0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV

« Hide

        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL 
        60         70         80         90        100
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV 
       110        120        130        140        150
REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP 
       160        170        180        190        200
ASRERETTMM PRASYEDRPR PWELHQLPAL DTAPEPPPAP LLSTPRCPWL 
       210        220        230 
AVLLTPSTSA RPSSPGEISP CPTPMSSWTG RICAVV

Note: No experimental confirmation available.

Show »

Length:236

Mass (Da):26,083

Checksum:ⁱ6FEDE51C9AA13183

GO

Isoform 3 (identifier: P0C7W0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
99-189: Missing.

« Hide

        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL 
        60         70         80         90 
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QESCAPTPTP QCHRDCGC

Note: No experimental confirmation available.

Show »

Length:98

Mass (Da):10,435

Checksum:ⁱ32B699C855AF48C9

GO

Isoform 4 (identifier: P0C7W0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
22-28: Missing.

« Hide

        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PLSWAVPPAP PQPGRVKEDL LELMMLQNAQ 
        60         70         80         90        100
MHQLLLSRLV AGALQPRPAS PCPQVYLEVP QEEPEEEEEE MDVREKGPLV 
       110        120        130        140        150
FHHHYLPYLM PSPGALLPWP APFFPTPACQ PYLQDVPRIQ HCPASREREV 
       160        170        180 
RAVPPPPPPS ATGTVGADVP PASDYYDAES LL

Note: No experimental confirmation available.

Show »

Length:182

Mass (Da):19,843

Checksum:ⁱ4E95DE87606A402F

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KRR4	J3KRR4_HUMAN	Proline-rich protein 29 Proline-rich protein 29	PRR29	156	Annotation score:
J3QR92	J3QR92_HUMAN	Proline-rich protein 29 Proline-rich protein 29	PRR29	138	Annotation score:
J3KRF4	J3KRF4_HUMAN	Proline-rich protein 29 Proline-rich protein 29	PRR29	37	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	145	R → S in BAG51052 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069055	24	T → S1 PublicationCorresponds to variant dbSNP:rs62070903Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046997	22 – 28	Missing in isoform 4. 1 Publication	7
Alternative sequenceⁱVSP_045344	82 – 98	VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3. 1 PublicationAdd BLAST	17
Alternative sequenceⁱVSP_045345	99 – 189	Missing in isoform 3. 1 PublicationAdd BLAST	91
Alternative sequenceⁱVSP_045346	157 – 189	VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2. 1 PublicationAdd BLAST	33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK021786 mRNA Translation: BAG51052.1 AK302960 mRNA Translation: BAG64111.1 AK304254 mRNA Translation: BAG65120.1 DB037384 mRNA No translation available. AC005803 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS54157.1 [P0C7W0-2] CCDS54158.1 [P0C7W0-1] CCDS54159.1 [P0C7W0-3] CCDS58586.1 [P0C7W0-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001157729.1, NM_001164257.1 [P0C7W0-1] NP_001177958.1, NM_001191029.1 [P0C7W0-2] NP_001177959.1, NM_001191030.1 [P0C7W0-4] NP_001177960.1, NM_001191031.1 [P0C7W0-3]
UniGeneⁱ	Hs.708161

Genome annotation databases

Ensemblⁱ	ENST00000412177; ENSP00000400986; ENSG00000224383 [P0C7W0-1] ENST00000425164; ENSP00000396936; ENSG00000224383 [P0C7W0-2] ENST00000577953; ENSP00000463279; ENSG00000224383 [P0C7W0-3] ENST00000579184; ENSP00000462097; ENSG00000224383 [P0C7W0-4]
GeneIDⁱ	92340
KEGGⁱ	hsa:92340
UCSC genome browser More...UCSCⁱ	uc002jdt.5 human [P0C7W0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P0C7W0	Proline-rich protein 29		HUMAN		138	UniRef100_P0C7W0
HCG1657684, isoform CRA_c		HUMAN		139
P0C7W0-3	PRR29 isoform 9		PANTR		98	UniRef100_A0A2I3RHB8
UPI000511E57B		PANTR		158

Protein	Similar proteins		Species	Score	Length	Source
P0C7W0	Proline-rich protein 29		HUMAN		138	UniRef90_P0C7W0
PRR29 isoform 4		PONAB		190
Proline rich 29		GORGO		190
Uncharacterized protein		PANPA		188
PRR29 isoform 6		PANTR		182
+7
P0C7W0-2	PRR29 isoform 5		PONAB		237	UniRef90_P0C7W0-2
Proline rich 29		GORGO		237
Uncharacterized protein		PANPA		236
P0C7W0-3	PRR29 isoform 9		PANTR		98	UniRef90_A0A2I3RHB8
UPI000511E57B		PANTR		158

Protein	Similar proteins		Species	Score	Length	Source
P0C7W0	Proline-rich protein 29		MOUSE		187	UniRef50_P0C7W0
Proline-rich protein 29		HUMAN		138
Proline rich 29		GORGO		190
PRR29 isoform 4		PONAB		190
Uncharacterized protein		PANPA		188
+67
P0C7W0-2	PRR29 isoform 5		PONAB		237	UniRef50_P0C7W0-2
Proline rich 29		GORGO		237
Uncharacterized protein		PANPA		236
Uncharacterized protein		MACFA		190
Uncharacterized protein		MACNE		190
+27
P0C7W0-3	PRR29 isoform 9		PANTR		98	UniRef50_A0A2I3RHB8
Uncharacterized protein		RHIBE		183
UPI0006443A15		OTOGA		156
UPI0006574847		HETGA		181
UPI000511E57B		PANTR		158
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK021786 mRNA Translation: BAG51052.1 AK302960 mRNA Translation: BAG64111.1 AK304254 mRNA Translation: BAG65120.1 DB037384 mRNA No translation available. AC005803 Genomic DNA No translation available.
CCDSⁱ	CCDS54157.1 [P0C7W0-2] CCDS54158.1 [P0C7W0-1] CCDS54159.1 [P0C7W0-3] CCDS58586.1 [P0C7W0-4]
RefSeqⁱ	NP_001157729.1, NM_001164257.1 [P0C7W0-1] NP_001177958.1, NM_001191029.1 [P0C7W0-2] NP_001177959.1, NM_001191030.1 [P0C7W0-4] NP_001177960.1, NM_001191031.1 [P0C7W0-3]
UniGeneⁱ	Hs.708161

3D structure databases

ProteinModelPortalⁱ	P0C7W0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000396936

STRINGⁱ

9606.ENSP00000396936

Polymorphism and mutation databases

BioMutaⁱ	C17orf72

BioMutaⁱ

C17orf72

Proteomic databases

PaxDbⁱ	P0C7W0
PRIDEⁱ	P0C7W0
ProteomicsDBⁱ	52380

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000412177; ENSP00000400986; ENSG00000224383 [P0C7W0-1] ENST00000425164; ENSP00000396936; ENSG00000224383 [P0C7W0-2] ENST00000577953; ENSP00000463279; ENSG00000224383 [P0C7W0-3] ENST00000579184; ENSP00000462097; ENSG00000224383 [P0C7W0-4]
GeneIDⁱ	92340
KEGGⁱ	hsa:92340
UCSCⁱ	uc002jdt.5 human [P0C7W0-1]

Organism-specific databases

CTDⁱ	92340
EuPathDBⁱ	HostDB:ENSG00000224383.7
GeneCardsⁱ	PRR29
HGNCⁱ	HGNC:25673 PRR29
neXtProtⁱ	NX_P0C7W0
OpenTargetsⁱ	ENSG00000224383
PharmGKBⁱ	PA142672220
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4MP Eukaryota ENOG4112CSZ LUCA
GeneTreeⁱ	ENSGT00390000002000
HOGENOMⁱ	HOG000111941
HOVERGENⁱ	HBG107756
InParanoidⁱ	P0C7W0
OMAⁱ	RIQHCPP
OrthoDBⁱ	EOG091G0SKX

Miscellaneous databases

ChiTaRSⁱ	PRR29 human
GenomeRNAiⁱ	92340
Protein Ontology More...PROⁱ	PR:P0C7W0

Gene expression databases

Bgeeⁱ	ENSG00000224383 Expressed in 161 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_C17orf72
ExpressionAtlasⁱ	P0C7W0 baseline and differential
Genevisibleⁱ	P0C7W0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027904 DUF4587 IPR038915 PRR29-like
PANTHERⁱ	PTHR28604 PTHR28604, 1 hit
Pfamⁱ	View protein in Pfam PF15248 DUF4587, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRR29_HUMAN
Accessionⁱ	P0C7W0Primary (citable) accession number: P0C7W0 Secondary accession number(s): B3KMP0 , B4DZJ9, B4E2F8, E9PGL5, J3QKX4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
	Last sequence update:	February 6, 2013
	Last modified:	September 12, 2018
	This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - P0C7W0 (PRR29_HUMAN)

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Proline-rich protein 29

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ