UniProtKB - P0C6W9 (R1AB_CVBM)
Replicase polyprotein 1ab
rep
Functioni
Catalytic activityi
- TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1074 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1225 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1671 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1828 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3287 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3391 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 5302 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5305 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5313 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5316 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5323 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5326 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5330 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5336 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5347 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5352 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5369 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5372 | Zinc 3PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1151 – 1179 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1749 – 1785 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4306 – 4322 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4348 – 4361 | By similarityAdd BLAST | 14 | |
Nucleotide bindingi | 5578 – 5585 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- endonuclease activity Source: UniProtKB-KW
- exonuclease activity Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- single-stranded RNA binding Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of catabolism of host mRNA Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host ISG15 activity Source: UniProtKB-KW
- suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral protein processing Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abShort name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Alternative name(s): p28 Alternative name(s): p65 Alternative name(s): Non-structural protein 3 Short name: nsp3 p210 Alternative name(s): Peptide HD2 p44 Alternative name(s): M-PRO nsp5 p27 Alternative name(s): p10 Alternative name(s): p22 Alternative name(s): p12 Alternative name(s): Growth factor-like peptide Short name: GFL p15 Alternative name(s): nsp12 p100 Alternative name(s): nsp13 p67 Alternative name(s): nsp14 Alternative name(s): NendoU nsp15 p35 Alternative name(s): nsp16 |
Gene namesi | Name:rep ORF Names:1a-1b |
Organismi | Bovine coronavirus (strain Mebus) (BCoV) (BCV) |
Taxonomic identifieri | 11132 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
Subcellular locationi
- Host membrane ; Multi-pass membrane protein
- Host cytoplasm Note: Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- Host endoplasmic reticulum-Golgi intermediate compartment Curated Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2138 – 2158 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2199 – 2219 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2221 – 2241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2313 – 2333 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2343 – 2363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2365 – 2385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2752 – 2772 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3031 – 3051 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3063 – 3083 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3090 – 3110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3115 – 3135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3558 – 3578 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3588 – 3608 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3615 – 3635 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3657 – 3677 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3684 – 3704 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3711 – 3731 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3755 – 3775 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000037259 | 1 – 246 | Host translation inhibitor nsp1By similarityAdd BLAST | 246 | |
ChainiPRO_0000037260 | 247 – 851 | Non-structural protein 2By similarityAdd BLAST | 605 | |
ChainiPRO_0000037261 | 852 – 2750 | Papain-like proteinaseBy similarityAdd BLAST | 1899 | |
ChainiPRO_0000037262 | 2751 – 3246 | Non-structural protein 4By similarityAdd BLAST | 496 | |
ChainiPRO_0000037263 | 3247 – 3549 | 3C-like proteinaseBy similarityAdd BLAST | 303 | |
ChainiPRO_0000037264 | 3550 – 3836 | Non-structural protein 6By similarityAdd BLAST | 287 | |
ChainiPRO_0000037265 | 3837 – 3925 | Non-structural protein 7By similarityAdd BLAST | 89 | |
ChainiPRO_0000037266 | 3926 – 4122 | Non-structural protein 8By similarityAdd BLAST | 197 | |
ChainiPRO_0000037267 | 4123 – 4232 | Non-structural protein 9By similarityAdd BLAST | 110 | |
ChainiPRO_0000037268 | 4233 – 4369 | Non-structural protein 10By similarityAdd BLAST | 137 | |
ChainiPRO_0000037269 | 4370 – 5297 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 928 | |
ChainiPRO_0000037270 | 5298 – 5900 | HelicaseBy similarityAdd BLAST | 603 | |
ChainiPRO_0000037271 | 5901 – 6421 | Guanine-N7 methyltransferaseBy similarityAdd BLAST | 521 | |
ChainiPRO_0000037272 | 6422 – 6795 | Uridylate-specific endoribonucleaseBy similarityAdd BLAST | 374 | |
ChainiPRO_0000037273 | 6796 – 7094 | 2'-O-methyltransferaseBy similarityAdd BLAST | 299 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 246 – 247 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 851 – 852 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 2750 – 2751 | Cleavage; by PL2-PROBy similarity | 2 | |
Sitei | 3246 – 3247 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3549 – 3550 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3836 – 3837 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3925 – 3926 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4122 – 4123 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4232 – 4233 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4369 – 4370 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5297 – 5298 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5900 – 5901 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6421 – 6422 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6795 – 6796 | Cleavage; by 3CL-PROBy similarity | 2 |
Interactioni
Subunit structurei
Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1036 – 1274 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 239 | |
Domaini | 1275 – 1435 | MacroPROSITE-ProRule annotationAdd BLAST | 161 | |
Domaini | 1631 – 1892 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 3247 – 3549 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 303 | |
Domaini | 4977 – 5139 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 163 | |
Domaini | 5298 – 5381 | CV ZBDPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 5553 – 5734 | (+)RNA virus helicase ATP-bindingAdd BLAST | 182 | |
Domaini | 5735 – 5904 | (+)RNA virus helicase C-terminalAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2138 – 2385 | HD1Add BLAST | 248 | |
Regioni | 2752 – 3135 | HD2Add BLAST | 384 | |
Regioni | 3558 – 3775 | HD3Add BLAST | 218 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1151 – 1179 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 1749 – 1785 | C4-type 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Zinc fingeri | 4306 – 4322 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4348 – 4361 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKINKYGLE LHWAPEFPWM FEDAEEKLDN PSSSEVDIVC STTAQKLETG
60 70 80 90 100
GICPENHVMV DCRRLLKQEC CVQSSLIREI VMNTRPYDLE VLLQDALQSR
110 120 130 140 150
EAVLVTPPLG MSLEACYVRG CNPNGWTMGL FRRRSVCNTG RCAVNKHVAY
160 170 180 190 200
QLYMIDPAGV CFGAGQFVGW VIPLAFMPVQ SRKFIVPWVM YLRKCGEKGA
210 220 230 240 250
YNKDHKRGGF EHVYNFKVED AYDLVHDEPK GKFSKKAYAL IRGYRGVKPL
260 270 280 290 300
LYVDQYGCDY TGGLADGLEA YADKTLQEMK ALFPIWSQEL PFDVTVAWHV
310 320 330 340 350
VRDPRYVMRL QSASTIRSVA YVANPTEDLC DGSVVIKEPV HVYADDSIIL
360 370 380 390 400
RQHNLVDIMS CFYMEADAVV NAFYGVDLKD CGFVMQFGYI DCEQDLCDFK
410 420 430 440 450
GWVPGNMIDG FACTTCGHVY ETGDLLAQSS GVLPVNPVLH TKSAAGYGGF
460 470 480 490 500
GCKDSFTLYG QTVVYFGGCV YWSPARNIWI PILKSSVKSY DGLVYTGVVG
510 520 530 540 550
CKAIVKETNL ICKALYLDYV QHKCGNLHQR ELLGVSDVWH KQLLLNRGVY
560 570 580 590 600
KPLLENIDYF NMRRAKFSLE TFTVCADGFM PFLLDDLVPR AYYLAVSGQA
610 620 630 640 650
FCDYAGKICH AVVSKSKELL DVSLDSLGAA IHYLNSKIVD LAQHFSDFGT
660 670 680 690 700
SFVSKIVHFF KTFTTSTALA FAWVLFHVLH GAYIVVESDI YFVKNIPRYA
710 720 730 740 750
SAVAQAFRSV AKVVLDSLRV TFIDGLSCFK IGRRRICLSG SKIYEVERGL
760 770 780 790 800
LHSSQLPLDV YDLTMPSQVQ KTKQKPIYLK GSGSDFSLAD SVVEVVTTSL
810 820 830 840 850
TPCGYSEPPK VADKICIVDN VYMAKAGDKY YPVVVDGHVG LLDQAWRVPC
860 870 880 890 900
AGRCVTFKEQ PTVNEIASTP KTIKVFYELD KDFNTILNTA CGVFEVDDTV
910 920 930 940 950
DMEEFYAVVI DAIEEKLSPC KELEGVGAKV SAFLQKLEDN SLFLFDEAGE
960 970 980 990 1000
EVLAPKLYCA FTAPEDDDFL EESGVEEDDV EGEETDLTVT SAGEPCVASE
1010 1020 1030 1040 1050
QEESSEILED TLDDGPCVET SDSQVEEDVQ MSDFVDLESV IQDYENVCFE
1060 1070 1080 1090 1100
FYTTEPEFVK VLDLYVPKAT RNNCWLRSVL AVMQKLPCQF KDKNLQDLWV
1110 1120 1130 1140 1150
LYKQQYSQLF VDTLVNKIPA NIVVPQGGYV ADFAYWFLTL CDWQCVAYWK
1160 1170 1180 1190 1200
CIKCDLALKL KGLDAMFFYG DVVSHVCKCG ESMVLIDVDV PFTAHFALKD
1210 1220 1230 1240 1250
KLFCAFITKR SVYKAACVVD VNDSHSMAVV DGKQIDDHRI TSITSDKFDF
1260 1270 1280 1290 1300
IIGHGMSFSM TTFEIAQLYG SCITPNVCFV KGDIIKVSKR VKAEVVVNPA
1310 1320 1330 1340 1350
NGHMAHGGGV AKAIAVAAGQ QFVKETTDMV KSKGVCATGD CYVSTGGKLC
1360 1370 1380 1390 1400
KTVLNVVGPD ARTQGKQSYA LLERVYKHLN KYDCVVTTLI SAGIFSVPSD
1410 1420 1430 1440 1450
VSLTYLLGTA KKQVVLVSNN QEDFDLISKC QITAVEGTKK LAERLSFNVG
1460 1470 1480 1490 1500
RSIVYETDAN KLILSNDVAF VSTFNVLQDV LSLRHDIALD DDARTFVQSN
1510 1520 1530 1540 1550
VDVVPEGWRV VNKFYQINGV RTVKYFECPG GIDICSQDKV FGYVQQGSFN
1560 1570 1580 1590 1600
KATVAQIKAL FLDKVDILLT VDGVNFTNRF VPVGESFGKS LGNVFCDGVN
1610 1620 1630 1640 1650
VTKHKCDINY KGKVFFQFDN LSSEDLKAVR SSFNFDQKEL LAYYNMLVNC
1660 1670 1680 1690 1700
SKWQVVFNGK YFTFKQANNN CFVNVSCLML QSLNLKFKIV QWQEAWLEFR
1710 1720 1730 1740 1750
SGRPARFVSL VLAKGGFKFG DPADSRDFLR VVFSQVDLTG AICDFEIACK
1760 1770 1780 1790 1800
CGVKQEQRTG VDAVMHFGTL SREDLEIGYT VDCSCGKKLI HCVRFDVPFL
1810 1820 1830 1840 1850
ICSNTPASVK LPKGVGSANI FKGDKVGHYV HVKCEQSYQL YDASNVKKVT
1860 1870 1880 1890 1900
DVTGNLSDCL YLKNLKQTFK SVLTTYYLDD VKKIEYKPDL SQYYCDGGKY
1910 1920 1930 1940 1950
YTQRIIKAQF KTFEKVDGVY TNFKLIGHTV CDILNAKLGF DSSKEFVEYK
1960 1970 1980 1990 2000
VTEWPTATGD VVLATDDLYV KRYERGCITF GKPVIWLSHE QASLNSLTYF
2010 2020 2030 2040 2050
NRPLLVDENK FDVLKVDDVD DGGDISESDA KEPKEINIIK LSGVKKPFKV
2060 2070 2080 2090 2100
EDSVIVNDDT SEIKYVKSLS IVDVYDMWLT GCRCVVRTAN ALSRAVNVPT
2110 2120 2130 2140 2150
IRKFIKFGMT LVSIPIDLLN LREIKPVFNV VKAVRNKISA CFNFIKWLFV
2160 2170 2180 2190 2200
LLFGWIKISA DNKVIYTTEV ASKLTCKLVA LAFKNAFLTF KWSVVARGAC
2210 2220 2230 2240 2250
IIATIFLLWF NFIYANVIFS DFYLPKIGFL PTFVGKIAQW IKNTFSLVTI
2260 2270 2280 2290 2300
CDLYSIQDVG FKNQYCNGSI ACQFCLAGFD MLDNYKAIDV VQYEADRRAF
2310 2320 2330 2340 2350
VDYTGVLKIV IELIVSYALY TAWFYPLFAL ISIQILTTWL PELFMLSTLH
2360 2370 2380 2390 2400
WSVRLLVSLA NMLPAHVFMR FYIIIASFIK LFSLFRHVAY GCSKSGCLFC
2410 2420 2430 2440 2450
YKRNRSLRVK CSTIVGGMIR YYDAMANGGT GFCSKHQWNC IDCDSYKPGN
2460 2470 2480 2490 2500
TFITVEAALD LSKELKRPIQ PTDVAYHTVT DVKQVGCYMR LFYDRDGQRT
2510 2520 2530 2540 2550
YDDVNASLFV DYSNLLHSKV KSVPNMHVVV VENDADKANF LNAAVFYAQS
2560 2570 2580 2590 2600
LFRPILMVDK NLITTANTGT SVTETMFDVY VDTFLSMFDV DKKSLNALIA
2610 2620 2630 2640 2650
TAHSSIKQGT QICKVLDTFL SCARKSCSID SDVDTKCLAD SVMSAVSAGL
2660 2670 2680 2690 2700
ELTDESCNNL VPTYLKGDNI VAADLGVLIQ NSAKHVQGNV AKIAGVSCIW
2710 2720 2730 2740 2750
SVDAFNQLSS DFQHKLKKAC CKTGLKLKLT YNKQMANVSV LTTPFSLKGG
2760 2770 2780 2790 2800
AVFSYFVYVC FVLSLVCFIG LWCLMPTYTV HKSDFQLPVY ASYKVLDNGV
2810 2820 2830 2840 2850
IRDVSVEDVC FANKFEQFDQ WYESTFGLSY YSNSMACPIV VAVVDQDFGS
2860 2870 2880 2890 2900
TVFNVPTKVL RYGYHVLHFI THALSADGVQ CYTPHSQISY SNFYASGCVL
2910 2920 2930 2940 2950
SSACTMFAMA DGSPQPYCYT DGLMQNASLY SSLVPHVRYN LANAKGFIRF
2960 2970 2980 2990 3000
PEVLREGLVR IVRTRSMPYC RVGLCEEADE GICFNFNGSW VLNNDYYRSL
3010 3020 3030 3040 3050
PGTFCGRDVF DLIYQLFKGL AQPVDFLALT ASSIAGAILA VIVVLVFYYL
3060 3070 3080 3090 3100
IKLKRAFGDY TSIVFVNVIV WCVNFMMLFV FQVYPTLSCV YAICYFYATL
3110 3120 3130 3140 3150
YFPSEISVIM HLQWLVMYGT IMPLWFCLLY ISVVVSNHAF WVFSYCRQLG
3160 3170 3180 3190 3200
TSVRSDGTFE EMALTTFMIT KDSYCKLKNS LSDVAFNRYL SLYNKYRYYS
3210 3220 3230 3240 3250
GKMDTAAYRE AACSQLAKAM DTFTNNNGSD VLYQPPTASV STSFLQSGIV
3260 3270 3280 3290 3300
KMVNPTSKVE PCIVSVTYGN MTLNGLWLGD KVYCPRHVIC SASDMTNPDY
3310 3320 3330 3340 3350
TNLLCRVTSS DFTVLFDRLS LTVMSYQMQG CMLVLTVTLQ NSRTPKYTFG
3360 3370 3380 3390 3400
VVKPGETFTV LAAYNGKPQG AFHVTMRSSY TIKGSFLCGS CGSVVYVIMG
3410 3420 3430 3440 3450
DCVKFVYMHQ LELSTGCHTG TDFNGDFYGP YKDAQVVQLP VQDYIQSVNF
3460 3470 3480 3490 3500
VAWLYAAILN NCNWFVQSDK CSVEDFNVWA LSNGFSQVKS DLVIDALASM
3510 3520 3530 3540 3550
TGVSLETLLA AIKHLKNGFQ GRQIMGSCSF EDELTPSDVY QQLAGIKLQS
3560 3570 3580 3590 3600
KRTRLVKGIV CWIMASTFLF SCIITAFVKW TMFMYVTTNM LSITFCALCV
3610 3620 3630 3640 3650
ISLTMLLVKH KHLYLTMYII PVLFTLLYNN YLVVYKQTFR GYVYAWLSYY
3660 3670 3680 3690 3700
VPSVEYTYTD EVIYGMLLLI GMVFVTLRSI NQYLFSFIMF VGRVISVVSL
3710 3720 3730 3740 3750
WYMGSNLEEE ILLMLASLFG TYTWTTALSM AAAKVIAKWV AVNVLYFTDI
3760 3770 3780 3790 3800
PQIKIVLVCY LFIGYIISCY WGLFSLMNSL FRMPLGVYNY KISVQELRYM
3810 3820 3830 3840 3850
NANGLRPPKN SFEALMLNFK LLGIGGVPII EVSQFQSKLT DVKCANVVLL
3860 3870 3880 3890 3900
NCLQHLHVAS NSKLWQYCST LHNEILATSD LGVAFEKLAQ LLIVLFANPA
3910 3920 3930 3940 3950
AVDSKCLTSI EEVCDDYAKD NTVLQALQSE FVNMASFVEY EVAKKNLDEA
3960 3970 3980 3990 4000
CSSGSANQQQ LKQLEKACNI AKSAYERDRA VARKLERMAD LALTNMYKEA
4010 4020 4030 4040 4050
RINDKKSKVV SALQTMLFSM VRKLDNQALN SILDNAVKGC VPLNAIPSLA
4060 4070 4080 4090 4100
ANTLTIIVPD KSVYDQVVDN VYVTYAGNVW QIQTIQDSDG TNKQLHEISD
4110 4120 4130 4140 4150
DCNWPLVIIA NRHNEVSATA LQNNELMPAK LKTQVVNSGP DQTCNTPTQC
4160 4170 4180 4190 4200
YYNNSYNGKI VYAILSDVDG LKYTKILKDD GNFVVLELDP PCKFTVQDVK
4210 4220 4230 4240 4250
GLKIKYLYFV KGCNTLARGW VVGTISSTVR LQAGTATEYA SNSSILSLCA
4260 4270 4280 4290 4300
FSVDPKKTYL DFIQQGGTPI ANCVKMLCDH AGTGMAITVK PDATTSQDSY
4310 4320 4330 4340 4350
GGASVCIYCR ARVEHPDVDG LCKLRGKFVQ VPVGIKDPVS YVLTHDVCQV
4360 4370 4380 4390 4400
CGFWRDGSCS CVSTDTTVQS KDTNFLNRVR GTSVDARLVP CASGLSTDVQ
4410 4420 4430 4440 4450
LRAFDICNAS VAGIGLHLKV NCCRFQRVDE NGDKLDQFFV VKRTDLTIYN
4460 4470 4480 4490 4500
REMECYERVK DCKFVAEHDF FTFDVEGSRV PHIVRKDLTK YTMLDLCYAL
4510 4520 4530 4540 4550
RHFDRNDCML LCDILSIYAG CEQSYFTKKD WYDFVENPDI INVYKKLGPI
4560 4570 4580 4590 4600
FNRALVSATE FADKLVEVGL VGILTLDNQD LNGKWYDFGD YVIAAPGCGV
4610 4620 4630 4640 4650
AIADSYYSYM MPMLTMCHAL DCELYVNNAY RLFDLVQYDF TDYKLELFNK
4660 4670 4680 4690 4700
YFKHWSMPYH PNTVDCQDDR CIIRCANFNI LFSMVLPNTC FGPLVRQIFV
4710 4720 4730 4740 4750
DGVPFVVSIG YHYKELGIVM NMDVDTHRYR LSLKDLLLYA ADPALHVASA
4760 4770 4780 4790 4800
SALYDLRTCC FSVAAITSGV KFQTVKPGNF NQDFYDFILS KGLLKEGSSV
4810 4820 4830 4840 4850
DLKHFFFTQD GNAAITDYNY YKYNLPTMVD IKQLLFVLEV VYKYFEIYDG
4860 4870 4880 4890 4900
GCIPASQVIV NNYDKSAGYP FNKFGKARLY YEALSFEEQD EIYAYTKRNV
4910 4920 4930 4940 4950
LPTLTQMNLK YAISAKNRAR TVAGVSILST MTGRMFHQKC LKSIAATRGV
4960 4970 4980 4990 5000
PVVIGTTKFY GGWDDMLRRL IKDVDNPVLM GWDYPKCDRA MPNILRIVSS
5010 5020 5030 5040 5050
LVLARKHEAC CSQSDRFYRL ANEYAQVLSE IVMCGGCYYV KPGGTSSGDA
5060 5070 5080 5090 5100
TTAFANSVFN ICQAVSANVC ALMSCNGNKI EDLSIRALQK RLYSHVYRSD
5110 5120 5130 5140 5150
MVDSTFVTEY YEFLNKHFSM MILSDDGVVC YNSDYASKGY IANISAFQQV
5160 5170 5180 5190 5200
LYYQNNVFMS ESKCWVENDI NNGPHEFCSQ HTMLVKMDGD DVYLPYPDPS
5210 5220 5230 5240 5250
RILGAGCFVD DLLKTDSVLL IERFVSLAID AYPLVYHENE EYQKVFRVYL
5260 5270 5280 5290 5300
EYIKKLYNEL GNQILDSYSV ILSTCDGQKF TDESFYKNMY LRSAVMQSVG
5310 5320 5330 5340 5350
ACVVCSSQTS LRCGSCIRKP LLCCKCCYDH VMATDHKYVL SVSPYVCNAP
5360 5370 5380 5390 5400
GCDVNDVTKL YLGGMSYYCE DHKPQYSFKL VMNGMVFGLY KQSCTGSPYI
5410 5420 5430 5440 5450
DDFNRIASCK WTDVDDYILA NECTERLKLF AAETQKATEE AFKQSYASAT
5460 5470 5480 5490 5500
IQEIVSEREL ILSWEIGKVK PPLNKNYVFT GYHFTKNGKT VLGEYVFDKS
5510 5520 5530 5540 5550
ELTNGVYYRA TTTYKLSVGD VFVLTSHSVA NLSAPTLVPQ ENYSSIRFAS
5560 5570 5580 5590 5600
VYSVLETFQN NVVNYQHIGM KRYCTVQGPP GTGKSHLAIG LAVYYCTARV
5610 5620 5630 5640 5650
VYTAASHAAV DALCEKAYKF LNINDCTRIV PAKVRVECYD KFKINDTTRK
5660 5670 5680 5690 5700
YVFTTINALP EMVTDIVVVD EVSMLTNYEL SVINARIRAK HYVYIGDPAQ
5710 5720 5730 5740 5750
LPAPRVLLSK GTLEPKYFNT VTKLMCCLGP DIFLGTCYRC PKEIVDTVSA
5760 5770 5780 5790 5800
LVYENKLKAK NESSSLCFKV YYKGVTTHES SSAVNMQQIY LINKFLKANP
5810 5820 5830 5840 5850
LWHKAVFISP YNSQNFAARR VLGLQTQTVD SAQGSEYDYV IYSQTAETAH
5860 5870 5880 5890 5900
SVNVNRFNVA ITRAKKGILC VMSNMQLFEA LQFTTLTVDK VPQAVETRVQ
5910 5920 5930 5940 5950
CSTNLFKDCS KSYSGYHPAH APSFLAVDDK YKATGDLAVC LGIGDSAVTY
5960 5970 5980 5990 6000
SRLTSLMGFK LDVTLDGYCK LFITKEEAVK RVRAWVGFDA EGAHATRDSI
6010 6020 6030 6040 6050
GTNFPLQLGF STGIDFVVEA TGLFADRDGY SFKKAVAKAP PGEQFKHLIP
6060 6070 6080 6090 6100
LMTRGQRWDV VRPRIVQMFA DHLIDLSDCV VLVTWAANFE LTCLRYFAKV
6110 6120 6130 6140 6150
GREISCNVCT KRATAYNSRT GYYGCWRHSV TCDYLYNPLI VDIQQWGYIG
6160 6170 6180 6190 6200
SLSSNHDLYC SVHKGAHVAS SDAIMTRCLA VYDCFCNNIN WNVEYPIISN
6210 6220 6230 6240 6250
ELSINTSCRV LQRVMLKAAM LCNRYTLCYD IGNPKAIACV KDFDFKFYDA
6260 6270 6280 6290 6300
QPIVKSVKTL LYFFEAHKDS FKDGLCMFWN CNVDKYPPNA VVCRFDTRVL
6310 6320 6330 6340 6350
NNLNLPGCNG GSLYVNKHAF HTKPFSRAAF EHLKPMPFFY YSDTPCVYMD
6360 6370 6380 6390 6400
GMDAKQVDYV PLKSATCITR CNLVGAVCLK HAEEYREYLN SYNTATTAGF
6410 6420 6430 6440 6450
TFWVYKTFDF YNLWNTFTKL QSLENVVYNL VKTGHYTGQA GEMPCAIIND
6460 6470 6480 6490 6500
KVVAKIDKED VVIFINNTTY PTNVAVELFA KRSIRHHPEL KLFRNLNIDV
6510 6520 6530 6540 6550
CWKHVIWDYA RESIFCSNTY GVCMYTDLKF IDKLNVLFDG RDNGALEAFK
6560 6570 6580 6590 6600
RSNNGVYIST TKVKSLSMIR GPPRAELNGV VVDKVGDTDC VFYFAVRKEG
6610 6620 6630 6640 6650
QDVIFSQFDS LRVSSNQSPQ GNLGSNEPGN VGGNDALATS TIFTQSRVIS
6660 6670 6680 6690 6700
SFTCRTDMEK DFIALDQDVF IQKYGLEDYA FEHIVYGNFN QKIIGGLHLL
6710 6720 6730 6740 6750
IGLYRRQQTS NLVIQEFVSY DSSIHSYFIT DEKSGGSKSV CTVIDILLDD
6760 6770 6780 6790 6800
FVALVKSLNL NCVSKVVNVN VDFKDFQFML WCNDEKVMTF YLRLQAASDW
6810 6820 6830 6840 6850
KPGYSMPVLY KYLNSPMERV SLWNYGKPVT LPTGCMMNVA KYTQLCQYLN
6860 6870 6880 6890 6900
TTTLAVPVNM RVLHLGAGSE KGVAPGSAVL RQWLPAGTIL VDNDLYPFVS
6910 6920 6930 6940 6950
DSVATYFGDC ITLPFDCQWD LIISDMYDPI TKNIGEYNVS KDGFFTYICH
6960 6970 6980 6990 7000
MIRDKLALGG SVAIKITEFS WNAELYKLMG YFAFWTVFCT NANASSSEGF
7010 7020 7030 7040 7050
LIGINYLGKP KVEIDGNVMH ANYLFWRNST VWNGGAYSLF DMAKFPLKLA
7060 7070 7080 7090
GTAVINLRAD QINDMVYSLL EKGKLLVRDT NKEVFVGDSM VNVI
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5024 | Y → C in AAD32989 (PubMed:10392726).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00735 Genomic RNA Translation: AAA64744.2 AF124985 Genomic RNA Translation: AAD32989.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00735 Genomic RNA Translation: AAA64744.2 AF124985 Genomic RNA Translation: AAD32989.1 |
3D structure databases
SMRi | P0C6W9 |
ModBasei | Search... |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR022570, B-CoV_NSP1 IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032592, NSP3_NAR_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR002705, Pept_C30/C16_B_coronavir IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16251, bCoV_NAR, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF11963, DUF3477, 1 hit PF01661, Macro, 1 hit PF01831, Peptidase_C16, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_CVBM | |
Accessioni | P0C6W9Primary (citable) accession number: P0C6W9 Secondary accession number(s): Q66198, Q9WQ81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |