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Protein

DDB1- and CUL4-associated factor 8-like protein 2

Gene

DCAF8L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiP0C7V8

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 8-like protein 2
Alternative name(s):
WD repeat-containing protein 42C
Gene namesi
Name:DCAF8L2
Synonyms:WDR42C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189186.10
HGNCiHGNC:31811 DCAF8L2
neXtProtiNX_P0C7V8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189186

Polymorphism and mutation databases

BioMutaiDCAF8L2
DMDMi519668665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444621 – 631DDB1- and CUL4-associated factor 8-like protein 2Add BLAST631

Proteomic databases

EPDiP0C7V8
MaxQBiP0C7V8
PaxDbiP0C7V8
PeptideAtlasiP0C7V8
PRIDEiP0C7V8
ProteomicsDBi52378

PTM databases

iPTMnetiP0C7V8
PhosphoSitePlusiP0C7V8

Expressioni

Gene expression databases

BgeeiENSG00000189186
CleanExiHS_WDR42C
ExpressionAtlasiP0C7V8 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi131438, 15 interactors
STRINGi9606.ENSP00000462745

Structurei

3D structure databases

ProteinModelPortaliP0C7V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati226 – 265WD 1Add BLAST40
Repeati269 – 310WD 2Add BLAST42
Repeati316 – 356WD 3Add BLAST41
Repeati364 – 404WD 4Add BLAST41
Repeati420 – 459WD 5Add BLAST40
Repeati467 – 507WD 6Add BLAST41
Repeati511 – 550WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 178Glu-richAdd BLAST74

Sequence similaritiesi

Belongs to the WD repeat DCAF8 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00530000062951
HOVERGENiHBG053807
InParanoidiP0C7V8
OMAiDHDGRAH
OrthoDBiEOG091G056C
TreeFamiTF326071

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV
60 70 80 90 100
TGDGSDSRDG GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMSGESL
110 120 130 140 150
FHYPLVGEEE TEREEEDEEI QEEGGEEEEE EEEEEEEEEE EEEEEEEQPR
160 170 180 190 200
AGPQGSGGNH EQYSLEEDQA LEEWVSSETS ALPRPRWQVV TALHQRQLGS
210 220 230 240 250
RPRFVYEACG ARAFVQRFRL QYRLADHVGC VNTVHFNQRG TRLASSGDDL
260 270 280 290 300
KVIVWDWVRQ RPVLNFESGH TNNVFQAKFL PNCGDSTLAM CARDGQVRVA
310 320 330 340 350
ELINASYFNN TKCVAQHRGP AHKLALEPDS PYKFLTSGED AVVFTIDLRQ
360 370 380 390 400
DRPASKVVVT RENDKKVGLY TITVNPANTY QFAVGGQDQF VRIYDQRKID
410 420 430 440 450
KKENNGVLKK FTPHHLVNCD FPTNITCVVY SHDGTELLAS YNDDDIYLFN
460 470 480 490 500
SSHSDGAQYS KRFKGHRNNT TVKGVNFYGP RSEFVVSGSD CGHIFFWEKS
510 520 530 540 550
SCQIIQFLKG SREGTINCLE PHPYLPVLAC SGLDHDVKIW TPTAKAATEL
560 570 580 590 600
TGLKKVIKKN KWERDEDSLH HGSLFDQYML WFLLRHVTQR GRHQDWRSGE
610 620 630
AEFPDEESDE SSSTSETSEE EVQDRVQCMP S
Length:631
Mass (Da):71,191
Last modified:June 26, 2013 - v2
Checksum:i04C398AEE033EB3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145 – 147Missing in AAI57860 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045620345T → A. Corresponds to variant dbSNP:rs5926895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157859 mRNA Translation: AAI57860.1
AC006210 Genomic DNA No translation available.
AC079902 Genomic DNA No translation available.
AC107613 Genomic DNA No translation available.
CCDSiCCDS59162.1
RefSeqiNP_001130005.1, NM_001136533.1
UniGeneiHs.720885
Hs.722222

Genome annotation databases

EnsembliENST00000451261; ENSP00000462745; ENSG00000189186
ENST00000545306; ENSP00000479800; ENSG00000189186
UCSCiuc011mjy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDC8L2_HUMAN
AccessioniPrimary (citable) accession number: P0C7V8
Secondary accession number(s): B2RXH9, J3KT06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 26, 2013
Last modified: June 20, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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