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Entry version 84 (13 Feb 2019)
Sequence version 2 (09 Feb 2010)
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Protein

Protein SLFN14

Gene

SLFN14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities.1 Publication
C-terminally truncated SLFN14 endoribonuclease: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.By similarity1 Publication2 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: C-terminally truncated SLFN14 endoribonuclease requires manganese and magnesium for its endoribonuclease activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi593 – 600ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • endoribonuclease activity Source: UniProtKB
  • ribosome binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SLFN14Curated
Cleaved into the following chain:
C-terminally truncated SLFN14 endoribonucleaseCurated (EC:3.1.-.-By similarity)
Alternative name(s):
Schlafen family member 14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLFN14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000236320.3

Human Gene Nomenclature Database

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HGNCi
HGNC:32689 SLFN14

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614958 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C7P3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Bleeding disorder, platelet-type 20 (BDPLT20)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT20 is characterized by moderate thrombocytopenia and platelet secretion defects. Inheritance is autosomal dominant.
See also OMIM:616913
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075786218K → E in BDPLT20; the mutation results in strongly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320716EnsemblClinVar.1
Natural variantiVAR_075787219K → N in BDPLT20; the mutation results in strongly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320715EnsemblClinVar.1
Natural variantiVAR_075788220V → D in BDPLT20; the mutation results in weakly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320714EnsemblClinVar.1
Natural variantiVAR_076796223R → W in BDPLT20. 1 PublicationCorresponds to variant dbSNP:rs757188030EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi248D → A: Reduces endoribonuclease activity. 1 Publication1
Mutagenesisi249D → A: Abolishes endoribonuclease activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
342618

MalaCards human disease database

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MalaCardsi
SLFN14
MIMi616913 phenotype

Open Targets

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OpenTargetsi
ENSG00000236320

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
466806 Autosomal dominant thrombocytopenia with platelet secretion defect

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA144596361

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLFN14

Domain mapping of disease mutations (DMDM)

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DMDMi
288558826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003423391 – 912Protein SLFN14Add BLAST912
ChainiPRO_00004361531 – ?C-terminally truncated SLFN14 endoribonuclease

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P0C7P3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P0C7P3

PeptideAtlas

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PeptideAtlasi
P0C7P3

PRoteomics IDEntifications database

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PRIDEi
P0C7P3

ProteomicsDB human proteome resource

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ProteomicsDBi
52355
52356 [P0C7P3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P0C7P3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C7P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in megakaryocytes and platelets (at protein level) (PubMed:26280575). Weakly expressed in melanocytes and malignant melanoma cells (PubMed:20956525).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000236320 Expressed in 15 organ(s), highest expression level in leukocyte

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022994
HPA023065

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

C-terminally truncated SLFN14 endoribonuclease: Associates with ribosomes in an ATP-independent manner (PubMed:25996083).1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P0C7P3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P0C7P3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0C7P3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 391Required for endoribonuclease activity1 PublicationAdd BLAST186
Regioni392 – 571Required for ribosome binding1 PublicationAdd BLAST180

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Schlafen family. Subgroup III subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJEW Eukaryota
ENOG410Z5MV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00410000025651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049135

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056880

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P0C7P3

Identification of Orthologs from Complete Genome Data

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OMAi
ELFIHCF

Database of Orthologous Groups

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OrthoDBi
211385at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C7P3

TreeFam database of animal gene trees

More...
TreeFami
TF337168

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.950.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029677 SLFN14

The PANTHER Classification System

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PANTHERi
PTHR12155 PTHR12155, 1 hit
PTHR12155:SF30 PTHR12155:SF30, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04326 AlbA_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P0C7P3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESLKTDTEM PYPEVIVDVG RVIFGEENRK KMTNSCLKRS ENSRIIRAIC
60 70 80 90 100
ALLNSGGGVI KAEIDDKTYS YQCHGLGQDL ETSFQKLLPS GSQKYLDYMQ
110 120 130 140 150
QGHNLLIFVK SWSPDVFSLP LRICSLRSNL YRRDVTSAIN LSASSALELL
160 170 180 190 200
REKGFRAQRG RPRVKKLHPQ QVLNRCIQEE EDMRILASEF FKKDKLMYKE
210 220 230 240 250
KLNFTESTHV EFKRFTTKKV IPRIKEMLPH YVSAFANTQG GYVLIGVDDK
260 270 280 290 300
SKEVVGCKWE KVNPDLLKKE IENCIEKLPT FHFCCEKPKV NFTTKILNVY
310 320 330 340 350
QKDVLDGYVC VIQVEPFCCV VFAEAPDSWI MKDNSVTRLT AEQWVVMMLD
360 370 380 390 400
TQSAPPSLVT DYNSCLISSA SSARKSPGYP IKVHKFKEAL QRHLFPVTQE
410 420 430 440 450
EVQFKPESLC KKLFSDHKEL EGLMKTLIHP CSQGIVIFSR SWAGDVGFRK
460 470 480 490 500
EQNVLCDALL IAVNSPVVLY TILIDPNWPG GLEYARNTAH QLKQKLQTVG
510 520 530 540 550
GYTGKVCIIP RLIHLSSTQS RPGEIPLRYP RSYRLADEEE MEDLLQALVV
560 570 580 590 600
VSLSSRSLLS DQMGCEFFNL LIMEQSQLLS ESLQKTRELF IYCFPGVRKT
610 620 630 640 650
ALAIKIMEKI KDLFHCKPKE ILYVCESDSL KDFVTQQTTC QAVTRKTFMQ
660 670 680 690 700
GEFLKIKHIV MDETENFCSK YGNWYMKAKN ITHPKAKGTG SENLHHGILW
710 720 730 740 750
LFLDPFQIHH ADVNGLPPPS AQFPRKTITS GIHCALEIAK VMKEEMKRIK
760 770 780 790 800
ENPPSNMSPD TLALFSETAY EEATCAQALP GVCETKTNLT TEQIANYVAR
810 820 830 840 850
KCHSLFQCGY LPKDIAILCR RGEDRGRYRL ALLKAMELIE THRPSEVVFS
860 870 880 890 900
PATGVWGSHI VLDSIQQFSG LERTVVFGLS PECDQSEEFH KLCFASRAIK
910
HLYLLYEKRA AY
Length:912
Mass (Da):103,907
Last modified:February 9, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i391054668F58FFAB
GO
Isoform 2 (identifier: P0C7P3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-368: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):102,259
Checksum:iC2114A3CE48C089C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti356P → S in AAI40848 (PubMed:15489334).Curated1
Sequence conflicti356P → S in AAI57878 (PubMed:15489334).Curated1
Sequence conflicti356P → S in AAI57880 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04417793Q → R. Corresponds to variant dbSNP:rs10512472Ensembl.1
Natural variantiVAR_075786218K → E in BDPLT20; the mutation results in strongly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320716EnsemblClinVar.1
Natural variantiVAR_075787219K → N in BDPLT20; the mutation results in strongly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320715EnsemblClinVar.1
Natural variantiVAR_075788220V → D in BDPLT20; the mutation results in weakly reduced protein stability. 1 PublicationCorresponds to variant dbSNP:rs869320714EnsemblClinVar.1
Natural variantiVAR_076796223R → W in BDPLT20. 1 PublicationCorresponds to variant dbSNP:rs757188030EnsemblClinVar.1
Natural variantiVAR_044178385K → E1 PublicationCorresponds to variant dbSNP:rs321612Ensembl.1
Natural variantiVAR_044179870G → S. Corresponds to variant dbSNP:rs1350011Ensembl.1
Natural variantiVAR_044180880S → I. Corresponds to variant dbSNP:rs1350010Ensembl.1
Natural variantiVAR_044181905L → F. Corresponds to variant dbSNP:rs9907259Ensembl.1
Natural variantiVAR_044182912Y → F. Corresponds to variant dbSNP:rs8073060Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034414353 – 368Missing in isoform 2. CuratedAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC015911 Genomic DNA No translation available.
BC140847 mRNA Translation: AAI40848.1
BC157877 mRNA Translation: AAI57878.1
BC157879 mRNA Translation: AAI57880.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45650.1 [P0C7P3-1]

NCBI Reference Sequences

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RefSeqi
NP_001123292.1, NM_001129820.1 [P0C7P3-1]
XP_016880065.1, XM_017024576.1 [P0C7P3-1]
XP_016880066.1, XM_017024577.1 [P0C7P3-1]
XP_016880067.1, XM_017024578.1 [P0C7P3-1]
XP_016880068.1, XM_017024579.1 [P0C7P3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591193

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000415846; ENSP00000391101; ENSG00000236320 [P0C7P3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
342618

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:342618

UCSC genome browser

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UCSCi
uc010ctu.2 human [P0C7P3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015911 Genomic DNA No translation available.
BC140847 mRNA Translation: AAI40848.1
BC157877 mRNA Translation: AAI57878.1
BC157879 mRNA Translation: AAI57880.1
CCDSiCCDS45650.1 [P0C7P3-1]
RefSeqiNP_001123292.1, NM_001129820.1 [P0C7P3-1]
XP_016880065.1, XM_017024576.1 [P0C7P3-1]
XP_016880066.1, XM_017024577.1 [P0C7P3-1]
XP_016880067.1, XM_017024578.1 [P0C7P3-1]
XP_016880068.1, XM_017024579.1 [P0C7P3-1]
UniGeneiHs.591193

3D structure databases

ProteinModelPortaliP0C7P3
SMRiP0C7P3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0C7P3, 1 interactor

PTM databases

iPTMnetiP0C7P3
PhosphoSitePlusiP0C7P3

Polymorphism and mutation databases

BioMutaiSLFN14
DMDMi288558826

Proteomic databases

MaxQBiP0C7P3
PaxDbiP0C7P3
PeptideAtlasiP0C7P3
PRIDEiP0C7P3
ProteomicsDBi52355
52356 [P0C7P3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415846; ENSP00000391101; ENSG00000236320 [P0C7P3-1]
GeneIDi342618
KEGGihsa:342618
UCSCiuc010ctu.2 human [P0C7P3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
342618
DisGeNETi342618
EuPathDBiHostDB:ENSG00000236320.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLFN14
HGNCiHGNC:32689 SLFN14
HPAiHPA022994
HPA023065
MalaCardsiSLFN14
MIMi614958 gene
616913 phenotype
neXtProtiNX_P0C7P3
OpenTargetsiENSG00000236320
Orphaneti466806 Autosomal dominant thrombocytopenia with platelet secretion defect
PharmGKBiPA144596361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
HOVERGENiHBG056880
InParanoidiP0C7P3
OMAiELFIHCF
OrthoDBi211385at2759
PhylomeDBiP0C7P3
TreeFamiTF337168

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342618

Protein Ontology

More...
PROi
PR:P0C7P3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000236320 Expressed in 15 organ(s), highest expression level in leukocyte

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029677 SLFN14
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF30 PTHR12155:SF30, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLN14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C7P3
Secondary accession number(s): B2RTW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 9, 2010
Last modified: February 13, 2019
This is version 84 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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