UniProtKB - P0C6X1 (R1AB_CVH22)
Protein
Replicase polyprotein 1ab
Gene
rep
Organism
Human coronavirus 229E (HCoV-229E)
Status
Functioni
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).By similarity
Responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G).
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1054 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1205 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1701 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1863 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3006 | For 3CL-PRO activity | 1 | |
Active sitei | 3109 | For 3CL-PRO activity | 1 | |
Metal bindingi | 5000 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5003 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5011 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5014 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5021 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5024 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5028 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5034 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5045 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5050 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5067 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5070 | Zinc 3PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1126 – 1157 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1780 – 1815 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 4007 – 4023 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4049 – 4062 | By similarityAdd BLAST | 14 | |
Nucleotide bindingi | 5278 – 5285 | ATPCurated | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- endonuclease activity Source: UniProtKB-KW
- exonuclease activity Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of host autophagy Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host IRF3 activity Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral protein processing Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Enzyme and pathway databases
BRENDAi | 3.6.4.12, 8801 |
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abShort name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Alternative name(s): p9 Alternative name(s): p87 Alternative name(s): PL1-PRO/PL2-PRO PLP1/PLP2 Papain-like proteinases 1/2 p195 Alternative name(s): Peptide HD2 Alternative name(s): M-PRO nsp5 p34 Alternative name(s): p5 Alternative name(s): p23 Alternative name(s): p12 Alternative name(s): Growth factor-like peptide Short name: GFL p16 Alternative name(s): nsp12 p100 Alternative name(s): nsp13 p66 p66-HEL Alternative name(s): nsp14 Alternative name(s): NendoU nsp15 p41 Alternative name(s): nsp16 |
Gene namesi | Name:rep ORF Names:1a-1b |
Organismi | Human coronavirus 229E (HCoV-229E) |
Taxonomic identifieri | 11137 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Alphacoronavirus › Duvinacovirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- Host endoplasmic reticulum-Golgi intermediate compartment Curated Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1925 – 1945 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1998 – 2018 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2068 – 2088 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2095 – 2115 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2491 – 2511 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2731 – 2751 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2755 – 2775 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2782 – 2802 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2809 – 2829 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2834 – 2854 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3281 – 3301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3304 – 3324 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3328 – 3348 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3367 – 3387 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3401 – 3421 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3422 – 3442 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3467 – 3487 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1048 | K → E: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1054 | C → A, G or S: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1099 | G → A: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1099 | G → P: No effect. 1 Publication | 1 | |
Mutagenesisi | 1102 | G → A or S: No effect. 1 Publication | 1 | |
Mutagenesisi | 1126 | C → D or H: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1128 | C → A, D or P: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1154 | C → A, H or D: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1155 | Missing : Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1157 | C → A, D, H or P: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1163 | C → A or D: No effect. 1 Publication | 1 | |
Mutagenesisi | 1175 | V → H or P: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1175 | V → N or T: No effect. 1 Publication | 1 | |
Mutagenesisi | 1203 | C → A: Complete loss of PL1-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 1203 | C → D: No effect. 1 Publication | 1 | |
Mutagenesisi | 1218 | D → A, E, H, K, N or Q: No effect. 1 Publication | 1 | |
Mutagenesisi | 1702 | W → L: Complete loss of PL2-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3006 | H → G, S, T or Y: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3028 | H → G or T: No loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3029 | N → A, D, E or Q: Increase of 3CL-PRO activity. 2 Publications | 1 | |
Mutagenesisi | 3029 | N → G: No loss of 3CL-PRO activity. 2 Publications | 1 | |
Mutagenesisi | 3029 | N → P: 95% loss of 3CL-PRO activity. 2 Publications | 1 | |
Mutagenesisi | 3074 | E → H: No loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3099 | T → D: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3109 | C → P, S or V: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3127 | H → S: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3136 | H → A: 67% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3136 | H → S: 77% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3136 | H → T: 93% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3267 | Q → A: No loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 5284 | K → A: Almost complete loss of helicase activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000037293 | 1 – 111 | Non-structural protein 1Add BLAST | 111 | |
ChainiPRO_0000037294 | 112 – 897 | Non-structural protein 2Add BLAST | 786 | |
ChainiPRO_0000037295 | 898 – 2484 | Non-structural protein 3Add BLAST | 1587 | |
ChainiPRO_0000037296 | 2485 – 2965 | Non-structural protein 4Add BLAST | 481 | |
ChainiPRO_0000037297 | 2966 – 3267 | 3C-like proteinaseAdd BLAST | 302 | |
ChainiPRO_0000037298 | 3268 – 3546 | Non-structural protein 6Add BLAST | 279 | |
ChainiPRO_0000037299 | 3547 – 3629 | Non-structural protein 7Add BLAST | 83 | |
ChainiPRO_0000037300 | 3630 – 3824 | Non-structural protein 8Add BLAST | 195 | |
ChainiPRO_0000037301 | 3825 – 3933 | Non-structural protein 9Add BLAST | 109 | |
ChainiPRO_0000037302 | 3934 – 4068 | Non-structural protein 10Add BLAST | 135 | |
ChainiPRO_0000037303 | 4069 – 4995 | RNA-directed RNA polymeraseAdd BLAST | 927 | |
ChainiPRO_0000037304 | 4996 – 5592 | HelicaseAdd BLAST | 597 | |
ChainiPRO_0000037305 | 5593 – 6110 | ExoribonucleaseBy similarityAdd BLAST | 518 | |
ChainiPRO_0000037306 | 6111 – 6458 | Uridylate-specific endoribonucleaseBy similarityAdd BLAST | 348 | |
ChainiPRO_0000037307 | 6459 – 6758 | Putative 2'-O-methyl transferaseBy similarityAdd BLAST | 300 |
Post-translational modificationi
Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed.3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 111 – 112 | Cleavage; by PL1-PRO | 2 | |
Sitei | 897 – 898 | Cleavage; by PL1-PRO | 2 | |
Sitei | 2484 – 2485 | Cleavage; by PL2-PRO | 2 | |
Sitei | 2965 – 2966 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 3267 – 3268 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 3546 – 3547 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 3629 – 3630 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 3824 – 3825 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 3933 – 3934 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 4068 – 4069 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 4995 – 4996 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 5592 – 5593 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 6110 – 6111 | Cleavage; by 3CL-PRO | 2 | |
Sitei | 6458 – 6459 | Cleavage; by 3CL-PRO | 2 |
Proteomic databases
PRIDEi | P0C6X1 |
Interactioni
Subunit structurei
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
By similarityProtein-protein interaction databases
IntActi | P0C6X1, 1 interactor |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P0C6X1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0C6X1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1016 – 1268 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 253 | |
Domaini | 1269 – 1436 | MacroPROSITE-ProRule annotationAdd BLAST | 168 | |
Domaini | 1663 – 1914 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 2966 – 3267 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 302 | |
Domaini | 4675 – 4837 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 163 | |
Domaini | 4996 – 5079 | CV ZBDPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 5253 – 5434 | (+)RNA virus helicase ATP-bindingAdd BLAST | 182 | |
Domaini | 5435 – 5607 | (+)RNA virus helicase C-terminalAdd BLAST | 173 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1925 – 2115 | HD1Add BLAST | 191 | |
Regioni | 2491 – 2854 | HD2Add BLAST | 364 | |
Regioni | 3281 – 3487 | HD3Add BLAST | 207 |
Domaini
The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.
Sequence similaritiesi
Belongs to the coronaviruses polyprotein 1ab family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1126 – 1157 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1780 – 1815 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 4007 – 4023 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4049 – 4062 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketIsoform Replicase polyprotein 1ab (identifier: P0C6X1-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MACNRVTLAV ASDSEISANG CSTIAQAVRR YSEAASNGFR ACRFVSLDLQ
60 70 80 90 100
DCIVGIADDT YVMGLHGNQT LFCNIMKFSD RPFMLHGWLV FSNSNYLLEE
110 120 130 140 150
FDVVFGKRGG GNVTYTDQYL CGADGKPVMS EDLWQFVDHF GENEEIIING
160 170 180 190 200
HTYVCAWLTK RKPLDYKRQN NLAIEEIEYV HGDALHTLRN GSVLEMAKEV
210 220 230 240 250
KTSSKVVLSD ALDKLYKVFG SPVMTNGSNI LEAFTKPVFI SALVQCTCGT
260 270 280 290 300
KSWSVGDWTG FKSSCCNVIS NKLCVVPGNV KPGDAVITTQ QAGAGIKYFC
310 320 330 340 350
GMTLKFVANI EGVSVWRVIA LQSVDCFVAS STFVEEEHVN RMDTFCFNVR
360 370 380 390 400
NSVTDECRLA MLGAEMTSNV RRQVASGVID ISTGWFDVYD DIFAESKPWF
410 420 430 440 450
VRKAEDIFGP CWSALASALK QLKVTTGELV RFVKSICNSA VAVVGGTIQI
460 470 480 490 500
LASVPEKFLN AFDVFVTAIQ TVFDCAVETC TIAGKAFDKV FDYVLLDNAL
510 520 530 540 550
VKLVTTKLKG VRERGLNKVK YATVVVGSTE EVKSSRVERS TAVLTIANNY
560 570 580 590 600
SKLFDEGYTV VIGDVAYFVS DGYFRLMASP NSVLTTAVYK PLFAFNVNVM
610 620 630 640 650
GTRPEKFPTT VTCENLESAV LFVNDKITEF QLDYSIDVID NEIIVKPNIS
660 670 680 690 700
LCVPLYVRDY VDKWDDFCRQ YSNESWFEDD YRAFISVLDI TDAAVKAAES
710 720 730 740 750
KAFVDTIVPP CPSILKVIDG GKIWNGVIKN VNSVRDWLKS LKLNLTQQGL
760 770 780 790 800
LGTCAKRFKR WLGILLEAYN AFLDTVVSTV KIGGLTFKTY AFDKPYIVIR
810 820 830 840 850
DIVCKVENKT EAEWIELFPH NDRIKSFSTF ESAYMPIADP THFDIEEVEL
860 870 880 890 900
LDAEFVEPGC GGILAVIDEH VFYKKDGVYY PSNGTNILPV AFTKAAGGKV
910 920 930 940 950
SFSDDVEVKD IEPVYRVKLC FEFEDEKLVD VCEKAIGKKI KHEGDWDSFC
960 970 980 990 1000
KTIQSALSVV SCYVNLPTYY IYDEEGGNDL SLPVMISEWP LSVQQAQQEA
1010 1020 1030 1040 1050
TLPDIAEDVV DQVEEVNSIF DIETVDVKHD VSPFEMPFEE LNGLKILKQL
1060 1070 1080 1090 1100
DNNCWVNSVM LQIQLTGILD GDYAMQFFKM GRVAKMIERC YTAEQCIRGA
1110 1120 1130 1140 1150
MGDVGLCMYR LLKDLHTGFM VMDYKCSCTS GRLEESGAVL FCTPTKKAFP
1160 1170 1180 1190 1200
YGTCLNCNAP RMCTIRQLQG TIIFVQQKPE PVNPVSFVVK PVCSSIFRGA
1210 1220 1230 1240 1250
VSCGHYQTNI YSQNLCVDGF GVNKIQPWTN DALNTICIKD ADYNAKVEIS
1260 1270 1280 1290 1300
VTPIKNTVDT TPKEEFVVKE KLNAFLVHDN VAFYQGDVDT VVNGVDFDFI
1310 1320 1330 1340 1350
VNAANENLAH GGGLAKALDV YTKGKLQRLS KEHIGLAGKV KVGTGVMVEC
1360 1370 1380 1390 1400
DSLRIFNVVG PRKGKHERDL LIKAYNTINN EQGTPLTPIL SCGIFGIKLE
1410 1420 1430 1440 1450
TSLEVLLDVC NTKEVKVFVY TDTEVCKVKD FVSGLVNVQK VEQPKIEPKP
1460 1470 1480 1490 1500
VSVIKVAPKP YRVDGKFSYF TEDLLCVADD KPIVLFTDSM LTLDDRGLAL
1510 1520 1530 1540 1550
DNALSGVLSA AIKDCVDINK AIPSGNLIKF DIGSVVVYMC VVPSEKDKHL
1560 1570 1580 1590 1600
DNNVQRCTRK LNRLMCDIVC TIPADYILPL VLSSLTCNVS FVGELKAAEA
1610 1620 1630 1640 1650
KVITIKVTED GVNVHDVTVT TDKSFEQQVG VIADKDKDLS GAVPSDLNTS
1660 1670 1680 1690 1700
ELLTKAIDVD WVEFYGFKDA VTFATVDHSA FAYESAVVNG IRVLKTSDNN
1710 1720 1730 1740 1750
CWVNAVCIAL QYSKPHFISQ GLDAAWNKFV LGDVEIFVAF VYYVARLMKG
1760 1770 1780 1790 1800
DKGDAEDTLT KLSKYLANEA QVQLEHYSSC VECDAKFKNS VASINSAIVC
1810 1820 1830 1840 1850
ASVKRDGVQV GYCVHGIKYY SRVRSVRGRA IIVSVEQLEP CAQSRLLSGV
1860 1870 1880 1890 1900
AYTAFSGPVD KGHYTVYDTA KKSMYDGDRF VKHDLSLLSV TSVVMVGGYV
1910 1920 1930 1940 1950
APVNTVKPKP VINQLDEKAQ KFFDFGDFLI HNFVIFFTWL LSMFTLCKTA
1960 1970 1980 1990 2000
VTTGDVKIMA KAPQRTGVVL KRSLKYNLKA SAAVLKSKWW LLAKFTKLLL
2010 2020 2030 2040 2050
LIYTLYSVVL LCVRFGPFNF CSETVNGYAK SNFVKDDYCD GSLGCKMCLF
2060 2070 2080 2090 2100
GYQELSQFSH LDVVWKHITD PLFSNMQPFI VMVLLLIFGD NYLRCFLLYF
2110 2120 2130 2140 2150
VAQMISTVGV FLGYKETNWF LHFIPFDVIC DELLVTVIVI KVISFVRHVL
2160 2170 2180 2190 2200
FGCENPDCIA CSKSARLKRF PVNTIVNGVQ RSFYVNANGG SKFCKKHRFF
2210 2220 2230 2240 2250
CVDCDSYGYG STFITPEVSR ELGNITKTNV QPTGPAYVMI DKVEFENGFY
2260 2270 2280 2290 2300
RLYSCETFWR YNFDITESKY SCKEVFKNCN VLDDFIVFNN NGTNVTQVKN
2310 2320 2330 2340 2350
ASVYFSQLLC RPIKLVDSEL LSTLSVDFNG VLHKAYIDVL RNSFGKDLNA
2360 2370 2380 2390 2400
NMSLAECKRA LGLSISDHEF TSAISNAHRC DVLLSDLSFN NFVSSYAKPE
2410 2420 2430 2440 2450
EKLSAYDLAC CMRAGAKVVN ANVLTKDQTP IVWHAKDFNS LSAEGRKYIV
2460 2470 2480 2490 2500
KTSKAKGLTF LLTINENQAV TQIPATSIVA KQGAGDAGHS LTWLWLLCGL
2510 2520 2530 2540 2550
VCLIQFYLCF FMPYFMYDIV SSFEGYDFKY IENGQLKNFE APLKCVRNVF
2560 2570 2580 2590 2600
ENFEDWHYAK FGFTPLNKQS CPIVVGVSEI VNTVAGIPSN VYLVGKTLIF
2610 2620 2630 2640 2650
TLQAAFGNAG VCYDIFGVTT PEKCIFTSAC TRLEGLGGNN VYCYNTALME
2660 2670 2680 2690 2700
GSLPYSSIQA NAYYKYDNGN FIKLPEVIAQ GFGFRTVRTI ATKYCRVGEC
2710 2720 2730 2740 2750
VESNAGVCFG FDKWFVNDGR VANGYVCGTG LWNLVFNILS MFSSSFSVAA
2760 2770 2780 2790 2800
MSGQILLNCA LGAFAIFCCF LVTKFRRMFG DLSVGVCTVV VAVLLNNVSY
2810 2820 2830 2840 2850
IVTQNLVTMI AYAILYFFAT RSLRYAWIWC AAYLIAYISF APWWLCAWYF
2860 2870 2880 2890 2900
LAMLTGLLPS LLKLKVSTNL FEGDKFVGTF ESAAAGTFVI DMRSYEKLAN
2910 2920 2930 2940 2950
SISPEKLKSY AASYNRYKYY SGNANEADYR CACYAYLAKA MLDFSRDHND
2960 2970 2980 2990 3000
ILYTPPTVSY GSTLQAGLRK MAQPSGFVEK CVVRVCYGNT VLNGLWLGDI
3010 3020 3030 3040 3050
VYCPRHVIAS NTTSAIDYDH EYSIMRLHNF SIISGTAFLG VVGATMHGVT
3060 3070 3080 3090 3100
LKIKVSQTNM HTPRHSFRTL KSGEGFNILA CYDGCAQGVF GVNMRTNWTI
3110 3120 3130 3140 3150
RGSFINGACG SPGYNLKNGE VEFVYMHQIE LGSGSHVGSS FDGVMYGGFE
3160 3170 3180 3190 3200
DQPNLQVESA NQMLTVNVVA FLYAAILNGC TWWLKGEKLF VEHYNEWAQA
3210 3220 3230 3240 3250
NGFTAMNGED AFSILAAKTG VCVERLLHAI QVLNNGFGGK QILGYSSLND
3260 3270 3280 3290 3300
EFSINEVVKQ MFGVNLQSGK TTSMFKSISL FAGFFVMFWA ELFVYTTTIW
3310 3320 3330 3340 3350
VNPGFLTPFM ILLVALSLCL TFVVKHKVLF LQVFLLPSII VAAIQNCAWD
3360 3370 3380 3390 3400
YHVTKVLAEK FDYNVSVMQM DIQGFVNIFI CLFVALLHTW RFAKERCTHW
3410 3420 3430 3440 3450
CTYLFSLIAV LYTALYSYDY VSLLVMLLCA ISNEWYIGAI IFRICRFGVA
3460 3470 3480 3490 3500
FLPVEYVSYF DGVKTVLLFY MLLGFVSCMY YGLLYWINRF CKCTLGVYDF
3510 3520 3530 3540 3550
CVSPAEFKYM VANGLNAPNG PFDALFLSFK LMGIGGPRTI KVSTVQSKLT
3560 3570 3580 3590 3600
DLKCTNVVLM GILSNMNIAS NSKEWAYCVE MHNKINLCDD PETAQELLLA
3610 3620 3630 3640 3650
LLAFFLSKHS DFGLGDLVDS YFENDSILQS VASSFVGMPS FVAYETARQE
3660 3670 3680 3690 3700
YENAVANGSS PQIIKQLKKA MNVAKAEFDR ESSVQKKINR MAEQAAAAMY
3710 3720 3730 3740 3750
KEARAVNRKS KVVSAMHSLL FGMLRRLDMS SVDTILNMAR NGVVPLSVIP
3760 3770 3780 3790 3800
ATSAARLVVV VPDHDSFVKM MVDGFVHYAG VVWTLQEVKD NDGKNVHLKD
3810 3820 3830 3840 3850
VTKENQEILV WPLILTCERV VKLQNNEIMP GKMKVKATKG EGDGGITSEG
3860 3870 3880 3890 3900
NALYNNEGGR AFMYAYVTTK PGMKYVKWEH DSGVVTVELE PPCRFVIDTP
3910 3920 3930 3940 3950
TGPQIKYLYF VKNLNNLRRG AVLGYIGATV RLQAGKQTEF VSNSHLLTHC
3960 3970 3980 3990 4000
SFAVDPAAAY LDAVKQGAKP VGNCVKMLTN GSGSGQAITC TIDSNTTQDT
4010 4020 4030 4040 4050
YGGASVCIYC RAHVAHPTMD GFCQYKGKWV QVPIGTNDPI RFCLENTVCK
4060 4070 4080 4090 4100
VCGCWLNHGC TCDRTAIQSF DNSYLNRVRG SSAARLEPCN GTDIDYCVRA
4110 4120 4130 4140 4150
FDVYNKDASF IGKNLKSNCV RFKNVDKDDA FYIVKRCIKS VMDHEQSMYN
4160 4170 4180 4190 4200
LLKGCNAVAK HDFFTWHEGR TIYGNVSRQD LTKYTMMDLC FALRNFDEKD
4210 4220 4230 4240 4250
CEVFKEILVL TGCCSTDYFE MKNWFDPIEN EDIHRVYAAL GKVVANAMLK
4260 4270 4280 4290 4300
CVAFCDEMVL KGVVGVLTLD NQDLNGNFYD FGDFVLCPPG MGIPYCTSYY
4310 4320 4330 4340 4350
SYMMPVMGMT NCLASECFMK SDIFGQDFKT FDLLKYDFTE HKEVLFNKYF
4360 4370 4380 4390 4400
KYWGQDYHPD CVDCHDEMCI LHCSNFNTLF ATTIPNTAFG PLCRKVFIDG
4410 4420 4430 4440 4450
VPVVATAGYH FKQLGLVWNK DVNTHSTRLT ITELLQFVTD PTLIVASSPA
4460 4470 4480 4490 4500
LVDKRTVCFS VAALSTGLTS QTVKPGHFNK EFYDFLRSQG FFDEGSELTL
4510 4520 4530 4540 4550
KHFFFTQKGD AAIKDFDYYR YNRPTMLDIG QARVAYQVAA RYFDCYEGGC
4560 4570 4580 4590 4600
ITSREVVVTN LNKSAGWPLN KFGKAGLYYE SISYEEQDAI FSLTKRNILP
4610 4620 4630 4640 4650
TMTQLNLKYA ISGKERARTV GGVSLLATMT TRQFHQKCLK SIVATRNATV
4660 4670 4680 4690 4700
VIGTTKFYGG WDNMLKNLMA DVDDPKLMGW DYPKCDRAMP SMIRMLSAMI
4710 4720 4730 4740 4750
LGSKHVTCCT ASDKFYRLSN ELAQVLTEVV YSNGGFYFKP GGTTSGDATT
4760 4770 4780 4790 4800
AYANSVFNIF QAVSSNINCV LSVNSSNCNN FNVKKLQRQL YDNCYRNSNV
4810 4820 4830 4840 4850
DESFVDDFYG YLQKHFSMMI LSDDSVVCYN KTYAGLGYIA DISAFKATLY
4860 4870 4880 4890 4900
YQNGVFMSTA KCWTEEDLSI GPHEFCSQHT MQIVDENGKY YLPYPDPSRI
4910 4920 4930 4940 4950
ISAGVFVDDI TKTDAVILLE RYVSLAIDAY PLSKHPKPEY RKVFYALLDW
4960 4970 4980 4990 5000
VKHLNKTLNE GVLESFSVTL LDEHESKFWD ESFYASMYEK STVLQAAGLC
5010 5020 5030 5040 5050
VVCGSQTVLR CGDCLRRPML CTKCAYDHVF GTDHKFILAI TPYVCNTSGC
5060 5070 5080 5090 5100
NVNDVTKLYL GGLNYYCVDH KPHLSFPLCS AGNVFGLYKS SALGSMDIDV
5110 5120 5130 5140 5150
FNKLSTSDWS DIRDYKLAND AKESLRLFAA ETVKAKEESV KSSYAYATLK
5160 5170 5180 5190 5200
EIVGPKELLL LWESGKAKPP LNRNSVFTCF QITKDSKFQV GEFVFEKVDY
5210 5220 5230 5240 5250
GSDTVTYKST ATTKLVPGML FILTSHNVAP LRAPTMANQE KYSTIYKLHP
5260 5270 5280 5290 5300
SFNVSDAYAN LVPYYQLIGK QRITTIQGPP GSGKSHCSIG IGVYYPGARI
5310 5320 5330 5340 5350
VFTACSHAAV DSLCAKAVTA YSVDKCTRII PARARVECYS GFKPNNNSAQ
5360 5370 5380 5390 5400
YVFSTVNALP EVNADIVVVD EVSMCTNYDL SVINQRISYK HIVYVGDPQQ
5410 5420 5430 5440 5450
LPAPRVLISK GVMEPIDYNV VTQRMCAIGP DVFLHKCYRC PAEIVNTVSE
5460 5470 5480 5490 5500
LVYENKFVPV KEASKQCFKI FERGSVQVDN GSSINRRQLD VVKRFIHKNS
5510 5520 5530 5540 5550
TWSKAVFISP YNSQNYVAAR LLGLQTQTVD SAQGSEYDYV IFAQTSDTAH
5560 5570 5580 5590 5600
ACNANRFNVA ITRAKKGIFC IMSDRTLFDA LKFFEITMTD LQSESSCGLF
5610 5620 5630 5640 5650
KDCARNPIDL PPSHATTYLS LSDRFKTSGD LAVQIGNNNV CTYEHVISYM
5660 5670 5680 5690 5700
GFRFDVSMPG SHSLFCTRDF AMRHVRGWLG MDVEGAHVTG DNVGTNVPLQ
5710 5720 5730 5740 5750
VGFSNGVDFV AQPEGCVLTN TGSVVKPVRA RAPPGEQFTH IVPLLRKGQP
5760 5770 5780 5790 5800
WSVLRKRIVQ MIADFLAGSS DVLVFVLWAG GLELTTMRYF VKIGAVKHCQ
5810 5820 5830 5840 5850
CGTVATCYNS VSNDYCCFKH ALGCDYVYNP YVIDIQQWGY VGSLSTNHHA
5860 5870 5880 5890 5900
ICNVHRNEHV ASGDAIMTRC LAVYDCFVKN VDWSITYPMI ANENAINKGG
5910 5920 5930 5940 5950
RTVQSHIMRA AIKLYNPKAI HDIGNPKGIR CAVTDAKWYC YDKNPINSNV
5960 5970 5980 5990 6000
KTLEYDYMTH GQMDGLCLFW NCNVDMYPEF SIVCRFDTRT RSTLNLEGVN
6010 6020 6030 6040 6050
GGSLYVNNHA FHTPAYDKRA MAKLKPAPFF YYDDGSCEVV HDQVNYVPLR
6060 6070 6080 6090 6100
ATNCITKCNI GGAVCSKHAN LYRAYVESYN IFTQAGFNIW VPTTFDCYNL
6110 6120 6130 6140 6150
WQTFTEVNLQ GLENIAFNVV NKGSFVGADG ELPVAISGDK VFVRDGNTDN
6160 6170 6180 6190 6200
LVFVNKTSLP TNIAFELFAK RKVGLTPPLS ILKNLGVVAT YKFVLWDYEA
6210 6220 6230 6240 6250
ERPLTSFTKS VCGYTDFAED VCTCYDNSIQ GSYERFTLST NAVLFSATAV
6260 6270 6280 6290 6300
KTGGKSLPAI KLNFGMLNGN AIATVKSEDG NIKNINWFVY VRKDGKPVDH
6310 6320 6330 6340 6350
YDGFYTQGRN LQDFLPRSTM EEDFLNMDIG VFIQKYGLED FNFEHVVYGD
6360 6370 6380 6390 6400
VSKTTLGGLH LLISQVRLSK MGILKAEEFV AASDITLKCC TVTYLNDPSS
6410 6420 6430 6440 6450
KTVCTYMDLL LDDFVSVLKS LDLTVVSKVH EVIIDNKPWR WMLWCKDNAV
6460 6470 6480 6490 6500
ATFYPQLQSA EWKCGYSMPG IYKTQRMCLE PCNLYNYGAG LKLPSGIMFN
6510 6520 6530 6540 6550
VVKYTQLCQY FNSTTLCVPH NMRVLHLGAG SDYGVAPGTA VLKRWLPHDA
6560 6570 6580 6590 6600
IVVDNDVVDY VSDADFSVTG DCATVYLEDK FDLLISDMYD GRTKAIDGEN
6610 6620 6630 6640 6650
VSKEGFFTYI NGFICEKLAI GGSIAIKVTE YSWNKKLYEL VQRFSFWTMF
6660 6670 6680 6690 6700
CTSVNTSSSE AFVVGINYLG DFAQGPFIDG NIIHANYVFW RNSTVMSLSY
6710 6720 6730 6740 6750
NSVLDLSKFN CKHKATVVVQ LKDSDINEMV LSLVRSGKLL VRGNGKCLSF
SNHLVSTK
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Isoform Replicase polyprotein 1a (identifier: P0C6U2-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6U2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1982 | A → Q Ref (PubMed:11369870).Curated | 1 | |
Sequence conflicti | 1982 | A → Q 1 (PubMed:11369870).Curated | 1 | |
Sequence conflicti | 4042 | F → S Ref (PubMed:11369870).Curated | 1 | |
Sequence conflicti | 4042 | F → S 1 (PubMed:11369870).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF304460 Genomic RNA Translation: AAG48591.1 |
PIRi | S28600 |
RefSeqi | NP_073549.1, NC_002645.1 [P0C6X1-1] |
Genome annotation databases
GeneIDi | 918764 |
KEGGi | vg:918764 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Proteic grace - Issue 77 of December 2006 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF304460 Genomic RNA Translation: AAG48591.1 |
PIRi | S28600 |
RefSeqi | NP_073549.1, NC_002645.1 [P0C6X1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1P9S | X-ray | 2.54 | A/B | 2966-3265 | [»] | |
2J97 | X-ray | 1.75 | A | 3825-3933 | [»] | |
2J98 | X-ray | 1.80 | A/B | 3825-3933 | [»] | |
3EJG | X-ray | 1.78 | A | 1270-1434 | [»] | |
4RS4 | X-ray | 2.96 | A/B/C/D/E/F | 6111-6458 | [»] | |
4S1T | X-ray | 2.50 | A/B/C/D/E/F | 6111-6458 | [»] | |
SMRi | P0C6X1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P0C6X1, 1 interactor |
Proteomic databases
PRIDEi | P0C6X1 |
Genome annotation databases
GeneIDi | 918764 |
KEGGi | vg:918764 |
Enzyme and pathway databases
BRENDAi | 3.6.4.12, 8801 |
Miscellaneous databases
EvolutionaryTracei | P0C6X1 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_CVH22 | |
Accessioni | P0C6X1Primary (citable) accession number: P0C6X1 Secondary accession number(s): Q05002, Q9DLN0, Q9DLN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries