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UniProtKB - P0C6W5 (R1AB_BCHK9)

>sp|P0C6W5|R1AB_BCHK9 Replicase polyprotein 1ab OS=Bat coronavirus HKU9 OX=694006 GN=rep PE=1 SV=1
MEGVPDPPKLKSMVVTTLKWCDPFANPNVTGWDIPIEEALEYAKQQLRTPEPQLVFVPYY
LSHAPGISGDRVVITDSIWYATNFGWQPIRELAMDKDGVRYGRGGTHGVLLPMQDPSFIM
GDIDIQIRKYGIGANSPPDVLPLWDGFSDPGPDVGPYLDFPDNCCPTKPKAKRGGDVYLS
DQYGFDNNGILVEPVMKLLGVIKSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRK
AVPVLKQSIFTVVGVTEQLVPGYYYPFSTSSVVEHTKPTRGGPVGKTVEAVMLSLYGTNN
YNPATPVARLKCSYCDYYGWTPLKDIGTVNCLCGAEFQLTSSCVDAESAGVIKPGCVMLL
DKSPGMRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIVAGEHSGAVGSGDTVAIN
KELVEYLIEGIRVDADTLDNPTCATFIANLDCDTKAPVVHTVESLQGLCLANKIMLGDKP
LPTDEFHPFIVGLAYHVQRACWYGALASRTFEAFRDFVRTEEERFAQFFGKVCAPINGCV
YLAYTTGRVTLFSAYQVLNTAIAKSKDAFGGVAAIVVDMLKPILEWVLKKMSIAKGAWLP
YAEGLLALFKAQFTVVKGKFQFLRASLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALY
TGTYYYFSRKGVLTEVQLCAKRLGLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGV
LEEVFGASDVKLVKGTLVSLASKLFVRTEDGFLYRYVKSGGVLGKAFRLRGGGVSKVTFG
DEEVHTIPNTVTVNFSYDVCEGLDAILDKVMAPFQVEEGTKLEDLACVVQKAVYERLSDL
FSDCPAELRPINLEDFLTSECFVYSKDYEKILMPEMYFSLEDAVPVDDEMVDDIEDTVEQ
ASDSDDQWLGDEGAEDCDNTIQDVDVATSMTTPCGYTKIAEHVYIKCADIVQEARNYSYA
VLVNAANVNLHHGGGVAGALNRATNNAMQKESSEYIKANGSLQPGGHVLLSSHGLASHGI
LHVVGPDKRLGQDLALLDAVYAAYTGFDSVLTPLVSAGIFGFTVEESLCSLVKNVACTTY
VVVYDRQLYERALATSFDVPGPQSSVQHVPAIDWAEAVEVQESIVDQVETPSLGAVDTVD
SNADSGLNETARSPENVVGSVPDDVVADVESCVRDLVRQVVKKVKRDKRPPPIVPQQTVE
QQPQEISSPGDCNTVLVDVVSMSFSAMVNFGKEKGLLIPVVIDYPAFLKVLKRFSPKEGL
FSSNGYEFYGYSRDKPLHEVSKDLNSLGRPLIMIPFGFIVNGQTLAVSAVSMRGLTVPHT
VVVPSESSVPLYRAYFNGVFSGDTTAVQDFVVDILLNGARDWDVLQTTCTVDRKVYKTIC
KRGNTYLCFDDTNLYAITGDVVLKFATVSKARAYLETKLCAPEPLIKVLTTVDGINYSTV
LVSTAQSYRAQIGTVFCDGHDWSNKNPMPTDEGTHLYKQDNFSSAEVTAIREYYGVDDSN
IIARAMSIRKTVQTWPYTVVDGRVLLAQRDSNCYLNVAISLLQDIDVSFSTPWVCRAYDA
LKGGNPLPMAEVLIALGKATPGVSDDAHMVLSAVLNHGTVTARRVMQTVCEHCGVSQMVF
TGTDACTFYGSVVLDDLYAPVSVVCQCGRPAIRYVSEQKSPWLLMSCTPTQVPLDTSGIW
KTAIVFRGPVTAGHYMYAVNGTLISVYDANTRRRTSDLKLPATDILYGPTSFTSDSKVET
YYLDGVKRTTIDPDFSKYVKRGDYYFTTAPIEVVAAPKLVTSYDGFYLSSCQNPQLAESF
NKAINATKTGPMKLLTMYPNVAGDVVAISDDNVVAHPYGSLHMGKPVLFVTRPNTWKKLV
PLLSTVVVNTPNTYDVLAVDPLPVNNETSEEPISVKAPIPLYGLKATMVLNGTTYVPGNK
GHLLCLKEFTLTDLQTFYVEGVQPFVLLKASHLSKVLGLRVSDSSLHVNHLSKGVVYAYA
ATRLTTRVTTSLLGGLVTRSVRKTADFVRSTNPGSKCVGLLCLFYQLFMRFWLLVKKPPI
VKVSGIIAYNTGCGVTTCVLNYLRSRCGNISWSRLLKLLRYMLYIWFVWTCLTICGVWLS
EPYAPSLVTRFKYFLGIVMPCDYVLVNETGTGWLHHLCMAGMDSLDYPALRMQQHRYGSP
YNYTYILMLLEAFFAYLLYTPALPIVGILAVLHLIVLYLPIPLGNSWLVVFLYYIIRLVP
FTSMLRMYIVIAFLWLCYKGFLHVRYGCNNVACLMCYKKNVAKRIECSTVVNGVKRMFYV
NANGGTHFCTKHNWNCVSCDTYTVDSTFICRQVALDLSAQFKRPIIHTDEAYYEVTSVEV
RNGYVYCYFESDGQRSYERFPMDAFTNVSKLHYSELKGAAPAFNVLVFDATNRIEENAVK
TAAIYYAQLACKPILLVDKRMVGVVGDDATIARAMFEAYAQNYLLKYSIAMDKVKHLYST
ALQQISSGMTVESVLKVFVGSTRAEAKDLESDVDTNDLVSCIRLCHQEGWEWTTDSWNNL
VPTYIKQDTLSTLEVGQFMTANAKYVNANIAKGAAVNLIWRYADFIKLSESMRRQLKVAA
RKTGLNLLVTTSSLKADVPCMVTPFKIIGGHRRIVSWRRVLIHVFMLLVVLNPQWFTPWY
IMRPIEYNVVDFKVIDNAVIRDITSADQCFANKFSAFENWYSNRYGSYVNSRGCPMVVGV
VSDIVGSLVPGLPARFLRVGTTLLPLVNYGLGAVGSVCYTPHYAINYDVFDTSACVLAAT
CTLFSSASGERMPYCADAALIQNASRYDMLKPHVMYPFYEHSGYIRFPEVISAGVHIVRT
MAMEYCKVGRCDVSEAGLCMSLQPRWVVNNAYFRQQSGVYCGTSAFDLFMNMLLPIFTPV
GAVDITTSILMGALLAVVVSMSLYYLLRFRRAFGDYSGVIFTNILAFVLNVIVLCLEGPY
PMLPSIYAMVFLYATCYFGSDIACMMHVSFLIMFAGVVPLWVTVLYIVVVLSRHILWFAS
LCTKRTVQVGDLAFHSFQDAALQTFMLDKEVFLRLKREISSDAYFKYLAMYNKYKYYSGP
MDTAAYREAACSHLVMALEKYSNGGGDTIYQPPRCSVASAALQAGLTRMAHPSGLVEPCL
VKVNYGSMTLNGIWLDNFVICPRHVMCSRDELANPDYPRLSMRAANYDFHVSQNGHNIRV
IGHTMEGSLLKLTVDVNNPKTPAYSFIRVSTGQAMSLLACYDGLPTGVYTCTLRSNGTMR
ASFLCGSCGSPGFVMNGKEVQFCYLHQLELPNGTHTGTDFSGVFYGPFEDKQVPQLAAPD
CTITVNVLAWLYAAVLSGENWFLTKSSISPAEFNNCAVKYMCQSVTSESLQVLQPLAAKT
GISVERMLSALKVLLSAGFCGRTIMGSCSLEDEHTPYDIGRQMLGVKLQGKFQSMFRWTL
QWFAIIFVLTILILLQLAQWTFVGALPFTLLLPLIGFVAVCVGFVSLLIKHKHTYLTVYL
LPVAMVTAYYNFQYTPEGVQGYLLSLYNYVNPGRIDVIGTDLLTMLIISVACTLLSVRMV
RTDAYSRIWYVCTAVGWLYNCWTGSADTVAISYLTFMVSVFTNYTGVACASLYAAQFMVW
VLKFLDPTILLLYGRFRCVLVCYLLVGYLCTCYFGVFNLINRLFRCTLGNYEYVVSSQEL
RYMNSHGLLPPTNSWQALMLNIKLAGIGGIPIYRVSTIQSNMTDLKCTSVVLLSVLQQLR
VESSSKLWALCVKLHNEILASNSPTEAFEAFVSLLSVLLSLPGAINLDELCSSILENNSV
LQAVASEFSNLSSYVDYENAQKAYDTAVATGAPASTVNALKKAMNVAKSVLDKDVATTRK
LERMSELAMTAMYKQARAEDRRSKVTAAMQTMLFNMIRRLDSDALSNILNNARNGVVPLG
VIPRTAANKLLLVVPDFSVYTATITMPTLTYAGSAWDVMQVADADGKTVNATDITRENSV
NLAWPLVVTAQRQQATSPVKLQNNELMPQTVKRMNVVAGVSQTACVTDAVAYYNATKEGR
HVMAILADTDGLAFAKVEKSTGDGFVILELEPPCKFMVDTPKGPALKYLYFTKGLKNLCR
GTVLGTLACTVRLHAGSATEVASNSSILSLCSFSVDPEATYKDYLDNGGSPIGNCVKMLT
PHTGTGLAITAKPDANIDQESFGGASCCLYCRCHIEHPGASGVCKYKGKFVQIPLVGVND
PIGFCIRNVVCAVCNMWQGYGCPCSSLREINLQARDECFLNRVRGTSGVARLVPLGSGVQ
PDIVLRAFDICNTKVAGFGLHLKNNCCRYQELDADGTQLDSYFVVKRHTESNYLLEQRCY
EKLKDCGVVARHDFFKFNIEGVMTPHVSRERLTKYTMADLVYSLRHFDNNNCDTLKEILV
LRGCCTADYFDRKDWYDPVENPDIIRVYHNLGETVRKAVLSAVKMADSMVEQGLIGVLTL
DNQDLNGQWYDFGDFIEGPAGAGVAVMDTYYSLAMPVYTMTNMLAAECHVDGDFSKPKRV
WDICKYDYTQFKYSLFSKYFKYWDMQYHPNCVACADDRCILHCANFNILFSMVLPNTSFG
PLVQKIYVDGVPFVVSTGYHYRELGVVMNQDIRQHAQRLSLRELLVYAADPAMHVAASNA
LADKRTVCMSVAAMTTGVTFQTVKPGQFNEDFYNFAVKCGFFKEGSTISFKHFFYAQDGN
AAISDYDYYRYNLPTMCDIKQLLFSLEVVDKYFDCYDGGCLQASQVVVANYDKSAGFPFN
KFGKARLYYESLSYADQDELFAYTKRNVLPTITQMNLKYAISAKNRARTVAGVSIASTMT
NRQFHQKMLKSIAAARGASVVIGTTKFYGGWNRMLRTLCEGVENPHLMGWDYPKCDRAMP
NLLRIFASLILARKHATCCNASERFYRLANECAQVLSEMVLCGGGFYVKPGGTSSGDSTT
AYANSVFNICQAVSANLNTFLSIDGNKIYTTYVQELQRRLYLGIYRSNTVDNELVLDYYN
YLRKHFSMMILSDDGVVCYNADYAQKGYVADIQGFKELLYFQNNVFMSESKCWVEPDITK
GPHEFCSQHTMLVDMKGEQVYLPYPDPSRILGAGCFVDDLLKTDGTLMMERYVSLAIDAY
PLTKHPDPEYQNVFWCYLQYIKKLHEELTGHLLDTYSVMLASDNASKYWEVEFYENMYME
SATLQSVGTCVVCNSQTSLRCGGCIRRPFLCCKCCYDHVVSTTHKLVLSVTPYVCNNPSC
DVADVTQLYLGGMSYYCRDHRPPISFPLCANGQVFGLYKNICTGSPDVADFNSLATCDWS
NSKDYVLANTATERLKLFAAETLRATEENAKQAYASAVVKEVLSDRELVLSWETGKTRPP
LNRNYVFTGFHITKNSKVQLGEYIFEKGDYGDVVNYRSSTTYKLQVGDYFVLTSHSVQPL
SSPTLLPQERYTKLVGLYPAMNVPESFASNVVHYQRVGMSRYTTVQGPPGTGKSHLSIGL
ALYYPSAKIVYTACSHAAVDALCEKAHKNLPINRCSRIVPAKARVECFSKFKVNDVGAQY
VFSTINALPETTADILVVDEVSMCTNYDLSMINARVRAKHIVYVGDPAQLPAPRTLLTKG
TLAPEHFNSVCRLMVAVGPDIFLATCYRCPKEIVDTVSALVYDKKLKANKVTTGECYKCY
YKGSVTHDSSSAINKPQLGLVKEFLIKNPKWQSAVFISPYNSQNSVARRMLGLQTQTVDS
SQGSEFDYVIYCQTSDTAHALNVNRFNVAITRAKKGILCVMSDSTLYESLEFTPLDVNDY
VKPKMQSEVTVGLFKDCAKAEPLGPAYAPTFVSVNDKFKLNESLCVHFDTTELQMPYNRL
ISKMGFKFDLNIPGYSKLFITREQAIREVRGWVGFDVEGAHACGPNIGTNLPLQIGFSTG
VNFVVTPSGYIDTESGSRLANVVSKAPPGDQFKHLIPLMRKGEPWSVVRKRIVEMLCDTL
DGVSDTVTFVTWAHGFELTTLHYFAKVGPERKCFMCPRRATLFSSVYGAYSCWSHHRHIG
GADFVYNPFLVDVQQWGYVGNLQVNHDNVCDVHKGAHVASCDAIMTRCLAIHDCFCGEVN
WDVEYPIIANELAINRACRSVQRVVLKAAVKALHIETIYDIGNPKAIKVYGVNVNNWNFY
DTNPVVEGVKQLHYVYDVHRDQFKDGLAMFWNCNVDCYPHNALVCRFDTRVLSKLNLAGC
NGGSLYVNQHAFHTDAFNKNAFVNLKPLPFFYYSDTACENATGVSTNYVSEVDYVPLKSN
VCITRCNLGGAVCKKHADEYRNFLESYNTMVSAGFTLWVDKTFDVFNLWSTFVKLQSLEN
VAYNVLKSGHFTAVAGELPVAILNDRLYIKEDGADKLLFTNNTCLPTNVAFELWAKRSVN
VVPEVKLLRNLGVTCTYNLVIWDYESNAPLVPNTVGICTYTDLTKLDDQVVLVDGRQLDA
YSKFCQLKNAIYFSPSKPKCVCTRGPTHASINGVVVEAPDRGTAFWYAMRKDGAFVQPTD
GYFTQSRTVDDFQPRTQLEIDFLDLEQSCFLDKYDLHDLGLEHIVYGQFDGTIGGLHLLI
GAVRRKRTAHLVMETVLGTDTVTSYAVIDQPTASSKQVCSVVDIILDDFIALIKAQDRSV
VSKVVQCCLDFKVFRFMLWCKGGKISTFYPQLQAKQDWKPGYSMPALYKVQNAVLEPCLL
HNYGQAARLPSGTLMNVAKYTQLCQYLNTCSLAVPAKMRVMHFGAGSDKGVCPGTAVLKQ
WLPADAYLVDNDLCYCASDADSTYVGSCETFFSVNKWDFIFSDMYDARTKNTSGDNTSKE
GFFTYLTGFIRSKLALGGSIAIKITEHSWSADLYAIMGHFNWWTCFCTSVNSSSSEAFLI
GVNYIGVGALLDGWQMHANYVFWRNSTVMQLSSYSLYDLQRFPLRLKGTPVMSLKEDQLN
ELVLNLIRAGRLIVRDAVDIGVRGVACSGV

Entry version 96 (23 Feb 2022)
Sequence version 1 (10 Jun 2008)
Previous versions | rss

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Protein

Replicase polyprotein 1ab

Gene

rep

Organism

Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.

By similarity

Host translation inhibitor nsp1:

Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

By similarity1 Publication

Non-structural protein 2:

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

By similarity

Papain-like proteinase:

Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.

By similarity

Non-structural protein 4:

Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.

By similarity

3C-like proteinase:

Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).

PROSITE-ProRule annotationBy similarity

Non-structural protein 6:

Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.

By similarity

Non-structural protein 7:

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

Non-structural protein 8:

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

By similarity

Non-structural protein 9:

May participate in viral replication by acting as a ssRNA-binding protein.

By similarity

Non-structural protein 10:

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

By similarity

RNA-directed RNA polymerase:

Responsible for replication and transcription of the viral RNA genome.

By similarity

Helicase:

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.

By similarity

Guanine-N7 methyltransferase:

Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.

By similarity

Uridylate-specific endoribonuclease:

Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (By similarity).

Acts by degrading the 5'-polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs. Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (By similarity).

If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (By similarity).

By similarity

2'-O-methyltransferase:

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

By similarity

Catalytic activityⁱ

Papain-like proteinase:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Cofactorⁱ

Uridylate-specific endoribonuclease:

Mn²⁺By similarityNote: Likely affects Nsp15 binding to RNA.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	1533	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	1694	For PL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3144	For 3CL-PRO activityPROSITE-ProRule annotation	1
Active siteⁱ	3248	For 3CL-PRO activityPROSITE-ProRule annotation	1
Metal bindingⁱ	4168	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	4171	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	4177	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	4184	Zinc 1PROSITE-ProRule annotation	1
Metal bindingⁱ	4211	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	4214	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	4222	Zinc 2PROSITE-ProRule annotation	1
Metal bindingⁱ	4224	Zinc 2PROSITE-ProRule annotation	1
Active siteⁱ	4992	PROSITE-ProRule annotation	1
Active siteⁱ	4993	PROSITE-ProRule annotation	1
Active siteⁱ	4994	PROSITE-ProRule annotation	1
Metal bindingⁱ	5170	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5173	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5181	Zinc 4PROSITE-ProRule annotation	1
Metal bindingⁱ	5184	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5191	Zinc 3PROSITE-ProRule annotation	1
Metal bindingⁱ	5194	Zinc 4PROSITE-ProRule annotation	1
Metal bindingⁱ	5198	Zinc 4PROSITE-ProRule annotation	1
Metal bindingⁱ	5204	Zinc 4PROSITE-ProRule annotation	1
Metal bindingⁱ	5215	Zinc 5PROSITE-ProRule annotation	1
Metal bindingⁱ	5220	Zinc 5PROSITE-ProRule annotation	1
Metal bindingⁱ	5237	Zinc 5PROSITE-ProRule annotation	1
Metal bindingⁱ	5240	Zinc 5PROSITE-ProRule annotation	1
Active siteⁱ	5856	PROSITE-ProRule annotation	1
Active siteⁱ	5858	PROSITE-ProRule annotation	1
Active siteⁱ	5957	PROSITE-ProRule annotation	1
Metal bindingⁱ	5973	Zinc 6PROSITE-ProRule annotation	1
Metal bindingⁱ	5976	Zinc 6PROSITE-ProRule annotation	1
Metal bindingⁱ	5992	Zinc 6PROSITE-ProRule annotation	1
Metal bindingⁱ	5995	Zinc 6PROSITE-ProRule annotation	1
Metal bindingⁱ	6026	Zinc 7PROSITE-ProRule annotation	1
Metal bindingⁱ	6030	Zinc 7PROSITE-ProRule annotation	1
Metal bindingⁱ	6033	Zinc 7PROSITE-ProRule annotation	1
Active siteⁱ	6037	PROSITE-ProRule annotation	1
Active siteⁱ	6042	PROSITE-ProRule annotation	1
Metal bindingⁱ	6048	Zinc 7PROSITE-ProRule annotation	1
Metal bindingⁱ	6218	Zinc 8PROSITE-ProRule annotation	1
Metal bindingⁱ	6242	Zinc 8PROSITE-ProRule annotation	1
Metal bindingⁱ	6253	Zinc 8PROSITE-ProRule annotation	1
Metal bindingⁱ	6256	Zinc 8PROSITE-ProRule annotation	1
Active siteⁱ	6523	PROSITE-ProRule annotation	1
Active siteⁱ	6537	PROSITE-ProRule annotation	1
Active siteⁱ	6576	PROSITE-ProRule annotation	1
Active siteⁱ	6679	PROSITE-ProRule annotation	1
Active siteⁱ	6763	PROSITE-ProRule annotation	1
Active siteⁱ	6803	PROSITE-ProRule annotation	1
Active siteⁱ	6836	PROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1610 – 1647	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4168 – 4184	By similarityAdd BLAST	17
Zinc fingerⁱ	4211 – 4224	By similarityAdd BLAST	14
Nucleotide bindingⁱ	5447 – 5454	ATPSequence analysis	8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP hydrolysis activity Source: RHEA
cysteine-type endopeptidase activity Source: InterPro
DNA helicase activity Source: UniProtKB-EC
endonuclease activity Source: UniProtKB-KW
exoribonuclease activity Source: InterPro
G-quadruplex RNA binding Source: InterPro
lyase activity Source: UniProtKB-KW
methyltransferase activity Source: UniProtKB-KW
RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
RNA helicase activity Source: UniProtKB-EC
single-stranded RNA binding Source: InterPro
thiol-dependent deubiquitinase Source: UniProtKB-EC
zinc ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

induction by virus of catabolism of host mRNA Source: UniProtKB-KW
induction by virus of host autophagy Source: UniProtKB-KW
methylation Source: UniProtKB-KW
modulation by virus of host protein ubiquitination Source: UniProtKB-KW
suppression by virus of host gene expression Source: UniProtKB-KW
suppression by virus of host ISG15-protein conjugation Source: UniProtKB-KW
suppression by virus of host NF-kappaB cascade Source: UniProtKB-KW
suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
transcription, DNA-templated Source: InterPro
viral protein processing Source: InterPro
viral RNA genome replication Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endonuclease, Exonuclease, Helicase, Hydrolase, Lyase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological process	Activation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Replicase polyprotein 1ab Short name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 15 chains: Host translation inhibitor nsp1 Short name: nsp1 Alternative name(s): Leader protein Non-structural protein 2 Short name: nsp2 Alternative name(s): p65 homolog Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.-) Short name: PL-PRO Alternative name(s): Non-structural protein 3 Short name: nsp3 Non-structural protein 4 Short name: nsp4 3C-like proteinase (EC:3.4.22.-) Short name: 3CL-PRO Short name: 3CLp Alternative name(s): nsp5 Non-structural protein 6 Short name: nsp6 Non-structural protein 7 Short name: nsp7 Non-structural protein 8 Short name: nsp8 Non-structural protein 9 Short name: nsp9 Non-structural protein 10 Short name: nsp10 Alternative name(s): Growth factor-like peptide Short name: GFL RNA-directed RNA polymerase (EC:2.7.7.48) Short name: Pol Short name: RdRp Alternative name(s): nsp12 Helicase (EC:3.6.4.12, EC:3.6.4.13) Short name: Hel Alternative name(s): nsp13 Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-) Short name: ExoN Alternative name(s): nsp14 Uridylate-specific endoribonuclease (EC:4.6.1.-) Alternative name(s): NendoU nsp15 2'-O-methyltransferase (EC:2.1.1.57) Alternative name(s): nsp16
Gene namesⁱ	Name:rep ORF Names:1a-1b
Organismⁱ	Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)
Taxonomic identifierⁱ	694006 [NCBI]
Taxonomic lineageⁱ	Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Nobecovirus
Virus hostⁱ	Rousettus leschenaultii (Leschenault's rousette) [TaxID: 9408]
Proteomesⁱ	UP000006576 Componentⁱ: Genome

Subcellular locationⁱ

Papain-like proteinase:

Non-structural protein 4:

Host membrane ; Multi-pass membrane protein
Host cytoplasm

Note:

Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity

Non-structural protein 6:

Host membrane Curated; Multi-pass membrane protein Curated

Non-structural protein 7:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 8:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 9:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Non-structural protein 10:

host perinuclear region By similarity

Note:

nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Helicase:

Host endoplasmic reticulum-Golgi intermediate compartment Curated

Note:

The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity

Uridylate-specific endoribonuclease:

host perinuclear region By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	2015 – 2035	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2040 – 2060	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2081 – 2101	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2162 – 2182	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2183 – 2203	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2218 – 2238	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2621 – 2641	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2719 – 2739	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2865 – 2885	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2887 – 2907	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2916 – 2936	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2946 – 2966	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	2970 – 2990	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3423 – 3443	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3449 – 3469	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3474 – 3494	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3517 – 3537	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3569 – 3589	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3592 – 3612	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	3620 – 3640	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Host cytoplasm, Host membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000291350	1 – 175	Host translation inhibitor nsp1By similarityAdd BLAST	175
ChainⁱPRO_0000291351	176 – 772	Non-structural protein 2By similarityAdd BLAST	597
ChainⁱPRO_0000291352	773 – 2609	Papain-like proteinaseBy similarityAdd BLAST	1837
ChainⁱPRO_0000291353	2610 – 3103	Non-structural protein 4By similarityAdd BLAST	494
ChainⁱPRO_0000291354	3104 – 3409	3C-like proteinaseBy similarityAdd BLAST	306
ChainⁱPRO_0000291355	3410 – 3699	Non-structural protein 6By similarityAdd BLAST	290
ChainⁱPRO_0000291356	3700 – 3782	Non-structural protein 7By similarityAdd BLAST	83
ChainⁱPRO_0000291357	3783 – 3982	Non-structural protein 8By similarityAdd BLAST	200
ChainⁱPRO_0000291358	3983 – 4094	Non-structural protein 9By similarityAdd BLAST	112
ChainⁱPRO_0000291359	4095 – 4233	Non-structural protein 10By similarityAdd BLAST	139
ChainⁱPRO_0000291360	4234 – 5165	RNA-directed RNA polymeraseBy similarityAdd BLAST	932
ChainⁱPRO_0000291361	5166 – 5766	HelicaseBy similarityAdd BLAST	601
ChainⁱPRO_0000291362	5767 – 6296	Guanine-N7 methyltransferaseBy similarityAdd BLAST	530
ChainⁱPRO_0000291363	6297 – 6633	Uridylate-specific endoribonucleaseBy similarityAdd BLAST	337
ChainⁱPRO_0000291364	6634 – 6930	2'-O-methyltransferaseBy similarityAdd BLAST	297

Post-translational modificationⁱ

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	175 – 176	CleavageSequence analysis	2
Siteⁱ	772 – 773	Cleavage; by PL-PROSequence analysis	2
Siteⁱ	2609 – 2610	Cleavage; by PL-PROSequence analysis	2
Siteⁱ	3103 – 3104	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3409 – 3410	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3699 – 3700	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3782 – 3783	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	3982 – 3983	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	4094 – 4095	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	4233 – 4234	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	5165 – 5166	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	5766 – 5767	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	6296 – 6297	Cleavage; by 3CL-PROSequence analysis	2
Siteⁱ	6633 – 6634	Cleavage; by 3CL-PROSequence analysis	2

Interactionⁱ

Subunit structureⁱ

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

Chemistry databases

BindingDBⁱ	P0C6W5

BindingDBⁱ

P0C6W5

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1346 – 1355	Combined sources	10
Beta strandⁱ	1360 – 1364	Combined sources	5
Beta strandⁱ	1368 – 1371	Combined sources	4
Beta strandⁱ	1374 – 1382	Combined sources	9
Beta strandⁱ	1385 – 1389	Combined sources	5
Beta strandⁱ	1394 – 1398	Combined sources	5
Beta strandⁱ	1401 – 1404	Combined sources	4
Beta strandⁱ	1406 – 1408	Combined sources	3
Helixⁱ	1409 – 1415	Combined sources	7

Show more details

3D structure databases

SMRⁱ	P0C6W5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	10 – 134	CoV Nsp1 globularPROSITE-ProRule annotationAdd BLAST	125
Domainⁱ	149 – 175	BetaCoV Nsp1 C-terminalPROSITE-ProRule annotationAdd BLAST	27
Domainⁱ	774 – 885	Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	930 – 1097	Macro 1PROSITE-ProRule annotationAdd BLAST	168
Domainⁱ	1216 – 1340	Macro 2PROSITE-ProRule annotationAdd BLAST	125
Domainⁱ	1345 – 1417	DPUPPROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	1423 – 1478	Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	1492 – 1757	Peptidase C16PROSITE-ProRule annotationAdd BLAST	266
Domainⁱ	1770 – 1870	Nucleic acid-bindingPROSITE-ProRule annotationAdd BLAST	101
Domainⁱ	3007 – 3103	Nsp4CPROSITE-ProRule annotationAdd BLAST	97
Domainⁱ	3104 – 3409	Peptidase C30PROSITE-ProRule annotationAdd BLAST	306
Domainⁱ	3700 – 3782	RdRp Nsp7 cofactorPROSITE-ProRule annotationAdd BLAST	83
Domainⁱ	3783 – 3982	RdRp Nsp8 cofactorPROSITE-ProRule annotationAdd BLAST	200
Domainⁱ	3983 – 4094	Nsp9 ssRNA-bindingPROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	4095 – 4233	ExoN/MTase coactivatorPROSITE-ProRule annotationAdd BLAST	139
Domainⁱ	4239 – 4494	NiRANPROSITE-ProRule annotationAdd BLAST	256
Domainⁱ	4598 – 5165	Nsp12 RNA-dependent RNA polymerasePROSITE-ProRule annotationAdd BLAST	568
Domainⁱ	4845 – 5007	RdRp catalyticPROSITE-ProRule annotationAdd BLAST	163
Domainⁱ	5166 – 5249	CV ZBDPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	5412 – 5603	(+)RNA virus helicase ATP-bindingAdd BLAST	192
Domainⁱ	5604 – 5778	(+)RNA virus helicase C-terminalAdd BLAST	175
Domainⁱ	5838 – 6056	ExoNPROSITE-ProRule annotationAdd BLAST	219
Domainⁱ	6065 – 6296	N7-MTasePROSITE-ProRule annotationAdd BLAST	232
Domainⁱ	6297 – 6357	Nsp15 N-terminal oligomerizationPROSITE-ProRule annotationAdd BLAST	61
Domainⁱ	6358 – 6476	AV-Nsp11N/CoV-Nsp15MPROSITE-ProRule annotationAdd BLAST	119
Domainⁱ	6493 – 6630	NendoUPROSITE-ProRule annotationAdd BLAST	138
Domainⁱ	6635 – 6928	Nidovirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST	294

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1188 – 1207	DisorderedSequence analysisAdd BLAST	20
Regionⁱ	2015 – 2238	HD1By similarityAdd BLAST	224
Regionⁱ	2621 – 2990	HD2By similarityAdd BLAST	370
Regionⁱ	3423 – 3640	HD3By similarityAdd BLAST	218
Regionⁱ	6100 – 6106	SAM-bindingPROSITE-ProRule annotation	7
Regionⁱ	6180 – 6194	GpppA-bindingPROSITE-ProRule annotationAdd BLAST	15

Domainⁱ

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Sequence similaritiesⁱ

Belongs to the coronaviruses polyprotein 1ab family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	1610 – 1647	C4-typePROSITE-ProRule annotationAdd BLAST	38
Zinc fingerⁱ	4168 – 4184	By similarityAdd BLAST	17
Zinc fingerⁱ	4211 – 4224	By similarityAdd BLAST	14

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd21409, 1B_cv_Nsp13-like, 1 hit cd21596, batCoV-HKU9-like_RdRp, 1 hit cd21560, betaCoV-Nsp6, 1 hit cd21659, betaCoV_Nsp14, 1 hit cd21666, betaCoV_Nsp5_Mpro, 1 hit cd20762, capping_2-OMTase_Nidovirales, 1 hit cd21518, cv_beta_Nsp2_HKU9-like, 1 hit cd21473, cv_Nsp4_TM, 1 hit cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit cd21557, Macro_X_Nsp3-like, 1 hit cd21161, NendoU_cv_Nsp15-like, 1 hit cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit cd21537, SUD_C_HKU9_CoV_Nsp3, 1 hit cd21467, Ubl1_cv_Nsp3_N-like, 1 hit cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Dⁱ	1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.60.120.1680, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.30.160.820, 1 hit 3.30.70.3540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit 3.40.50.11580, 1 hit 3.40.50.300, 2 hits
InterProⁱ	View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043502, DNA/RNA_pol_sf IPR022733, DPUP_SUD_C_bCoV IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR044371, Macro_X_NSP3-like IPR042570, NAR_sf IPR043609, NendoU_nidovirus IPR044863, NIRAN IPR036333, NSP10_sf_CoV IPR044343, NSP13_1B_dom_CoV IPR027352, NSP13_ZBD_CoV-like IPR044315, NSP14_betaCoV IPR009466, NSP14_CoV IPR044330, NSP15_alpha_betaCoV_N IPR044322, NSP15_M_alpha_beta_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR044401, NSP15_NendoU_CoV IPR009461, NSP16_CoV-like IPR021590, NSP1_bCoV IPR044386, NSP2_HKU9-like IPR043615, NSP2_N_CoV IPR024375, NSP3_bCoV IPR032592, NSP3_NAB_bCoV IPR038400, NSP3_SUD-M_sf_bCoV IPR044352, Nsp3_SUD_C_HKU9_CoV IPR044357, NSP3_Ubl1_dom_CoV IPR044353, Nsp3_Ubl2_dom_CoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR044367, NSP6_betaCoV IPR043610, NSP6_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR044349, RdRp_batCoV_HKU9-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11501, bCoV_NSP1, 1 hit PF11633, bCoV_SUD_M, 1 hit PF06471, CoV_ExoN, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit PF01443, Viral_helicase1, 1 hit
SMARTⁱ	View protein in SMART SM00506, A1pp, 1 hit
SUPFAMⁱ	SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit
PROSITEⁱ	View protein in PROSITE PS51961, AV_NSP11N_COV_NSP15M, 1 hit PS51963, BCOV_NSP1_C, 1 hit PS51942, BCOV_NSP3C_C, 1 hit PS51941, BCOV_NSP3C_M, 1 hit PS51945, BCOV_NSP3E_NAB, 1 hit PS51952, COV_EXON_MTASE_COACT, 1 hit PS51954, COV_N7_MTASE, 1 hit PS51962, COV_NSP1, 1 hit PS51948, COV_NSP12_RDRP, 1 hit PS51960, COV_NSP15_NTD, 1 hit PS51943, COV_NSP3A_UBL, 1 hit PS51944, COV_NSP3D_UBL, 1 hit PS51946, COV_NSP4C, 1 hit PS51949, COV_NSP7, 1 hit PS51950, COV_NSP8, 1 hit PS51951, COV_NSP9_SSRNA_BD, 1 hit PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51958, NENDOU, 1 hit PS51947, NIRAN, 1 hit PS51955, NIV_2_O_MTASE, 1 hit PS51953, NIV_EXON, 1 hit PS51124, PEPTIDASE_C16, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by ribosomal frameshifting. Align Add to basket

Isoform Replicase polyprotein 1ab (identifier: P0C6W5-1) [UniParc]FASTA Add to basket

Also known as: pp1ab

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEGVPDPPKL KSMVVTTLKW CDPFANPNVT GWDIPIEEAL EYAKQQLRTP 
        60         70         80         90        100
EPQLVFVPYY LSHAPGISGD RVVITDSIWY ATNFGWQPIR ELAMDKDGVR 
       110        120        130        140        150
YGRGGTHGVL LPMQDPSFIM GDIDIQIRKY GIGANSPPDV LPLWDGFSDP 
       160        170        180        190        200
GPDVGPYLDF PDNCCPTKPK AKRGGDVYLS DQYGFDNNGI LVEPVMKLLG 
       210        220        230        240        250
VIKSDFTLEQ LLAALGKYRT EDGYDLPDGY VKVAIKVGRK AVPVLKQSIF 
       260        270        280        290        300
TVVGVTEQLV PGYYYPFSTS SVVEHTKPTR GGPVGKTVEA VMLSLYGTNN 
       310        320        330        340        350
YNPATPVARL KCSYCDYYGW TPLKDIGTVN CLCGAEFQLT SSCVDAESAG 
       360        370        380        390        400
VIKPGCVMLL DKSPGMRLIP GNRTYVSFGG AIWSPIGKVN GVTVWVPRAY 
       410        420        430        440        450
SIVAGEHSGA VGSGDTVAIN KELVEYLIEG IRVDADTLDN PTCATFIANL 
       460        470        480        490        500
DCDTKAPVVH TVESLQGLCL ANKIMLGDKP LPTDEFHPFI VGLAYHVQRA 
       510        520        530        540        550
CWYGALASRT FEAFRDFVRT EEERFAQFFG KVCAPINGCV YLAYTTGRVT 
       560        570        580        590        600
LFSAYQVLNT AIAKSKDAFG GVAAIVVDML KPILEWVLKK MSIAKGAWLP 
       610        620        630        640        650
YAEGLLALFK AQFTVVKGKF QFLRASLNSK CHSLCDLLTT IMSKLLTSVK 
       660        670        680        690        700
WAGCKVDALY TGTYYYFSRK GVLTEVQLCA KRLGLLLTPK QQKMEVEVLD 
       710        720        730        740        750
GDFDAPVTLT DLELEECTGV LEEVFGASDV KLVKGTLVSL ASKLFVRTED 
       760        770        780        790        800
GFLYRYVKSG GVLGKAFRLR GGGVSKVTFG DEEVHTIPNT VTVNFSYDVC 
       810        820        830        840        850
EGLDAILDKV MAPFQVEEGT KLEDLACVVQ KAVYERLSDL FSDCPAELRP 
       860        870        880        890        900
INLEDFLTSE CFVYSKDYEK ILMPEMYFSL EDAVPVDDEM VDDIEDTVEQ 
       910        920        930        940        950
ASDSDDQWLG DEGAEDCDNT IQDVDVATSM TTPCGYTKIA EHVYIKCADI 
       960        970        980        990       1000
VQEARNYSYA VLVNAANVNL HHGGGVAGAL NRATNNAMQK ESSEYIKANG 
      1010       1020       1030       1040       1050
SLQPGGHVLL SSHGLASHGI LHVVGPDKRL GQDLALLDAV YAAYTGFDSV 
      1060       1070       1080       1090       1100
LTPLVSAGIF GFTVEESLCS LVKNVACTTY VVVYDRQLYE RALATSFDVP 
      1110       1120       1130       1140       1150
GPQSSVQHVP AIDWAEAVEV QESIVDQVET PSLGAVDTVD SNADSGLNET 
      1160       1170       1180       1190       1200
ARSPENVVGS VPDDVVADVE SCVRDLVRQV VKKVKRDKRP PPIVPQQTVE 
      1210       1220       1230       1240       1250
QQPQEISSPG DCNTVLVDVV SMSFSAMVNF GKEKGLLIPV VIDYPAFLKV 
      1260       1270       1280       1290       1300
LKRFSPKEGL FSSNGYEFYG YSRDKPLHEV SKDLNSLGRP LIMIPFGFIV 
      1310       1320       1330       1340       1350
NGQTLAVSAV SMRGLTVPHT VVVPSESSVP LYRAYFNGVF SGDTTAVQDF 
      1360       1370       1380       1390       1400
VVDILLNGAR DWDVLQTTCT VDRKVYKTIC KRGNTYLCFD DTNLYAITGD 
      1410       1420       1430       1440       1450
VVLKFATVSK ARAYLETKLC APEPLIKVLT TVDGINYSTV LVSTAQSYRA 
      1460       1470       1480       1490       1500
QIGTVFCDGH DWSNKNPMPT DEGTHLYKQD NFSSAEVTAI REYYGVDDSN 
      1510       1520       1530       1540       1550
IIARAMSIRK TVQTWPYTVV DGRVLLAQRD SNCYLNVAIS LLQDIDVSFS 
      1560       1570       1580       1590       1600
TPWVCRAYDA LKGGNPLPMA EVLIALGKAT PGVSDDAHMV LSAVLNHGTV 
      1610       1620       1630       1640       1650
TARRVMQTVC EHCGVSQMVF TGTDACTFYG SVVLDDLYAP VSVVCQCGRP 
      1660       1670       1680       1690       1700
AIRYVSEQKS PWLLMSCTPT QVPLDTSGIW KTAIVFRGPV TAGHYMYAVN 
      1710       1720       1730       1740       1750
GTLISVYDAN TRRRTSDLKL PATDILYGPT SFTSDSKVET YYLDGVKRTT 
      1760       1770       1780       1790       1800
IDPDFSKYVK RGDYYFTTAP IEVVAAPKLV TSYDGFYLSS CQNPQLAESF 
      1810       1820       1830       1840       1850
NKAINATKTG PMKLLTMYPN VAGDVVAISD DNVVAHPYGS LHMGKPVLFV 
      1860       1870       1880       1890       1900
TRPNTWKKLV PLLSTVVVNT PNTYDVLAVD PLPVNNETSE EPISVKAPIP 
      1910       1920       1930       1940       1950
LYGLKATMVL NGTTYVPGNK GHLLCLKEFT LTDLQTFYVE GVQPFVLLKA 
      1960       1970       1980       1990       2000
SHLSKVLGLR VSDSSLHVNH LSKGVVYAYA ATRLTTRVTT SLLGGLVTRS 
      2010       2020       2030       2040       2050
VRKTADFVRS TNPGSKCVGL LCLFYQLFMR FWLLVKKPPI VKVSGIIAYN 
      2060       2070       2080       2090       2100
TGCGVTTCVL NYLRSRCGNI SWSRLLKLLR YMLYIWFVWT CLTICGVWLS 
      2110       2120       2130       2140       2150
EPYAPSLVTR FKYFLGIVMP CDYVLVNETG TGWLHHLCMA GMDSLDYPAL 
      2160       2170       2180       2190       2200
RMQQHRYGSP YNYTYILMLL EAFFAYLLYT PALPIVGILA VLHLIVLYLP 
      2210       2220       2230       2240       2250
IPLGNSWLVV FLYYIIRLVP FTSMLRMYIV IAFLWLCYKG FLHVRYGCNN 
      2260       2270       2280       2290       2300
VACLMCYKKN VAKRIECSTV VNGVKRMFYV NANGGTHFCT KHNWNCVSCD 
      2310       2320       2330       2340       2350
TYTVDSTFIC RQVALDLSAQ FKRPIIHTDE AYYEVTSVEV RNGYVYCYFE 
      2360       2370       2380       2390       2400
SDGQRSYERF PMDAFTNVSK LHYSELKGAA PAFNVLVFDA TNRIEENAVK 
      2410       2420       2430       2440       2450
TAAIYYAQLA CKPILLVDKR MVGVVGDDAT IARAMFEAYA QNYLLKYSIA 
      2460       2470       2480       2490       2500
MDKVKHLYST ALQQISSGMT VESVLKVFVG STRAEAKDLE SDVDTNDLVS 
      2510       2520       2530       2540       2550
CIRLCHQEGW EWTTDSWNNL VPTYIKQDTL STLEVGQFMT ANAKYVNANI 
      2560       2570       2580       2590       2600
AKGAAVNLIW RYADFIKLSE SMRRQLKVAA RKTGLNLLVT TSSLKADVPC 
      2610       2620       2630       2640       2650
MVTPFKIIGG HRRIVSWRRV LIHVFMLLVV LNPQWFTPWY IMRPIEYNVV 
      2660       2670       2680       2690       2700
DFKVIDNAVI RDITSADQCF ANKFSAFENW YSNRYGSYVN SRGCPMVVGV 
      2710       2720       2730       2740       2750
VSDIVGSLVP GLPARFLRVG TTLLPLVNYG LGAVGSVCYT PHYAINYDVF 
      2760       2770       2780       2790       2800
DTSACVLAAT CTLFSSASGE RMPYCADAAL IQNASRYDML KPHVMYPFYE 
      2810       2820       2830       2840       2850
HSGYIRFPEV ISAGVHIVRT MAMEYCKVGR CDVSEAGLCM SLQPRWVVNN 
      2860       2870       2880       2890       2900
AYFRQQSGVY CGTSAFDLFM NMLLPIFTPV GAVDITTSIL MGALLAVVVS 
      2910       2920       2930       2940       2950
MSLYYLLRFR RAFGDYSGVI FTNILAFVLN VIVLCLEGPY PMLPSIYAMV 
      2960       2970       2980       2990       3000
FLYATCYFGS DIACMMHVSF LIMFAGVVPL WVTVLYIVVV LSRHILWFAS 
      3010       3020       3030       3040       3050
LCTKRTVQVG DLAFHSFQDA ALQTFMLDKE VFLRLKREIS SDAYFKYLAM 
      3060       3070       3080       3090       3100
YNKYKYYSGP MDTAAYREAA CSHLVMALEK YSNGGGDTIY QPPRCSVASA 
      3110       3120       3130       3140       3150
ALQAGLTRMA HPSGLVEPCL VKVNYGSMTL NGIWLDNFVI CPRHVMCSRD 
      3160       3170       3180       3190       3200
ELANPDYPRL SMRAANYDFH VSQNGHNIRV IGHTMEGSLL KLTVDVNNPK 
      3210       3220       3230       3240       3250
TPAYSFIRVS TGQAMSLLAC YDGLPTGVYT CTLRSNGTMR ASFLCGSCGS 
      3260       3270       3280       3290       3300
PGFVMNGKEV QFCYLHQLEL PNGTHTGTDF SGVFYGPFED KQVPQLAAPD 
      3310       3320       3330       3340       3350
CTITVNVLAW LYAAVLSGEN WFLTKSSISP AEFNNCAVKY MCQSVTSESL 
      3360       3370       3380       3390       3400
QVLQPLAAKT GISVERMLSA LKVLLSAGFC GRTIMGSCSL EDEHTPYDIG 
      3410       3420       3430       3440       3450
RQMLGVKLQG KFQSMFRWTL QWFAIIFVLT ILILLQLAQW TFVGALPFTL 
      3460       3470       3480       3490       3500
LLPLIGFVAV CVGFVSLLIK HKHTYLTVYL LPVAMVTAYY NFQYTPEGVQ 
      3510       3520       3530       3540       3550
GYLLSLYNYV NPGRIDVIGT DLLTMLIISV ACTLLSVRMV RTDAYSRIWY 
      3560       3570       3580       3590       3600
VCTAVGWLYN CWTGSADTVA ISYLTFMVSV FTNYTGVACA SLYAAQFMVW 
      3610       3620       3630       3640       3650
VLKFLDPTIL LLYGRFRCVL VCYLLVGYLC TCYFGVFNLI NRLFRCTLGN 
      3660       3670       3680       3690       3700
YEYVVSSQEL RYMNSHGLLP PTNSWQALML NIKLAGIGGI PIYRVSTIQS 
      3710       3720       3730       3740       3750
NMTDLKCTSV VLLSVLQQLR VESSSKLWAL CVKLHNEILA SNSPTEAFEA 
      3760       3770       3780       3790       3800
FVSLLSVLLS LPGAINLDEL CSSILENNSV LQAVASEFSN LSSYVDYENA 
      3810       3820       3830       3840       3850
QKAYDTAVAT GAPASTVNAL KKAMNVAKSV LDKDVATTRK LERMSELAMT 
      3860       3870       3880       3890       3900
AMYKQARAED RRSKVTAAMQ TMLFNMIRRL DSDALSNILN NARNGVVPLG 
      3910       3920       3930       3940       3950
VIPRTAANKL LLVVPDFSVY TATITMPTLT YAGSAWDVMQ VADADGKTVN 
      3960       3970       3980       3990       4000
ATDITRENSV NLAWPLVVTA QRQQATSPVK LQNNELMPQT VKRMNVVAGV 
      4010       4020       4030       4040       4050
SQTACVTDAV AYYNATKEGR HVMAILADTD GLAFAKVEKS TGDGFVILEL 
      4060       4070       4080       4090       4100
EPPCKFMVDT PKGPALKYLY FTKGLKNLCR GTVLGTLACT VRLHAGSATE 
      4110       4120       4130       4140       4150
VASNSSILSL CSFSVDPEAT YKDYLDNGGS PIGNCVKMLT PHTGTGLAIT 
      4160       4170       4180       4190       4200
AKPDANIDQE SFGGASCCLY CRCHIEHPGA SGVCKYKGKF VQIPLVGVND 
      4210       4220       4230       4240       4250
PIGFCIRNVV CAVCNMWQGY GCPCSSLREI NLQARDECFL NRVRGTSGVA 
      4260       4270       4280       4290       4300
RLVPLGSGVQ PDIVLRAFDI CNTKVAGFGL HLKNNCCRYQ ELDADGTQLD 
      4310       4320       4330       4340       4350
SYFVVKRHTE SNYLLEQRCY EKLKDCGVVA RHDFFKFNIE GVMTPHVSRE 
      4360       4370       4380       4390       4400
RLTKYTMADL VYSLRHFDNN NCDTLKEILV LRGCCTADYF DRKDWYDPVE 
      4410       4420       4430       4440       4450
NPDIIRVYHN LGETVRKAVL SAVKMADSMV EQGLIGVLTL DNQDLNGQWY 
      4460       4470       4480       4490       4500
DFGDFIEGPA GAGVAVMDTY YSLAMPVYTM TNMLAAECHV DGDFSKPKRV 
      4510       4520       4530       4540       4550
WDICKYDYTQ FKYSLFSKYF KYWDMQYHPN CVACADDRCI LHCANFNILF 
      4560       4570       4580       4590       4600
SMVLPNTSFG PLVQKIYVDG VPFVVSTGYH YRELGVVMNQ DIRQHAQRLS 
      4610       4620       4630       4640       4650
LRELLVYAAD PAMHVAASNA LADKRTVCMS VAAMTTGVTF QTVKPGQFNE 
      4660       4670       4680       4690       4700
DFYNFAVKCG FFKEGSTISF KHFFYAQDGN AAISDYDYYR YNLPTMCDIK 
      4710       4720       4730       4740       4750
QLLFSLEVVD KYFDCYDGGC LQASQVVVAN YDKSAGFPFN KFGKARLYYE 
      4760       4770       4780       4790       4800
SLSYADQDEL FAYTKRNVLP TITQMNLKYA ISAKNRARTV AGVSIASTMT 
      4810       4820       4830       4840       4850
NRQFHQKMLK SIAAARGASV VIGTTKFYGG WNRMLRTLCE GVENPHLMGW 
      4860       4870       4880       4890       4900
DYPKCDRAMP NLLRIFASLI LARKHATCCN ASERFYRLAN ECAQVLSEMV 
      4910       4920       4930       4940       4950
LCGGGFYVKP GGTSSGDSTT AYANSVFNIC QAVSANLNTF LSIDGNKIYT 
      4960       4970       4980       4990       5000
TYVQELQRRL YLGIYRSNTV DNELVLDYYN YLRKHFSMMI LSDDGVVCYN 
      5010       5020       5030       5040       5050
ADYAQKGYVA DIQGFKELLY FQNNVFMSES KCWVEPDITK GPHEFCSQHT 
      5060       5070       5080       5090       5100
MLVDMKGEQV YLPYPDPSRI LGAGCFVDDL LKTDGTLMME RYVSLAIDAY 
      5110       5120       5130       5140       5150
PLTKHPDPEY QNVFWCYLQY IKKLHEELTG HLLDTYSVML ASDNASKYWE 
      5160       5170       5180       5190       5200
VEFYENMYME SATLQSVGTC VVCNSQTSLR CGGCIRRPFL CCKCCYDHVV 
      5210       5220       5230       5240       5250
STTHKLVLSV TPYVCNNPSC DVADVTQLYL GGMSYYCRDH RPPISFPLCA 
      5260       5270       5280       5290       5300
NGQVFGLYKN ICTGSPDVAD FNSLATCDWS NSKDYVLANT ATERLKLFAA 
      5310       5320       5330       5340       5350
ETLRATEENA KQAYASAVVK EVLSDRELVL SWETGKTRPP LNRNYVFTGF 
      5360       5370       5380       5390       5400
HITKNSKVQL GEYIFEKGDY GDVVNYRSST TYKLQVGDYF VLTSHSVQPL 
      5410       5420       5430       5440       5450
SSPTLLPQER YTKLVGLYPA MNVPESFASN VVHYQRVGMS RYTTVQGPPG 
      5460       5470       5480       5490       5500
TGKSHLSIGL ALYYPSAKIV YTACSHAAVD ALCEKAHKNL PINRCSRIVP 
      5510       5520       5530       5540       5550
AKARVECFSK FKVNDVGAQY VFSTINALPE TTADILVVDE VSMCTNYDLS 
      5560       5570       5580       5590       5600
MINARVRAKH IVYVGDPAQL PAPRTLLTKG TLAPEHFNSV CRLMVAVGPD 
      5610       5620       5630       5640       5650
IFLATCYRCP KEIVDTVSAL VYDKKLKANK VTTGECYKCY YKGSVTHDSS 
      5660       5670       5680       5690       5700
SAINKPQLGL VKEFLIKNPK WQSAVFISPY NSQNSVARRM LGLQTQTVDS 
      5710       5720       5730       5740       5750
SQGSEFDYVI YCQTSDTAHA LNVNRFNVAI TRAKKGILCV MSDSTLYESL 
      5760       5770       5780       5790       5800
EFTPLDVNDY VKPKMQSEVT VGLFKDCAKA EPLGPAYAPT FVSVNDKFKL 
      5810       5820       5830       5840       5850
NESLCVHFDT TELQMPYNRL ISKMGFKFDL NIPGYSKLFI TREQAIREVR 
      5860       5870       5880       5890       5900
GWVGFDVEGA HACGPNIGTN LPLQIGFSTG VNFVVTPSGY IDTESGSRLA 
      5910       5920       5930       5940       5950
NVVSKAPPGD QFKHLIPLMR KGEPWSVVRK RIVEMLCDTL DGVSDTVTFV 
      5960       5970       5980       5990       6000
TWAHGFELTT LHYFAKVGPE RKCFMCPRRA TLFSSVYGAY SCWSHHRHIG 
      6010       6020       6030       6040       6050
GADFVYNPFL VDVQQWGYVG NLQVNHDNVC DVHKGAHVAS CDAIMTRCLA 
      6060       6070       6080       6090       6100
IHDCFCGEVN WDVEYPIIAN ELAINRACRS VQRVVLKAAV KALHIETIYD 
      6110       6120       6130       6140       6150
IGNPKAIKVY GVNVNNWNFY DTNPVVEGVK QLHYVYDVHR DQFKDGLAMF 
      6160       6170       6180       6190       6200
WNCNVDCYPH NALVCRFDTR VLSKLNLAGC NGGSLYVNQH AFHTDAFNKN 
      6210       6220       6230       6240       6250
AFVNLKPLPF FYYSDTACEN ATGVSTNYVS EVDYVPLKSN VCITRCNLGG 
      6260       6270       6280       6290       6300
AVCKKHADEY RNFLESYNTM VSAGFTLWVD KTFDVFNLWS TFVKLQSLEN 
      6310       6320       6330       6340       6350
VAYNVLKSGH FTAVAGELPV AILNDRLYIK EDGADKLLFT NNTCLPTNVA 
      6360       6370       6380       6390       6400
FELWAKRSVN VVPEVKLLRN LGVTCTYNLV IWDYESNAPL VPNTVGICTY 
      6410       6420       6430       6440       6450
TDLTKLDDQV VLVDGRQLDA YSKFCQLKNA IYFSPSKPKC VCTRGPTHAS 
      6460       6470       6480       6490       6500
INGVVVEAPD RGTAFWYAMR KDGAFVQPTD GYFTQSRTVD DFQPRTQLEI 
      6510       6520       6530       6540       6550
DFLDLEQSCF LDKYDLHDLG LEHIVYGQFD GTIGGLHLLI GAVRRKRTAH 
      6560       6570       6580       6590       6600
LVMETVLGTD TVTSYAVIDQ PTASSKQVCS VVDIILDDFI ALIKAQDRSV 
      6610       6620       6630       6640       6650
VSKVVQCCLD FKVFRFMLWC KGGKISTFYP QLQAKQDWKP GYSMPALYKV 
      6660       6670       6680       6690       6700
QNAVLEPCLL HNYGQAARLP SGTLMNVAKY TQLCQYLNTC SLAVPAKMRV 
      6710       6720       6730       6740       6750
MHFGAGSDKG VCPGTAVLKQ WLPADAYLVD NDLCYCASDA DSTYVGSCET 
      6760       6770       6780       6790       6800
FFSVNKWDFI FSDMYDARTK NTSGDNTSKE GFFTYLTGFI RSKLALGGSI 
      6810       6820       6830       6840       6850
AIKITEHSWS ADLYAIMGHF NWWTCFCTSV NSSSSEAFLI GVNYIGVGAL 
      6860       6870       6880       6890       6900
LDGWQMHANY VFWRNSTVMQ LSSYSLYDLQ RFPLRLKGTP VMSLKEDQLN 
      6910       6920       6930
ELVLNLIRAG RLIVRDAVDI GVRGVACSGV

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Length:6,930

Mass (Da):769,729

Last modified:June 10, 2008 - v1

Checksum:ⁱ9ED06D0888C7EC7B

Isoform Replicase polyprotein 1a (identifier: P0C6T6-1) [UniParc]FASTA Add to basket

Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform can be found in the external entry P0C6T6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Length:4,248

Mass (Da):468,590

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF065513 Genomic RNA Translation: ABN10910.1
NCBI Reference Sequences More...RefSeqⁱ	YP_001039970.1, NC_009021.1 [P0C6W5-1]

Genome annotation databases

GeneIDⁱ	4836014
KEGGⁱ	vg:4836014

Keywords - Coding sequence diversityⁱ

Ribosomal frameshifting

Protein	Similar proteins		Species	Score	Length	Source
P0C6W5	ORF1ab polyprotein (Fragment)		Kenya bat coronavirus BtKY76		135	UniRef100_P0C6W5
RNA-dependent RNA polymerase (Fragment)		BCHK9		133
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY78		142
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY77		142
RNA-dependent RNA polymerase (Fragment)		Bat coronavirus HKU9-1		140
+85

Protein	Similar proteins		Species	Score	Length	Source
P0C6W5	ORF1ab polyprotein (Fragment)		Kenya bat coronavirus BtKY76		135	UniRef90_P0C6W5
RNA-dependent RNA polymerase (Fragment)		BCHK9		133
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY78		142
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY77		142
RNA-dependent RNA polymerase (Fragment)		Bat coronavirus HKU9-1		140
+86

Protein	Similar proteins		Species	Score	Length	Source
P0C6W5	ORF1ab polyprotein (Fragment)		Kenya bat coronavirus BtKY76		135	UniRef50_P0C6W5
RNA-dependent RNA polymerase (Fragment)		BCHK9		133
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY78		142
RNA-dependent RNA polymerase (Fragment)		Kenya bat coronavirus BtKY77		142
RNA-dependent RNA polymerase (Fragment)		Bat coronavirus HKU9-1		140
+544

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF065513 Genomic RNA Translation: ABN10910.1
RefSeqⁱ	YP_001039970.1, NC_009021.1 [P0C6W5-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5UTV	NMR	-	A	1345-1418	[»]
SMRⁱ	P0C6W5
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Chemistry databases

BindingDBⁱ	P0C6W5

BindingDBⁱ

P0C6W5

Genome annotation databases

GeneIDⁱ	4836014
KEGGⁱ	vg:4836014

Family and domain databases

CDDⁱ	cd21409, 1B_cv_Nsp13-like, 1 hit cd21596, batCoV-HKU9-like_RdRp, 1 hit cd21560, betaCoV-Nsp6, 1 hit cd21659, betaCoV_Nsp14, 1 hit cd21666, betaCoV_Nsp5_Mpro, 1 hit cd20762, capping_2-OMTase_Nidovirales, 1 hit cd21518, cv_beta_Nsp2_HKU9-like, 1 hit cd21473, cv_Nsp4_TM, 1 hit cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit cd21557, Macro_X_Nsp3-like, 1 hit cd21161, NendoU_cv_Nsp15-like, 1 hit cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit cd21537, SUD_C_HKU9_CoV_Nsp3, 1 hit cd21467, Ubl1_cv_Nsp3_N-like, 1 hit cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Dⁱ	1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.60.120.1680, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.30.160.820, 1 hit 3.30.70.3540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit 3.40.50.11580, 1 hit 3.40.50.300, 2 hits
InterProⁱ	View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043502, DNA/RNA_pol_sf IPR022733, DPUP_SUD_C_bCoV IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR044371, Macro_X_NSP3-like IPR042570, NAR_sf IPR043609, NendoU_nidovirus IPR044863, NIRAN IPR036333, NSP10_sf_CoV IPR044343, NSP13_1B_dom_CoV IPR027352, NSP13_ZBD_CoV-like IPR044315, NSP14_betaCoV IPR009466, NSP14_CoV IPR044330, NSP15_alpha_betaCoV_N IPR044322, NSP15_M_alpha_beta_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR044401, NSP15_NendoU_CoV IPR009461, NSP16_CoV-like IPR021590, NSP1_bCoV IPR044386, NSP2_HKU9-like IPR043615, NSP2_N_CoV IPR024375, NSP3_bCoV IPR032592, NSP3_NAB_bCoV IPR038400, NSP3_SUD-M_sf_bCoV IPR044352, Nsp3_SUD_C_HKU9_CoV IPR044357, NSP3_Ubl1_dom_CoV IPR044353, Nsp3_Ubl2_dom_CoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR044367, NSP6_betaCoV IPR043610, NSP6_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR044349, RdRp_batCoV_HKU9-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases
Pfamⁱ	View protein in Pfam PF11501, bCoV_NSP1, 1 hit PF11633, bCoV_SUD_M, 1 hit PF06471, CoV_ExoN, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit PF01443, Viral_helicase1, 1 hit
SMARTⁱ	View protein in SMART SM00506, A1pp, 1 hit
SUPFAMⁱ	SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit
PROSITEⁱ	View protein in PROSITE PS51961, AV_NSP11N_COV_NSP15M, 1 hit PS51963, BCOV_NSP1_C, 1 hit PS51942, BCOV_NSP3C_C, 1 hit PS51941, BCOV_NSP3C_M, 1 hit PS51945, BCOV_NSP3E_NAB, 1 hit PS51952, COV_EXON_MTASE_COACT, 1 hit PS51954, COV_N7_MTASE, 1 hit PS51962, COV_NSP1, 1 hit PS51948, COV_NSP12_RDRP, 1 hit PS51960, COV_NSP15_NTD, 1 hit PS51943, COV_NSP3A_UBL, 1 hit PS51944, COV_NSP3D_UBL, 1 hit PS51946, COV_NSP4C, 1 hit PS51949, COV_NSP7, 1 hit PS51950, COV_NSP8, 1 hit PS51951, COV_NSP9_SSRNA_BD, 1 hit PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51958, NENDOU, 1 hit PS51947, NIRAN, 1 hit PS51955, NIV_2_O_MTASE, 1 hit PS51953, NIV_EXON, 1 hit PS51124, PEPTIDASE_C16, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	R1AB_BCHK9
Accessionⁱ	P0C6W5Primary (citable) accession number: P0C6W5 Secondary accession number(s): A3EXG5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	February 23, 2022
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

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UniProtKB - P0C6W5 (R1AB_BCHK9)

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Replicase polyprotein 1ab

rep

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Family and domain databases

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ