UniProtKB - P0C7P0 (CISD3_HUMAN)
Protein
CDGSH iron-sulfur domain-containing protein 3, mitochondrial
Gene
CISD3
Organism
Homo sapiens (Human)
Status
Functioni
Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function.1 Publication
Cofactori
[2Fe-2S] cluster1 Publication1 PublicationNote: Binds 2 [2Fe-2S] clusters per subunit.1 Publication1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 60 | Iron-sulfur 1 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 62 | Iron-sulfur 1 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 71 | Iron-sulfur 1 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 75 | Iron-sulfur 1 (2Fe-2S); via pros nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 98 | Iron-sulfur 2 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 100 | Iron-sulfur 2 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 109 | Iron-sulfur 2 (2Fe-2S)Combined sources1 Publication | 1 | |
Metal bindingi | 113 | Iron-sulfur 2 (2Fe-2S); via pros nitrogenCombined sources1 Publication | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB
- metal ion binding Source: UniProtKB
GO - Biological processi
- protein maturation by [2Fe-2S] cluster transfer Source: UniProtKB
Keywordsi
Ligand | 2Fe-2S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P0C7P0 |
Names & Taxonomyi
Protein namesi | Recommended name: CDGSH iron-sulfur domain-containing protein 3, mitochondrialAlternative name(s): MitoNEET-related protein 2 Short name: Miner2 Mitochondrial inner NEET protein1 Publication Short name: MiNT1 Publication |
Gene namesi | Name:CISD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27578, CISD3 |
MIMi | 611933, gene |
neXtProti | NX_P0C7P0 |
VEuPathDBi | HostDB:ENSG00000277972.1 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 75 | H → C: Increases iron-sulfur cluster stability; when associated with C-113. 1 Publication | 1 | |
Mutagenesisi | 113 | H → C: Increases iron-sulfur cluster stability; when associated with C-75. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 284106 |
OpenTargetsi | ENSG00000277972 |
PharmGKBi | PA162382311 |
Miscellaneous databases
Pharosi | P0C7P0, Tdark |
Genetic variation databases
BioMutai | CISD3 |
DMDMi | 190358744 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 14 | MitochondrionSequence analysisAdd BLAST | 14 | |
ChainiPRO_0000341405 | 15 – 127 | CDGSH iron-sulfur domain-containing protein 3, mitochondrialAdd BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 55 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 86 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P0C7P0 |
jPOSTi | P0C7P0 |
MassIVEi | P0C7P0 |
MaxQBi | P0C7P0 |
PaxDbi | P0C7P0 |
PeptideAtlasi | P0C7P0 |
PRIDEi | P0C7P0 |
ProteomicsDBi | 52352 |
PTM databases
iPTMneti | P0C7P0 |
PhosphoSitePlusi | P0C7P0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000277972, Expressed in muscle tissue and 197 other tissues |
Genevisiblei | P0C7P0, HS |
Organism-specific databases
HPAi | ENSG00000277972, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 129759, 82 interactors |
IntActi | P0C7P0, 91 interactors |
STRINGi | 9606.ENSP00000483781 |
Miscellaneous databases
RNActi | P0C7P0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0C7P0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CISD protein family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4605, Eukaryota |
GeneTreei | ENSGT00390000004574 |
HOGENOMi | CLU_145019_1_0_1 |
InParanoidi | P0C7P0 |
OMAi | GTHKSER |
OrthoDBi | 1565094at2759 |
PhylomeDBi | P0C7P0 |
TreeFami | TF313111 |
Family and domain databases
Gene3Di | 3.40.5.90, 1 hit |
InterProi | View protein in InterPro IPR018967, FeS-contain_CDGSH-typ IPR042216, FeS-contain_mitoNEET_C |
Pfami | View protein in Pfam PF09360, zf-CDGSH, 2 hits |
SMARTi | View protein in SMART SM00704, ZnF_CDGSH, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0C7P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGAGAILRP AARGARDLNP RRDISSWLAQ WFPRTPARSV VALKTPIKVE
60 70 80 90 100
LVAGKTYRWC VCGRSKKQPF CDGSHFFQRT GLSPLKFKAQ ETRMVALCTC
110 120
KATQRPPYCD GTHRSERVQK AEVGSPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006449 Genomic DNA No translation available. BM546511 mRNA No translation available. |
CCDSi | CCDS45662.1 |
RefSeqi | NP_001129970.1, NM_001136498.1 |
Genome annotation databases
Ensembli | ENST00000613478; ENSP00000483781; ENSG00000277972 ENST00000620783; ENSP00000484950; ENSG00000274768 |
GeneIDi | 284106 |
KEGGi | hsa:284106 |
UCSCi | uc010wds.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006449 Genomic DNA No translation available. BM546511 mRNA No translation available. |
CCDSi | CCDS45662.1 |
RefSeqi | NP_001129970.1, NM_001136498.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AVJ | X-ray | 1.90 | A/B/C | 36-127 | [»] | |
SMRi | P0C7P0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129759, 82 interactors |
IntActi | P0C7P0, 91 interactors |
STRINGi | 9606.ENSP00000483781 |
PTM databases
iPTMneti | P0C7P0 |
PhosphoSitePlusi | P0C7P0 |
Genetic variation databases
BioMutai | CISD3 |
DMDMi | 190358744 |
Proteomic databases
EPDi | P0C7P0 |
jPOSTi | P0C7P0 |
MassIVEi | P0C7P0 |
MaxQBi | P0C7P0 |
PaxDbi | P0C7P0 |
PeptideAtlasi | P0C7P0 |
PRIDEi | P0C7P0 |
ProteomicsDBi | 52352 |
Protocols and materials databases
Antibodypediai | 75426, 8 antibodies |
Genome annotation databases
Ensembli | ENST00000613478; ENSP00000483781; ENSG00000277972 ENST00000620783; ENSP00000484950; ENSG00000274768 |
GeneIDi | 284106 |
KEGGi | hsa:284106 |
UCSCi | uc010wds.2, human |
Organism-specific databases
CTDi | 284106 |
DisGeNETi | 284106 |
GeneCardsi | CISD3 |
HGNCi | HGNC:27578, CISD3 |
HPAi | ENSG00000277972, Low tissue specificity |
MIMi | 611933, gene |
neXtProti | NX_P0C7P0 |
OpenTargetsi | ENSG00000277972 |
PharmGKBi | PA162382311 |
VEuPathDBi | HostDB:ENSG00000277972.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4605, Eukaryota |
GeneTreei | ENSGT00390000004574 |
HOGENOMi | CLU_145019_1_0_1 |
InParanoidi | P0C7P0 |
OMAi | GTHKSER |
OrthoDBi | 1565094at2759 |
PhylomeDBi | P0C7P0 |
TreeFami | TF313111 |
Enzyme and pathway databases
PathwayCommonsi | P0C7P0 |
Miscellaneous databases
BioGRID-ORCSi | 284106, 13 hits in 993 CRISPR screens |
ChiTaRSi | CISD3, human |
GenomeRNAii | 284106 |
Pharosi | P0C7P0, Tdark |
PROi | PR:P0C7P0 |
RNActi | P0C7P0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000277972, Expressed in muscle tissue and 197 other tissues |
Genevisiblei | P0C7P0, HS |
Family and domain databases
Gene3Di | 3.40.5.90, 1 hit |
InterProi | View protein in InterPro IPR018967, FeS-contain_CDGSH-typ IPR042216, FeS-contain_mitoNEET_C |
Pfami | View protein in Pfam PF09360, zf-CDGSH, 2 hits |
SMARTi | View protein in SMART SM00704, ZnF_CDGSH, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISD3_HUMAN | |
Accessioni | P0C7P0Primary (citable) accession number: P0C7P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | April 7, 2021 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families