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Protein

Keratin-associated protein 2-3

Gene

KRTAP2-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 2-3
Alternative name(s):
High sulfur keratin-associated protein 2.4
Keratin-associated protein 2.3
Gene namesi
Name:KRTAP2-3
Synonyms:KAP2.3, KRTAP2.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000212724.3
HGNCiHGNC:18906 KRTAP2-3
neXtProtiNX_P0C7H8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212724
ENSG00000213417

Polymorphism and mutation databases

BioMutaiKRTAP2-3
DMDMi425906047

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314521 – 128Keratin-associated protein 2-3Add BLAST128

Proteomic databases

PaxDbiP0C7H8
PeptideAtlasiP0C7H8
PRIDEiP0C7H8
ProteomicsDBi52334

Expressioni

Gene expression databases

BgeeiENSG00000212724 Expressed in 26 organ(s), highest expression level in amniotic fluid
GenevisibleiP0C7H8 HS

Organism-specific databases

HPAiHPA059203

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi124458, 10 interactors
IntActiP0C7H8, 95 interactors

Structurei

3D structure databases

ProteinModelPortaliP0C7H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 11210 X 5 AA repeats of C-C-[CDPQRWG]-[APRS]-[CIPSTVD]Add BLAST108

Sequence similaritiesi

Belongs to the KRTAP type 2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
HOGENOMiHOG000234030
HOVERGENiHBG108074
InParanoidiP0C7H8
OMAiCHLACGC
OrthoDBiEOG091G16MC
PhylomeDBiP0C7H8

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF01500 Keratin_B2, 1 hit
PF13885 Keratin_B2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C7H8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGSCCGSTL SSLSYGGGCC QPCCCRDPCC CRPVTCQTTV CRPVTCVPRC
60 70 80 90 100
TRPICEPCRR PVCCDPCSLQ EGCCRPITCC PSSCTAVVCR PCCWATTCCQ
110 120
PVSVQSPCCR PPCGQPTPCS TTCRTSSC
Length:128
Mass (Da):13,480
Last modified:November 28, 2012 - v2
Checksum:i1617AA40943D90F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100808 Genomic DNA No translation available.
CCDSiCCDS54123.1
RefSeqiNP_001158724.1, NM_001165252.1
NP_149440.1, NM_033184.3
UniGeneiHs.406714
Hs.560502

Genome annotation databases

EnsembliENST00000391418; ENSP00000375237; ENSG00000212724
ENST00000570303; ENSP00000459261; ENSG00000262862
GeneIDi730755
85294
KEGGihsa:730755
hsa:85294

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100808 Genomic DNA No translation available.
CCDSiCCDS54123.1
RefSeqiNP_001158724.1, NM_001165252.1
NP_149440.1, NM_033184.3
UniGeneiHs.406714
Hs.560502

3D structure databases

ProteinModelPortaliP0C7H8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124458, 10 interactors
IntActiP0C7H8, 95 interactors

Polymorphism and mutation databases

BioMutaiKRTAP2-3
DMDMi425906047

Proteomic databases

PaxDbiP0C7H8
PeptideAtlasiP0C7H8
PRIDEiP0C7H8
ProteomicsDBi52334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391418; ENSP00000375237; ENSG00000212724
ENST00000570303; ENSP00000459261; ENSG00000262862
GeneIDi730755
85294
KEGGihsa:730755
hsa:85294

Organism-specific databases

CTDi730755
85294
EuPathDBiHostDB:ENSG00000212724.3
GeneCardsiKRTAP2-3
HGNCiHGNC:18906 KRTAP2-3
HPAiHPA059203
neXtProtiNX_P0C7H8
OpenTargetsiENSG00000212724
ENSG00000213417
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
HOGENOMiHOG000234030
HOVERGENiHBG108074
InParanoidiP0C7H8
OMAiCHLACGC
OrthoDBiEOG091G16MC
PhylomeDBiP0C7H8

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

PROiPR:P0C7H8

Gene expression databases

BgeeiENSG00000212724 Expressed in 26 organ(s), highest expression level in amniotic fluid
GenevisibleiP0C7H8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit
PfamiView protein in Pfam
PF01500 Keratin_B2, 1 hit
PF13885 Keratin_B2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRA23_HUMAN
AccessioniPrimary (citable) accession number: P0C7H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 28, 2012
Last modified: November 7, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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