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UniProtKB - P0C7L3 (PAAJ_ECOLX)
Protein
Beta-ketoadipyl-CoA thiolase
Gene
paaJ
Organism
Escherichia coli
Status
Functioni
Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA.
By similarityCatalytic activityi
- EC:2.3.1.174
: phenylacetate degradation Pathwayi
This protein is involved in the pathway phenylacetate degradation, which is part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the pathway phenylacetate degradation and in Aromatic compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 90 | Acyl-thioester intermediateBy similarity | 1 | |
Active sitei | 357 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 387 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoadipyl-CoA thiolase activity Source: UniProtKB-EC
GO - Biological processi
- 3,4-dihydroxybenzoate catabolic process Source: InterPro
- phenylacetate catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00930 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-ketoadipyl-CoA thiolase (EC:2.3.1.174)Alternative name(s): 3-oxoadipyl-CoA thiolase |
Gene namesi | Name:paaJ |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337827 | 1 – 401 | Beta-ketoadipyl-CoA thiolaseAdd BLAST | 401 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
OMAi | MSRVPMW |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR012793, PcaF IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit TIGR02430, pcaF, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C7L3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREAFICDGI RTPIGRYGGA LSGVRADDLA AIPLRELLVR NPRLDAECID
60 70 80 90 100
DVILGCANQA GEDNRNVARM ATLLAGLPQS VSGTTINRLC GSGLDALGFA
110 120 130 140 150
ARAIKAGDGD LLIAGGVESM SRAPFVMGKA TSAFSRQAEM FDTTIGWRFV
160 170 180 190 200
NPLMAQQFGT DSMPETAENV AELLKISRED QDSFALRSQQ RTAKAQSSGI
210 220 230 240 250
LAEEIVPVVL KNKKGVVTEI QHDEHLRPET TLEQLRGLKA PFRANGVITA
260 270 280 290 300
GNASGVNDGA AALIIASEQM AAAQGLTPRA RIVAMATAGV EPRLMGLGPV
310 320 330 340 350
PATRRVLERA GLSIHDMDVI ELNEAFAAQA LGVLRELGLP DDAPHVNPNG
360 370 380 390 400
GAIALGHPLG MSGARLALAA SHELHRRNGR YALCTMCIGV GQGIAMILER
V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66099.1 |
RefSeqi | WP_001206190.1, NZ_WVWF01000010.1 |
Genome annotation databases
GeneIDi | 66674746 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97452 Genomic DNA Translation: CAA66099.1 |
RefSeqi | WP_001206190.1, NZ_WVWF01000010.1 |
3D structure databases
AlphaFoldDBi | P0C7L3 |
SMRi | P0C7L3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 585034.ECIAI1_1397 |
Genome annotation databases
GeneIDi | 66674746 |
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
OMAi | MSRVPMW |
Enzyme and pathway databases
UniPathwayi | UPA00930 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR012793, PcaF IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit TIGR02430, pcaF, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAAJ_ECOLX | |
Accessioni | P0C7L3Primary (citable) accession number: P0C7L3 Secondary accession number(s): O53017, P77525 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | May 25, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families