UniProtKB - P0C6X6 (R1AB_CVHOC)
Replicase polyprotein 1ab
rep
Functioni
Miscellaneous
Catalytic activityi
- TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1074 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1225 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1671 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1828 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3287 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3391 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 5302 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5305 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5313 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5316 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5323 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5326 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5330 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5336 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5347 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5352 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5369 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5372 | Zinc 3PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1151 – 1179 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1749 – 1785 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4306 – 4322 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4348 – 4361 | By similarityAdd BLAST | 14 | |
Nucleotide bindingi | 5578 – 5585 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- endonuclease activity Source: UniProtKB-KW
- exonuclease activity Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- single-stranded RNA binding Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of catabolism of host mRNA Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host ISG15 activity Source: UniProtKB-KW
- suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral protein processing Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Protein family/group databases
MEROPSi | C16.006 |
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abShort name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Alternative name(s): p28 Alternative name(s): p65 Alternative name(s): Non-structural protein 3 Short name: nsp3 p210 Alternative name(s): Peptide HD2 p44 Alternative name(s): M-PRO nsp5 p27 Alternative name(s): p10 Alternative name(s): p22 Alternative name(s): p12 Alternative name(s): Growth factor-like peptide Short name: GFL p15 Alternative name(s): nsp12 p100 Alternative name(s): nsp13 p67 Alternative name(s): nsp14 Alternative name(s): NendoU nsp15 p35 Alternative name(s): nsp16 |
Gene namesi | Name:rep ORF Names:1a-1b |
Organismi | Human coronavirus OC43 (HCoV-OC43) |
Taxonomic identifieri | 31631 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- Host endoplasmic reticulum-Golgi intermediate compartment Curated Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2138 – 2158 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2199 – 2219 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2221 – 2241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2313 – 2333 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2343 – 2363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2365 – 2385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2752 – 2772 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2824 – 2844 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3009 – 3029 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3031 – 3051 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3063 – 3083 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3090 – 3110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3115 – 3135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3558 – 3578 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3588 – 3608 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3615 – 3635 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3657 – 3677 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3684 – 3704 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3711 – 3731 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3755 – 3775 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283826 | 1 – 246 | Host translation inhibitor nsp1By similarityAdd BLAST | 246 | |
ChainiPRO_0000283827 | 247 – 851 | Non-structural protein 2By similarityAdd BLAST | 605 | |
ChainiPRO_0000283828 | 852 – 2750 | Papain-like proteinaseBy similarityAdd BLAST | 1899 | |
ChainiPRO_0000283829 | 2751 – 3246 | Non-structural protein 4By similarityAdd BLAST | 496 | |
ChainiPRO_0000283830 | 3247 – 3549 | 3C-like proteinaseBy similarityAdd BLAST | 303 | |
ChainiPRO_0000283831 | 3550 – 3836 | Non-structural protein 6By similarityAdd BLAST | 287 | |
ChainiPRO_0000283832 | 3837 – 3925 | Non-structural protein 7By similarityAdd BLAST | 89 | |
ChainiPRO_0000283833 | 3926 – 4122 | Non-structural protein 8By similarityAdd BLAST | 197 | |
ChainiPRO_0000283834 | 4123 – 4232 | Non-structural protein 9By similarityAdd BLAST | 110 | |
ChainiPRO_0000283835 | 4233 – 4369 | Non-structural protein 10By similarityAdd BLAST | 137 | |
ChainiPRO_0000037308 | 4370 – 5297 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 928 | |
ChainiPRO_0000283836 | 5298 – 5900 | HelicaseBy similarityAdd BLAST | 603 | |
ChainiPRO_0000283837 | 5901 – 6421 | Guanine-N7 methyltransferaseBy similarityAdd BLAST | 521 | |
ChainiPRO_0000283838 | 6422 – 6796 | Uridylate-specific endoribonucleaseBy similarityAdd BLAST | 375 | |
ChainiPRO_0000283839 | 6797 – 7095 | 2'-O-methyltransferaseBy similarityAdd BLAST | 299 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 246 – 247 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 851 – 852 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 2750 – 2751 | Cleavage; by PL2-PROBy similarity | 2 | |
Sitei | 3246 – 3247 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3549 – 3550 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3836 – 3837 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3925 – 3926 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4122 – 4123 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4232 – 4233 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4369 – 4370 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5297 – 5298 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5900 – 5901 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6421 – 6422 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6796 – 6797 | Cleavage; by 3CL-PROBy similarity | 2 |
Proteomic databases
PRIDEi | P0C6X6 |
Interactioni
Subunit structurei
Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1036 – 1274 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 239 | |
Domaini | 1275 – 1435 | MacroPROSITE-ProRule annotationAdd BLAST | 161 | |
Domaini | 1631 – 1892 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 3247 – 3549 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 303 | |
Domaini | 4977 – 5139 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 163 | |
Domaini | 5298 – 5381 | CV ZBDPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 5553 – 5734 | (+)RNA virus helicase ATP-bindingAdd BLAST | 182 | |
Domaini | 5735 – 5904 | (+)RNA virus helicase C-terminalAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2138 – 2385 | HD1By similarityAdd BLAST | 248 | |
Regioni | 2752 – 3135 | HD2By similarityAdd BLAST | 384 | |
Regioni | 3319 – 3775 | HD3By similarityAdd BLAST | 457 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1151 – 1179 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1749 – 1785 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4306 – 4322 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4348 – 4361 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKINKYGLE LHWAPEFPWM FEDAEEKLDN PSSSEVDMIC STTAQKLETD
60 70 80 90 100
GICPENHVMV DCRRLLKQEC CVQSSLIREI VMNASPYHLE VLLQDALQSR
110 120 130 140 150
EAVLVTTPLG MSLEACYVRG CNPKGWTMGL FRRRSVCNTG RCTVNKHVAY
160 170 180 190 200
QLYMIDPAGV CLGAGQFVGW VIPLAFMPVQ SRKFIVPWVM YLRKRGEKGA
210 220 230 240 250
YNKDHGCGGF GHVYDFKVED AYDQVHDEPK GKFSKKAYAL IRGYRGVKPL
260 270 280 290 300
LYVDQYGCDY TGSLADGLEA YADKTLQEMK ALFPTWSQEL PFDVIVAWHV
310 320 330 340 350
VRDPRYVMRL QSAATICSVA YVANPTEDLC DGSVVIKEPV HVYADDSIIL
360 370 380 390 400
RQYNLFDIMS HFYMEADTVV NAFYGVALKD CGFVMQFGYI DCEQDSCDFK
410 420 430 440 450
GWIPGNMIDG FACTTCGHVY EVGDLIAQSS GVLPVNPVLH TKSAAGYGGF
460 470 480 490 500
GCKDSFTLYG QTVVYFGGCV YWSPARNIWI PILKSSVKSY DSLVYTGVLG
510 520 530 540 550
CKAIVKETNL ICKALYLDYV QHKCGNLHQR ELLGVSDVWH KQLLINRGVY
560 570 580 590 600
KPLLENIDYF NMRRAKFSLE TFTVCADGFM PFLLDDLVPR AYYLAVSGQA
610 620 630 640 650
FCDYADKLCH AVVSKSKELL DVSLDSLGAA IHYLNSKIVD LAQHFSDFGT
660 670 680 690 700
SFVSKIVHFF KTFTTSTALA FAWVLFHVLH GAYIVVESDI YFVKNIPRYA
710 720 730 740 750
SAVAQAFQSV AKVVLDSLRV TFIDGLSCFK IGRRRICLSG RKIYEVERGL
760 770 780 790 800
LHSSQLPLDV YDLTMPSQVQ KAKQKPIYLK GSGSDFSLAD SVVEVVTTSL
810 820 830 840 850
TPCGYSEPPK VADKICIVDN VYMAKAGDKY YPVVVDDHVG LLDQAWRVPC
860 870 880 890 900
AGRRVTFKEQ PTVKEIISMP KIIKVFYELD NDFNTILNTA CGVFEVDDTV
910 920 930 940 950
DMEEFYAVVI DAIEEKLSPC KELEGVGAKV SAFLQKLEDN PLFLFDEAGE
960 970 980 990 1000
EVFAPKLYCA FTAPEDDDFL EESDVEEDDV EGEETDLTIT SAGQPCVASE
1010 1020 1030 1040 1050
QEESSEVLED TLDDGPSVET SDSQVEEDVE MSDFVDLESV IQDYENVCFE
1060 1070 1080 1090 1100
FYTTEPEFVK VLGLYVPKAT RNNCWLRSVL AVMQKLPCQF KDKNLQDLWV
1110 1120 1130 1140 1150
LYKQQYSQLF VDTLVNKIPA NIVLPQGGYV ADFAYWFLTL CDWQCVAYWK
1160 1170 1180 1190 1200
CIKCDLALKL KGLDAMFFYG DVVSHICKCG ESMVLIDVDV PFTAHFALKD
1210 1220 1230 1240 1250
KLFCAFITKR IVYKAACVVD VNDSHSMAVV DGKQIDDHRI TSITSDKFDF
1260 1270 1280 1290 1300
IIGHGMSFSM TTFEIAQLYG SCITPNVCFV KGDIIKVSKL VKAEVVVNPA
1310 1320 1330 1340 1350
NGHMVHGGGV AKAIAVAAGQ QFVKETTNMV KSKGVCATGD CYVSTGGKLC
1360 1370 1380 1390 1400
KTVLNVVGPD ARTQGKQSYV LLERVYKHFN NYDCVVTTLI SAGIFSVPSD
1410 1420 1430 1440 1450
VSLTYLLGTA KKQVVLVSNN QEDFDLISKC QITAVEGTKK LAARLSFNVG
1460 1470 1480 1490 1500
RSIVYETDAN KLILINDVAF VSTFNVLQDV LSLRHDIALD DDARTFVQSN
1510 1520 1530 1540 1550
VDVLPEGWRV VNKFYQINGV RTVKYFECTG GIDICSQDKV FGYVQQGIFN
1560 1570 1580 1590 1600
KATVAQIKAL FLDKVDILLT VDGVNFTNRF VPVGESFGKS LGNVFCDGVN
1610 1620 1630 1640 1650
VTKHKCDINY KGKVFFQFDN LSSEDLKAVR SSFNFDQKEL LAYYNMLVNC
1660 1670 1680 1690 1700
FKWQVVVNGK YFTFKQANNN CFVNVSCLML QSLHLTFKIV QWQEAWLEFR
1710 1720 1730 1740 1750
SGRPARFVAL VLAKGGFKFG DPADSRDFLR VVFSQVDLTG AICDFEIACK
1760 1770 1780 1790 1800
CGVKQEQRTG LDAVMHFGTL SREDLEIGYT VDCSCGKKLI HCVRFDVPFL
1810 1820 1830 1840 1850
ICSNTPASVK LPKGVGSANI FIGDNVGHYV HVKCEQSYQL YDASNVKKVT
1860 1870 1880 1890 1900
DVTGKLSDCL YLKNLKQTFK SVLTTYYLDD VKKIEYKPDL SQYYCDGGKY
1910 1920 1930 1940 1950
YTQRIIKAQF KTFEKVDGVY TNFKLIGHTV CDSLNSKLGF DSSKEFVEYK
1960 1970 1980 1990 2000
ITEWPTATGD VVLANDDLYV KRYERGCITF GKPVIWLSHE KASLNSLTYF
2010 2020 2030 2040 2050
NRPLLVDDNK FDVLKVDDVD DSGDSSESGA KETKEINIIK LSGVKKPFKV
2060 2070 2080 2090 2100
EDSVIVNDDT SETKYVKSLS IVDVYDMWLT GCKYVVRTAN ALSRAVNVPT
2110 2120 2130 2140 2150
IRKFIKFGMT LVSIPIDLLN LREIKPAVNV VKAVRNKTSA CFNFIKWLFV
2160 2170 2180 2190 2200
LLFGWIKISA DNKVIYTTEI ASKLTCKLVA LAFKNAFLTF KWSMVARGAC
2210 2220 2230 2240 2250
IIATIFLLWF NFIYANVIFS DFYLPKIGFL PTFVGKIAQW IKNTFSLVTI
2260 2270 2280 2290 2300
CDLYSIQDVG FKNQYCNGSI ACQFCLAGFD MLDNYKAIDV VQYEADRRAF
2310 2320 2330 2340 2350
VDYTGVLKIV IELIVSYALY TAWFYPLFAL ISIQILTTWL PELFMLSTLH
2360 2370 2380 2390 2400
WSFRLLVALA NMLPAHVFMR FYIIIASFIK LFSLFKHVAY GCSKSGCLFC
2410 2420 2430 2440 2450
YKRNRSLRVK CSTIVGGMIR YYDVMANGGT GFCSKHQWNC IDCDSYKPGN
2460 2470 2480 2490 2500
TFITVEAALD LSKELKRPIQ PTDVAYHTVT DVKQVGCSMR LFYDRDGQRI
2510 2520 2530 2540 2550
YDDVNASLFV DYSNLLHSKV KSVPNMHVVV VENDADKANF LNAAVFYAQS
2560 2570 2580 2590 2600
LFRPILMVDK NLITTANTGT SVTETMFDVY VDTFLSMFDV DKKSLNALIA
2610 2620 2630 2640 2650
TAHSSIKQGT QIYKVLDTFL SCARKSCSID SDVDTKCLAD SVMSAVSAGL
2660 2670 2680 2690 2700
ELTDESCNNL VPTYLKSDNI VAADLGVLIQ NSAKHVQGNV AKIAGVSCIW
2710 2720 2730 2740 2750
SVDAFNQFSS DFQHKLKKAC CKTGLKLKLT YNKQMANVSV LTTPFSLKGG
2760 2770 2780 2790 2800
AVFSYFVYVC FVLSLVCFIG LWCLMPTYTV HKSDFQLPVY ASYKVLDNGV
2810 2820 2830 2840 2850
IRDVSVEDVC FANKFEQFDQ WYESTFGLSY YSNSMACPIV VAVIDQDFGS
2860 2870 2880 2890 2900
TVFNVPTKVL RYGYHVLHFI THALSADGVQ CYTPHSQISY SNFYASGCVL
2910 2920 2930 2940 2950
SSACTMFTMA DGSPQPYCYT DGLMQNASLY SSLVPHVRYN LANAKGFIRF
2960 2970 2980 2990 3000
PEVLREGLVR VVRTRSMSYC RVGLCEEADE GICFNFNGSW VLNNDYYRSL
3010 3020 3030 3040 3050
PGTFCGRDVF DLIYQLFKGL AQPVDFLALT ASSIAGAILA VIVVLVFYYL
3060 3070 3080 3090 3100
IKLKRAFGDY TSVVFVNVIV WCVNFMMLFV FQVYPTLSCV YAICYFYATL
3110 3120 3130 3140 3150
YFPSEISVIM HLQWLVMYGT IMPLWFCLLY IAVVVSNHAF WVFSYCRKLG
3160 3170 3180 3190 3200
TSVRSDGTFE EMALTTFMIT KDSYCKLKNS LSDVAFNRYL SLYNKYRYYS
3210 3220 3230 3240 3250
GKMDTAAYRE AACSQLAKAM DTFTNNNGSD VLYQPPTASV STSFLQSGIV
3260 3270 3280 3290 3300
KMVNPTSKVE PCVVSVTYGN MTLNGLWLDD KVYCPRHVIC SASDMTNPDY
3310 3320 3330 3340 3350
TNLLCRVTSS DFTVLFDRLS LTVMSYQMRG CMLVLTVTLQ NSRTPKYTFG
3360 3370 3380 3390 3400
VVKPGETFTV LAAYNGKPQG AFHVTMRSSY TIKGSFLCGS CGSVGYVIMG
3410 3420 3430 3440 3450
DCVKFVYMHQ LELSTGCHTG TDFNGDFYGP YKDAQVVQLP IQDYIQSVNF
3460 3470 3480 3490 3500
LAWLYAAILN NCNWFIQSDK CSVEDFNVWA LSNGFSQVKS DLVIDALASM
3510 3520 3530 3540 3550
TGVSLETLLA AIKRLKNGFQ GRQIMGSCSF EDELTPSDVY QQLAGIKLQS
3560 3570 3580 3590 3600
KRTRLFKGTV CWIMASTFLF SCIITAFVKW TMFMYVTTNM FSITFCALCV
3610 3620 3630 3640 3650
ISLAMLLVKH KHLYLTMYIT PVLFTLLYNN YLVVYKHTFR GYVYAWLSYY
3660 3670 3680 3690 3700
VPSVEYTYTD EVIYGMLLLV GMVFVTLRSI NHDLFSFIMF VGRLISVFSL
3710 3720 3730 3740 3750
WYKGSNLEEE ILLMLASLFG TYTWTTVLSM AVAKVIAKWV AVNVLYFTDI
3760 3770 3780 3790 3800
PQIKIVLLCY LFIGYIISCY WGLFSLMNSL FRMPLGVYNY KISVQELRYM
3810 3820 3830 3840 3850
NANGLRPPKN SFEALMLNFK LLGIGGVPII EVSQFQSKLT DVKCANVVLL
3860 3870 3880 3890 3900
NCLQHLHVAS NSKLWHYCST LHNEILATSD LSVAFEKLAQ LLIVLFANPA
3910 3920 3930 3940 3950
AVDSKCLTSI EEVCDDYAKD NTVLQALQSE FVNMASFVEY EVAKKNLDEA
3960 3970 3980 3990 4000
RFSGSANQQQ LKQLEKACNI AKSAYERDRA VAKKLERMAD LALTNMYKEA
4010 4020 4030 4040 4050
RINDKKSKVV SALQTMLFSM VRKLDNQALN SILDNAVKGC VPLNAIPSLA
4060 4070 4080 4090 4100
ANTLNIIVPD KSVYDQIVDN IYVTYAGNVW QIQTIQDSDG TNKQLNEISD
4110 4120 4130 4140 4150
DCNWPLVIIA NRYNEVSATV LQNNELMPAK LKIQVVNSGP DQTCNTPTQC
4160 4170 4180 4190 4200
YYNNSNNGKI VYAILSDVDG LKYTKILKDD GNFVVLELDP PCKFTVQDAK
4210 4220 4230 4240 4250
GLKIKYLYFV KGCNTLARGW VVGTISSTVR LQAGTATEYA SNSSILSLCA
4260 4270 4280 4290 4300
FSVDPKKTYL DFIQQGGTPI ANCVKMLCDH AGTGMAITVK PDATTSQDSY
4310 4320 4330 4340 4350
GGASVCIYCR ARVEHPDVDG LCKLRGKFVQ VPVGIKDPVS YVLTHDVCRV
4360 4370 4380 4390 4400
CGFWRDGSCS CVSTDTTVQS KDTNFLNRVR GASVDARLVP CASGLSTDVQ
4410 4420 4430 4440 4450
LRAFDIYNAS VAGIGLHLKV NCCRFQRVDE NGDKLDQFFV VKRTDLTIYN
4460 4470 4480 4490 4500
REMKCYERVK DCKFVAEHDF FTFDVEGSRV PHIVRKDLTK YTMLDLCYAL
4510 4520 4530 4540 4550
RHFDRNDCML LCDILSIYAG CEQSYFTKKD WYDFVENPDI INVYKKLGPI
4560 4570 4580 4590 4600
FNRALVSATE FADKLVEVGL VGVLTLDNQD LNGKWYDFGD YVIAAPGCGV
4610 4620 4630 4640 4650
AIADSYYSYI MPMLTMCHAL DCELYVNNAY RLFDLVQYDF TDYKLELFNK
4660 4670 4680 4690 4700
YFKHWSMPYH PNTVDCQDDR CIIHCANFNI LFSMVLPNTC FGPLVRQIFV
4710 4720 4730 4740 4750
DGVPFVVSIG YHYKELGIVM NMDVDTHRYR LSLKDLLLYA ADPALHVASA
4760 4770 4780 4790 4800
SALYDLRTCC FSVAAITSGV KFQTVKPGNF NQDFYDFVLS KGLLKEGSSV
4810 4820 4830 4840 4850
DLKHFFFTQD GNAAITDYNY YKYNLPTMVD IKQLLFVLEV VYKYFEIYDG
4860 4870 4880 4890 4900
GCIPASQVIV NNYDKSAGYP FNKFGKARLY YEALSFEEQD EIYAYTKRNV
4910 4920 4930 4940 4950
LPTLTQMNLK YAISAKNRAR TVAGVSILST MTGRMFHQKC LKSIAATRGV
4960 4970 4980 4990 5000
PVVIGTTKFY GGWDDMLRRL IKDVDNPVLM GWDYPKCDRA MPNILRIVSS
5010 5020 5030 5040 5050
LVLARKHETC CSQSDRFYRL ANECAQVLSE IVMCGGCYYV KPGGTSSGDA
5060 5070 5080 5090 5100
TTAFANSVFN ICQAVSANVC ALMSCNGNKI EDLSIRALQK RLYSHVYRSD
5110 5120 5130 5140 5150
KVDSTFVTEY YEFLNKHFSM MILSDDGVVC YNSDYASKGY IANISAFQQV
5160 5170 5180 5190 5200
LYYQNNVFMS ESKCWVEHDI NNGPHEFCSQ HTMLVKMDGD DVYLPYPNPS
5210 5220 5230 5240 5250
RILGAGCFVD DLLKTDSVLL IERFVSLAID AYPLVYHENE EYQKVFRVYL
5260 5270 5280 5290 5300
AYIKKLYNDL GNQILDSYSV ILSTCDGQKF TDESFYKNMY LRSAVMQSVG
5310 5320 5330 5340 5350
ACVVCSSQTS LRCGSCIRKP LLCCKCCYDH VMATDHKYVL SVSPYVCNAP
5360 5370 5380 5390 5400
GCDVNDVTKL YLGGMSYYCE DHKPQYSFKL VMNGLVFGLY KQSCTGSPYI
5410 5420 5430 5440 5450
DDFNRIASCK WTDVDDYILA NECTERLKLF AAETQKATEE AFKQSYASAT
5460 5470 5480 5490 5500
IQEIVSEREL ILSWEIGKVK PPLNKNYVFT GYHFTKNGKT VLGEYVFDKS
5510 5520 5530 5540 5550
ELTNGVYYRA TTTYKLSVGD VFVLTSHSVA NLSAPTLVPQ ENYSSIRFAS
5560 5570 5580 5590 5600
VYSVLETFQN NVVNYQHIGM KRYCTVQGPP GTGKSHLAIG LAVFYCTARV
5610 5620 5630 5640 5650
VYTAASHAAV DALCEKAYKF LNINDCTRIV PAKVRVECYD KFKINDTTRK
5660 5670 5680 5690 5700
YVFTTINALP EMVTDIVVVD EVSMLTNYEL SVINARIRAK HYVYIGDPAQ
5710 5720 5730 5740 5750
LPAPRVLLSK GTLEPKYFNT VTKLMCCLGP DIFLGTCYRC PKEIVDTVSA
5760 5770 5780 5790 5800
LVYENKLKAK NESSLLCFKV YYKGVTTHES SSAVNMQQIY LINKFLKANP
5810 5820 5830 5840 5850
LWHKAVFISP YNSQNFAAKR VLGLQTQTVD SAQGSEYDYV IYSQTAETAH
5860 5870 5880 5890 5900
SVNVNRFNVA ITRAKKGILC VMSNMQLFEA LQFTTLTLDK VPQAVETKVQ
5910 5920 5930 5940 5950
CSTNLFKDCS KSYSGYHPAH APSFLAVDDK YKATGDLAVC LGIGDSAVTY
5960 5970 5980 5990 6000
SRLISLMGFK LDVTLDGYCK LFITKEEAVK RVRAWVGFDA EGAHATLDSI
6010 6020 6030 6040 6050
GTNFPLQLGF STGIDFVVEA TGLFADRDGY SFKKAVAKAP PGEQFKHLIP
6060 6070 6080 6090 6100
LMTRGHRWDV VRPRIVQMFA DHLIDLSDCV VLVTWAANFE LTCLRYFAKV
6110 6120 6130 6140 6150
GREISCNVCT KRATVYNSRT GYYGCWRHSV TCDYLYNPLI VDIQQWGYIG
6160 6170 6180 6190 6200
SLSSNHDLYC SVHKGAHVAS SDAIMTRCLA VYDCFCNNIN WNVEYPIISN
6210 6220 6230 6240 6250
ELSINTSCRV LQRVILKAAM LCNRYTLCYD IGNPKGIACV KDFDFKFYDA
6260 6270 6280 6290 6300
QPIVKSVKTL LYSFEAHKDS FKDGLCMFWN CNVDKYPPNA VVCRFDTRVL
6310 6320 6330 6340 6350
NNLNLPGCNG GSLYVNKHAF HTKPFARAAF EHLKPMPFFY YSDTPCVYMD
6360 6370 6380 6390 6400
GMDAKQVDYV PLKSATCITR CNLGGAVCLK HAEEYREYLE SYNTATTAGF
6410 6420 6430 6440 6450
TFWVYKTFDF YNLWNTFTKL QSLENVVYNL VKTGHYTGQA GEMPCAIIND
6460 6470 6480 6490 6500
KVVTKIDKED VVIFINNTTY PTNVAVELFA KRSVRHHPEL KLFRNLNIDV
6510 6520 6530 6540 6550
CWKHVIWDYA RESIFCSNTY GVCMYTDLKF IDKLNVLFDG RDNGAFEAFK
6560 6570 6580 6590 6600
RSNNGVYIST TKVKSLSMIR GPPRAELNGV VVDKVGDTDC VFYFAVRKEG
6610 6620 6630 6640 6650
QDVIFSQFDS LGVSSNQSPQ GNLGSNGKPG NVGGNDALSI STIFTQSRVI
6660 6670 6680 6690 6700
SSFTCRTDME KDFIALDQDV FIQKYGLEDY AFEHIVYGNF NQKIIGGLHL
6710 6720 6730 6740 6750
LIGLYRRQQT SNLVVQEFVS YDSSIHSYFI TDEKSGGSKS VCTVIDILLD
6760 6770 6780 6790 6800
DFVTLVKSLN LNCVSKVVNV NVDFKDFQFM LWCNDEKVMT FYPRLQAASD
6810 6820 6830 6840 6850
WKPGYSMPVL YKYLNSPMER VSLWNYGKPV TLPTGCMMNV AKYTQLCQYL
6860 6870 6880 6890 6900
NTTTLAVPVN MRVLHLGAGS EKGVAPGSAV LRQWLPAGTI LVDNDLYPFV
6910 6920 6930 6940 6950
SDSVATYFGD CITLPFDCQW DLIISDMYDP ITKNIGEYNV SKDGFFTYIC
6960 6970 6980 6990 7000
HMIRDKLALG GSVAIKITEF SWNAELYKLM GYFAFWTVFC TNANASSSEG
7010 7020 7030 7040 7050
FLIGINYLCK PKVEIDGNVM HANYLFWRNS TVWNGGAYSL FDMAKFPLKL
7060 7070 7080 7090
AGTAVINLRA DQINDMVYSL LEKGKLLIRD TNKEVFVGDS LVNVI
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 426 | I → M in AAT84359 (PubMed:15650185).Curated | 1 | |
Sequence conflicti | 426 | I → M in AAT84351 (PubMed:15650185).Curated | 1 | |
Sequence conflicti | 813 | D → A in AAT84359 (PubMed:15650185).Curated | 1 | |
Sequence conflicti | 813 | D → A in AAT84351 (PubMed:15650185).Curated | 1 | |
Sequence conflicti | 4376 – 4377 | LN → FK in AAR01012 (PubMed:15280490).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 88 | H → D in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 207 | C → R in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 291 | P → L in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 317 | C → R in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 356 | F → V in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 545 | I → L in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 762 | D → N in strain: Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 953 | F → L in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 989 | I → V in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 1305 | V → A in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 1328 | N → D in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 1379 | F → L in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 1504 | L → V in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 1740 | G → E in strain: Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 1825 | N → K in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 1936 | S → A in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 1965 | N → T in strain: ATCC VR-759, Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 2004 | L → S in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 2022 | S → G in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 2138 – 2140 | TSA → ISV in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 3 | |
Natural varianti | 2256 | I → M in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 2257 | Q → H in strain: Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 2386 | K → R in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 2500 | I → T in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 2921 | D → E in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 2961 | V → I in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 3086 | T → I in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 3440 | P → L in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 3451 | L → V in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 3466 | I → V in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 4067 | I → V in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 4071 | I → V in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 4382 | A → T in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 4994 | I → L in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate Tulsa 1999 and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 5014 – 5015 | SD → RT in strain: Isolate Tulsa 1999. | 2 | |
Natural varianti | 5765 | L → S in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 5997 | L → R in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 6236 | G → A in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 6454 | T → A in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 | |
Natural varianti | 6546 | F → L in strain: ATCC VR-759, Isolate clinical OC43-Paris and Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 6636 | D → E in strain: Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 6665 | A → T in strain: Isolate 87309 Belgium 2003. | 1 | |
Natural varianti | 6754 | T → A in strain: ATCC VR-759 and Isolate clinical OC43-Paris. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY903459 Genomic RNA Translation: AAX85666.1 AY903460 Genomic RNA Translation: AAX85675.1 AY585228 Genomic RNA Translation: AAT84351.1 AY585229 Genomic RNA Translation: AAT84359.1 AY391777 Genomic RNA Translation: AAR01012.1 AF124989 Genomic RNA Translation: AAD32993.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY903459 Genomic RNA Translation: AAX85666.1 AY903460 Genomic RNA Translation: AAX85675.1 AY585228 Genomic RNA Translation: AAT84351.1 AY585229 Genomic RNA Translation: AAT84359.1 AY391777 Genomic RNA Translation: AAR01012.1 AF124989 Genomic RNA Translation: AAD32993.1 |
3D structure databases
SMRi | P0C6X6 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | C16.006 |
Proteomic databases
PRIDEi | P0C6X6 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_CVHOC | |
Accessioni | P0C6X6Primary (citable) accession number: P0C6X6 Secondary accession number(s): Q4VID8 Q9WAC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families