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UniProtKB - P0C7A1 (ENASE_CHICK)
Protein
Cytosolic endo-beta-N-acetylglucosaminidase
Gene
ENGASE
Organism
Gallus gallus (Chicken)
Status
Functioni
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
Catalytic activityi
- Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)(2))Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein, the rest of the oligosaccharide is released intact. EC:3.2.1.96
GO - Molecular functioni
- beta-N-acetylglucosaminidase activity Source: AgBase
- hydrolase activity Source: AgBase
- hydrolase activity, hydrolyzing O-glycosyl compounds Source: GO_Central
- mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC
GO - Biological processi
- protein deglycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ENGASE |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Cytosol
- cytosol Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: AgBase
Lysosome
- lysosome Source: AgBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328869 | 1 – 728 | Cytosolic endo-beta-N-acetylglucosaminidaseAdd BLAST | 728 |
Proteomic databases
PaxDbi | P0C7A1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 287 – 381 | BRCTAdd BLAST | 95 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 85 family.Curated
Phylogenomic databases
eggNOGi | KOG2331, Eukaryota |
InParanoidi | P0C7A1 |
OrthoDBi | 722800at2759 |
PhylomeDBi | P0C7A1 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR032979, ENGase IPR005201, Glyco_hydro_85 IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR13246, PTHR13246, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF03644, Glyco_hydro_85, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
P0C7A1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSQSVMLEL REQDEVWVRL YKGERENAVF SDEYDTYITF SGHLINFQPA
60 70 80 90 100
AEPLGTTVLH AAVDTRPQPA RYFDTGTTEP VSFFLSGLEE LLAWHPSSDD
110 120 130 140 150
EFNVCAVPLA QRQPPLHSRR PRTLLCHDMR GGYLEDRFIQ GSATRNPYVF
160 170 180 190 200
YHWRYVDIFV YFSHHTVTIP PVCWTNAAHR NGVPVLGTFI TEWADGEKLC
210 220 230 240 250
EAFLAGGEDA YRAVSHQLAR IAQHYRFDGW LINIENALSA AAVGNLSPFL
260 270 280 290 300
RHLTAEVHGA VPGGLVIWYD SILESGTLRW QNELNQQNRV FFDACDGLFV
310 320 330 340 350
NYNWKEEHLE RTRELAGQRH ADVYIGVDVF ARGDVVGGGF DTNKSLSLIR
360 370 380 390 400
KHGLSAAIFA PGWVYKHLGE ENFLLNEDKF WGLLEDYLPT HSICTLPLAT
410 420 430 440 450
SFSVGMGTGM FLAGKEEEAG PWYNLSAQEI QPLYPERRGW LSTSCCLQDA
460 470 480 490 500
WCGGSSLRVQ GTIPPGEERV AIRLSLWVDL GSSGFSLSIC GTLASGPHRD
510 520 530 540 550
DFTVALELTT WHSSRCHDGT VTVLPSEDEP HGRHHPHLLP APPPALSRML
560 570 580 590 600
AACSHGAQGW TSRCYEQELR GCSLRDLSLL VSRQQASPQE TSFSCLLGEL
610 620 630 640 650
RVLDAGSMAA SPPQVQSLTA SQLWWQDGPS AEQLSLSLTL RWAFPPGRAA
660 670 680 690 700
CFRVLSQGAR CHRAQPAQPQ LLGLAHGCQY RAVGLAVPRP APGQSCQLEL
710 720
LVEPVLPSEL PVGPERWGRL LLVYSEPA
Similar proteinsi
Cross-referencesi
3D structure databases
AlphaFoldDBi | P0C7A1 |
SMRi | P0C7A1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000019265 |
Chemistry databases
ChEMBLi | CHEMBL1075083 |
Proteomic databases
PaxDbi | P0C7A1 |
Phylogenomic databases
eggNOGi | KOG2331, Eukaryota |
InParanoidi | P0C7A1 |
OrthoDBi | 722800at2759 |
PhylomeDBi | P0C7A1 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR032979, ENGase IPR005201, Glyco_hydro_85 IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR13246, PTHR13246, 1 hit |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF03644, Glyco_hydro_85, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ENASE_CHICK | |
Accessioni | P0C7A1Primary (citable) accession number: P0C7A1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | May 25, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families