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UniProtKB - P0C6Y2 (R1AB_IBVBC)

Entry version 79 (02 Dec 2020)
Sequence version 1 (10 Jun 2008)
Previous versions | rss
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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Avian infectious bronchitis virus (strain Beaudette CK) (IBV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity).By similarity
Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK.PROSITE-ProRule annotation
The peptide p16 might be involved in the EGF signaling pathway.By similarity
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).By similarity
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1274For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1437For PL-PRO activityPROSITE-ProRule annotation1
Active sitei2820For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei2922For 3CL-PRO activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4873Zinc 1PROSITE-ProRule annotation1
Metal bindingi4876Zinc 1PROSITE-ProRule annotation1
Metal bindingi4884Zinc 2PROSITE-ProRule annotation1
Metal bindingi4887Zinc 1PROSITE-ProRule annotation1
Metal bindingi4894Zinc 1PROSITE-ProRule annotation1
Metal bindingi4897Zinc 2PROSITE-ProRule annotation1
Metal bindingi4901Zinc 2PROSITE-ProRule annotation1
Metal bindingi4907Zinc 2PROSITE-ProRule annotation1
Metal bindingi4918Zinc 3PROSITE-ProRule annotation1
Metal bindingi4923Zinc 3PROSITE-ProRule annotation1
Metal bindingi4940Zinc 3PROSITE-ProRule annotation1
Metal bindingi4943Zinc 3PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1353 – 1390C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri3858 – 3878By similarityAdd BLAST21
Zinc fingeri3904 – 3917By similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi5150 – 5157ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processActivation of host autophagy by virus, Host-virus interaction, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 14 chains:
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p87
Non-structural protein 3 (EC:3.4.22.-)
Short name:
nsp3
Alternative name(s):
Papain-like proteinase
Short name:
PL-PRO
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
p41
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
p33
Non-structural protein 6
Short name:
nsp6
Alternative name(s):
p34
Non-structural protein 7
Short name:
nsp7
Alternative name(s):
p9
Non-structural protein 8
Short name:
nsp8
Alternative name(s):
p24
Non-structural protein 9
Short name:
nsp9
Alternative name(s):
p10
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
p16
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
p100
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
p68
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
p58
Uridylate-specific endoribonuclease (EC:3.1.-.-)
Alternative name(s):
NendoU
nsp15
p39
Putative 2'-O-methyl transferase (EC:2.1.1.-)
Alternative name(s):
nsp16
p35
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAvian infectious bronchitis virus (strain Beaudette CK) (IBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri160235 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Gammacoronavirus › Igacovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiGallus gallus (Chicken) [TaxID: 9031]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000114388 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1721 – 1741HelicalSequence analysisAdd BLAST21
Transmembranei1751 – 1771HelicalSequence analysisAdd BLAST21
Transmembranei1844 – 1864HelicalSequence analysisAdd BLAST21
Transmembranei1869 – 1888HelicalSequence analysisAdd BLAST20
Transmembranei2281 – 2301HelicalSequence analysisAdd BLAST21
Transmembranei2560 – 2580HelicalSequence analysisAdd BLAST21
Transmembranei2589 – 2609HelicalSequence analysisAdd BLAST21
Transmembranei2612 – 2632HelicalSequence analysisAdd BLAST21
Transmembranei2644 – 2664HelicalSequence analysisAdd BLAST21
Transmembranei3101 – 3121HelicalSequence analysisAdd BLAST21
Transmembranei3122 – 3142HelicalSequence analysisAdd BLAST21
Transmembranei3152 – 3172HelicalSequence analysisAdd BLAST21
Transmembranei3189 – 3209HelicalSequence analysisAdd BLAST21
Transmembranei3220 – 3240HelicalSequence analysisAdd BLAST21
Transmembranei3258 – 3278HelicalSequence analysisAdd BLAST21
Transmembranei3297 – 3317HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000374181 – 673Non-structural protein 2By similarityAdd BLAST673
ChainiPRO_0000037419674 – 2265Non-structural protein 3By similarityAdd BLAST1592
ChainiPRO_00000374202266 – 2779Non-structural protein 4By similarityAdd BLAST514
ChainiPRO_00000374212780 – 30863C-like proteinaseBy similarityAdd BLAST307
ChainiPRO_00000374223087 – 3379Non-structural protein 6By similarityAdd BLAST293
ChainiPRO_00000374233380 – 3462Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00000374243463 – 3672Non-structural protein 8By similarityAdd BLAST210
ChainiPRO_00000374253673 – 3783Non-structural protein 9By similarityAdd BLAST111
ChainiPRO_00000374263784 – 3928Non-structural protein 10By similarityAdd BLAST145
ChainiPRO_00000374273929 – 4868RNA-directed RNA polymeraseBy similarityAdd BLAST940
ChainiPRO_00000374284869 – 5468HelicaseBy similarityAdd BLAST600
ChainiPRO_00000374295469 – 5989ExoribonucleaseBy similarityAdd BLAST521
ChainiPRO_00000374305990 – 6327Uridylate-specific endoribonucleaseBy similarityAdd BLAST338
ChainiPRO_00000374316328 – 6629Putative 2'-O-methyl transferaseBy similarityAdd BLAST302

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei673 – 674Cleavage; by PL-PROBy similarity2
Sitei2265 – 2266Cleavage; by PL-PROBy similarity2
Sitei2779 – 2780Cleavage; by 3CL-PROBy similarity2
Sitei3086 – 3087Cleavage; by 3CL-PROBy similarity2
Sitei3379 – 3380Cleavage; by 3CL-PROBy similarity2
Sitei3462 – 3463Cleavage; by 3CL-PROBy similarity2
Sitei3672 – 3673Cleavage; by 3CL-PROBy similarity2
Sitei3783 – 3784Cleavage; by 3CL-PROBy similarity2
Sitei3928 – 3929Cleavage; by 3CL-PROBy similarity2
Sitei4868 – 4869Cleavage; by 3CL-PROBy similarity2
Sitei5468 – 5469Cleavage; by 3CL-PROBy similarity2
Sitei5989 – 5990Cleavage; by 3CL-PROBy similarity2
Sitei6327 – 6328Cleavage; by 3CL-PROBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P0C6Y2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3CL-PRO exists as monomer and homodimer. The three peptides nsp2, nsp3 and nsp4 may form a complex. Nsp9 is a dimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp10 forms a dodecamer (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6Y2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1003 – 1179MacroPROSITE-ProRule annotationAdd BLAST177
Domaini1236 – 1497Peptidase C16PROSITE-ProRule annotationAdd BLAST262
Domaini2780 – 3086Peptidase C30PROSITE-ProRule annotationAdd BLAST307
Domaini4548 – 4710RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
Domaini4869 – 4952CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5125 – 5305(+)RNA virus helicase ATP-bindingAdd BLAST181
Domaini5306 – 5477(+)RNA virus helicase C-terminalAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1721 – 1888HD1Add BLAST168
Regioni2281 – 2664HD2Add BLAST384
Regioni2885 – 3317HD3Add BLAST433

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1353 – 1390C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri3858 – 3878By similarityAdd BLAST21
Zinc fingeri3904 – 3917By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database

More...CDDi		cd18808, SF1_C_Upf1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR003593, AAA+_ATPase
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR040795, Nsp1a_N
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF17896, Nsp2a_N, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: P0C6Y2-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSLKQGVS PKPRDVILVS KDIPEQLCDA LFFYTSHNPK DYADAFAVRQ 
        60         70         80         90        100
KFDRSLQTGK QFKFETVCGL FLLKGVDKIT PGVPAKVLKA TSKLADLEDI 
       110        120        130        140        150
FGVSPLARKY RELLKTACQW SLTVEALDVR AQTLDEIFDP TEILWLQVAA 
       160        170        180        190        200
KIHVSSMAMR RLVGEVTAKV MDALGSNLSA LFQIVKQQIA RIFQKALAIF 
       210        220        230        240        250
ENVNELPQRI AALKMAFAKC ARSITVVVVE RTLVVKEFAG TCLASINGAV 
       260        270        280        290        300
AKFFEELPNG FMGSKIFTTL AFFKEAAVRV VENIPNAPRG TKGFEVVGNA 
       310        320        330        340        350
KGTQVVVRGM RNDLTLLDQK ADIPVEPEGW SAILDGHLCY VFRSGDRFYA 
       360        370        380        390        400
APLSGNFALS DVHCCERVVC LSDGVTPEIN DGLILAAIYS SFSVSELVTA 
       410        420        430        440        450
LKKGEPFKFL GHKFVYAKDA AVSFTLAKAA TIADVLRLFQ SARVIAEDVW 
       460        470        480        490        500
SSFTEKSFEF WKLAYGKVRN LEEFVKTYVC KAQMSIVILA AVLGEDIWHL 
       510        520        530        540        550
VSQVIYKLGV LFTKVVDFCD KHWKGFCVQL KRAKLIVTET FCVLKGVAQH 
       560        570        580        590        600
CFQLLLDAIH SLYKSFKKCA LGRIHGDLLF WKGGVHKIVQ DGDEIWFDAI 
       610        620        630        640        650
DSVDVEDLGV VQEKSIDFEV CDDVTLPENQ PGHMVQIEDD GKNYMFFRFK 
       660        670        680        690        700
KDENIYYTPM SQLGAINVVC KAGGKTVTFG ETTVQEIPPP DVVPIKVSIE 
       710        720        730        740        750
CCGEPWNTIF KKAYKEPIEV DTDLTVEQLL SVIYEKMCDD LKLFPEAPEP 
       760        770        780        790        800
PPFENVALVD KNGKDLDCIK SCHLIYRDYE SDDDIEEEDA EECDTDSGEA 
       810        820        830        840        850
EECDTNSECE EEDEDTKVLA LIQDPASIKY PLPLDEDYSV YNGCIVHKDA 
       860        870        880        890        900
LDVVNLPSGE ETFVVNNCFE GAVKPLPQKV VDVLGDWGEA VDAQEQLCQQ 
       910        920        930        940        950
EPLQHTFEEP VENSTGSSKT MTEQVVVEDQ ELPVVEQDQD VVVYTPTDLE 
       960        970        980        990       1000
VAKETAEEVD EFILIFAVPK EEVVSQKDGA QIKQEPIQVV KPQREKKAKK 
      1010       1020       1030       1040       1050
FKVKPATCEK PKFLEYKTCV GDLTVVIAKA LDEFKEFCIV NAANEHMTHG 
      1060       1070       1080       1090       1100
SGVAKAIADF CGLDFVEYCE DYVKKHGPQQ RLVTPSFVKG IQCVNNVVGP 
      1110       1120       1130       1140       1150
RHGDNNLHEK LVAAYKNVLV DGVVNYVVPV LSLGIFGVDF KMSIDAMREA 
      1160       1170       1180       1190       1200
FEGCTIRVLL FSLSQEHIDY FDVTCKQKTI YLTEDGVKYR SIVLKPGDSL 
      1210       1220       1230       1240       1250
GQFGQVYAKN KIVFTADDVE DKEILYVPTT DKSILEYYGL DAQKYVIYLQ 
      1260       1270       1280       1290       1300
TLAQKWNVQY RDNFLILEWR DGNCWISSAI VLLQAAKIRF KGFLTEAWAK 
      1310       1320       1330       1340       1350
LLGGDPTDFV AWCYASCTAK VGDFSDANWL LANLAEHFDA DYTNAFLKKR 
      1360       1370       1380       1390       1400
VSCNCGIKSY ELRGLEACIQ PVRATNLLHF KTQYSNCPTC GANNTDEVIE 
      1410       1420       1430       1440       1450
ASLPYLLLFA TDGPATVDCD EDAVGTVVFV GSTNSGHCYT QAAGQAFDNL 
      1460       1470       1480       1490       1500
AKDRKFGKKS PYITAMYTRF AFKNETSLPV AKQSKGKSKS VKEDVSNLAT 
      1510       1520       1530       1540       1550
SSKASFDNLT DFEQWYDSNI YESLKVQESP DNFDKYVSFT TKEDSKLPLT 
      1560       1570       1580       1590       1600
LKVRGIKSVV DFRSKDGFIY KLTPDTDENS KAPVYYPVLD AISLKAIWVE 
      1610       1620       1630       1640       1650
GNANFVVGHP NYYSKSLHIP TFWENAENFV KMGDKIGGVT MGLWRAEHLN 
      1660       1670       1680       1690       1700
KPNLERIFNI AKKAIVGSSV VTTQCGKLIG KAATFIADKV GGGVVRNITD 
      1710       1720       1730       1740       1750
SIKGLCGITR GHFERKMSPQ FLKTLMFFLF YFLKASVKSV VASYKTVLCK 
      1760       1770       1780       1790       1800
VVLATLLIVW FVYTSNPVMF TGIRVLDFLF EGSLCGPYKD YGKDSFDVLR 
      1810       1820       1830       1840       1850
YCADDFICRV CLHDKDSLHL YKHAYSVEQV YKDAASGFIF NWNWLYLVFL 
      1860       1870       1880       1890       1900
ILFVKPVAGF VIICYCVKYL VLNSTVLQTG VCFLDWFVQT VFSHFNFMGA 
      1910       1920       1930       1940       1950
GFYFWLFYKI YIQVHHILYC KDVTCEVCKR VARSNRQEVS VVVGGRKQIV 
      1960       1970       1980       1990       2000
HVYTNSGYNF CKRHNWYCRN CDDYGHQNTF MSPEVAGELS EKLKRHVKPT 
      2010       2020       2030       2040       2050
AYAYHVVDEA CLVDDFVNLK YKAATPGKDS ASSAVKCFSV TDFLKKAVFL 
      2060       2070       2080       2090       2100
KEALKCEQIS NDGFIVCNTQ SAHALEEAKN AAIYYAQYLC KPILILDQAL 
      2110       2120       2130       2140       2150
YEQLVVEPVS KSVIDKVCSI LSSIISVDTA ALNYKAGTLR DALLSITKDE 
      2160       2170       2180       2190       2200
EAVDMAIFCH NHDVDYTGDG FTNVIPSYGI DTGKLTPRDR GFLINADASI 
      2210       2220       2230       2240       2250
ANLRVKNAPP VVWKFSELIK LSDSCLKYLI SATVKSGVRF FITKSGAKQV 
      2260       2270       2280       2290       2300
IACHTQKLLV EKKAGGIVSG TFKCFKSYFK WLLIFYILFT ACCSGYYYME 
      2310       2320       2330       2340       2350
VSKSFVHPMY DVNSTLHVEG FKVIDKGVLR EIVPEDTCFS NKFVNFDAFW 
      2360       2370       2380       2390       2400
GRPYDNSRNC PIVTAVIDGD GTVATGVPGF VSWVMDGVMF IHMTQTERKP 
      2410       2420       2430       2440       2450
WYIPTWFNRE IVGYTQDSII TEGSFYTSIA LFSARCLYLT ASNTPQLYCF 
      2460       2470       2480       2490       2500
NGDNDAPGAL PFGSIIPHRV YFQPNGVRLI VPQQILHTPY VVKFVSDSYC 
      2510       2520       2530       2540       2550
RGSVCEYTRP GYCVSLNPQW VLFNDEYTSK PGVFCGSTVR ELMFSMVSTF 
      2560       2570       2580       2590       2600
FTGVNPNIYM QLATMFLILV VVVLIFAMVI KFQGVFKAYA TTVFITMLVW 
      2610       2620       2630       2640       2650
VINAFILCVH SYNSVLAVIL LVLYCYASLV TSRNTVIIMH CWLVFTFGLI 
      2660       2670       2680       2690       2700
VPTWLACCYL GFIIYMYTPL FLWCYGTTKN TRKLYDGNEF VGNYDLAAKS 
      2710       2720       2730       2740       2750
TFVIRGSEFV KLTNEIGDKF EAYLSAYARL KYYSGTGSEQ DYLQACRAWL 
      2760       2770       2780       2790       2800
AYALDQYRNS GVEIVYTPPR YSIGVSRLQS GFKKLVSPSS AVEKCIVSVS 
      2810       2820       2830       2840       2850
YRGNNLNGLW LGDTIYCPRH VLGKFSGDQW NDVLNLANNH EFEVTTQHGV 
      2860       2870       2880       2890       2900
TLNVVSRRLK GAVLILQTAV ANAETPKYKF IKANCGDSFT IACAYGGTVV 
      2910       2920       2930       2940       2950
GLYPVTMRSN GTIRASFLAG ACGSVGFNIE KGVVNFFYMH HLELPNALHT 
      2960       2970       2980       2990       3000
GTDLMGEFYG GYVDEEVAQR VPPDNLVTNN IVAWLYAAII SVKESSFSLP 
      3010       3020       3030       3040       3050
KWLESTTVSV DDYNKWAGDN GFTPFSTSTA ITKLSAITGV DVCKLLRTIM 
      3060       3070       3080       3090       3100
VKNSQWGGDP ILGQYNFEDE LTPESVFNQI GGVRLQSSFV RKATSWFWSR 
      3110       3120       3130       3140       3150
CVLACFLFVL CAIVLFTAVP LKFYVYAAVI LLMAVLFISF TVKHVMAYMD 
      3160       3170       3180       3190       3200
TFLLPTLITV IIGVCAEVPF IYNTLISQVV IFLSQWYDPV VFDTMVPWMF 
      3210       3220       3230       3240       3250
LPLVLYTAFK CVQGCYMNSF NTSLLMLYQF VKLGFVIYTS SNTLTAYTEG 
      3260       3270       3280       3290       3300
NWELFFELVH TTVLANVSSN SLIGLFVFKC AKWMLYYCNA TYLNNYVLMA 
      3310       3320       3330       3340       3350
VMVNCIGWLC TCYFGLYWWV NKVFGLTLGK YNFKVSVDQY RYMCLHKINP 
      3360       3370       3380       3390       3400
PKTVWEVFST NILIQGIGGD RVLPIATVQA KLSDVKCTTV VLMQLLTKLN 
      3410       3420       3430       3440       3450
VEANSKMHVY LVELHNKILA SDDVGECMDN LLGMLITLFC IDSTIDLSEY 
      3460       3470       3480       3490       3500
CDDILKRSTV LQSVTQEFSH IPSYAEYERA KNLYEKVLVD SKNGGVTQQE 
      3510       3520       3530       3540       3550
LAAYRKAANI AKSVFDRDLA VQKKLDSMAE RAMTTMYKEA RVTDRRAKLV 
      3560       3570       3580       3590       3600
SSLHALLFSM LKKIDSEKLN VLFDQASSGV VPLATVPIVC SNKLTLVIPD 
      3610       3620       3630       3640       3650
PETWVKCVEG VHVTYSTVVW NIDTVIDADG TELHPTSTGS GLTYCISGAN 
      3660       3670       3680       3690       3700
IAWPLKVNLT RNGHNKVDVV LQNNELMPHG VKTKACVAGV DQAHCSVESK 
      3710       3720       3730       3740       3750
CYYTNISGNS VVAAITSSNP NLKVASFLNE AGNQIYVDLD PPCKFGMKVG 
      3760       3770       3780       3790       3800
VKVEVVYLYF IKNTRSIVRG MVLGAISNVV VLQSKGHETE EVDAVGILSL 
      3810       3820       3830       3840       3850
CSFAVDPADT YCKYVAAGNQ PLGNCVKMLT VHNGSGFAIT SKPSPTPDQD 
      3860       3870       3880       3890       3900
SYGGASVCLY CRAHIAHPGS VGNLDGRCQF KGSFVQIPTT EKDPVGFCLR 
      3910       3920       3930       3940       3950
NKVCTVCQCW IGYGCQCDSL RQPKSSVQSV AGASDFDKNY LNRVRGSSEA 
      3960       3970       3980       3990       4000
RLIPLASGCD PDVVKRAFDV CNKESAGMFQ NLKRNCARFQ ELRDTEDGNL 
      4010       4020       4030       4040       4050
EYLDSYFVVK QTTPSNYEHE KSCYEDLKSE VTADHDFFVF NKNIYNISRQ 
      4060       4070       4080       4090       4100
RLTKYTMMDF CYALRHFDPK DCEVLKEILV TYGCIEDYHP KWFEENKDWY 
      4110       4120       4130       4140       4150
DPIENSKYYV MLAKMGPIVR RALLNAIEFG NLMVEKGYVG VITLDNQDLN 
      4160       4170       4180       4190       4200
GKFYDFGDFQ KTAPGAGVPV FDTYYSYMMP IIAMTDALAP ERYFEYDVHK 
      4210       4220       4230       4240       4250
GYKSYDLLKY DYTEEKQELF QKYFKYWDQE YHPNCRDCSD DRCLIHCANF 
      4260       4270       4280       4290       4300
NILFSTLIPQ TSFGNLCRKV FVDGVPFIAT CGYHSKELGV IMNQDNTMSF 
      4310       4320       4330       4340       4350
SKMGLSQLMQ FVGDPALLVG TSNNLVDLRT SCFSVCALTS GITHQTVKPG 
      4360       4370       4380       4390       4400
HFNKDFYDFA EKAGMFKEGS SIPLKHFFYP QTGNAAINDY DYYRYNRPTM 
      4410       4420       4430       4440       4450
FDICQLLFCL EVTSKYFECY EGGCIPASQV VVNNLDKSAG YPFNKFGKAR 
      4460       4470       4480       4490       4500
LYYEMSLEEQ DQLFEITKKN VLPTITQMNL KYAISAKNRA RTVAGVSILS 
      4510       4520       4530       4540       4550
TMTNRQFHQK ILKSIVNTRN ASVVIGTTKF YGGWDNMLRN LIQGVEDPIL 
      4560       4570       4580       4590       4600
MGWDYPKCDR AMPNLLRIAA SLVLARKHTN CCSWSERIYR LYNECAQVLS 
      4610       4620       4630       4640       4650
ETVLATGGIY VKPGGTSSGD ATTAYANSVF NIIQATSANV ARLLSVITRD 
      4660       4670       4680       4690       4700
IVYDNIKSLQ YELYQQVYRR VNFDPAFVEK FYSYLCKNFS LMILSDDGVV 
      4710       4720       4730       4740       4750
CYNNTLAKQG LVADISGFRE VLYYQNNVFM ADSKCWVEPD LEKGPHEFCS 
      4760       4770       4780       4790       4800
QHTMLVEVDG EPKYLPYPDP SRILGACVFV DDVDKTEPVA VMERYIALAI 
      4810       4820       4830       4840       4850
DAYPLVHHEN EEYKKVFFVL LAYIRKLYQE LSQNMLMDYS FVMDIDKGSK 
      4860       4870       4880       4890       4900
FWEQEFYENM YRAPTTLQSC GVCVVCNSQT ILRCGNCIRK PFLCCKCCYD 
      4910       4920       4930       4940       4950
HVMHTDHKNV LSINPYICSQ LGCGEADVTK LYLGGMSYFC GNHKPKLSIP 
      4960       4970       4980       4990       5000
LVSNGTVFGI YRANCAGSEN VDDFNQLATT NWSIVEPYIL ANRCSDSLRR 
      5010       5020       5030       5040       5050
FAAETVKATE ELHKQQFASA EVREVFSDRE LILSWEPGKT RPPLNRNYVF 
      5060       5070       5080       5090       5100
TGYHFTRTSK VQLGDFTFEK GEGKDVVYYK ATSTAKLSVG DIFVLTSHNV 
      5110       5120       5130       5140       5150
VSLVAPTLCP QQTFSRFVNL RPNVMVPECF VNNIPLYHLV GKQKRTTVQG 
      5160       5170       5180       5190       5200
PPGSGKSHFA IGLAVYFSSA RVVFTACSHA AVDALCEKAF KFLKVDDCTR 
      5210       5220       5230       5240       5250
IVPQRTTVDC FSKFKANDTG KKYIFSTINA LPEVSCDILL VDEVSMLTNY 
      5260       5270       5280       5290       5300
ELSFINGKIN YQYVVYVGDP AQLPAPRTLL NGSLSPKDYN VVTNLMVCVK 
      5310       5320       5330       5340       5350
PDIFLAKCYR CPKEIVDTVS TLVYDGKFIA NNPESRECFK VIVNNGNSDV 
      5360       5370       5380       5390       5400
GHESGSAYNT TQLEFVKDFV CRNKQWREAI FISPYNAMNQ RAYRMLGLNV 
      5410       5420       5430       5440       5450
QTVDSSQGSE YDYVIFCVTA DSQHALNINR FNVALTRAKR GILVVMRQRD 
      5460       5470       5480       5490       5500
ELYSALKFTE LDSETSLQGT GLFKICNKEF SGVHPAYAVT TKALAATYKV 
      5510       5520       5530       5540       5550
NDELAALVNV EAGSEITYKH LISLLGFKMS VNVEGCHNMF ITRDEAIRNV 
      5560       5570       5580       5590       5600
RGWVGFDVEA THACGTNIGT NLPFQVGFST GADFVVTPEG LVDTSIGNNF 
      5610       5620       5630       5640       5650
EPVNSKAPPG EQFNHLRVLF KSAKPWHVIR PRIVQMLADN LCNVSDCVVF 
      5660       5670       5680       5690       5700
VTWCHGLELT TLRYFVKIGK EQVCSCGSRA TTFNSHTQAY ACWKHCLGFD 
      5710       5720       5730       5740       5750
FVYNPLLVDI QQWGYSGNLQ FNHDLHCNVH GHAHVASVDA IMTRCLAINN 
      5760       5770       5780       5790       5800
AFCQDVNWDL TYPHIANEDE VNSSCRYLQR MYLNACVDAL KVNVVYDIGN 
      5810       5820       5830       5840       5850
PKGIKCVRRG DVNFRFYDKN PIVRNVKQFE YDYNQHKDKF ADGLCMFWNC 
      5860       5870       5880       5890       5900
NVDCYPDNSL VCRYDTRNLS VFNLPGCNGG SLYVNKHAFY TPKFDRISFR 
      5910       5920       5930       5940       5950
NLKAMPFFFY DSSPCETIQV DGVAQDLVSL ATKDCITKCN IGGAVCKKHA 
      5960       5970       5980       5990       6000
QMYAEFVTSY NAAVTAGFTF WVTNKLNPYN LWKSFSALQS IDNIAYNMYK 
      6010       6020       6030       6040       6050
GGHYDAIAGE MPTVITGDKV FVIDQGVEKA VFVNQTTLPT SVAFELYAKR 
      6060       6070       6080       6090       6100
NIRTLPNNRI LKGLGVDVTN GFVIWDYANQ TPLYRNTVKV CAYTDIEPNG 
      6110       6120       6130       6140       6150
LVVLYDDRYG DYQSFLAADN AVLVSTQCYK RYSYVEIPSN LLVQNGMPLK 
      6160       6170       6180       6190       6200
DGANLYVYKR VNGAFVTLPN TINTQGRSYE TFEPRSDIER DFLAMSEESF 
      6210       6220       6230       6240       6250
VERYGKDLGL QHILYGEVDK PQLGGLHTVI GMYRLLRANK LNAKSVTNSD 
      6260       6270       6280       6290       6300
SDVMQNYFVL SDNGSYKQVC TVVDLLLDDF LELLRNILKE YGTNKSKVVT 
      6310       6320       6330       6340       6350
VSIDYHSINF MTWFEDGSIK TCYPQLQSAW TCGYNMPELY KVQNCVMEPC 
      6360       6370       6380       6390       6400
NIPNYGVGIT LPSGILMNVA KYTQLCQYLL KTTICVPHNM RVMHFGAGSD 
      6410       6420       6430       6440       6450
KGVAPGSTVL KQWLPEGTLL VDNDIVDYVS DAHVSVLSDC NKYNTEHKFD 
      6460       6470       6480       6490       6500
LVISDMYTDN DSKRKHEGVI ANNGNDDVFI YLSSFLRNNL ALGGSFAVKV 
      6510       6520       6530       6540       6550
TETSWHEVLY DIAQDCAWWT MFCTAVNASS SEAFLIGVNY LGASEKVKVS 
      6560       6570       6580       6590       6600
GKTLHANYIF WRNCNYLQTS AYSIFDVAKF DLRLKATPVV NLKTEQKTDL 
      6610       6620 
VFNLIKCGKL LVRDVGNTSF TSDSFVCTM
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:6,629
Mass (Da):744,566
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i887869F7EA653270
GO
Isoform Replicase polyprotein 1a (identifier: P0C6V4-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6V4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:3,951
Mass (Da):441,126
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC39112 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ311317 Genomic RNA Translation: CAC39112.1 Sequence problems.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311317 Genomic RNA Translation: CAC39112.1 Sequence problems.

3D structure databases

SMRiP0C6Y2
ModBaseiSearch...

Proteomic databases

PRIDEiP0C6Y2

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.40.220.10, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR003593, AAA+_ATPase
IPR043609, CoV_NSP15_C
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR027352, CV_ZBD
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR009466, NSP14_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR009461, NSP16_CoV-like
IPR040795, Nsp1a_N
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043503, PLpro_palm_finger_dom_CoV
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF17896, Nsp2a_N, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SM00382, AAA, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_IBVBC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6Y2
Secondary accession number(s): Q91QT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 2, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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