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Entry version 95 (11 Dec. 2019)
Sequence version 1 (10 Jun. 2008)
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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.By similarity
Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.By similarity
May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.By similarity
Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.By similarity
Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.By similarity
Proteinase 3CL-PRO: Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).PROSITE-ProRule annotationBy similarity
Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes.By similarity
Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity
Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.By similarity
May participate in viral replication by acting as a ssRNA-binding protein.By similarity
Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.By similarity
Responsible for replication and transcription of the viral RNA genome.By similarity
Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.By similarity
Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity.By similarity
Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity
Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1668For PL-PRO activityPROSITE-ProRule annotation1
Active sitei1838For PL-PRO activityPROSITE-ProRule annotation1
Active sitei3379For 3CL-PRO activityPROSITE-ProRule annotation1
Active sitei3486For 3CL-PRO activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5406Zinc 1PROSITE-ProRule annotation1
Metal bindingi5409Zinc 1PROSITE-ProRule annotation1
Metal bindingi5417Zinc 2PROSITE-ProRule annotation1
Metal bindingi5420Zinc 1PROSITE-ProRule annotation1
Metal bindingi5427Zinc 1PROSITE-ProRule annotation1
Metal bindingi5430Zinc 2PROSITE-ProRule annotation1
Metal bindingi5434Zinc 2PROSITE-ProRule annotation1
Metal bindingi5440Zinc 2PROSITE-ProRule annotation1
Metal bindingi5451Zinc 3PROSITE-ProRule annotation1
Metal bindingi5456Zinc 3PROSITE-ProRule annotation1
Metal bindingi5473Zinc 3PROSITE-ProRule annotation1
Metal bindingi5476Zinc 3PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1748 – 1785C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4402 – 4418By similarityAdd BLAST17
Zinc fingeri4444 – 4457By similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi5683 – 5690ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processActivation of host autophagy by virus, Decay of host mRNAs by virus, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Inhibition of host NF-kappa-B by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C16.011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 15 chains:
Alternative name(s):
Leader protein
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
p65 homolog
Papain-like proteinase (EC:3.4.19.12, EC:3.4.22.69)
Short name:
PL-PRO
Alternative name(s):
Non-structural protein 3
Short name:
nsp3
Non-structural protein 4
Short name:
nsp4
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Alternative name(s):
Growth factor-like peptide
Short name:
GFL
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
Guanine-N7 methyltransferase (EC:2.1.1.-, EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Uridylate-specific endoribonuclease (EC:3.1.-.-)
Alternative name(s):
NendoU
nsp15
2'-O-methyltransferase (EC:2.1.1.-)
Alternative name(s):
nsp16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri694008 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusMerbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPipistrellus abramus (Japanese pipistrelle) (Pipistrellus javanicus abramus) [TaxID: 105295]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007451 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2158 – 2178HelicalSequence analysisAdd BLAST21
Transmembranei2196 – 2216HelicalSequence analysisAdd BLAST21
Transmembranei2268 – 2288HelicalSequence analysisAdd BLAST21
Transmembranei2372 – 2392HelicalSequence analysisAdd BLAST21
Transmembranei2396 – 2416HelicalSequence analysisAdd BLAST21
Transmembranei2421 – 2441HelicalSequence analysisAdd BLAST21
Transmembranei2848 – 2868HelicalSequence analysisAdd BLAST21
Transmembranei3119 – 3139HelicalSequence analysisAdd BLAST21
Transmembranei3152 – 3172HelicalSequence analysisAdd BLAST21
Transmembranei3203 – 3223HelicalSequence analysisAdd BLAST21
Transmembranei3650 – 3670HelicalSequence analysisAdd BLAST21
Transmembranei3684 – 3704HelicalSequence analysisAdd BLAST21
Transmembranei3709 – 3729HelicalSequence analysisAdd BLAST21
Transmembranei3760 – 3777HelicalSequence analysisAdd BLAST18
Transmembranei3782 – 3802HelicalSequence analysisAdd BLAST21
Transmembranei3823 – 3843HelicalSequence analysisAdd BLAST21
Transmembranei3855 – 3875HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002903031 – 195Host translation inhibitor nsp1By similarityAdd BLAST195
ChainiPRO_0000290304196 – 851Non-structural protein 2By similarityAdd BLAST656
ChainiPRO_0000290305852 – 2830Papain-like proteinaseBy similarityAdd BLAST1979
ChainiPRO_00002903062831 – 3338Non-structural protein 4By similarityAdd BLAST508
ChainiPRO_00002903073339 – 36443C-like proteinaseBy similarityAdd BLAST306
ChainiPRO_00002903083645 – 3936Non-structural protein 6By similarityAdd BLAST292
ChainiPRO_00002903093937 – 4019Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_00002903104020 – 4218Non-structural protein 8By similarityAdd BLAST199
ChainiPRO_00002903114219 – 4328Non-structural protein 9By similarityAdd BLAST110
ChainiPRO_00002903124329 – 4467Non-structural protein 10By similarityAdd BLAST139
ChainiPRO_00002903134468 – 5401RNA-directed RNA polymeraseBy similarityAdd BLAST934
ChainiPRO_00002903145402 – 5999HelicaseBy similarityAdd BLAST598
ChainiPRO_00002903156000 – 6523Guanine-N7 methyltransferaseBy similarityAdd BLAST524
ChainiPRO_00002903166524 – 6874Uridylate-specific endoribonucleaseBy similarityAdd BLAST351
ChainiPRO_00002903176875 – 71822'-O-methyltransferaseBy similarityAdd BLAST308

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei195 – 196CleavageSequence analysis2
Sitei851 – 852Cleavage; by PL-PROSequence analysis2
Sitei2830 – 2831Cleavage; by PL-PROSequence analysis2
Sitei3338 – 3339Cleavage; by 3CL-PROSequence analysis2
Sitei3644 – 3645Cleavage; by 3CL-PROSequence analysis2
Sitei3936 – 3937Cleavage; by 3CL-PROSequence analysis2
Sitei4019 – 4020Cleavage; by 3CL-PROSequence analysis2
Sitei4218 – 4219Cleavage; by 3CL-PROSequence analysis2
Sitei4328 – 4329Cleavage; by 3CL-PROSequence analysis2
Sitei4467 – 4468Cleavage; by 3CL-PROSequence analysis2
Sitei5401 – 5402Cleavage; by 3CL-PROSequence analysis2
Sitei5999 – 6000Cleavage; by 3CL-PROSequence analysis2
Sitei6523 – 6524Cleavage; by 3CL-PROSequence analysis2
Sitei6874 – 6875Cleavage; by 3CL-PROSequence analysis2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P0C6W4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities. Nsp14 interacts (via N-terminus) with DDX1.

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1186 – 1345MacroPROSITE-ProRule annotationAdd BLAST160
Domaini1628 – 1902Peptidase C16PROSITE-ProRule annotationAdd BLAST275
Domaini3339 – 3644Peptidase C30PROSITE-ProRule annotationAdd BLAST306
Domaini5081 – 5243RdRp catalyticPROSITE-ProRule annotationAdd BLAST163
Domaini5402 – 5485CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5658 – 5839(+)RNA virus helicase ATP-bindingAdd BLAST182
Domaini5840 – 6014(+)RNA virus helicase C-terminalAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2158 – 2441HD1By similarityAdd BLAST284
Regioni2848 – 3223HD2By similarityAdd BLAST376
Regioni3650 – 3875HD3By similarityAdd BLAST226

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi964 – 1066Glu-richAdd BLAST103
Compositional biasi5406 – 5431Cys-richAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1748 – 1785C4-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri4402 – 4418By similarityAdd BLAST17
Zinc fingeri4444 – 4457By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
20at10239

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR041679 DNA2/NAM7-like_AAA
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR032592 NAR_dom
IPR042570 NAR_sf
IPR036333 NSP10_sf
IPR009466 NSP11
IPR042515 Nsp15_N
IPR024375 Nsp3_coronavir
IPR038400 Nsp3_coronavir_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR038083 R1a/1ab
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13087 AAA_12, 1 hit
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF16251 NAR, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF00680 RdRP_1, 1 hit
PF11633 SUD-M, 1 hit
PF08715 Viral_protease, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00506 A1pp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF159936 SSF159936, 1 hit
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: P0C6W4-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFVAGVAPQ GARGKYRAEL NTEKRTDHVS LKASLCDAGD LVLKISPWFM
60 70 80 90 100
DGESAYKHVS EQLSKGSKLL FVPQTLKGFI RHLPGPRVYL VERLTGGTYS
110 120 130 140 150
DPFMVNQLAY QNAAGEGVIG TTLQGKRVGM FFPFDADLVT GEFQFLLRKK
160 170 180 190 200
GFGGNRFRDA PWDYNWTPYS DLMDALEADP CGKYSQSLLK KLVGGDFTPI
210 220 230 240 250
DQYMCGKNGK PIAEFAALMA SEGITKLADV EAEVKSRTDS DRYIVFKNKL
260 270 280 290 300
YRIVWNVQRK DVAYSKQSAF TMNSIVQLDT MEDVPRHSFT IGSEIQVIAP
310 320 330 340 350
STAVQANGHL NLKQRLLYAF YGKQAVSEPN YIYHSAYVDC TSCGKGSWLT
360 370 380 390 400
GNAVQGFACD CGAHYCANDV DLQSSGLVRK NAVLLTTCPC NKDGECKHTL
410 420 430 440 450
PQLVSMMTDK CDVEVVGKTF ILTYGGVIYA YMGCSGGTMH FIPRAKSCVS
460 470 480 490 500
KIGDAIFTGC TGTWSKVCET ANLFLERAQH AINFVNEFVL TETVVALLSG
510 520 530 540 550
TTSSIEELRD LCRNATFEKV RDYLTPRGWI VTMGSYIEGV INVGAAGVCN
560 570 580 590 600
AALNAPFIVL SGLGESFKKV AATPWKLCSS LRETLDHYAD SITYRVFPYD
610 620 630 640 650
IPCDVTDYTA LLLDCAVLTG ASAYFVARYV DEKVEQLTNL VFSSCQSAVA
660 670 680 690 700
AFVQACMSTY KATAKFISDM FTLIKVVSER LYVYTSVGFV VVGDYSSQLL
710 720 730 740 750
KQFMHILSKA MQLLHTTVSW AGSKLPSVVY NGRDSLVFPS GTYYCVSTQG
760 770 780 790 800
RSLQDQFDLV IPGDLSKKQI GILEPTPNST TVDKKINTNV VEVVVGQLEP
810 820 830 840 850
TKEHSPELVV GDYVIISNKI FVRSVEDSET VFYPLCTDGK IVPTLFRLKG
860 870 880 890 900
GAPPKGVKFG GEQTKEITAV RSVSVDYDVH PVLDALLAGS ELATFTVEKD
910 920 930 940 950
LPVKDFVDVV KDEVIELLSK LLRGYNVDGF DLEDFADTPC YVYNAEGDLA
960 970 980 990 1000
WSSTMTFSVN PVEEVEEECD DDYVEDEYLS EEMLVEEDEN SWAAAVEAVI
1010 1020 1030 1040 1050
PMEDVQLDTL VAEIDVSEPA DDVAEQASTE EVEVPSACVL EASQVANAAE
1060 1070 1080 1090 1100
VESCEAEVSS SIPLHEDANA AKANDCAEGM PALDSTETVS KLSVDTPVGD
1110 1120 1130 1140 1150
VTQDDATSSN ATVISEDVHT ATHSKGLVAV PEVVPEKALG TSVERMRSTS
1160 1170 1180 1190 1200
EWTVVETSLK QETAVIVKND SSAKPQRVKK PKAENPLKNF KHIVLNNDVT
1210 1220 1230 1240 1250
LVFGDAIAVA RATEDCILVN AANTHLKHGG GIAAAIDRAS GGLVQAESDD
1260 1270 1280 1290 1300
YVNFYGPLNV GDSTLLKGHG LATGILHVVG PDARANQDIQ LLKRCYKAFN
1310 1320 1330 1340 1350
KYPLVVSPLI SAGIFCVEPR VSLEYLLSVV HTKTYVVVNS EKVYNDLAAP
1360 1370 1380 1390 1400
KPPTGLTYSH EGWRGIIRNA KSFGFTCFIC TDQSANAKLL KGRGVDLTKK
1410 1420 1430 1440 1450
TQTVDGVKYY LYSSKDPLTD IITAANACKG ICAMPIGYVT HGLDLAQAGQ
1460 1470 1480 1490 1500
QVKKITVPYV CLLASKDQVP ILNSDVAVQT PEQSFINTVI ANGGYHCWHL
1510 1520 1530 1540 1550
VTGELIVKGV SYRKLLNWSD QTICYADNKF YVVKGQIALP FDSLEKCRTY
1560 1570 1580 1590 1600
LTSRAAQQKN VDVLVTIDGV NFRTVVLNNT TTYRVQLGSV FYKGSDISDT
1610 1620 1630 1640 1650
IPTEKMSGEA VYLADNLSEA EKAVLSEVYG TADTAFLHRY YSLLALVKKW
1660 1670 1680 1690 1700
KYTVHDGVKS LKLNSNNCYV NVTMLMLDML KEIKFIVPAL QAAYLKHKGG
1710 1720 1730 1740 1750
DSTEFIALIM AYGDCTYGEP DDASRLLHTI LSKAELTTQA KMVWRQWCNV
1760 1770 1780 1790 1800
CGVQDTTTTG LKACIYVGMN SLDELHATHE ECCQCGDVRK RQLVEHNAPW
1810 1820 1830 1840 1850
LLLSGLNEAK VMTPTSQSAG PDYTAFNVFQ GVETSVGHYL HVRVKDNLLY
1860 1870 1880 1890 1900
KYDSGSLSKT SDMKCKMTDV YYPKQRYSAD CNVVVYSLDG NTWADVDPDL
1910 1920 1930 1940 1950
SAFYMKDGKY FTKKPVIEYS PATILSGSVY TNSCLVGHDG TIGSDAISSS
1960 1970 1980 1990 2000
FNNLLGFDNS KPVSKKLTYS FFPDFEGDVI LTEYSTYDPI YKNGAMLHGK
2010 2020 2030 2040 2050
PILWVNNSKF DSALNKFNRA TLRQVYDIAP VTLENKYTVL QDNQIQQVEV
2060 2070 2080 2090 2100
EAPKEDAKPQ SPVQVAEDID NKLPIIKCKG LKKPFVKDGY SFVNDPQGVN
2110 2120 2130 2140 2150
VIDTLGIDDL RALYVDRNLR LIVLKENNWS ALFNIHTVEK GDLSVIAASG
2160 2170 2180 2190 2200
SITRRVKILL GASSLFAQFA SVTVNVTTAM GKALGRMTRN VITNTGIIGQ
2210 2220 2230 2240 2250
GFALLKMLLI LPFTFWKSKN QSTVKVEVGA LRTAGIVTTN VVKQCASAAY
2260 2270 2280 2290 2300
DVLVVKFKRI DWKSTLRLLF LICTTGLLLS SLYYLFLFHQ VLTSDVMLDG
2310 2320 2330 2340 2350
AEGMLATYRE LRSYLGIHSL CDGMVEAYRN VSYDVNDFCS NRSALCNWCL
2360 2370 2380 2390 2400
IGQDSLTRYS AFQMIQTHVT SYVINIDWVW FVMEFALAYV LYTSTFNVLL
2410 2420 2430 2440 2450
LVVSSQYFFS YTGAFVNWRS YNYLVSGYFF CVTHIPLLGL VRIYNFLACL
2460 2470 2480 2490 2500
WFLRRFYNHV INGCKDTACL LCYKRNRLTR VEASTVVCGS KRTFYIVANG
2510 2520 2530 2540 2550
GTSFCCRHNW NCVDCDTAGI GNTFICEEVA NDLTTSLRRL VKPTDKSHYY
2560 2570 2580 2590 2600
VESVTVKDSV VQLHYSREGA SCYERYPLCY FTNLDKLKFK EVCKTPTGIP
2610 2620 2630 2640 2650
EHNFLIYDSS DRGQENLARS ACVYYSQVLS KPMLLVDSNM VTTVGDSREI
2660 2670 2680 2690 2700
ASKMLDSYVN SFISLFGVNR DKLDKLVATA RDCVKRGDDF QTVIKTFTDA
2710 2720 2730 2740 2750
ARGPAGVESD VETSSIVDAL QYAYKHDLQL TTEGFNNYVP SYIKPDSVAT
2760 2770 2780 2790 2800
ADLGCLIDLN AASVNQTSIR NANGACIWNS SDYMKLSDSL KRQIRIACRK
2810 2820 2830 2840 2850
CNIPFRLTTS RLRSADNILS VKFSATKLSG GAPKWLLKLR DFTWKSYCVV
2860 2870 2880 2890 2900
TLVVFAMAVL SYLCLPAFNM SQVSFHEDRI LTYKVVENGI IRDITPSDTC
2910 2920 2930 2940 2950
FANKYQSFSK WFNEHYGGLF NNDISCPVTV AVIAGVAGAR VPNLPANVAW
2960 2970 2980 2990 3000
VGRQIVLFVS RVFASSNNVC YTPTAEIPYE RFSDSGCVLA SECTLFRDAE
3010 3020 3030 3040 3050
GKINPYCYDP TVLPGASAYD QMKPHVRYDM YDSDMYIKFP EVVFESTLRI
3060 3070 3080 3090 3100
TKTLATRYCR FGSCEDANEG VCITTNGSWA IYNDHYANKP GVYCGDNYFD
3110 3120 3130 3140 3150
IVRRLGLSLF QPVTYFQLST SLALGVMLCI FLTIAFYYVN KVKRALADYT
3160 3170 3180 3190 3200
QCAVVAVAAA LLNSLCLCFV VSNPLLVLPY TALYYYATFY LTGEPAFVMH
3210 3220 3230 3240 3250
VSWFVMFGTV VPIWMVFAYI VGVCLRHLLW VMAYFSKKHV EVFTDGKLNC
3260 3270 3280 3290 3300
SFQDAAANIF VINKDTYVAL RNSITQDSYN RYLSMFNKYK YYSGAMDTAS
3310 3320 3330 3340 3350
YREASAAHLC KALQVYSETG SDVLFQPPNC SVTSSVLQSG LVKMAAPSGV
3360 3370 3380 3390 3400
VENCMVQVTC GSMTLNGLWL DNYVWCPRHV MCPADQLSDP NYDALLVSKT
3410 3420 3430 3440 3450
NLSFIVQKNV GAPANLRVVG HTMVGTLLKL TVESANPQTP AYTFTTVKPG
3460 3470 3480 3490 3500
ASFSVLACYN GRPTGVFMVN MRQNSTIKGS FLCGSCGSVG YTQEGNVINF
3510 3520 3530 3540 3550
CYMHQMELSN GTHTGCAFDG VMYGAFEDRQ VHQVQLSDKY CTINIVAWLY
3560 3570 3580 3590 3600
AAILNGCNWF VKPNKTGIAT FNEWAMSNQF TEFIGTQSVD MLAHKTGVSV
3610 3620 3630 3640 3650
EQLLYAIQTL HKGFQGKTIL GNSMLEDEFT PDDVNMQVMG VVMQSGVKRI
3660 3670 3680 3690 3700
SYGLVHWLFT TLLLAYVATL QLTKFTIWNY LFEVIPLQLT PLVLCVMACV
3710 3720 3730 3740 3750
MLTVKHKHTF LTLFLLPTAI CLTYANIVYE PQTPVSSALI AVANWLNPAS
3760 3770 3780 3790 3800
VYMRTTHTDL GVYLSLCFAL AVVVRRLYRP NASNLALALG SAMVWFYTYT
3810 3820 3830 3840 3850
TGDCSSPLTY LMFLTTLTSD YTVTVFLAVN VAKFFARVVF LYAPHAGFIF
3860 3870 3880 3890 3900
PEVKLVLLMY LAVGYFCTVY FGVFSLLNLK LRVPLGVYDY TVSTQEFRYL
3910 3920 3930 3940 3950
TGNGLHAPRN SWEALRLNMK LIGIGGTPCI KIASVQSKLT DLKCTSVVLL
3960 3970 3980 3990 4000
SVLQQLHLEA NSKAWAHCVK LHNDILAATD PTEAFDNFVC LFATLMSFSA
4010 4020 4030 4040 4050
NVDLEALASD LLDHPSVLQA TLSEFSHLAS YAELEAAQSS YQKALNSGDA
4060 4070 4080 4090 4100
SPQVLKALQK AVNIAKNAYE KDKAVARKLE RMAEQAMTSM YKQARAEDKK
4110 4120 4130 4140 4150
AKIVSAMQTM LFGMIKKLDN DVLNGVISNA RNGCVPLSVV PLCASNKLRV
4160 4170 4180 4190 4200
VIPDITIWNK VVTWPSLSYA GALWDISLIN NVDGEVVKSS DVTETNESLT
4210 4220 4230 4240 4250
WPLVLECTRA ASSAVTLQNN EIRPSGLKTM VVSAGIDHAN CNTSSLAYYE
4260 4270 4280 4290 4300
PVEGRKMLMG ILSENAHLKW AKVEGRDGFV NIELQPPCKF LIAGPKGPEV
4310 4320 4330 4340 4350
RYLYFVKNLN NLHRGQLLGH IAATVRLQAG SNTEFAINSS VLSAVTFSVD
4360 4370 4380 4390 4400
PGKAYLDFVN AGGAPLTNCV KMLTPKTGTG IAVSVKPEAN ADQDTYGGAS
4410 4420 4430 4440 4450
VCLYCRAHIE HPDVTGVCKF KGKFVQVPLH IRDPVGFCLQ NTPCNVCQFW
4460 4470 4480 4490 4500
IGHGCNCDAL RGTTIPQSKD SNFLNRVRGS IVNARIEPCA SGLTTDVVFR
4510 4520 4530 4540 4550
AFDICNYKAK VAGIGKYYKT NTCRFVEVDD EGHRLDSFFV VKRHTMENYE
4560 4570 4580 4590 4600
LEKRCYDLVK DCDAVAVHDF FIFDVDKVKT PHIVRQRLTE YTMMDLVYAL
4610 4620 4630 4640 4650
RHFDQNNCEV LKSILVKYGC CDASYFDNKL WFDFVENPNV ISVYHKLGER
4660 4670 4680 4690 4700
IRQAVLNTVK FCDQMVKSGL VGVLTLDNQD LNGKWYDFGD FVITQPGAGV
4710 4720 4730 4740 4750
AIVDSYYSYL MPVLSMTNCL AAETHRDCDL TKPLIEWPLL EYDYTDYKIG
4760 4770 4780 4790 4800
LFEKYFKXWD QQYHPNCVNC TDDRCVLHCA NFNVLFSMTL PGTSFGPIVR
4810 4820 4830 4840 4850
KIFVDGVPFV ISCGYHYKEL GLVMNMDVSL HRHRLSLKEL MMYAADPAMH
4860 4870 4880 4890 4900
IASASALWDL RTPCFSVAAL TTGLTFQTVR PGNFNKDFYD FVVSKGFFKE
4910 4920 4930 4940 4950
GSSVTLRHFF FAQDGHAAIT DYSYYAYNLP TMCDIKQMLF CMEVVDRYFE
4960 4970 4980 4990 5000
IYDGGCLNAS EVIVNNLDKS AGHPFNKFGK ARVYYESLSY QEQDELFAMT
5010 5020 5030 5040 5050
KRNVLPTITQ MNLKYAISAK NRARTVAGVS ILSTMTNRQY HQKMLKSMAA
5060 5070 5080 5090 5100
TRGSTCVIGT TKFYGGWDFM LKTLYKDVDN PHLMGWDYPK CDRAMPNMCR
5110 5120 5130 5140 5150
IFASLILARK HSTCCTNTDR FYRLANECAQ VLSEYVLCGG GYYVKPGGTS
5160 5170 5180 5190 5200
SGDATTAYAN SVFNILQATT ANVSALMGAN GNTIVDEEVK DMQFELYVNV
5210 5220 5230 5240 5250
YRKSQPDPKF VDRYYAFLNK HFSMMILSDD GVVCYNSDYA TKGYIASIQN
5260 5270 5280 5290 5300
FKETLYYQNN VFMSEAKCWV ETDLKKGPHE FCSQHTLFIK DGDDGYFLPY
5310 5320 5330 5340 5350
PDPSRILSAG CFVDDIVKTD GTLMVERFVS LAIDAYPLTK HDDPEYQNVF
5360 5370 5380 5390 5400
WVYLQYIEKL YKDLTGHMLD SYSVMLCGDN SAKFWEESFY RDLYTAPTTL
5410 5420 5430 5440 5450
QAVGSCVVCH SQTSLRCGTC IRRPFLCCKC CYDHVIATPH KMVLSVSPYV
5460 5470 5480 5490 5500
CNAPGCDVAD VTKLYLGGMS YFCIDHRPVC SFPLCANGLV FGLYKNMCTG
5510 5520 5530 5540 5550
SPSVTEFNRL ATCDWTESGD YTLANTTTEP LKLFAAETLR ATEEASKQSY
5560 5570 5580 5590 5600
AIATIKEIVG ERELLLVWEA GKAKPPLNRN YVFTGYHITK NSKVQLGEYV
5610 5620 5630 5640 5650
FERIDYSDAV SYKSSTTYKL AVGDIFVLTS HSVATLQAPT IVNQERYVKI
5660 5670 5680 5690 5700
TGLYPTLTVP EEFANHVANF QKAGFSKFVT VQGPPGTGKS HFAIGLAIYY
5710 5720 5730 5740 5750
PTARVVYTAC SHAAVDALCE KAFKYLNIAK CSRIIPAKAR VECYDQFKVN
5760 5770 5780 5790 5800
ETNSQYLFST INALPETSAD ILVVDEVSMC TNYDLSVINA RIKAKHIVYV
5810 5820 5830 5840 5850
GDPAQLPAPR TLLTRGTLEP ENFNSVTRLM CNLGPDIFLS VCYRCPEEIV
5860 5870 5880 5890 5900
NTVSALVYNN KLVAKKPASG QCFKILYKGS VTHDASSAIN RPQLNFVKSF
5910 5920 5930 5940 5950
IAANPNWSKA VFISPYNSQN AVARSVLGLT TQTVDSSQGS EYPYVIFCQT
5960 5970 5980 5990 6000
ADTAHANNIN RFNVAVTRAQ KGILCVMTSQ ALFDSLEFAE VSLNNYKLQS
6010 6020 6030 6040 6050
QIVTGLYKDC SRESSGLHPA YAPTYVSVDD KYKTSDELCV NLNVPANVPY
6060 6070 6080 6090 6100
SRVISRMGFK LDASIPNYPK LFITRDEAIR QVRSWIGFDV EGAHASRNAC
6110 6120 6130 6140 6150
GTNVPLQLGF STGVNFVVQP VGVVDTEWGS MLTSIAARPP PGEQFKHLVP
6160 6170 6180 6190 6200
LMNKGAAWPI VRRRIVQMLS DTLDKLSDYC TFVCWAHGFE LTSASYFCKI
6210 6220 6230 6240 6250
GKEQRCCMCN RRASTYSSPL HSYACWSHSS GYDYVYNPFF VDVQQWGYIG
6260 6270 6280 6290 6300
NLATNHDRYC SVHQGAHVAS NDAVMTRCLA IHDCFIERVE WDITYPYISH
6310 6320 6330 6340 6350
EKRLNSCCRA VERNVVRAAL LAGRFERVYD IGNPKGIPIV DDPVVDWHYY
6360 6370 6380 6390 6400
DAQPLSKKVQ QLFYTEDCAK NFSDGLCLFW NCNVPRYPNN AIVCRFDTRV
6410 6420 6430 6440 6450
HSEFNLPGCD GGSLYVNKHA FHTPAYDASA FRDLKPLPFF YYSTTPCEVH
6460 6470 6480 6490 6500
GNGNMLEDID YVPLKSAVCI TACNLGGAVC RKHAAEYRDY MEAYNLVSAS
6510 6520 6530 6540 6550
GFRLWCYKTF DVYNLWSTFT KIQGLENIAY NVIKQGHFTG VEGELPVAVV
6560 6570 6580 6590 6600
NDKIYTKSDV NDVCIFENKT TLPTNIAFEL YAKRAVRSHP DFNLLRNLEV
6610 6620 6630 6640 6650
DVCYKFVLWD YERSNIYGSA TIGVCKYTDI DVNSALNICF DIRDNGSLER
6660 6670 6680 6690 6700
FMSLPNGILI SDRKVKNYPC IVSSNYAYFN GTLIRDNTGN SQSSDGEVKQ
6710 6720 6730 6740 6750
PVTFYIYKKV NNEFVQFTDT YYTLGRTVSD FTPVSEMEKD FLALDSDVFI
6760 6770 6780 6790 6800
KKYKLEAYAF EHVVYGDFSR TTLGGLHLLI GLYKKHQEGH IIMEEMLKER
6810 6820 6830 6840 6850
ATVHNYFVTE SNTASFKAVC SVIDLKLDDF VDIIKAMDLS VVSKVVKIPI
6860 6870 6880 6890 6900
DLTMIEFMLW CKDGQVQTFY PRLQAINDWK PGLAMPSLFK VQNSNLEPCM
6910 6920 6930 6940 6950
LPNYKQSIPM PQGVHMNIAK YMQLCQYLNT CTIAVPANMR VMHFGAGSDK
6960 6970 6980 6990 7000
GVAPGSSVLR QWLPTDAILI DNDLNEYVSD ADITLFGDCV TVRVGQQVDL
7010 7020 7030 7040 7050
LISDMYDPST KVVGETNEAK ALFFVYLCNF IKNNLALGGS VAIKITEHSW
7060 7070 7080 7090 7100
SAELYELMGR FAWWTVFCTN ANASSSEGFL IGINYLGELK EVIDGNVMHA
7110 7120 7130 7140 7150
NYIFWRNTTL MNLSTYSLFD LSRFPLKLKG TPVLQLKESQ INELVISLLS
7160 7170 7180
QGKLIIRDND TLSVSTDVLV NFYRKPHKRS KC
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:7,182
Mass (Da):799,932
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i455E36D8EF6FD1E1
GO
Isoform Replicase polyprotein 1a (identifier: P0C6T5-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein
The sequence of this isoform can be found in the external entry P0C6T5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:4,481
Mass (Da):494,801
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF065509 Genomic RNA Translation: ABN10874.1

NCBI Reference Sequences

More...
RefSeqi
YP_001039961.1, NC_009020.1 [P0C6W4-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4836003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:4836003

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF065509 Genomic RNA Translation: ABN10874.1
RefSeqiYP_001039961.1, NC_009020.1 [P0C6W4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein family/group databases

MEROPSiC16.011

Proteomic databases

PRIDEiP0C6W4

Genome annotation databases

GeneIDi4836003
KEGGivg:4836003

Phylogenomic databases

OrthoDBi20at10239

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.40.220.20, 1 hit
3.40.50.11020, 1 hit
InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR041679 DNA2/NAM7-like_AAA
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR032592 NAR_dom
IPR042570 NAR_sf
IPR036333 NSP10_sf
IPR009466 NSP11
IPR042515 Nsp15_N
IPR024375 Nsp3_coronavir
IPR038400 Nsp3_coronavir_sf
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR038083 R1a/1ab
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease
PfamiView protein in Pfam
PF13087 AAA_12, 1 hit
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF16251 NAR, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF00680 RdRP_1, 1 hit
PF11633 SUD-M, 1 hit
PF08715 Viral_protease, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SUPFAMiSSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF159936 SSF159936, 1 hit
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_BCHK5
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C6W4
Secondary accession number(s): A3EXC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 11, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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