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UniProtKB - P0C6Y0 (R1AB_CVMJH)

Entry version 97 (23 Feb 2022)
Sequence version 1 (10 Jun 2008)
Previous versions | rss
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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

By similarity

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

By similarity

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

By similarity

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.

By similarity

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.

By similarity

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).

PROSITE-ProRule annotationBy similarity

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.

By similarity

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

May participate in viral replication by acting as a ssRNA-binding protein.

By similarity

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

By similarity

Responsible for replication and transcription of the viral RNA genome.

By similarity

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.

By similarity

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.

By similarity

Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (By similarity).

Acts by degrading the 5'-polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs. Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (By similarity).

If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (By similarity).

By similarity

2'-O-methyltransferase: Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Uridylate-specific endoribonuclease:
Mn2+By similarityNote: Likely affects Nsp15 binding to RNA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1120For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1271For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1715For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei1872For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei3377For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3481For 3CL-PRO activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4397Zinc 1PROSITE-ProRule annotation1
Metal bindingi4400Zinc 1PROSITE-ProRule annotation1
Metal bindingi4406Zinc 1PROSITE-ProRule annotation1
Metal bindingi4413Zinc 1PROSITE-ProRule annotation1
Metal bindingi4439Zinc 2PROSITE-ProRule annotation1
Metal bindingi4442Zinc 2PROSITE-ProRule annotation1
Metal bindingi4450Zinc 2PROSITE-ProRule annotation1
Metal bindingi4452Zinc 2PROSITE-ProRule annotation1
Active sitei5215PROSITE-ProRule annotation1
Active sitei5216PROSITE-ProRule annotation1
Active sitei5217PROSITE-ProRule annotation1
Metal bindingi5393Zinc 3PROSITE-ProRule annotation1
Metal bindingi5396Zinc 3PROSITE-ProRule annotation1
Metal bindingi5404Zinc 4PROSITE-ProRule annotation1
Metal bindingi5407Zinc 3PROSITE-ProRule annotation1
Metal bindingi5414Zinc 3PROSITE-ProRule annotation1
Metal bindingi5417Zinc 4PROSITE-ProRule annotation1
Metal bindingi5421Zinc 4PROSITE-ProRule annotation1
Metal bindingi5427Zinc 4PROSITE-ProRule annotation1
Metal bindingi5438Zinc 5PROSITE-ProRule annotation1
Metal bindingi5443Zinc 5PROSITE-ProRule annotation1
Metal bindingi5460Zinc 5PROSITE-ProRule annotation1
Metal bindingi5463Zinc 5PROSITE-ProRule annotation1
Active sitei6075PROSITE-ProRule annotation1
Active sitei6077PROSITE-ProRule annotation1
Active sitei6176PROSITE-ProRule annotation1
Metal bindingi6192Zinc 6PROSITE-ProRule annotation1
Metal bindingi6195Zinc 6PROSITE-ProRule annotation1
Metal bindingi6211Zinc 6PROSITE-ProRule annotation1
Metal bindingi6214Zinc 6PROSITE-ProRule annotation1
Metal bindingi6242Zinc 7PROSITE-ProRule annotation1
Metal bindingi6246Zinc 7PROSITE-ProRule annotation1
Metal bindingi6249Zinc 7PROSITE-ProRule annotation1
Active sitei6253PROSITE-ProRule annotation1
Active sitei6258PROSITE-ProRule annotation1
Metal bindingi6264Zinc 7PROSITE-ProRule annotation1
Metal bindingi6432Zinc 8PROSITE-ProRule annotation1
Metal bindingi6453Zinc 8PROSITE-ProRule annotation1
Metal bindingi6464Zinc 8PROSITE-ProRule annotation1
Metal bindingi6467Zinc 8PROSITE-ProRule annotation1
Active sitei6927PROSITE-ProRule annotation1
Active sitei7011PROSITE-ProRule annotation1
Active sitei7051PROSITE-ProRule annotation1
Active sitei7084PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1197 – 1225C4-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri1793 – 1829C4-type 2PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri4397 – 4413By similarityAdd BLAST17
Zinc fingeri4439 – 4452By similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi5669 – 5676ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Lyase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 15 chains:
Host translation inhibitor nsp1
Short name:
nsp1
Alternative name(s):
p28
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65
Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.-)
Short name:
PL-PRO
Alternative name(s):
Non-structural protein 3
Short name:
nsp3
p210
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
p44
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
p27
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Alternative name(s):
p10
Non-structural protein 8
Short name:
nsp8
Alternative name(s):
p22
Non-structural protein 9
Short name:
nsp9
Alternative name(s):
p12
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
p15
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
p100
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
p67
Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Uridylate-specific endoribonuclease (EC:4.6.1.-)
Alternative name(s):
NendoU
nsp15
p35
2'-O-methyl transferase (EC:2.1.1.57)
Alternative name(s):
nsp16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11144 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiMus musculus (Mouse) [TaxID: 10090]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007193 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
    • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2228 – 2248HelicalSequence analysisAdd BLAST21
Transmembranei2289 – 2309HelicalSequence analysisAdd BLAST21
Transmembranei2320 – 2340HelicalSequence analysisAdd BLAST21
Transmembranei2403 – 2423HelicalSequence analysisAdd BLAST21
Transmembranei2445 – 2465HelicalSequence analysisAdd BLAST21
Transmembranei2846 – 2866HelicalSequence analysisAdd BLAST21
Transmembranei3099 – 3119HelicalSequence analysisAdd BLAST21
Transmembranei3121 – 3141HelicalSequence analysisAdd BLAST21
Transmembranei3153 – 3173HelicalSequence analysisAdd BLAST21
Transmembranei3180 – 3200HelicalSequence analysisAdd BLAST21
Transmembranei3205 – 3225HelicalSequence analysisAdd BLAST21
Transmembranei3648 – 3668HelicalSequence analysisAdd BLAST21
Transmembranei3678 – 3698HelicalSequence analysisAdd BLAST21
Transmembranei3705 – 3725HelicalSequence analysisAdd BLAST21
Transmembranei3748 – 3768HelicalSequence analysisAdd BLAST21
Transmembranei3775 – 3795HelicalSequence analysisAdd BLAST21
Transmembranei3802 – 3822HelicalSequence analysisAdd BLAST21
Transmembranei3846 – 3866HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2835F → A: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2836S → A: No effect. 1 Publication1
Mutagenesisi2837L → A: No effect. 1 Publication1
Mutagenesisi2838K → A: No effect. 1 Publication1
Mutagenesisi2838K → N: No effect. 1 Publication1
Mutagenesisi2839G → A: Partial processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2839G → N: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2839G → V: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2840G → A: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2840G → N: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2840G → V: No processing between p210 and peptide HD2. 1 Publication1
Mutagenesisi2841A → N: No effect. 1 Publication1
Mutagenesisi2842V → N or M: No effect. 1 Publication1
Mutagenesisi2846V → M: No effect. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000373541 – 247Host translation inhibitor nsp1By similarityAdd BLAST247
ChainiPRO_0000037355248 – 832Non-structural protein 2By similarityAdd BLAST585
ChainiPRO_0000037356833 – 2840Papain-like proteinaseBy similarityAdd BLAST2008
ChainiPRO_00000373572841 – 3336Non-structural protein 4By similarityAdd BLAST496
ChainiPRO_00000373583337 – 36393C-like proteinaseBy similarityAdd BLAST303
ChainiPRO_00000373593640 – 3927Non-structural protein 6By similarityAdd BLAST288
ChainiPRO_00000373603928 – 4019Non-structural protein 7By similarityAdd BLAST92
ChainiPRO_00000373614020 – 4213Non-structural protein 8By similarityAdd BLAST194
ChainiPRO_00000373624214 – 4323Non-structural protein 9By similarityAdd BLAST110
ChainiPRO_00000373634324 – 4460Non-structural protein 10By similarityAdd BLAST137
ChainiPRO_00000373644461 – 5388RNA-directed RNA polymeraseBy similarityAdd BLAST928
ChainiPRO_00000373655389 – 5988HelicaseBy similarityAdd BLAST600
ChainiPRO_00000373665989 – 6507Guanine-N7 methyltransferaseBy similarityAdd BLAST519
ChainiPRO_00000373676508 – 6881Uridylate-specific endoribonucleaseBy similarityAdd BLAST374
ChainiPRO_00000373686882 – 71802'-O-methyl transferaseBy similarityAdd BLAST299

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei247 – 248Cleavage; by PL1-PROCurated2
Sitei832 – 833Cleavage; by PL1-PROCurated2
Sitei2840 – 2841Cleavage; by PL2-PROCurated2
Sitei3336 – 3337Cleavage; by 3CL-PROCurated2
Sitei3639 – 3640Cleavage; by 3CL-PROCurated2
Sitei3927 – 3928Cleavage; by 3CL-PROCurated2
Sitei4019 – 4020Cleavage; by 3CL-PROCurated2
Sitei4213 – 4214Cleavage; by 3CL-PROCurated2
Sitei4323 – 4324Cleavage; by 3CL-PROCurated2
Sitei4460 – 4461Cleavage; by 3CL-PROCurated2
Sitei5388 – 5389Cleavage; by 3CL-PROCurated2
Sitei5988 – 5989Cleavage; by 3CL-PROCurated2
Sitei6507 – 6508Cleavage; by 3CL-PROCurated2
Sitei6881 – 6882Cleavage; by 3CL-PROCurated2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P0C6Y0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P0C6Y0, 5 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P0C6Y0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 196CoV Nsp1 globularPROSITE-ProRule annotationAdd BLAST143
Domaini217 – 247BetaCoV Nsp1 C-terminalPROSITE-ProRule annotationAdd BLAST31
Domaini833 – 946Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST114
Domaini1083 – 1320Peptidase C16 1PROSITE-ProRule annotationAdd BLAST238
Domaini1321 – 1481MacroPROSITE-ProRule annotationAdd BLAST161
Domaini1536 – 1608DPUPPROSITE-ProRule annotationAdd BLAST73
Domaini1607 – 1662Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini1677 – 1936Peptidase C16 2PROSITE-ProRule annotationAdd BLAST260
Domaini1950 – 2051Nucleic acid-bindingPROSITE-ProRule annotationAdd BLAST102
Domaini3239 – 3336Nsp4CPROSITE-ProRule annotationAdd BLAST98
Domaini3337 – 3639Peptidase C30PROSITE-ProRule annotationAdd BLAST303
Domaini3928 – 4016RdRp Nsp7 cofactorPROSITE-ProRule annotationAdd BLAST89
Domaini4017 – 4213RdRp Nsp8 cofactorPROSITE-ProRule annotationAdd BLAST197
Domaini4214 – 4323Nsp9 ssRNA-bindingPROSITE-ProRule annotationAdd BLAST110
Domaini4324 – 4461ExoN/MTase coactivatorPROSITE-ProRule annotationAdd BLAST138
Domaini4466 – 4721NiRANPROSITE-ProRule annotationAdd BLAST256
Domaini4821 – 5388Nsp12 RNA-dependent RNA polymerasePROSITE-ProRule annotationAdd BLAST568
Domaini5068 – 5230RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
Domaini5389 – 5472CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5644 – 5825(+)RNA virus helicase ATP-bindingAdd BLAST182
Domaini5826 – 6003(+)RNA virus helicase C-terminalAdd BLAST178
Domaini6057 – 6272ExoNPROSITE-ProRule annotationAdd BLAST216
Domaini6281 – 6507N7-MTasePROSITE-ProRule annotationAdd BLAST227
Domaini6508 – 6568Nsp15 N-terminal oligomerizationPROSITE-ProRule annotationAdd BLAST61
Domaini6569 – 6689AV-Nsp11N/CoV-Nsp15MPROSITE-ProRule annotationAdd BLAST121
Domaini6739 – 6878NendoUPROSITE-ProRule annotationAdd BLAST140
Domaini6883 – 7177Nidovirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2228 – 2465HD1Add BLAST238
Regioni2846 – 3225HD2Add BLAST380
Regioni3648 – 3866HD3Add BLAST219
Regioni6316 – 6322SAM-bindingPROSITE-ProRule annotation7
Regioni6394 – 6408GpppA-bindingPROSITE-ProRule annotationAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1197 – 1225C4-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri1793 – 1829C4-type 2PROSITE-ProRule annotationAdd BLAST37
Zinc fingeri4397 – 4413By similarityAdd BLAST17
Zinc fingeri4439 – 4452By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database

More...CDDi		cd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21519, cv_beta_Nsp2_MHV-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21524, DPUP_MHV_Nsp3, 1 hit
cd21593, HCoV_HKU1-like_RdRp, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 2 hits
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.60.120.1680, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.30.160.820, 1 hit
3.30.70.3540, 1 hit
3.40.220.10, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR022570, B-CoV_A_NSP1
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR044863, NIRAN
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR044384, NSP2_MHV-like
IPR044381, NSP3_DPUP_MHV
IPR032592, NSP3_NAB_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044347, RdRp_HCoV_HKU1-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13087, AAA_12, 1 hit
PF16251, bCoV_NAR, 1 hit
PF06471, CoV_ExoN, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF11963, DUF3477, 2 hits
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51963, BCOV_NSP1_C, 1 hit
PS51942, BCOV_NSP3C_C, 1 hit
PS51945, BCOV_NSP3E_NAB, 1 hit
PS51952, COV_EXON_MTASE_COACT, 1 hit
PS51954, COV_N7_MTASE, 1 hit
PS51962, COV_NSP1, 1 hit
PS51948, COV_NSP12_RDRP, 1 hit
PS51960, COV_NSP15_NTD, 1 hit
PS51943, COV_NSP3A_UBL, 1 hit
PS51944, COV_NSP3D_UBL, 1 hit
PS51946, COV_NSP4C, 1 hit
PS51949, COV_NSP7, 1 hit
PS51950, COV_NSP8, 1 hit
PS51951, COV_NSP9_SSRNA_BD, 1 hit
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: P0C6Y0-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKMGKYGLG FKWAPEFPWM LPNASEKLGN PERSEEDGFC PSAAQEPKVK 
        60         70         80         90        100
GKTLVNHVRV DCSRLPALEC CVQSAIIRDI FVDEDPQKVE ASTMMALQFG 
       110        120        130        140        150
SAVLVKPSKR LSVQAWAKLG VLPKTPAMGL FKRFCLCNTR ECVCDAHVAF 
       160        170        180        190        200
QLFTVQPDGV CLGNGRFIGW FVPVTAIPEY AKQWLQPWSI LLRKGGNKGS 
       210        220        230        240        250
VTSGHFRRAV TMPVYDFNVE DACEEVHLNP RGKYSCKAYA LLRGYRGVKP 
       260        270        280        290        300
ILFVDQYGCD YTGCLAKGLE DYGDLTLSEM KELSPVWRDS LDNEVVVAWH 
       310        320        330        340        350
VDRDPRAVMR LQTLATVRSI EYVGQPIEDM VDGDVVMREP AHLLAPNAIV 
       360        370        380        390        400
KRLPRLVETM LYTDSSVTEF CYKTKLCDCG FITQFGYVDC CGDTCGFRGW 
       410        420        430        440        450
VPGNMMDGFP CPGCCKSYMP WELEAQSSGV IPEGGVLFTQ STDTVNRESF 
       460        470        480        490        500
KLYGHAVVPF GGAAYWSPYP GMWLPVIWSS VKSYSYLTYT GVVGCKAIVQ 
       510        520        530        540        550
ETDAICRFLY MDYVQHKCGN LEQRAILGLD DVYHRQLLVN RGDYSLLLEN 
       560        570        580        590        600
VDLFVKRRAE FACKFATCGD GLVPLLLDGL VPRSYYLIKS GQAFTSLMVN 
       610        620        630        640        650
FSREVVDMCM DMALLFMHDV KVATKYVKKV TGKVAVRFKA LGIAVVRKIT 
       660        670        680        690        700
EWFDLAVDTA ASAAGWLCYQ LVNGLFAVAN GVITFIQEVP ELVKNFVDKF 
       710        720        730        740        750
KTFFKVLIDS MSVSILSGLT VVKTASNRVC LAGSKVYEVV QKSLPAYIMP 
       760        770        780        790        800
VGCSEATCLV GEIEPAVFED DVVDVVKAPL TYQGCCKPPS SFEKICIVDK 
       810        820        830        840        850
LYMAKCGDQF YPVVVDNDTV GVLDQCWRFP CAGKKVVFND KPKVKEVPST 
       860        870        880        890        900
RKIKIIFALD ATFDSVLSKA CSEFEVDKDV TLDELLDVVL DAVESTLSPC 
       910        920        930        940        950
KEHGVIGTKV CALLERLVDD YVYLFDEGGE EVIASRMYCS FSAPDEDCVA 
       960        970        980        990       1000
TDVVYADENQ DDDADDPVVL VADTQEEDGV AREQVDSADS EICVAHTGGQ 
      1010       1020       1030       1040       1050
EMTEPDVVGS QTPIASAEET EVGEACDREG IAEVKATVCA DALDACPDQV 
      1060       1070       1080       1090       1100
EAFDIEKVED SILSELQTEL NAPADKTYED VLAFDAIYSE TLSAFYAVPS 
      1110       1120       1130       1140       1150
DETHFKVCGF YSPAIERTNC WLRSTLIVMQ SLPLEFKDLG MQKLWLSYKA 
      1160       1170       1180       1190       1200
GYDQCFVDKL VKSAPKSIIL PQGGYVADFA YFFLSQCSFK VHANWRCLKC 
      1210       1220       1230       1240       1250
GMELKLQGLD AVFFYGDVVS HMCKCGNSMT LLSADIPYTF DFGVRDDKFC 
      1260       1270       1280       1290       1300
AFYTPRKVFR AACAVDVNDC HSMAVVDGKQ IDGKVVTKFN GDKFDFMVGH 
      1310       1320       1330       1340       1350
GMTFSMSPFE IAQLYGSCIT PNVCFVKGDV IKVLRRVGAE VIVNPANGRM 
      1360       1370       1380       1390       1400
AHGAGVAGAI AKAAGKAFIN ETADMVKAQG VCQVGGCYES TGGKLCKKVL 
      1410       1420       1430       1440       1450
NIVGPDARGH GNECYSLLER AYQHINKCDN VVTTLISAGI FSVPTDVSLT 
      1460       1470       1480       1490       1500
YLLGVVTKNV ILVSNNQDDF DVIEKCQVTS VAGTKALSFQ LAKNLCRDVK 
      1510       1520       1530       1540       1550
FVTNACSSLF SESSFVSSYD VLQEVEALRH DIQLDDDARV FVQANMDCLP 
      1560       1570       1580       1590       1600
TDWRLVNKFD SVDGVRTIKY FECPGEVFVS SQGKKFGYVQ NGSFKEASVS 
      1610       1620       1630       1640       1650
QIRALLANKV DVLCTVDGVN FRSCCVAEGE VFGKTLGSVF CDGINVTKVR 
      1660       1670       1680       1690       1700
CSAIHKGKVF FQYSGLSAAD LAAVKDAFGF DEPQLLQYYS MLGMCKWPVV 
      1710       1720       1730       1740       1750
VCGNYFAFKQ SNNNCYINVA CLMLQHLSLK FPKWQWRRPG NEFRSGKPLR 
      1760       1770       1780       1790       1800
FVSLVLAKGS FKFNEPSDST DFIRVELREA DLSGATCDLE FICKCGVKQE 
      1810       1820       1830       1840       1850
QRKGVDAVMH FGTLDKSGLV KGYNIACTCG DKLVHCTQFN VPFLICSNTP 
      1860       1870       1880       1890       1900
EGKKLPDDVV AANIFTGGSV GHYTHVKCKP KYQLYDACNV SKVSEAKGNF 
      1910       1920       1930       1940       1950
TDCLYLKNLK QTFSSVLTTY YLDDVKCVAY KPDLSQYYCE SGKYYTKPII 
      1960       1970       1980       1990       2000
KAQFRTFEKV EGVYTNFKLV GHDIAEKLNA KLGFDCNSPF MEYKITEWPT 
      2010       2020       2030       2040       2050
ATGDVVLASD DLYVSRYSGG CVTFGKPVIW RGHEEASLKS LTYFNRPSVV 
      2060       2070       2080       2090       2100
CENKFNVLPV DVSEPTDRRP VPSAVLVTGA ASGADASAIS TEPGTAKEQK 
      2110       2120       2130       2140       2150
ACASDSVEDQ IVMEAQKKSS VTTVAVKEVK LNGVKKPVKW NCSVVVNDPT 
      2160       2170       2180       2190       2200
SETKVVKSLS IVDVYDMFLT GCRYVVWTAN ELSRLINSPT VREYVKWGMS 
      2210       2220       2230       2240       2250
KLIIPANLLL LRDEKQEFVA PKVVKAKAIA CYGAVKWFLL YCFSWIKFNT 
      2260       2270       2280       2290       2300
DNKVIYTTEV ASKLTFKLCC LAFKNALQTF NWSVVSRGFF LVATVFLLWF 
      2310       2320       2330       2340       2350
NFLYANVILS DFYLPNIGPL PMFVGQIVAW VKTTFGVLTI CDFYQVTDLG 
      2360       2370       2380       2390       2400
YRSSFCNGSM VCELCFSGFD MLDNYESINV VQHVVDRRVS FDYISLFKLV 
      2410       2420       2430       2440       2450
VELVIGYSLY TVCFYPLFVL VGMQLLTTWL PEFFMLGTMH WSARLFVFVA 
      2460       2470       2480       2490       2500
NMLPAFTLLR FYIVVTAMYK VYCLCRHVMY GCSKPGCLFC YKRNRSVRVK 
      2510       2520       2530       2540       2550
CSTVVGGSLR YYDVMANGGT GFCTKHQWNC LNCNSWKPGN TFITHEAAAD 
      2560       2570       2580       2590       2600
LSKELKRPVN PTDSAYYSVI EVKQVGCSMR LFYERDGQRV YDDVSASLFV 
      2610       2620       2630       2640       2650
DMNGLLHSKV KGVPETHVVV VENEADKAGF LNAAVFYAQS LYRPMLMVEK 
      2660       2670       2680       2690       2700
KLITTANTGL SVSRTMFDLY VYSLLRHLDV DRKSLTSFVN AAHNSLKEGV 
      2710       2720       2730       2740       2750
QLEQVMDTFV GCARRKCAID SDVETKSITK SVMAAVNAGV EVTDESCNNL 
      2760       2770       2780       2790       2800
VPTYVKSDTI VAADLGVLIQ NNAKHVQSNV AKAANVACIW SVDAFNQLSA 
      2810       2820       2830       2840       2850
DLQHRLRKAC VKTGLKIKLT YNKQEANVPI LTTPFSLKGG AVFSRVLQWL 
      2860       2870       2880       2890       2900
FVANLICFIV LWALMPTYAV HKSDMQLPLY ASFKVIDNGV LRDVSVTDAC 
      2910       2920       2930       2940       2950
FANKFNQFDQ WYESTFGLVY YRNSKACPVV VAVIDQDIGH TLFNVPTKVL 
      2960       2970       2980       2990       3000
RYGFHVLHFI THAFATDRVQ CYTPHMQIPY DNFYASGCVL SSLCTMLAHA 
      3010       3020       3030       3040       3050
DGTPHPYCYT EGVMHNASLY SSLVPHVRYN LASSNGYIRF PEVVSEGIVR 
      3060       3070       3080       3090       3100
VVRTRSMTYC RVGLCEEAEE GICFNFNSSW VLNNPYYRAM PGTFCGRNAF 
      3110       3120       3130       3140       3150
DLIHQVLGGL VQPIDFFALT ASSVAGAILA IIVVLAFYYL IKLKRAFGDY 
      3160       3170       3180       3190       3200
TSVVVINVIV WCINFLMLFV FQVYPTLSCL YACFYFYTTL YFPSEISVVM 
      3210       3220       3230       3240       3250
HLQWLVMYGA IMPLWFCITY VAVVVSNHAL WLFSYCRKIG TDVRSDGTFE 
      3260       3270       3280       3290       3300
EMALTTFMIT KESYCKLKNS VSDVAFNRYL SLYNKYRYFS GKMDTATYRE 
      3310       3320       3330       3340       3350
AACSQLAKAM ETFNHNNGND VLYQPPTASV TTSFLQSGIV KMVSPTSKVE 
      3360       3370       3380       3390       3400
PCVVSVTYGN MTLNGLWLDD KVYCPRHVIC SSADMTDPDY PNLLCRVTSS 
      3410       3420       3430       3440       3450
DFCVMSDRMS LTVMSYQMQG SLLVLTVTLQ NPNTPKYSFG VVKPGETFTV 
      3460       3470       3480       3490       3500
LAAYNGRPQG AFHVVMRSSH TIKGSFLCGS CGSVGYVLTG DSVRFVYMHQ 
      3510       3520       3530       3540       3550
LELSTGCHTG TDFSGNFYGP YRDAQVVQLP VQDYTQTVNV VAWLYAAILN 
      3560       3570       3580       3590       3600
RCNWFVQSDS CSLEEFNVWA MTNGFSSIKA DLVLDALASM TGVTVEQVLA 
      3610       3620       3630       3640       3650
AIKRLHSGFQ GKQILGSCVL EDELTPSDVY QQLAGVKLQS KRTRVIKGTC 
      3660       3670       3680       3690       3700
CWILASTFLF CSIISAFVKW TMFMYVTTHM LGVTLCALCF VIFAMLLIKH 
      3710       3720       3730       3740       3750
KHLYLTMYIM PVLCTLFYTN YLVVGYKQSF RGLAYAWLSY FVPAVDYTYM 
      3760       3770       3780       3790       3800
DEVLYGVVLL VAMVFVTMRS INHDVFSTMF LVGRLVSLVS MWYFGANLEE 
      3810       3820       3830       3840       3850
EVLLFLTSLF GTYTWTTMLS LATAKVIAKW LAVNVLYFTD IPQIKLVLLS 
      3860       3870       3880       3890       3900
YLCIGYVCCC YWGVLSLLNS IFRMPLGVYN YKISVQELRY MNANGLRPPR 
      3910       3920       3930       3940       3950
NSFEALMLNF KLLGIGGVPV IEVSQIQSRL TDVKCANVVL LNCLQHLHIA 
      3960       3970       3980       3990       4000
SNSKLWQYCS TLHNEILATS DLSVAFDKLA QLLVVLFANP AAVDSKCLAS 
      4010       4020       4030       4040       4050
IEEVSDDYVR DNTVLQALQS EFVNMASFVE YELAKKNLDE AKASGSANQQ 
      4060       4070       4080       4090       4100
QIKQLEKACN IAKSAYERDR AVARKLERMA DLALTNMYKE ARINDKKSKV 
      4110       4120       4130       4140       4150
VSALQTMLFS MVRKLDNQAL NSILDNAVKG CVPLNAIPPL TSNTLTIIVP 
      4160       4170       4180       4190       4200
DKQVFDQVVD NVYVTYAPNV WHIQSIQDAD GAVKQLNEID VNSTWPLVIS 
      4210       4220       4230       4240       4250
ANRHNEVSTV VLQNNELMPQ KLRTQVVNSG SDMNCNIPTQ CYYNTTGTGK 
      4260       4270       4280       4290       4300
IVYAILSDCD GLKYTKIVKE DGNCVVLELD PPCKFSVQDV KGLKIKYLYF 
      4310       4320       4330       4340       4350
VKGCNTLARG WVVGTLSSTV RLQAGTATEY ASNSAILSLC AFSVDPKKTY 
      4360       4370       4380       4390       4400
LDYIQQGGVP VTNCVKMLCD HAGTGMAITI KPEATTNQDS YGGASVCIYC 
      4410       4420       4430       4440       4450
RSRVEHPDVD GLCKLRGKFV QVPLGIKDPV SYVLTHDVCQ VCGFWRDGSC 
      4460       4470       4480       4490       4500
SCVGTGSQFQ SKDTNFLNRV RGTSVNARLV PCASGLDTDV QLRAFDICNA 
      4510       4520       4530       4540       4550
NRAGIGLYYK VNCFRFQRVD EEGNKLDKFF VVKRTNLEVY NKEKECYELT 
      4560       4570       4580       4590       4600
KDCGVVAEHE FFTFDVEGSR VPHIVRKDLS KFTMLDLCYA LRHFDRNDCS 
      4610       4620       4630       4640       4650
TLKEILLTYA ECDESYFQKK DWYDFVENPD IINVYKKLGP IFNRALLNTA 
      4660       4670       4680       4690       4700
NFADTLVEAG LVGVLTLDNQ DLYGQWYDFG DFVKTVPCCG VAVADSYYSY 
      4710       4720       4730       4740       4750
MMPMLTMCHA LDSELFVNGT YREFDLVQYD FTDFKLELFN KYFKHWSMTY 
      4760       4770       4780       4790       4800
HPNTSECEDD RCIIHCANFN ILFSMVLPKT CFGPLVRQIF VDGVPFVVSI 
      4810       4820       4830       4840       4850
GYHYKELGVV MNMDVDTHRY RLSLKDLLLY AADPALHVAS ASALLDLRTC 
      4860       4870       4880       4890       4900
CFSVAAITSG VKFQTVKPGN FNQDFYEFIL SKGLLKEGSS VDLKHFFFTQ 
      4910       4920       4930       4940       4950
DGNAAITDYN YYKYNLPTMV DIKQLLFVVE VVNKYFEIYE GGCIPATQVI 
      4960       4970       4980       4990       5000
VNNYDKSAGY PFNKFGKARL YYEALSFEEQ DEIYAYTKRN VLPTLTQMNL 
      5010       5020       5030       5040       5050
KYAISAKNRA RTVAGVSILS TMTGRMFHQK CLKSIAATRG VPVVIGTTKF 
      5060       5070       5080       5090       5100
YGGWDDMLRR LIKDVDSPVL MGWDYPKCDR AMPNILRIVS SLVLARKHDS 
      5110       5120       5130       5140       5150
CCSHTDRFYR LANECAQVLG EIVMCGGCYY VKPGGTSSGD ATTAFANSVF 
      5160       5170       5180       5190       5200
NICQAVSANV CSLMACNGHK IEDLSIRELQ KRLYSNVYRA DHVDPAFVSE 
      5210       5220       5230       5240       5250
YYEFLNKHFS MIILSDDGVV CYNSEFASKG YIANISDFQQ VLYYQNNVFM 
      5260       5270       5280       5290       5300
SEAKCWVETD IEKGPHEFCS QHTMLVKMDG DEVYLPYPDP SRILGAGCFV 
      5310       5320       5330       5340       5350
DDLLKTDSVL LIERFVSLAI DAYPLVYHEN PEYQNVFRVY LEYIKKLYND 
      5360       5370       5380       5390       5400
LGNQILDSIS VILSTCDGQK FTDETFYKNM YLRSAVMQSV GACVVCSSQT 
      5410       5420       5430       5440       5450
SLRCGSCIRK PLLCCKCAYD HVMSTDHKYV LSVSPYVCNS PGCDVNDVTK 
      5460       5470       5480       5490       5500
LYLGGMSYYC EAHKPQYSFK LVMNGMVFGL YKQSCTGSPY IEDFNKIASC 
      5510       5520       5530       5540       5550
KWTEVDDYVL ANECTERLKL FAAETQKATE EAFKQCYASA TIREIVSDRE 
      5560       5570       5580       5590       5600
LILSWEIGKV RPPLNKNYVF TGYHFTNNGK TVLGEYVFDK SELTNGVYYR 
      5610       5620       5630       5640       5650
ATTTYKLSVG DVFILTSHAV SSLSAPTLVP QENYTSVRFA SAYSVPETFQ 
      5660       5670       5680       5690       5700
NNVPNYQHIG IKRYCTVQGP PGTGKSHLAI GHAVYYCTAR VVYTAASHAA 
      5710       5720       5730       5740       5750
VDALCEKAHK FLNINDCARI VPAKLRVDCY DKFNVNDTTR KYVFTTINAL 
      5760       5770       5780       5790       5800
PELVTDIIVV DEVSMLTNYE LSVINSRVRA KHYVYIGDPA QLPAPRVLLN 
      5810       5820       5830       5840       5850
KGTLEPRYFN SVTKLMCCLG PDIFLGTCYR CPKEIVDTVS ALVYNNKLKA 
      5860       5870       5880       5890       5900
KNDNSAMCFK VYYKGQTTHE SSSAVNMQQI HLISKLLKAN PSWSNAVFIS 
      5910       5920       5930       5940       5950
PYNSQNYVAK RVLGLQTQTA DSAQGSAYDF VIYSQTAQTA HSVNVNRFNV 
      5960       5970       5980       5990       6000
AITRAKKGIL CVMSSMQLIG VFNFTTLTLD KINNPRLQCT TNLFKDCSKS 
      6010       6020       6030       6040       6050
YVGIPPCAFL LAVDDKYKVS GNLAVCLNVA DSAVTYSRLI SLMGFKLDLT 
      6060       6070       6080       6090       6100
LDGYCKLFIT RDEAIKRVRA WVGFDAEGAH ATRDSIGTNF PLQLGFSTGI 
      6110       6120       6130       6140       6150
DFVVEATGMF AERDGYVFKK AAARAPPGEQ FKHLVPLMSR GQKWDVVRIR 
      6160       6170       6180       6190       6200
IVQMLSDHLV DLADSVVLVT WAASFELTCL RYFAKVGKEV VCSVCNKRAT 
      6210       6220       6230       6240       6250
CFNSRTGYYG CWRHSYSCDY LYNPLIVDIQ QWGYTGSLTS NHDPICSVHK 
      6260       6270       6280       6290       6300
GAHVASSDAI MTRCLAVHDC FCKSVNWNLE YPIISNEVSV NTSCRLLQRV 
      6310       6320       6330       6340       6350
MFRAAMLCNR YDVCYDIGNP KGLACVKGYD FKFYDASPVV KSVKQFVYKY 
      6360       6370       6380       6390       6400
EAHKDQFLDG LCMFWNCNVD KYPANAVVCR FDTRVLSKLN LPGCNGGSLY 
      6410       6420       6430       6440       6450
VNKHAFHTNP FTRAAFENLK PMPFFYYSDT PCVYMEGMES KQVDYVPLRS 
      6460       6470       6480       6490       6500
ATCITRCNLG GAVCLKHAEE YREYLESYNT ATTAGFTFWV YKTFDFYNLW 
      6510       6520       6530       6540       6550
NTFTRLQSLE NVVYNLVNAG HFDGRAGELP CAVIGEKVIA KIQNEDVVVF 
      6560       6570       6580       6590       6600
KNNTPFPTNV AVELFAERSI RPHPELKLFR SSNIHVCWNH VLWDYAKDSV 
      6610       6620       6630       6640       6650
FCSSTYKVCK YTDLQCIESL NVLFDGRDNG ALEAFKKCRN GVYINTTKIK 
      6660       6670       6680       6690       6700
SLSMIKGPQR ADLNGVVVEK VGDSDVEFWF AMRRDGDDVI FSRTGSLEPS 
      6710       6720       6730       6740       6750
HYRSPQGNPG GNRVGDLSGN EALARGTIFT QSRFLSSFSP RSEMEKDFMD 
      6760       6770       6780       6790       6800
LDEDVFIAKY SLQDYAFEHV VYGSFNQKII GGLHLLIGLA RRPKKSNLVI 
      6810       6820       6830       6840       6850
QEFVPYDSSI HSYFITDENS GSSESVCTVI DLLLDDFVDI VKSLNLKCVS 
      6860       6870       6880       6890       6900
KVVNVNVDFK DFQFMLWCNE EKVMTFYPRL QAAADWKPGY VMPVLYKYLE 
      6910       6920       6930       6940       6950
SPMERVNLWN YGKPITLPTG CMMNVAKYTQ LCQYLSTTTL AVPANMRVLH 
      6960       6970       6980       6990       7000
LGAGSDKGVA PGSAVLRQWL PSGSILVDND MNPFVSDSVA SYYGNCITLP 
      7010       7020       7030       7040       7050
FDCQWDLIIS DMYDPLTKNI GEYNVSKDGF FTYLCHLIRD KLALGGSVAI 
      7060       7070       7080       7090       7100
KITEFSWNAE LYSLMGKFAF WTIFCTNVNA SSSEGFLIGI NWLNRTRNEI 
      7110       7120       7130       7140       7150
DGKTMHANYL FWRNSTMWNG GAYSLFDMTK FPLKAAGTAV VSLKPDQIND 
      7160       7170       7180
LVLSLIEKGK LLVRDTRKEV FVGDSLVNVK
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:7,180
Mass (Da):803,440
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i313A78E1CC87B347
GO
Isoform Replicase polyprotein 1a (identifier: P0C6V1-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6V1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:4,474
Mass (Da):497,595
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA46457 differs from that shown. Reason: Frameshift.Curated
The sequence AAA46457 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA46458 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M55148 Genomic RNA Translation: AAA46457.1 Sequence problems.
M55148 Genomic RNA Translation: AAA46458.2 Sequence problems.
M18040 Genomic RNA Translation: AAA46466.1
S51684 Genomic RNA Translation: AAB19566.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36815, RRIHM2
B36815, VFIHJH

NCBI Reference Sequences

More...RefSeqi		YP_209229.2, AC_000192.1 [P0C6Y0-1]

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:3283258

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55148 Genomic RNA Translation: AAA46457.1 Sequence problems.
M55148 Genomic RNA Translation: AAA46458.2 Sequence problems.
M18040 Genomic RNA Translation: AAA46466.1
S51684 Genomic RNA Translation: AAB19566.1
PIRiA36815, RRIHM2
B36815, VFIHJH
RefSeqiYP_209229.2, AC_000192.1 [P0C6Y0-1]

3D structure databases

SMRiP0C6Y0
ModBaseiSearch...

Protein-protein interaction databases

IntActiP0C6Y0, 5 interactors

Proteomic databases

PRIDEiP0C6Y0

Genome annotation databases

KEGGivg:3283258

Family and domain databases

CDDicd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21519, cv_beta_Nsp2_MHV-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21524, DPUP_MHV_Nsp3, 1 hit
cd21593, HCoV_HKU1-like_RdRp, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 2 hits
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.60.120.1680, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.30.160.820, 1 hit
3.30.70.3540, 1 hit
3.40.220.10, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR022570, B-CoV_A_NSP1
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR041679, DNA2/NAM7-like_C
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR044863, NIRAN
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR044384, NSP2_MHV-like
IPR044381, NSP3_DPUP_MHV
IPR032592, NSP3_NAB_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044347, RdRp_HCoV_HKU1-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF13087, AAA_12, 1 hit
PF16251, bCoV_NAR, 1 hit
PF06471, CoV_ExoN, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF11963, DUF3477, 2 hits
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51961, AV_NSP11N_COV_NSP15M, 1 hit
PS51963, BCOV_NSP1_C, 1 hit
PS51942, BCOV_NSP3C_C, 1 hit
PS51945, BCOV_NSP3E_NAB, 1 hit
PS51952, COV_EXON_MTASE_COACT, 1 hit
PS51954, COV_N7_MTASE, 1 hit
PS51962, COV_NSP1, 1 hit
PS51948, COV_NSP12_RDRP, 1 hit
PS51960, COV_NSP15_NTD, 1 hit
PS51943, COV_NSP3A_UBL, 1 hit
PS51944, COV_NSP3D_UBL, 1 hit
PS51946, COV_NSP4C, 1 hit
PS51949, COV_NSP7, 1 hit
PS51950, COV_NSP8, 1 hit
PS51951, COV_NSP9_SSRNA_BD, 1 hit
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51958, NENDOU, 1 hit
PS51947, NIRAN, 1 hit
PS51955, NIV_2_O_MTASE, 1 hit
PS51953, NIV_EXON, 1 hit
PS51124, PEPTIDASE_C16, 2 hits
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_CVMJH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6Y0
Secondary accession number(s): P19751
, P29982, Q66194, Q90045
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: February 23, 2022
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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