UniProtKB - P0C6X3 (R1AB_CVHN2)
Replicase polyprotein 1ab
rep
Functioni
Miscellaneous
Catalytic activityi
- TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1131 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1282 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1727 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1884 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3345 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3449 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 5360 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5363 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5371 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5374 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5381 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5384 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5388 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5394 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5405 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5410 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5427 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5430 | Zinc 3PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1208 – 1236 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1805 – 1841 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4364 – 4380 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4406 – 4419 | By similarityAdd BLAST | 14 | |
Nucleotide bindingi | 5636 – 5643 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- endonuclease activity Source: UniProtKB-KW
- exonuclease activity Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- single-stranded RNA binding Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of catabolism of host mRNA Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host ISG15 activity Source: UniProtKB-KW
- suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral genome replication Source: InterPro
- viral protein processing Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abShort name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Alternative name(s): p28 Alternative name(s): p65 Alternative name(s): Non-structural protein 3 Short name: nsp3 p210 Alternative name(s): Peptide HD2 p44 Alternative name(s): M-PRO nsp5 p27 Alternative name(s): p10 Alternative name(s): p22 Alternative name(s): p12 Alternative name(s): Growth factor-like peptide Short name: GFL p15 Alternative name(s): nsp12 p100 Alternative name(s): nsp13 p67 Alternative name(s): nsp14 Alternative name(s): NendoU nsp15 p35 Alternative name(s): nsp16 |
Gene namesi | Name:rep ORF Names:1a-1b |
Organismi | Human coronavirus HKU1 (isolate N2) (HCoV-HKU1) |
Taxonomic identifieri | 443240 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane ; Multi-pass membrane protein
- Host cytoplasm Note: Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
- Host endoplasmic reticulum-Golgi intermediate compartment Curated Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2196 – 2216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2257 – 2277 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2288 – 2308 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2371 – 2391 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2413 – 2433 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2814 – 2834 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3089 – 3109 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3121 – 3141 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3148 – 3168 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3173 – 3193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3621 – 3641 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3646 – 3666 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3671 – 3691 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3714 – 3734 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3742 – 3762 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3770 – 3790 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3813 – 3833 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297773 | 1 – 222 | Host translation inhibitor nsp1By similarityAdd BLAST | 222 | |
ChainiPRO_0000297774 | 223 – 809 | Non-structural protein 2By similarityAdd BLAST | 587 | |
ChainiPRO_0000297775 | 810 – 2808 | Papain-like proteinaseBy similarityAdd BLAST | 1999 | |
ChainiPRO_0000297776 | 2809 – 3304 | Non-structural protein 4By similarityAdd BLAST | 496 | |
ChainiPRO_0000297777 | 3305 – 3607 | 3C-like proteinaseBy similarityAdd BLAST | 303 | |
ChainiPRO_0000297778 | 3608 – 3894 | Non-structural protein 6By similarityAdd BLAST | 287 | |
ChainiPRO_0000297779 | 3895 – 3986 | Non-structural protein 7By similarityAdd BLAST | 92 | |
ChainiPRO_0000297780 | 3987 – 4180 | Non-structural protein 8By similarityAdd BLAST | 194 | |
ChainiPRO_0000297781 | 4181 – 4290 | Non-structural protein 9By similarityAdd BLAST | 110 | |
ChainiPRO_0000297782 | 4291 – 4427 | Non-structural protein 10By similarityAdd BLAST | 137 | |
ChainiPRO_0000297783 | 4428 – 5355 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 928 | |
ChainiPRO_0000297784 | 5356 – 5958 | HelicaseBy similarityAdd BLAST | 603 | |
ChainiPRO_0000297785 | 5959 – 6479 | Guanine-N7 methyltransferaseBy similarityAdd BLAST | 521 | |
ChainiPRO_0000297786 | 6480 – 6853 | Uridylate-specific endoribonucleaseBy similarityAdd BLAST | 374 | |
ChainiPRO_0000297787 | 6854 – 7152 | 2'-O-methyltransferaseBy similarityAdd BLAST | 299 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 222 – 223 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 809 – 810 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 2808 – 2809 | Cleavage; by PL2-PROBy similarity | 2 | |
Sitei | 3304 – 3305 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3607 – 3608 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3894 – 3895 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3986 – 3987 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4180 – 4181 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4290 – 4291 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4427 – 4428 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5355 – 5356 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6479 – 6480 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6853 – 6854 | Cleavage; by 3CL-PROBy similarity | 2 |
Proteomic databases
PRIDEi | P0C6X3 |
Interactioni
Subunit structurei
Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 945 – 954 | 1 | 10 | |
Repeati | 955 – 964 | 2 | 10 | |
Repeati | 965 – 974 | 3 | 10 | |
Repeati | 975 – 984 | 4 | 10 | |
Repeati | 985 – 994 | 5 | 10 | |
Repeati | 995 – 1004 | 6 | 10 | |
Repeati | 1005 – 1014 | 7 | 10 | |
Repeati | 1015 – 1024 | 8 | 10 | |
Repeati | 1025 – 1034 | 9 | 10 | |
Repeati | 1035 – 1044 | 10 | 10 | |
Repeati | 1045 – 1054 | 11 | 10 | |
Domaini | 1093 – 1343 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 251 | |
Domaini | 1321 – 1492 | MacroPROSITE-ProRule annotationAdd BLAST | 172 | |
Domaini | 1688 – 1948 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 261 | |
Domaini | 3305 – 3607 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 303 | |
Domaini | 5035 – 5197 | RdRp catalyticAdd BLAST | 163 | |
Domaini | 5356 – 5439 | CV ZBDPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 5611 – 5792 | (+)RNA virus helicase ATP-bindingAdd BLAST | 182 | |
Domaini | 5793 – 5962 | (+)RNA virus helicase C-terminalAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 945 – 1054 | 11 X 10 AA tandem repeat of N-[DN]-D-E-D-V-V-T-G-DAdd BLAST | 110 | |
Regioni | 2196 – 2433 | HD1By similarityAdd BLAST | 238 | |
Regioni | 2814 – 3193 | HD2By similarityAdd BLAST | 380 | |
Regioni | 3621 – 3833 | HD3By similarityAdd BLAST | 213 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 934 – 1086 | Asp-richAdd BLAST | 153 | |
Compositional biasi | 2199 – 2291 | Phe-richAdd BLAST | 93 | |
Compositional biasi | 2586 – 2589 | Poly-Val | 4 | |
Compositional biasi | 5360 – 5385 | Cys-richAdd BLAST | 26 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1208 – 1236 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1805 – 1841 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4364 – 4380 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4406 – 4419 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIKTSKYGLG FKWAPEFRWL LPDAAEELAS PMKSDEGGLC PSTGQAMESV
60 70 80 90 100
GFVYDNHVKI DCRCILGQEW HVQSNLIRDI FVHEDLHVVE VLTKTAVKSG
110 120 130 140 150
TAILIKSPLH SLGGFPKGYV MGLFRSYKTK RYVVHHLSMT TSTTNFGEDF
160 170 180 190 200
LGWIVPFGFM PSYVHKWFQF CRLYIEESDL IISNFKFDDY DFSVEDAYAE
210 220 230 240 250
VHAEPKGKYS QKAYALLRQY RGIKPVLFVD QYGCDYSGKL ADCLQAYGHY
260 270 280 290 300
SLQDMRQKQS VWLANCDFDI VVAWHVVRDS RFVMRLQTIA TICGIKYVAQ
310 320 330 340 350
PTEDVVDGAV VIREPVHLLS ADAIVLKLPS LMKVMTHMDD FSIKSIYNVD
360 370 380 390 400
LCDCGFVMQY GYVDCFNDNC DFYGWVSGNM MDGFSCPLCC TVYDSSEVKA
410 420 430 440 450
QSSGVIPENP VLFTNSTDTV NPDSFNLYGY SVTPFGSCIY WSPRPGLWIP
460 470 480 490 500
IIKSSVKSYD DLVYSGVVGC KSIVKETALI THALYLDYVQ CKCGNLEQNH
510 520 530 540 550
ILGVNNSWCR QLLLNRGDYN MLLKNIDLFV KRRADFACKF AVCGDGFVPF
560 570 580 590 600
LLDGLIPRSY YLIQSGIFFT SLMSQFSQEV SDMCLKMCIL FMDRVSVATF
610 620 630 640 650
YIEHYVNRLV TQFKLLGTTL VNKMVNWFNT MLDASAPATG WLLYQLLNGL
660 670 680 690 700
FVVSQANFNF VALIPDYAKI LVNKFYTFFK LLLECVTVDV LKDMPVLKTI
710 720 730 740 750
NGLVCIVGNK FYNVSTGLIP GFVLPCNAQE QQIYFFEGVA ESVIVEDDVI
760 770 780 790 800
ENVKSSLSSY EYCQPPKSVE KICIIDNMYM GKCGDKFFPI VMNDKNICLL
810 820 830 840 850
DQAWRFPCAG RKVNFNEKPV VMEIPSLMTV KVMFDLDSTF DDILGKVCSE
860 870 880 890 900
FEVEKGVTVD DFVAVVCDAI ENALNSCKDH PVVGYQVRAF LNKLNENVVY
910 920 930 940 950
LFDEAGDEAM ASRMYCTFAI EDVEDVISSE AVEDTIDGVV EDTINDDEDV
960 970 980 990 1000
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV
1010 1020 1030 1040 1050
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV
1060 1070 1080 1090 1100
VTGDNDDEEI VTGDNDDQIV VTGDDVDDIE SVYDFDTYKA LLVFNDVYND
1110 1120 1130 1140 1150
ALFVSYGSSV ETETYFKVNG LWSPTITHTN CWLRSVLLVM QKLPFKFKDL
1160 1170 1180 1190 1200
AIENMWLSYK VGYNQSFVDY LLTTIPKAIV LPQGGYVADF AYWFLNQFDI
1210 1220 1230 1240 1250
NAYANWCCLK CGFSFDLNGL DAVFFYGDIV SHVCKCGHNM TLIAADLPCT
1260 1270 1280 1290 1300
LHFSLFDDNF CAFCTPKKIF IAACAVDVNV CHSVAVIGDE QIDGKFVTKF
1310 1320 1330 1340 1350
SGDKFDFIVG YGMSFSMSSF ELAQLYGLCI TPNVCFVKGD IINVARLVKA
1360 1370 1380 1390 1400
DVIVNPANGH MLHGGGVAKA IAVAAGKKFS KETAAMVKSK GVCQVGDCYV
1410 1420 1430 1440 1450
STGGKLCKTI LNIVGPDARQ DGRQSYVLLA RAYKHLNNYD CCLSTLISAG
1460 1470 1480 1490 1500
IFSVPADVSL TYLLGVVDKQ VILVSNNKED FDIIQKCQIT SVVGTKALAV
1510 1520 1530 1540 1550
RLTANVGRVI KFETDAYKLF LSGDDCFVSN SSVIQEVLLL RHDIQLNNDV
1560 1570 1580 1590 1600
RDYLLSKMTS LPKDWRLINK FDVINGVKTV KYFECPNSIY ICSQGKDFGY
1610 1620 1630 1640 1650
VCDGSFYKAT VNQVCVLLAK KIDVLLTVDG VNFKSISLTV GEVFGKILGN
1660 1670 1680 1690 1700
VFCDGIDVTK LKCSDFYADK ILYQYENLSL ADISAVQSSF GFDQQQLLAY
1710 1720 1730 1740 1750
YNFLTVCKWS VVVNGPFFSF EQSHNNCYVN VACLMLQHIN LKFNKWQWQE
1760 1770 1780 1790 1800
AWYEFRAGRP HRLVALVLAK GHFKFDEPSD ATDFIRVVLK QADLSGAICE
1810 1820 1830 1840 1850
LELICDCGIK QESRVGVDAV MHFGTLAKTD LFNGYKIGCN CAGRIVHCTK
1860 1870 1880 1890 1900
LNVPFLICSN TPLSKDLPDD VVAANMFMGV GVGHYTHLKC GSPYQHYDAC
1910 1920 1930 1940 1950
SVKKYTGVSG CLTDCLYLKN LTQTFTSMLT NYFLDDVEMV AYNPDLSQYY
1960 1970 1980 1990 2000
CDNGKYYTKP IIKAQFKPFA KVDGVYTNFK LVGHDICAQL NDKLGFNVDL
2010 2020 2030 2040 2050
PFVEYKVTVW PVATGDVVLA SDDLYVKRYF KGCETFGKPV IWLCHDEASL
2060 2070 2080 2090 2100
NSLTYFNKPS FKSENRYSVL SVDSVSEESQ GNVVTSVMES QISTKEVKLK
2110 2120 2130 2140 2150
GVRKTVKIED AIIVNDENSS IKVVKSLSLV DVWDMYLTGC DYVVWVANEL
2160 2170 2180 2190 2200
SRLVKSPTVR EYIRYGIKPI TIPIDLLCLR DDNQTLLVPK IFKARAIEFY
2210 2220 2230 2240 2250
GFLKWLFIYV FSLLHFTNDK TIFYTTEIAS KFTFNLFCLA LKNAFQTFRW
2260 2270 2280 2290 2300
SIFIKGFLVV ATVFLFWFNF LYINVIFSDF YLPNISVFPI FVGRIVMWIK
2310 2320 2330 2340 2350
ATFGLVTICD FYSKLGVGFT SHFCNGSFIC ELCYSGFDML DTYAAIDFVQ
2360 2370 2380 2390 2400
YEVDRRVLFD YVSLVKLIVE LVIGYSLYTV WFYPLFCLIG LQLFTTWLPD
2410 2420 2430 2440 2450
LFMLETMHWL IRFIVFVANM LPAFVLLRFY IVVTAMYKVV GFIRHIVYGC
2460 2470 2480 2490 2500
NKAGCLFCYK RNCSVRVKCS TIVGGVIRYY DITANGGTGF CVKHQWNCFN
2510 2520 2530 2540 2550
CHSFKPGNTF ITVEAAIELS KELKRPVNPT DASHYVVTDI KQVGCMMRLF
2560 2570 2580 2590 2600
YDRDGQRVYD DVDASLFVDI NNLLHSKVKV VPNLYVVVVE SDADRANFLN
2610 2620 2630 2640 2650
AVVFYAQSLY RPILLVDKKL ITTACNGISV TQTMFDVYVD TFMSHFDVDR
2660 2670 2680 2690 2700
KSFNNFVNIA HASLREGVQL EKVLDTFVGC VRKCCSIDSD VETRFITKSM
2710 2720 2730 2740 2750
ISAVAAGLEF TDENYNNLVP TYLKSDNIVA ADLGVLIQNG AKHVQGNVAK
2760 2770 2780 2790 2800
AANISCIWFI DTFNQLTADL QHKLKKACVK TGLKLKLTFN KQEASVPILT
2810 2820 2830 2840 2850
TPFSLKGGVV LSNLLYILFF ISLICFILLW ALLPTYSVYK SDIHLPAYAS
2860 2870 2880 2890 2900
FKVIDNGVVR DISVNDLCFA NKFFQFDQWY ESTFGSFYYH NSMDCPIVVA
2910 2920 2930 2940 2950
VMDEDIGSTM FNVPTKVLRH GFHVLHFLTY AFASDSVQCY TPHIQISYND
2960 2970 2980 2990 3000
FYASGCVLSS LCTMFKRGDG TPHPYCYSDG VMKNASLYTS LVPHTRYSLA
3010 3020 3030 3040 3050
NSNGFIRFPD VISEGIVRIV RTRSMTYCRV GACEYAEEGI CFNFNSSWVL
3060 3070 3080 3090 3100
NNDYYRSMPG TFCGRDLFDL FYQFFSSLIR PIDFFSLTAS SIFGAILAIV
3110 3120 3130 3140 3150
VVLVFYYLIK LKRAFGDYTS VVVINVIVWC INFLMLFVFQ VYPICACVYA
3160 3170 3180 3190 3200
CFYFYVTLYF PSEISVIMHL QWIVMYGAIM PFWFCVTYVA MVIANHVLWL
3210 3220 3230 3240 3250
FSYCRKIGVN VCNDSTFEET SLTTFMITKD SYCRLKNSVS DVAYNRYLSL
3260 3270 3280 3290 3300
YNKYRYYSGK MDTAAYREAA CSQLAKAMET FNHNNGNDVL YQPPTASVST
3310 3320 3330 3340 3350
SFLQSGIVKM VSPTSKIEPC IVSVTYGSMT LNGLWLDDKV YCPRHVICLS
3360 3370 3380 3390 3400
SNMNEPDYSA LLCRVTLGDF TIMSGRMSLT VVSYQMQGCQ LVLTVSLQNP
3410 3420 3430 3440 3450
YTPKYTFGVV KPGETFTVLA AYNGRPQGAF HVTMRSSYTI KGSFLCGSCG
3460 3470 3480 3490 3500
SVGYVLTGDS VKFVYMHQLE LSTGCHTGTD FTGNFYGPYR DAQVVQLPVK
3510 3520 3530 3540 3550
DYVQTVNVIA WLYAAILNNC AWFVQNDVCS IEDFNVWAMT NGFSQVKADL
3560 3570 3580 3590 3600
VLDALASMTG VSIETLLAAI KRLYMGFQGR QILGSCTFED ELAPSDVYQQ
3610 3620 3630 3640 3650
LAGVKLQSKT KRFIKETIYW ILISTFLFSC IISAFVKWTI FMYINTHMIG
3660 3670 3680 3690 3700
VTLCVLCFVS FMMLLVKHKH FYLTMYIIPV LCTLFYVNYL VVYKEGFRGL
3710 3720 3730 3740 3750
TYVWLSYFVP AVNFTYVYEV FYGCILCVFA IFITMHSINH DIFSLMFLVG
3760 3770 3780 3790 3800
RIVTLISMWY FGSNLEEDVL LFITAFLGTY TWTTILSLAI AKIVANWLSV
3810 3820 3830 3840 3850
NIFYFTDVPY IKLILLSYLF IGYILSCYWG FFSLLNSVFR MPMGVYNYKI
3860 3870 3880 3890 3900
SVQELRYMNA NGLRPPRNSF EAILLNLKLL GIGGVPVIEV SQIQSKLTDV
3910 3920 3930 3940 3950
KCANVVLLNC LQHLHVASNS RLWQYCSILH NEILSTSDLS VAFDKLAQLL
3960 3970 3980 3990 4000
IVLFANPAAV DTKCLASIDE VSDDYVQDST VLQALQSEFV NMASFVEYEV
4010 4020 4030 4040 4050
AKKNLADAKN SGSVNQQQIK QLEKACNIAK SVYERDKAVA RKLERMADLA
4060 4070 4080 4090 4100
LTNMYKEARI NDKKSKVVSA LQTMLFSMVR KLDNQALNSI LDNAVKGCVP
4110 4120 4130 4140 4150
LNAIPALAAN TLTIIIPDKQ VFDKVVDNVY VAYAGSVWHI QTVQDADGIN
4160 4170 4180 4190 4200
KQLTDISVDS NWPLVIIANR YNEVANAVMQ NNELMPHKLK IQVVNSGSDM
4210 4220 4230 4240 4250
NCNIPTQCYY NNGSSGRIVY AVLSDVDGLK YTKIIKDDGN CVVLELDPPC
4260 4270 4280 4290 4300
KFSIQDVKGL KIKYLYFIKG CNTLARGWVV GTLSSTIRLQ AGVATEYAAN
4310 4320 4330 4340 4350
SSILSLCAFS VDPKKTYLDY IQQGGVPIIN CVKMLCDHAG TGMAITIKPE
4360 4370 4380 4390 4400
ATINQDSYGG ASVCIYCRAR VEHPDVDGLC KLRGKFVQVP LGIKDPILYV
4410 4420 4430 4440 4450
LTHDVCQVCG FWRDGSCSCV GSGVAVQSKD LNFLNRVRGT SVNARLVPCA
4460 4470 4480 4490 4500
SGLSTDVQLR AFDICNTNRA GIGLYYKVNC CRFQRIDDDG NKLDKFFVVK
4510 4520 4530 4540 4550
RTNLEVYNKE KTYYELTKSC GVVAEHDFFT FDIDGSRVPH IVRKNLSKYT
4560 4570 4580 4590 4600
MLDLCYALRH FDCNDCSVLC EILCEYADCK ESYFSKKDWY DFVENPDIIN
4610 4620 4630 4640 4650
IYKKLGPIFN RALLNTVSFA DTLVKVGLVG VLTLDNQDLY GQWYDFGDFI
4660 4670 4680 4690 4700
QTAPGFGVAV ADSYYSYMMP MLTMCHVLDC ELFVNDSYRQ FDLVQYDFTD
4710 4720 4730 4740 4750
YKLELFNKYF KYWGMKYHPN TVDCDNDRCI IHCANFNILF SMVLPNTCFG
4760 4770 4780 4790 4800
PLVRQIFVDG VPFVVSIGYH YKELGVVMNL DVDTHRYRLS LKDLLLYAAD
4810 4820 4830 4840 4850
PAMHVASASA LLDLRTCCFS VAAITSGIKF QTVKPGNFNQ DFYEFVKSKG
4860 4870 4880 4890 4900
LFKEGSTVDL KHFFFTQDGN AAITDYNYYK YNLPTMVDIK QLLFVLEVVY
4910 4920 4930 4940 4950
KYFEIYDGGC IPASQVIVNN YDKSAGYPFN KFGKARLYYE ALSFEEQNEI
4960 4970 4980 4990 5000
YAYTKRNVLP TLTQMNLKYA ISAKNRARTV AGVSILSTMT GRMFHQKCLK
5010 5020 5030 5040 5050
SIAATRGVPV VIGTTKFYGG WDDMLRHLIK DVDNPVLMGW DYPKCDRAMP
5060 5070 5080 5090 5100
NILRIVSSLV LARKHEFCCS HGDRFYRLAN ECAQVLSEIV MCGGCYYVKP
5110 5120 5130 5140 5150
GGTSSGDATT AFANSVFNIC QAVTANVCSL MACNGHKIED LSIRNLQKRL
5160 5170 5180 5190 5200
YSNVYRTDYV DYTFVNEYYE FLCKHFSMMI LSDDGVVCYN SDYASKGYIA
5210 5220 5230 5240 5250
NISVFQQVLY YQNNVFMSES KCWVENDITN GPHEFCSQHT MLVKIDGDYV
5260 5270 5280 5290 5300
YLPYPDPSRI LGAGCFVDDL LKTDSVLLIE RFVSLAIDAY PLVHHENEEY
5310 5320 5330 5340 5350
QKVFRVYLEY IKKLYNDLGN QILDSYSVIL STCDGLKFTD ESFYKNMYLK
5360 5370 5380 5390 5400
SAVMQSVGAC VVCSSQTSLR CGSCIRKPLL CCKCCYDHVM ATNHKYVLSV
5410 5420 5430 5440 5450
SPYVCNAPNC DVSDVTKLYL GGMSYYCENH KPHYSFKLVM NGMVFGLYKQ
5460 5470 5480 5490 5500
SCTGSPYIDD FNKIASCKWT EVDDYVLANE CIERLKLFAA ETQKATEEAF
5510 5520 5530 5540 5550
KQSYASATIQ EIVSDREIIL CWETGKVKPP LNKNYVFTGY HFTSTGKTVL
5560 5570 5580 5590 5600
GEYVFDKSEL TNGVYYRATT TYKLSIGDVF VLTSHSVANL SAPTLVPQEN
5610 5620 5630 5640 5650
YASIRFSSVY SVPLLFQTNV ANYQHIGMKR YCTVQGPPGT GKSHLAIGLA
5660 5670 5680 5690 5700
VYYYTARVVY TAASHAAVDA LCEKAYKFLN INDCTRIIPA KVRVDCYDKF
5710 5720 5730 5740 5750
KINDTTCKYV FTTINALPEL VTDIVVVDEV SMLTNYELSV INARVKAKHY
5760 5770 5780 5790 5800
VYIGDPAQLP APRVLLSKGS LEPRHFNSIT KIMCCLGPDI FLGNCYRCPK
5810 5820 5830 5840 5850
EIVETVSALV YDNKLKAKND NSSLCFKVYF KGQTTHESSS AVNIQQIYLI
5860 5870 5880 5890 5900
SKFLKANPVW NSAVFISPYN SQNYVAKRIL GVQTQTVDSA QGSEYDYVIY
5910 5920 5930 5940 5950
SQTAETAHSI NVNRFNVAIT RAKKGIFCVM SNMQLFESLN FITLPLDKIQ
5960 5970 5980 5990 6000
NQTLSRLHCT TNLFKDCSKN FLGYHPAHAP SFLSVDDKYK VNEDLAVCLN
6010 6020 6030 6040 6050
ICEPVLTYSR LISLMGFKLD LTLDGYSKFF ITKDEAIKRV RGWVGFDVEG
6060 6070 6080 6090 6100
AHATRDNIGT NFPLQIGFST GVDFVVEATG LFAERDCYIF KRTVAKAPPG
6110 6120 6130 6140 6150
DNFKHLIPLM SKGQKWDVVR IRIVQMLSDY LLDLSDSVVF ITWSASFELT
6160 6170 6180 6190 6200
CLRYFAKLGR ELNCDVCPNR ATCYNSRTGY YGCWRHSYTC DYVYNPLIVD
6210 6220 6230 6240 6250
IQQWGYTGSL TSNHDIICNV HKGAHVASSD AIMTRCLAIY DCFCKSVNWN
6260 6270 6280 6290 6300
LEYPIISNEV SINTSCRLLQ RVMLKAAMLC NRYNLCYDIG NPKGIACVKD
6310 6320 6330 6340 6350
YEFKFYDASP VVKSVKQLFY VYDVHKDNFK DGLCMFWNCN VDKYPSNSIV
6360 6370 6380 6390 6400
CRFDTRVLNK LNLPGCNGGS LYVNKHAFHT NPFTRTVFEN LKPMPFFYYS
6410 6420 6430 6440 6450
DTPCVYVDGL ESKQVDYVPL RSATCITRCN LGGAVCSKHA EDYCKYLESY
6460 6470 6480 6490 6500
NVATTAGFTF WVYKTFDFYN LWNTFTMLQS LENVIYNLVN AGHYDGRIGE
6510 6520 6530 6540 6550
LPCAIMNDKV VVKINNVDTV IFKNNTSLPT NIAVELFTKR SIRHHPELKI
6560 6570 6580 6590 6600
LRNLNIDICW KHVLWDYVKD SLFCSSTYGV CKYTDLNFIE NLNVLFDGRD
6610 6620 6630 6640 6650
NGALEAFRKA RNGVFISTGK LSSLSMIKGP QRADLNGVIV DKVGELNVEF
6660 6670 6680 6690 6700
WFAMRKDGDD VIFSRADSLS PSHYWSPQGN LGGNCAGNAS GNDALARFTI
6710 6720 6730 6740 6750
FTQSRVLSTF EPRSDLERDF IDMEDSLFIA KYGLEDYAFD HIVYGSFNYK
6760 6770 6780 6790 6800
VIGGLHLLIG LFRRLKKSNL VIQEFLQYDS SIHSYFITDQ ECGSSKSVCT
6810 6820 6830 6840 6850
VIDLLLDDFV VIVKSLNLNC VSKVVNINVD FKDFQFMLWC NDNKIMTFYP
6860 6870 6880 6890 6900
KMQATSDWKP GYSMPVLYKY LNVPLERVSL WNYGKAINLP TGCMMNVAKY
6910 6920 6930 6940 6950
TQLCQYLNTT TLAVPVNMRV LHLGAGSDKE VAPGSAVLRQ WLPSGSILVD
6960 6970 6980 6990 7000
NDLNPFVSDS LVTYFGDCMT LPFDCHWDLI ISDMYDPLTK NIGDYNVSKD
7010 7020 7030 7040 7050
GFFTYICYLI RDKLSLGGSV AIKITEFSWN ADLYKLMSYF AFWTVFCTNV
7060 7070 7080 7090 7100
NASSSEGFLI GINYLGKSCF EIDGNVMHAN YLFWRNSTTW NGGAYSLFDM
7110 7120 7130 7140 7150
SKFSLKLAGT AVVNLRPDQL NDLVYSLIER GKLLVRDTRK EIFVGDSLVN
TC
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY884001 Genomic RNA Translation: AAX76519.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY884001 Genomic RNA Translation: AAX76519.1 |
3D structure databases
SMRi | P0C6X3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P0C6X3 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_CVHN2 | |
Accessioni | P0C6X3Primary (citable) accession number: P0C6X3 Secondary accession number(s): Q14EB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |