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Protein

Putative inactive neutral ceramidase B

Gene

ASAH2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome 10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus other putative translation start site that might lead to several potential ORFs.

Caution

In contrast to other members of the family, ASAH2B has no predicted transmembrane domain, and lacks the active site, suggesting that it may be catalytically inactive.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive neutral ceramidase BCurated
Alternative name(s):
ASAH2-like proteinCurated
Putative inactive N-acylsphingosine amidohydrolase 2BCurated
Putative inactive non-lysosomal ceramidase BCurated
Gene namesi
Name:ASAH2BImported
Synonyms:ASAH2CImported, ASAH2LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204147.9
HGNCiHGNC:23456 ASAH2B
MIMi610987 gene
neXtProtiNX_P0C7U1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204147
PharmGKBiPA134977109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437411 – 165Putative inactive neutral ceramidase BAdd BLAST165

Proteomic databases

PaxDbiP0C7U1
PeptideAtlasiP0C7U1
PRIDEiP0C7U1
ProteomicsDBi52369

PTM databases

iPTMnetiP0C7U1
PhosphoSitePlusiP0C7U1

Expressioni

Tissue specificityi

Ubiquitous. Expression is reduced with increasing age and in late-onset Alzheimer disease (LOAD) patients. This reduction is even more pronounced in patients with an affected mother.1 Publication

Gene expression databases

BgeeiENSG00000204147 Expressed in 93 organ(s), highest expression level in caudate nucleus
CleanExiHS_ASAH2B
GenevisibleiP0C7U1 HS

Organism-specific databases

HPAiHPA061171

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363118

Structurei

3D structure databases

ProteinModelPortaliP0C7U1
SMRiP0C7U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neutral ceramidase family.Curated

Phylogenomic databases

eggNOGiKOG2232 Eukaryota
ENOG410XQWE LUCA
GeneTreeiENSGT00390000015792
HOGENOMiHOG000034083
HOVERGENiHBG105868
InParanoidiP0C7U1
OMAiWGRNFGD
OrthoDBiEOG091G0Q7F
PhylomeDBiP0C7U1

Family and domain databases

Gene3Di2.60.40.2300, 1 hit
InterProiView protein in InterPro
IPR006823 Ceramidase_alk
IPR038445 NCDase_C_sf
IPR031331 NEUT/ALK_ceramidase_C
PANTHERiPTHR12670 PTHR12670, 1 hit
PfamiView protein in Pfam
PF17048 Ceramidse_alk_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P0C7U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQHRQFMDR THYLLTFSSS ETLLRLLLRI VDRAPKGRTF GDVLQPAKPE
60 70 80 90 100
YRVGEVAEVI FVGANPKNSV QNQTHQTFLT VEKYEATSTS WQIVCNDASW
110 120 130 140 150
ETRFYWHKGL LGLSNATVEW HIPDTAQPGI YRIRYFGHNR KQDILKPAVI
160
LSFEGTSPAF EVVTI
Length:165
Mass (Da):19,025
Last modified:July 22, 2008 - v1
Checksum:iAB59B4F728F82D66
GO
Isoform 2 (identifier: P0C7U1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MRQHRQFMDRTHYLLTFSSSETLLRLLLR → MVANLSRGPEPPFFKQLIVPLIPS

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,026
Checksum:i25CB3AD9FFE817E0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y609A0A2R8Y609_HUMAN
Putative inactive neutral ceramidas...
ASAH2B
43Annotation score:
A0A2R8YGJ0A0A2R8YGJ0_HUMAN
Putative inactive neutral ceramidas...
ASAH2B
43Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569381 – 29MRQHR…RLLLR → MVANLSRGPEPPFFKQLIVP LIPS in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294369 mRNA Translation: BAH11747.1
AL589794 Genomic DNA No translation available.
CCDSiCCDS31203.1 [P0C7U1-1]
CCDS81465.1 [P0C7U1-2]
RefSeqiNP_001072984.1, NM_001079516.3 [P0C7U1-1]
NP_001308886.1, NM_001321957.1 [P0C7U1-1]
NP_001308887.1, NM_001321958.1 [P0C7U1-2]
NP_001308888.1, NM_001321959.1 [P0C7U1-2]
NP_001308889.1, NM_001321960.1 [P0C7U1-2]
UniGeneiHs.659820
Hs.710005

Genome annotation databases

EnsembliENST00000374006; ENSP00000363118; ENSG00000204147 [P0C7U1-1]
ENST00000374007; ENSP00000363119; ENSG00000204147 [P0C7U1-2]
ENST00000643851; ENSP00000495463; ENSG00000204147 [P0C7U1-1]
ENST00000647317; ENSP00000496089; ENSG00000204147 [P0C7U1-2]
GeneIDi653308
KEGGihsa:653308
UCSCiuc001jjg.5 human [P0C7U1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294369 mRNA Translation: BAH11747.1
AL589794 Genomic DNA No translation available.
CCDSiCCDS31203.1 [P0C7U1-1]
CCDS81465.1 [P0C7U1-2]
RefSeqiNP_001072984.1, NM_001079516.3 [P0C7U1-1]
NP_001308886.1, NM_001321957.1 [P0C7U1-1]
NP_001308887.1, NM_001321958.1 [P0C7U1-2]
NP_001308888.1, NM_001321959.1 [P0C7U1-2]
NP_001308889.1, NM_001321960.1 [P0C7U1-2]
UniGeneiHs.659820
Hs.710005

3D structure databases

ProteinModelPortaliP0C7U1
SMRiP0C7U1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363118

PTM databases

iPTMnetiP0C7U1
PhosphoSitePlusiP0C7U1

Proteomic databases

PaxDbiP0C7U1
PeptideAtlasiP0C7U1
PRIDEiP0C7U1
ProteomicsDBi52369

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374006; ENSP00000363118; ENSG00000204147 [P0C7U1-1]
ENST00000374007; ENSP00000363119; ENSG00000204147 [P0C7U1-2]
ENST00000643851; ENSP00000495463; ENSG00000204147 [P0C7U1-1]
ENST00000647317; ENSP00000496089; ENSG00000204147 [P0C7U1-2]
GeneIDi653308
KEGGihsa:653308
UCSCiuc001jjg.5 human [P0C7U1-1]

Organism-specific databases

CTDi653308
EuPathDBiHostDB:ENSG00000204147.9
GeneCardsiASAH2B
HGNCiHGNC:23456 ASAH2B
HPAiHPA061171
MIMi610987 gene
neXtProtiNX_P0C7U1
OpenTargetsiENSG00000204147
PharmGKBiPA134977109
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2232 Eukaryota
ENOG410XQWE LUCA
GeneTreeiENSGT00390000015792
HOGENOMiHOG000034083
HOVERGENiHBG105868
InParanoidiP0C7U1
OMAiWGRNFGD
OrthoDBiEOG091G0Q7F
PhylomeDBiP0C7U1

Miscellaneous databases

ChiTaRSiASAH2B human
GeneWikiiASAH2B
GenomeRNAii653308
PROiPR:P0C7U1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204147 Expressed in 93 organ(s), highest expression level in caudate nucleus
CleanExiHS_ASAH2B
GenevisibleiP0C7U1 HS

Family and domain databases

Gene3Di2.60.40.2300, 1 hit
InterProiView protein in InterPro
IPR006823 Ceramidase_alk
IPR038445 NCDase_C_sf
IPR031331 NEUT/ALK_ceramidase_C
PANTHERiPTHR12670 PTHR12670, 1 hit
PfamiView protein in Pfam
PF17048 Ceramidse_alk_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASA2B_HUMAN
AccessioniPrimary (citable) accession number: P0C7U1
Secondary accession number(s): B7Z261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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