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Protein

Proline-rich protein 29

Gene

PRR29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 29
Gene namesi
Name:PRR29
Synonyms:C17orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000224383.7
HGNCiHGNC:25673 PRR29
neXtProtiNX_P0C7W0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000224383
PharmGKBiPA142672220

Polymorphism and mutation databases

BioMutaiC17orf72

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444681 – 189Proline-rich protein 29Add BLAST189

Proteomic databases

PaxDbiP0C7W0
PRIDEiP0C7W0
ProteomicsDBi52380

Expressioni

Gene expression databases

BgeeiENSG00000224383 Expressed in 161 organ(s), highest expression level in right uterine tube
CleanExiHS_C17orf72
ExpressionAtlasiP0C7W0 baseline and differential
GenevisibleiP0C7W0 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396936

Structurei

3D structure databases

ProteinModelPortaliP0C7W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 166Pro-richAdd BLAST94

Phylogenomic databases

eggNOGiENOG410J4MP Eukaryota
ENOG4112CSZ LUCA
GeneTreeiENSGT00390000002000
HOGENOMiHOG000111941
HOVERGENiHBG107756
InParanoidiP0C7W0
OMAiRIQHCPP
OrthoDBiEOG091G0SKX

Family and domain databases

InterProiView protein in InterPro
IPR027904 DUF4587
IPR038915 PRR29-like
PANTHERiPTHR28604 PTHR28604, 1 hit
PfamiView protein in Pfam
PF15248 DUF4587, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P0C7W0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL
60 70 80 90 100
MMLQNAQMHQ LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV
110 120 130 140 150
REKGPLVFHH HYLPYLMPSP GALLPWPAPF FPTPACQPYL QDVPRIQHCP
160 170 180
ASREREVRAV PPPPPPSATG TVGADVPPAS DYYDAESLL
Length:189
Mass (Da):20,715
Last modified:February 6, 2013 - v2
Checksum:i1110D9410668AD7C
GO
Isoform 2 (identifier: P0C7W0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-189: VRAVPPPPPPSATGTVGADVPPASDYYDAESLL → TTMMPRASYE...SWTGRICAVV

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,083
Checksum:i6FEDE51C9AA13183
GO
Isoform 3 (identifier: P0C7W0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-98: VYLEVPQEEPEEEEEEM → ESCAPTPTPQCHRDCGC
     99-189: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):10,435
Checksum:i32B699C855AF48C9
GO
Isoform 4 (identifier: P0C7W0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-28: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):19,843
Checksum:i4E95DE87606A402F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRR4J3KRR4_HUMAN
Proline-rich protein 29
PRR29
156Annotation score:
J3QR92J3QR92_HUMAN
Proline-rich protein 29
PRR29
138Annotation score:
J3KRF4J3KRF4_HUMAN
Proline-rich protein 29
PRR29
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145R → S in BAG51052 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06905524T → S1 PublicationCorresponds to variant dbSNP:rs62070903Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04699722 – 28Missing in isoform 4. 1 Publication7
Alternative sequenceiVSP_04534482 – 98VYLEV…EEEEM → ESCAPTPTPQCHRDCGC in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_04534599 – 189Missing in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_045346157 – 189VRAVP…AESLL → TTMMPRASYEDRPRPWELHQ LPALDTAPEPPPAPLLSTPR CPWLAVLLTPSTSARPSSPG EISPCPTPMSSWTGRICAVV in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021786 mRNA Translation: BAG51052.1
AK302960 mRNA Translation: BAG64111.1
AK304254 mRNA Translation: BAG65120.1
DB037384 mRNA No translation available.
AC005803 Genomic DNA No translation available.
CCDSiCCDS54157.1 [P0C7W0-2]
CCDS54158.1 [P0C7W0-1]
CCDS54159.1 [P0C7W0-3]
CCDS58586.1 [P0C7W0-4]
RefSeqiNP_001157729.1, NM_001164257.1 [P0C7W0-1]
NP_001177958.1, NM_001191029.1 [P0C7W0-2]
NP_001177959.1, NM_001191030.1 [P0C7W0-4]
NP_001177960.1, NM_001191031.1 [P0C7W0-3]
UniGeneiHs.708161

Genome annotation databases

EnsembliENST00000412177; ENSP00000400986; ENSG00000224383 [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383 [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383 [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383 [P0C7W0-4]
GeneIDi92340
KEGGihsa:92340
UCSCiuc002jdt.5 human [P0C7W0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021786 mRNA Translation: BAG51052.1
AK302960 mRNA Translation: BAG64111.1
AK304254 mRNA Translation: BAG65120.1
DB037384 mRNA No translation available.
AC005803 Genomic DNA No translation available.
CCDSiCCDS54157.1 [P0C7W0-2]
CCDS54158.1 [P0C7W0-1]
CCDS54159.1 [P0C7W0-3]
CCDS58586.1 [P0C7W0-4]
RefSeqiNP_001157729.1, NM_001164257.1 [P0C7W0-1]
NP_001177958.1, NM_001191029.1 [P0C7W0-2]
NP_001177959.1, NM_001191030.1 [P0C7W0-4]
NP_001177960.1, NM_001191031.1 [P0C7W0-3]
UniGeneiHs.708161

3D structure databases

ProteinModelPortaliP0C7W0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396936

Polymorphism and mutation databases

BioMutaiC17orf72

Proteomic databases

PaxDbiP0C7W0
PRIDEiP0C7W0
ProteomicsDBi52380

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412177; ENSP00000400986; ENSG00000224383 [P0C7W0-1]
ENST00000425164; ENSP00000396936; ENSG00000224383 [P0C7W0-2]
ENST00000577953; ENSP00000463279; ENSG00000224383 [P0C7W0-3]
ENST00000579184; ENSP00000462097; ENSG00000224383 [P0C7W0-4]
GeneIDi92340
KEGGihsa:92340
UCSCiuc002jdt.5 human [P0C7W0-1]

Organism-specific databases

CTDi92340
EuPathDBiHostDB:ENSG00000224383.7
GeneCardsiPRR29
HGNCiHGNC:25673 PRR29
neXtProtiNX_P0C7W0
OpenTargetsiENSG00000224383
PharmGKBiPA142672220
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4MP Eukaryota
ENOG4112CSZ LUCA
GeneTreeiENSGT00390000002000
HOGENOMiHOG000111941
HOVERGENiHBG107756
InParanoidiP0C7W0
OMAiRIQHCPP
OrthoDBiEOG091G0SKX

Miscellaneous databases

ChiTaRSiPRR29 human
GenomeRNAii92340
PROiPR:P0C7W0

Gene expression databases

BgeeiENSG00000224383 Expressed in 161 organ(s), highest expression level in right uterine tube
CleanExiHS_C17orf72
ExpressionAtlasiP0C7W0 baseline and differential
GenevisibleiP0C7W0 HS

Family and domain databases

InterProiView protein in InterPro
IPR027904 DUF4587
IPR038915 PRR29-like
PANTHERiPTHR28604 PTHR28604, 1 hit
PfamiView protein in Pfam
PF15248 DUF4587, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRR29_HUMAN
AccessioniPrimary (citable) accession number: P0C7W0
Secondary accession number(s): B3KMP0
, B4DZJ9, B4E2F8, E9PGL5, J3QKX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 6, 2013
Last modified: September 12, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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