UniProtKB - P0C7I6 (CC159_HUMAN)
Protein
Coiled-coil domain-containing protein 159
Gene
CCDC159
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 159 |
Gene namesi | Name:CCDC159 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183401.11 |
HGNCi | HGNC:26996, CCDC159 |
neXtProti | NX_P0C7I6 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000183401 |
Miscellaneous databases
Pharosi | P0C7I6, Tdark |
Polymorphism and mutation databases
BioMutai | CCDC159 |
DMDMi | 189041677 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332996 | 1 – 297 | Coiled-coil domain-containing protein 159Add BLAST | 297 |
Proteomic databases
MassIVEi | P0C7I6 |
PaxDbi | P0C7I6 |
PeptideAtlasi | P0C7I6 |
PRIDEi | P0C7I6 |
ProteomicsDBi | 52338 [P0C7I6-2] |
PTM databases
iPTMneti | P0C7I6 |
PhosphoSitePlusi | P0C7I6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183401, Expressed in granulocyte and 188 other tissues |
ExpressionAtlasi | P0C7I6, baseline and differential |
Genevisiblei | P0C7I6, HS |
Organism-specific databases
HPAi | ENSG00000183401, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125955, 1 interactor |
STRINGi | 9606.ENSP00000468232 |
Miscellaneous databases
RNActi | P0C7I6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 147 – 297 | Sequence analysisAdd BLAST | 151 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S2FS, Eukaryota |
GeneTreei | ENSGT00390000008201 |
HOGENOMi | CLU_081600_0_0_1 |
InParanoidi | P0C7I6 |
OMAi | PLLPSWD |
OrthoDBi | 1360515at2759 |
PhylomeDBi | P0C7I6 |
Family and domain databases
InterProi | View protein in InterPro IPR039284, CCDC159/163 |
PANTHERi | PTHR34533, PTHR34533, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: P0C7I6-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEHEQVKPL ETSSSKVKAK TIVMIPDSQK LLRCELESLK SQLQAQTKAF
60 70 80 90 100
EFLNHSVTML EKESCLQQIK IQQLEEVLSP TGRQGEKEEH KWGMEQGRQE
110 120 130 140 150
LYGALTQGLQ GLEKTLRDSE EMQRARTTRC LQLLAQEIRD SKKFLWEELE
160 170 180 190 200
LVREEVTFIY QKLQAQEDEI SENLVNIQKM QKTQVKCRKI LTKMKQQGHE
210 220 230 240 250
TAACPETEEI PQGASGCWKD DLQKELSDIW SAVHVLQNSI DSLTLCSGAC
260 270 280 290
PKASSLRGHK GHQCLSPPLP SWDSDSDCDQ DLSQPPFSKS GRSFPPA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EN56 | K7EN56_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 193 | Annotation score: | ||
K7EJK8 | K7EJK8_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 155 | Annotation score: | ||
K7EKC7 | K7EKC7_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 140 | Annotation score: | ||
K7EKU9 | K7EKU9_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 129 | Annotation score: | ||
K7ENC2 | K7ENC2_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 109 | Annotation score: | ||
K7EKR4 | K7EKR4_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 36 | Annotation score: | ||
K7EPH8 | K7EPH8_HUMAN | Coiled-coil domain-containing prote... | CCDC159 | 38 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043032 | 278 | C → S. Corresponds to variant dbSNP:rs6887Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059513 | 1 – 6 | MGEHEQ → MNRWY in isoform 3 and isoform 4. | 6 | |
Alternative sequenceiVSP_059514 | 141 – 177 | SKKFL…NLVNI → RSGMAGGQLGVHRREGRPRT GEWRQDGGNGRCLGEGD in isoform 3 and isoform 5. Add BLAST | 37 | |
Alternative sequenceiVSP_059515 | 178 – 297 | Missing in isoform 3 and isoform 5. Add BLAST | 120 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293611 mRNA Translation: BAG57074.1 AK301653 mRNA Translation: BAG63130.1 Sequence problems. AK303641 mRNA Translation: BAG64645.1 AK316339 mRNA Translation: BAH14710.1 AC024575 Genomic DNA No translation available. BC038439 mRNA No translation available. |
CCDSi | CCDS45976.1 [P0C7I6-2] |
RefSeqi | NP_001073972.2, NM_001080503.2 [P0C7I6-2] XP_016881749.1, XM_017026260.1 [P0C7I6-7] |
Genome annotation databases
Ensembli | ENST00000458408; ENSP00000402239; ENSG00000183401 [P0C7I6-2] ENST00000588790; ENSP00000468232; ENSG00000183401 [P0C7I6-2] |
GeneIDi | 126075 |
KEGGi | hsa:126075 |
UCSCi | uc010xlt.3, human [P0C7I6-2] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293611 mRNA Translation: BAG57074.1 AK301653 mRNA Translation: BAG63130.1 Sequence problems. AK303641 mRNA Translation: BAG64645.1 AK316339 mRNA Translation: BAH14710.1 AC024575 Genomic DNA No translation available. BC038439 mRNA No translation available. |
CCDSi | CCDS45976.1 [P0C7I6-2] |
RefSeqi | NP_001073972.2, NM_001080503.2 [P0C7I6-2] XP_016881749.1, XM_017026260.1 [P0C7I6-7] |
3D structure databases
SMRi | P0C7I6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125955, 1 interactor |
STRINGi | 9606.ENSP00000468232 |
PTM databases
iPTMneti | P0C7I6 |
PhosphoSitePlusi | P0C7I6 |
Polymorphism and mutation databases
BioMutai | CCDC159 |
DMDMi | 189041677 |
Proteomic databases
MassIVEi | P0C7I6 |
PaxDbi | P0C7I6 |
PeptideAtlasi | P0C7I6 |
PRIDEi | P0C7I6 |
ProteomicsDBi | 52338 [P0C7I6-2] |
Protocols and materials databases
Antibodypediai | 52093, 15 antibodies |
Genome annotation databases
Ensembli | ENST00000458408; ENSP00000402239; ENSG00000183401 [P0C7I6-2] ENST00000588790; ENSP00000468232; ENSG00000183401 [P0C7I6-2] |
GeneIDi | 126075 |
KEGGi | hsa:126075 |
UCSCi | uc010xlt.3, human [P0C7I6-2] |
Organism-specific databases
CTDi | 126075 |
EuPathDBi | HostDB:ENSG00000183401.11 |
GeneCardsi | CCDC159 |
HGNCi | HGNC:26996, CCDC159 |
HPAi | ENSG00000183401, Low tissue specificity |
neXtProti | NX_P0C7I6 |
OpenTargetsi | ENSG00000183401 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2FS, Eukaryota |
GeneTreei | ENSGT00390000008201 |
HOGENOMi | CLU_081600_0_0_1 |
InParanoidi | P0C7I6 |
OMAi | PLLPSWD |
OrthoDBi | 1360515at2759 |
PhylomeDBi | P0C7I6 |
Enzyme and pathway databases
PathwayCommonsi | P0C7I6 |
Miscellaneous databases
BioGRID-ORCSi | 126075, 39 hits in 844 CRISPR screens |
GenomeRNAii | 126075 |
Pharosi | P0C7I6, Tdark |
PROi | PR:P0C7I6 |
RNActi | P0C7I6, protein |
Gene expression databases
Bgeei | ENSG00000183401, Expressed in granulocyte and 188 other tissues |
ExpressionAtlasi | P0C7I6, baseline and differential |
Genevisiblei | P0C7I6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039284, CCDC159/163 |
PANTHERi | PTHR34533, PTHR34533, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CC159_HUMAN | |
Accessioni | P0C7I6Primary (citable) accession number: P0C7I6 Secondary accession number(s): B4DEG3 B7ZAM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | March 28, 2018 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations